CN108671002A - A kind of composition of the extract containing Saussurea involucrata culture and its application - Google Patents
A kind of composition of the extract containing Saussurea involucrata culture and its application Download PDFInfo
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- CN108671002A CN108671002A CN201810548560.9A CN201810548560A CN108671002A CN 108671002 A CN108671002 A CN 108671002A CN 201810548560 A CN201810548560 A CN 201810548560A CN 108671002 A CN108671002 A CN 108671002A
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- Prior art keywords
- saussurea involucrata
- involucrata culture
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- extract
- composition
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Classifications
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of composition of extract containing Saussurea involucrata culture and its application, the composition of the extract containing Saussurea involucrata culture includes by weight：10~150 parts of 10~200 parts of Saussurea involucrata culture extract, 10~150 parts of Cordyceps militaris powder and notogenseng pollen.The invention also discloses the compositions of the extract containing Saussurea involucrata culture to prepare the application in preventing or treating the drug, health food, food of cardiovascular and cerebrovascular disease.The present invention discloses the Saussurea involucrata culture extracts in composition to be made using the extraction concentration of microwave negative pressure.The composition of the extract provided by the invention containing Saussurea involucrata culture has at distinguishing one from the other, clear efficacy, stable quality, the exclusive advantage of safety and environmental protection, and dosage form is for portable for eating, and preparation process is easy to operate, is suitable for industrialized production.
Description
Technical field
The present invention relates to a kind of food and preparation method thereof, more particularly to the composition of a kind of extract containing Saussurea involucrata culture
And its application.
Background technology
With the improvement of people ' s living standards and self nutrition and health care consciousness enhancing, diet nutritional supplement, health care
Food products market demand increases.Diet nutritional supplement currently on the market, health products type is various, and quality is irregular, production
The nutrition of product, health-care effect are indefinite." advocate natural, back to nature ", seek safely, effectively, trust, the health production of environmental protection
Product have become pursuit of the modern to quality life.
The natural herb medicinal plant product market share increases increasingly, and the sustainable supply of raw material has become major product
Board focus of attention；The introducing of modern biological project plant cell culture technology, rare draft medicinal plant from genetic superiority
It is converted into product advantage, reliable guarantee is provided for the sustainable supply of raw material, also more highlights draft medicinal plant
At distinguishing one from the other, clear efficacy, stable quality, the exclusive advantage of safety and environmental protection；Cell culture technology research and development are based oneself upon, are realized
The industrialization of rare and endangered medicinal plants reserve, preserves the ecological environment, maintaining ecological balance.
Saussurea involucrata culture is the best wild Herba Saussureae Involueratae introduces a collection of selection, with cell culture technology, in the training strictly controlled
Under the conditions of supporting, saussurea involucrata cell is made to obtain best living environment and sufficient nutrition, while passing through thousands of screenings, cultures,
High-quality, the high yield cell products obtained.Compared with wild Herba Saussureae Involueratae, ligustrin, chlorogenic acid, 1,5- bis- in Saussurea involucrata culture
Caffeoyl guinic acid content is the 6.15 of wild Herba Saussureae Involueratae, 3.83,16.3 times respectively；Saussurea involucrata culture chlorogenic acid and its derivative
Object amount is more abundant, accounts for 3.70% or more dry weight；Saussurea involucrata culture total polyphenols and general flavone content are 7.01% and 14.5%, are
6-7 times of wild Herba Saussureae Involueratae herb, bioavailability are 30 times of wild Herba Saussureae Involueratae.Ministry of Health of China is formal in 2010
Approval Saussurea involucrata culture is new resource food, is Chinese unique granted Medicinal Plant Cell class new resource food, can be used for general
The exploitation and production of logical food.Herba Saussureae Involueratae culture can supplement nutritional ingredient needed by human, moreover it is possible to powerful by its
Physiological hygiene function point analysis sub-health population, and appeal point is various, and applicable consumer is huge, especially to women population, makes
Herba Saussureae Involueratae culture will become the new development trend of functional food.
Contain a large amount of cordycepin in Cordyceps militaris, the special medical healthcare function of cordycepin has caused domestic and international expert's
Pay much attention to, has much launch such as the health products based on cordycepin, health food, cosmetics, drug.In China
The new drug of the treatment leukaemia synthesized by cordycepin is entered into phase clinic trial.The healthcare function ingredient of Cordyceps militaris not only has worm
Careless element.Cordyceps sinensis polysaccharide is the generally acknowledged human immunity reinforcing agent of International Medical, to chronic senile bronchitis, cor pulmonale
There is significant curative effect, liver detoxification ability can be improved, play liver protection effect, improves that body is antiviral and capability of resistance to radiation.Cordycepic acid has
Play the role of removing free radical, expansion blood vessel, reduce blood pressure.Studies have shown that the fruiting bodies of cordyceps militaris of artificial culture is to pacify completely
Complete, it can be widely used in functional food, nutritious food and other nourishing based foods.
Sanchi flower, is the highest part of notoginsenoside content in Radix Notoginseng complete stool, and nature and flavor sweet and cool-natured has heat-clearing, soothing the liver, decompression
The effect of, it is suitable for the diseases such as dizzy, dizzy, tinnitus, hypertension and acute laryngopharyngitis, can separately make tea, fry meat, Baoshang etc., pacifying
Also there is certain effect in terms of dormancy.Health State Family Planning Commission of Yunnan Province formally gives an written reply agreement using sanchi flower as common special local food
Raw material is managed, while having been turned on the project verification of sanchi flower food security provincial standard, promotes sanchi flower for the general of raw material by strong
Logical food development and its industry development.
Saussurea involucrata, Radix Notoginseng are traditional rare traditional Chinese medicine, and Cordyceps militaris is also gradually public institute as the substitute of cordyceps sinensis
It is known.Because of its particularity, product mostly compounds simple auxiliary material with folk prescription on the market, or directly boiling is edible, it is difficult to play different medicines
Synergistic effect between material.
Invention content
The first purpose of the invention is to provide a kind of compositions of extract containing Saussurea involucrata culture.
Second object of the present invention is to provide preparation made of the composition of the extract containing Saussurea involucrata culture.
Third object of the present invention is to provide the applications of the composition of the extract containing Saussurea involucrata culture.
To achieve the above object, technical scheme is as follows：
A kind of composition of the extract containing Saussurea involucrata culture includes by weight：Saussurea involucrata culture extract 10~200
10~150 parts of part, 10~150 parts of Cordyceps militaris powder and notogenseng pollen.
Preferably, the composition of the extract containing Saussurea involucrata culture includes by weight：Saussurea involucrata culture extract 10
50~150 parts of~100 parts, 50~150 parts of Cordyceps militaris powder and notogenseng pollen.
Preferably, the Saussurea involucrata culture extract is prepared by following methods：
It takes Saussurea involucrata culture, is added 60~95wt% ethyl alcohol, the volume ratio of Saussurea involucrata culture and ethyl alcohol is 1:(10~20),
Microwave negative pressure extract, extract 0.15~0.25MPa of pressure, temperature be 60~80 DEG C, at 100~500W extraction time 1~
10min, continuously extract 2~3 times, gained liquid to be concentrated under reduced pressure into concentrate,
Concentrate is dried through two sections of tempering formulas：Infrared-hot wind combination drying technology to moisture is less than in one section of dry use
30wt%, to after external diffusion, two sections are continued dry to be less than to moisture hygroscopic water using microwave intermittently drying technologies inside the transition region
10wt% obtains the Saussurea involucrata culture extract.
Further, in a preferred embodiment of the present invention, the wave-length coverage of infrared in-hot wind combination drying is 3~40 μm,
Temperature is 60~90 DEG C, and the microwave output power of microwave intermittently drying is 700~800W, and the intermittent time is than 10%~30%.
Preparation made of the composition of the extract containing Saussurea involucrata culture, including described extracts containing Saussurea involucrata culture
The composition of object and pharmaceutically acceptable auxiliary material.
The preparation is tablet, granule, capsule or oral solution, preferably tablet.
The tablet includes by weight：10~200 parts of Saussurea involucrata culture extract, 10~150 parts of Cordyceps militaris powder, Radix Notoginseng
1~15 part of 10~150 parts of pollen, 100~400 parts of sweetener class, 0~250 part of microcrystalline cellulose and magnesium stearate.
Preferably, the tablet includes by weight：10~100 parts of Saussurea involucrata culture extract, Cordyceps militaris powder 50~150
Part, 50~150 parts of notogenseng pollen, 150~400 parts of sweetener class, 100~250 parts of microcrystalline cellulose and magnesium stearate 1~15
Part.
The sweetener class is glucose, sucrose, D-mannital, D-sorbite, xylitol, arabinose, lactose, sweet tea
One or more of synanthrin glycosides, Sucralose.
The preparation method of the tablet is：Including by the parts by weight weigh Saussurea involucrata culture extract, Cordyceps militaris powder,
Notogenseng pollen, sweetener class, microcrystalline cellulose and magnesium stearate are made through mixing, tabletting.
Preferably, the preparation method of the tablet includes the following steps：
(1) it weighs：Saussurea involucrata culture extract, Cordyceps militaris powder, notogenseng pollen, sweetener are weighed by the parts by weight
Class, microcrystalline cellulose and magnesium stearate；
(2) it mixes：Saussurea involucrata culture extract is uniformly mixed with sweetener class, then with Cordyceps militaris powder, notogenseng pollen,
Microcrystalline cellulose mixes, and adds magnesium stearate, continues to mix, obtains total mixed powder；
(3) tabletting：By tablet press machine load a die tabletting to get.
The composition of the extract containing Saussurea involucrata culture is preparing the drug for preventing or treating cardiovascular and cerebrovascular disease, is protecting
Application in strong product or food.The composition of the extract containing Saussurea involucrata culture, which can increase, to be eliminated blood stasis, promotes haemocyte newly old
Metabolism, strengthen immunity.Preferably, the cardiovascular and cerebrovascular disease is hypertension, cerebral thrombus.
Chinese medicine mechanism：
Lanatechead saussurea herb with flower is warm-natured, sweet-bitter flavor, enters the warp of liver,spleen,kidney three, tool is except cold, establishing-Yang, menstruation regulating, hemostasis work(.《Compendium of Materia Medica
It picks up any lost article from the road》It carries：" nature and flavor：Hardship, slight bitter, temperature；Major function：Clearing heat and detoxicating, wind-damp dispelling, detumescence, analgesic ".Saussurea involucrata rich in protein,
Amino acid, flavone compound, alkaloid etc. have clearing and activating the channels and collaterals, dispelling cold and removing dampness, hemostasia and detumescence, exclusion endotoxin and other effects.
Cordyceps militaris contains cordycepin, cordycepic acid, Cordyceps sinensis polysaccharide and cordyceps sinensis SOD, and cordycepic acid can significantly reduce cranium pressure, promotes body new old generation
It thanks, alleviates cerebral hemorrhage and cerebral thrombosis disease；Cordycepin has antiviral, antibacterial, antineoplastic action.Sanchi flower, matter is crisp frangible,
Gas is micro-, sweet and slightly bitter taste, has the function of platelet aggregation-against, improves myocardial oxygen delivery ability, while can promote multipotency Hematopoietic Stem
The proliferation of cell, enhancing body's immunity,《A Supplement to the Compendium of Materia Medica》In have speech：" ginseng qi-tonifying first, Radix Notoginseng enrich blood first,
For the most precious person of Chinese medicine ".The present invention integrates the effect of sanchi flower and Cordyceps militaris cooling blood and relieving pain, while promoting body new old generation
It thanks, enhance body's immunity, then be subject to that lanatechead saussurea herb with flower is warming channel and expelling cold, nourishment for vitality, the effect of to reach eliminating evil, righting, solid member,
Especially there is good effect to cardiovascular and cerebrovascular disease crowd.
Advantageous effect：Compared with the existing technology, the present invention has the following advantages：
1, it is raw material that the present invention, which selects traditional Chinese medicine Herba Saussureae Involueratae, made of Cordyceps militaris, notogenseng pollen reasonable formula
Diet nutritional supplements series food, and rare draft medicinal plant is converted into product advantage from genetic superiority, has at distinguishing one from the other,
Clear efficacy, stable quality, the exclusive advantage of safety and environmental protection, dosage form are for portable for eating, and are promoting human health, are improving
It will play an important role above quality of life, and have a vast market foreground.Product meets country and is provided about traditional Chinese medicine is reinforced
Source protection, research, exploitation and the industrial policy rationally utilized, preserve the ecological environment, and realize the sustainable confession of resources of medicinal plant
It answers, benefits the nation and the people.
2, the present invention is translated into masses using saussurea involucrata, Radix Notoginseng, three taste medicinal material of Cordyceps militaris by formula, technical study
Acceptable product form, is easy to carry about with one and daily supplement, makes up deficiency of the existing market to such product R ＆ D, plays
The ingredient advantage of traditional rare medicinal herbs.
3, preparation method provided by the invention is easy to operate, safety, production cost are low, environmentally protective, is suitable for industrial metaplasia
Production.
Specific implementation mode
The Saussurea involucrata culture used in following embodiment obtains for saussurea involucrata in vitro tissue through extensive squamous subculture, purchased from big
Lian Puruikang Bioisystech Co., Ltd.Other are not specified actual conditions person, according to normal condition or manufacturer suggest condition into
Row.Reagents or instruments used without specified manufacturer is the conventional products that can be obtained by commercially available purchase.
Embodiment 1
Prepare Saussurea involucrata culture extract：Saussurea involucrata culture is taken, 70wt% ethyl alcohol, the body of Saussurea involucrata culture and ethyl alcohol is added
Product is than being 1:20, pressure 0.20MPa is extracted in the extraction of microwave negative pressure, and temperature is 60 DEG C, the extraction time 5min at 360W, continuously
Extraction 2 times, gained liquid pressure-reducing is concentrated into concentrate.
Concentrate is dried through two sections of tempering formulas：Infrared-hot wind combination drying technology in one section of dry use, 20 μm of wavelength,
80 DEG C of dryings of hot wind to moisture is less than 20%, and for hygroscopic water to after external diffusion, two sections dry using microwave 750W intervals inside the transition region
Dry, the intermittent time than 10%, continues drying to moisture and is less than 5%, obtain the Saussurea involucrata culture extract.
A kind of tablet of the extract containing Saussurea involucrata culture, is made of the component of following parts by weight：Saussurea involucrata culture extract
10 parts of 10 parts, 150 parts of Cordyceps militaris powder, 150 parts of notogenseng pollen, 250 parts of D-sorbite, 170 parts of microcrystalline cellulose and magnesium stearate.
A kind of preparation method of the tablet of the extract containing Saussurea involucrata culture, it is characterised in that：Include the following steps：
1) it weighs：Each supplementary material is weighed by the parts by weight, and is carefully checked.
2) it mixes：Saussurea involucrata culture extract is uniformly mixed with part sweetener by equal increments method, mixing machine is put into,
With other supplementary materials (removing magnesium stearate) in being mixed in mixing machine 10 minutes, magnesium stearate is added, is mixed 3 minutes, is obtained and always mix
Close powder.
3) tabletting：Check the weight of total mixed powder.Tablet press machine is loaded a die tabletting, it should be every 30 minutes in production process
Claim primary piece weight, piece weight will increase number of weighing when unstable, and perform record.The slice, thin piece pressed should weed out its surface dust.
Embodiment 2
Prepare Saussurea involucrata culture extract：Saussurea involucrata culture is taken, 95wt% ethyl alcohol, the body of Saussurea involucrata culture and ethyl alcohol is added
Product is than being 1:10, pressure 0.20MPa is extracted in the extraction of microwave negative pressure, and temperature is 60 DEG C, the extraction time 3min at 360W, continuously
Extraction 2 times, gained liquid pressure-reducing is concentrated into concentrate.
Concentrate is dried through two sections of tempering formulas：Infrared-hot wind combination drying technology in one section of dry use, 25 μm of wavelength,
60 DEG C of dryings of hot wind to moisture is less than 20%, and for hygroscopic water to after external diffusion, two sections dry using microwave 700W intervals inside the transition region
Dry, the intermittent time than 20%, continues drying to moisture and is less than 5%, obtain the Saussurea involucrata culture extract.
A kind of tablet of the extract containing Saussurea involucrata culture, is made of the component of following parts by weight：Saussurea involucrata culture extract
20 parts, 80 parts of Cordyceps militaris powder, 80 parts of notogenseng pollen, 244 parts of D-sorbite, 170 parts of microcrystalline cellulose, 6 parts of magnesium stearate.
The preparation method is the same as that of Example 1.
Embodiment 3
Prepare Saussurea involucrata culture extract：Saussurea involucrata culture is taken, 60wt% ethyl alcohol, the body of Saussurea involucrata culture and ethyl alcohol is added
Product is than being 1:20, pressure 0.25MPa is extracted in the extraction of microwave negative pressure, and temperature is 60 DEG C, the extraction time 10min at 360W, continuously
Extraction 2 times, gained liquid pressure-reducing is concentrated into concentrate.
Concentrate is dried through two sections of tempering formulas：Infrared-hot wind combination drying technology in one section of dry use, 35 μm of wavelength,
85 DEG C of dryings of hot wind to moisture is less than 20%, and for hygroscopic water to after external diffusion, two sections dry using microwave 780W intervals inside the transition region
Dry, the intermittent time than 30%, continues drying to moisture and is less than 5%, obtain the Saussurea involucrata culture extract.
A kind of tablet of the extract containing Saussurea involucrata culture, is made of the active component of following parts by weight：Saussurea involucrata culture carries
Take 50 parts of object, 50 parts of Cordyceps militaris powder, 150 parts of notogenseng pollen.
Preparation method：Saussurea involucrata culture extract, Cordyceps militaris powder, notogenseng pollen are uniformly mixed, it is mixed that pharmaceutic adjuvant is added
Capsule is prepared into after conjunction.
Embodiment 4
Prepare Saussurea involucrata culture extract：Saussurea involucrata culture is taken, 70wt% ethyl alcohol, the body of Saussurea involucrata culture and ethyl alcohol is added
Product is than being 1:20, pressure 0.15MPa is extracted in the extraction of microwave negative pressure, and temperature is 60 DEG C, the extraction time 10min at 500W, continuously
Extraction 2 times, gained liquid pressure-reducing is concentrated into concentrate.
Concentrate is dried through two sections of tempering formulas：Infrared-hot wind combination drying technology in one section of dry use, 3 μm of wavelength, heat
60 DEG C of dryings of wind to moisture is less than 20%, and for hygroscopic water to after external diffusion, two sections use microwave 700W intermittently dryings inside the transition region,
Intermittent time than 10%, continues drying to moisture and is less than 5%, obtain the Saussurea involucrata culture extract.
A kind of tablet of the extract containing Saussurea involucrata culture, is made of the active component of following parts by weight：Saussurea involucrata culture carries
Take 100 parts of object, 150 parts of Cordyceps militaris powder, 50 parts of notogenseng pollen.
Preparation method：Saussurea involucrata culture extract, Cordyceps militaris powder, notogenseng pollen are uniformly mixed, it is mixed that pharmaceutic adjuvant is added
Granule is prepared into after conjunction.
Embodiment 5
Prepare Saussurea involucrata culture extract：Saussurea involucrata culture is taken, 70wt% ethyl alcohol, the body of Saussurea involucrata culture and ethyl alcohol is added
Product is than being 1:20, pressure 0.15MPa is extracted in the extraction of microwave negative pressure, and temperature is 80 DEG C, the extraction time 1min at 100W, continuously
Extraction 3 times, gained liquid pressure-reducing is concentrated into concentrate.
Concentrate is dried through two sections of tempering formulas：Infrared-hot wind combination drying technology in one section of dry use, 40 μm of wavelength,
90 DEG C of dryings of hot wind to moisture is less than 20%, and for hygroscopic water to after external diffusion, two sections dry using microwave 800W intervals inside the transition region
Dry, the intermittent time than 30%, continues drying to moisture and is less than 5%, obtain the Saussurea involucrata culture extract.
A kind of tablet of the extract containing Saussurea involucrata culture, is made of the active component of following parts by weight：Saussurea involucrata culture carries
Take 50 parts of object, 50 parts of Cordyceps militaris powder, 50 parts of notogenseng pollen.
Preparation method：Saussurea involucrata culture extract, Cordyceps militaris powder, notogenseng pollen are uniformly mixed, it is mixed that pharmaceutic adjuvant is added
Oral solution is prepared into after conjunction.
Embodiment 6
Saussurea involucrata culture extract is prepared by preparation process in embodiment 1.
A kind of tablet of the extract containing Saussurea involucrata culture, is made of the active component of following parts by weight：Saussurea involucrata culture carries
Take 40 parts of object, 150 parts of Cordyceps militaris powder, 150 parts of notogenseng pollen.
Preparation method：Saussurea involucrata culture extract, Cordyceps militaris powder, notogenseng pollen are uniformly mixed, it is mixed that pharmaceutic adjuvant is added
Capsule is prepared into after conjunction.
7 present composition clinical test of embodiment
1, general information
800 hypertensive patients, the age, stochastic averagina was divided into eight groups between 30-60 Sui, respectively compareed 1 group, control
2 groups, control 3 groups, control 4 groups, control 5 groups, control 6 groups, 1 group of embodiment, 2 groups of embodiment, each group gender, age, course of disease etc.
It is statistically analyzed, no significant difference (P>0.05) it, is comparable.
All research objects are previously without other angiocardiopathies, serious liver and kidney dysfunction, diabetes, hepatitis, tuberculosis
Etc. communicable diseases.Clinical symptoms：Headache, dizzy, absent minded, failure of memory, extremity numbness, enuresis nocturna increase, the heart
Throb with fear, be uncomfortable in chest, is weak, vomiting, dizziness etc..Detect blood markers：Systolic pressure >=140mmHg, diastolic pressure >=90mmHg.
2, therapy
1. compareing 1 group, 2 groups of control, 3 groups of control, 4 groups of control, 5 groups of control, compareing 6 groups
Compare differing only in without Cordyceps militaris powder and Radix Notoginseng for the tablet that 1 group of composition tablet is prepared with embodiment 1
Pollen；Compare the tablet that 2 groups of composition tablet is prepared with embodiment 1 differ only in without Saussurea involucrata culture extract and
Notogenseng pollen；The composition tablet and differing only in for the tablet of the preparation of embodiment 1 for compareing 3 groups are extracted without Saussurea involucrata culture
Object and Cordyceps militaris powder；Compare differing only in without notogenseng pollen for the tablet of 4 groups of the preparation of composition tablet embodiment 1；It is right
The tablet prepared according to 5 groups of composition tablets and embodiment 1 is differed only in without Cordyceps militaris powder；Compare 6 groups of composition
The tablet that tablet is prepared with embodiment 1 is differed only in without Saussurea involucrata culture extract.
2. 2 groups of Example 1 and Example 2 of the present invention gained tablets of 1 group of embodiment and embodiment.
3. instructions of taking：To sufferer oral tablet, twice daily, three months as a treatment course, and the observation period is three months.
3, diagnostic criteria
Effectively：Blood pressure tends to be normal, and is discontinued after treatment in 3 months without rebound phenomenon；
It is effective：Hypertension becomes two level or level-one from three-level, and hypertension becomes level-one from two level；
In vain：Hypertension is not improved.
Side reaction：Headache, diarrhea, Nausea and vomiting, constipation, abdominal pain and abdominal distension, dizziness, drowsiness, weak, sleep disordered, sense
Feel the common adverse reactions such as abnormal.
4, treatment results
The total effective rate (%) that each group is treated eventually is investigated, the results are shown in Table 1.
Table 1
| Total (example) | (example) in vain | Effective (example) | Effectively (example) | Total effective rate | |
| Compare 1 group | 100 | 85 | 10 | 5 | 15% |
| Compare 2 groups | 100 | 61 | 20 | 19 | 39% |
| Compare 3 groups | 100 | 66 | 18 | 16 | 34% |
| Compare 4 groups | 100 | 52 | 23 | 25 | 48% |
| Compare 5 groups | 100 | 48 | 36 | 12 | 52% |
| Compare 6 groups | 100 | 24 | 48 | 28 | 76% |
| 1 group of embodiment | 100 | 2 | 38 | 60 | 98% |
| 2 groups of embodiment | 100 | 6 | 44 | 50 | 94% |
Note：Compared with the control group compared with * P<0.05.
By 1 result of upper table as it can be seen that compared with the control group compared with the embodiment of the present invention 1 and 2 is extract obtained, for hypertension
Treatment total effective rate significantly improve, it was demonstrated that it can effectively treat hypertension, significant effect, it was demonstrated that the present invention cultivates saussurea involucrata
Object extract, Cordyceps militaris and sanchi flower, which assemble, plays synergistic effect, achieves unexpected technique effect.
And over the course for the treatment of, each treatment group of the present invention occurs without side reaction.
Claims (10)
1. a kind of composition of extract containing Saussurea involucrata culture, which is characterized in that include by weight：Saussurea involucrata culture extract
10~150 parts of 10~200 parts, 10~150 parts of Cordyceps militaris powder and notogenseng pollen.
2. the composition of the extract according to claim 1 containing Saussurea involucrata culture, which is characterized in that include by weight：
50~150 parts of 10~100 parts of Saussurea involucrata culture extract, 50~150 parts of Cordyceps militaris powder and notogenseng pollen.
3. the composition according to claim 1 containing Saussurea involucrata culture, which is characterized in that the Saussurea involucrata culture extract
It is prepared by following methods：
It takes Saussurea involucrata culture, is added 60~95wt% ethyl alcohol, the volume ratio of Saussurea involucrata culture and ethyl alcohol is 1:(10~20), microwave
Negative pressure is extracted, and 0.15~0.25MPa of pressure is extracted, and temperature is 60~80 DEG C, 1~10min of extraction time at 100~500W,
Continuous extraction 2~3 times, gained liquid to be concentrated under reduced pressure into concentrate,
Concentrate is dried through two sections of tempering formulas：Infrared-hot wind combination drying technology to moisture is less than in one section of dry use
30wt%, to after external diffusion, two sections are continued dry to be less than to moisture hygroscopic water using microwave intermittently drying technologies inside the transition region
10wt% obtains the Saussurea involucrata culture extract.
4. preparation made of the composition of claim 1-3 any one of them extract containing Saussurea involucrata culture, which is characterized in that
Include the composition and pharmaceutically acceptable auxiliary material of the extract as claimed in claim 1 or 2 containing Saussurea involucrata culture.
5. preparation according to claim 4, which is characterized in that the preparation is tablet, granule, capsule or oral
Liquid.
6. preparation according to claim 5, which is characterized in that the tablet includes by weight：Saussurea involucrata culture extracts
10~200 parts of object, 10~150 parts of Cordyceps militaris powder, 10~150 parts of notogenseng pollen, 100~400 parts of sweetener class, microcrystalline cellulose
0~250 part and 1~15 part of magnesium stearate.
7. the preparation method of preparation described in claim 6, which is characterized in that the preparation method of the tablet includes pressing the weight
Number weighs Saussurea involucrata culture extract, Cordyceps militaris powder, notogenseng pollen, sweetener class, microcrystalline cellulose and magnesium stearate, through mixed
It closes, tabletting is made.
8. the preparation method of preparation described in claim 7, which is characterized in that include the following steps：
(1) it weighs：Saussurea involucrata culture extract, Cordyceps militaris powder, notogenseng pollen, sweetener class, micro- is weighed by the parts by weight
Crystalline cellulose and magnesium stearate；
(2) it mixes：Saussurea involucrata culture extract is uniformly mixed with sweetener class, then with Cordyceps militaris powder, notogenseng pollen, crystallite
Cellulose mixing adds magnesium stearate, continues to mix, obtains total mixed powder；
(3) tabletting：By tablet press machine load a die tabletting to get.
9. the composition of claim 1-3 any one of them extract containing Saussurea involucrata culture is preparing prevention or treatment heart and brain blood
Application in the drug of pipe disease, health products or food.
10. application according to claim 9, which is characterized in that the cardiovascular and cerebrovascular disease is hypertension or cerebral thrombus.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110250411A (en) * | 2019-07-13 | 2019-09-20 | 桐乡市博奥生物科技有限公司 | A kind of Saussurea involucrata culture health nutrient meal |
| CN110353138A (en) * | 2019-08-10 | 2019-10-22 | 江苏天绿食品科技有限公司 | A kind of functional beverage and preparation method thereof |
| CN112826918A (en) * | 2021-03-08 | 2021-05-25 | 郭宝叶 | A Chinese and western medicinal composition for improving cerebral blood supply, supplementing nutrition and improving arteriosclerosis, and its preparation method |
| CN116103219A (en) * | 2022-10-25 | 2023-05-12 | 山东益衡元健康科技有限公司 | Preparation method of saussurea involucrata stem cell powder and prepared bacteriostatic agent thereof |
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| CN107006840A (en) * | 2017-02-23 | 2017-08-04 | 北京众康生物科技有限公司 | A kind of Saussurea involucrata culture capsule and preparation method thereof |
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| CN107006840A (en) * | 2017-02-23 | 2017-08-04 | 北京众康生物科技有限公司 | A kind of Saussurea involucrata culture capsule and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110250411A (en) * | 2019-07-13 | 2019-09-20 | 桐乡市博奥生物科技有限公司 | A kind of Saussurea involucrata culture health nutrient meal |
| CN110353138A (en) * | 2019-08-10 | 2019-10-22 | 江苏天绿食品科技有限公司 | A kind of functional beverage and preparation method thereof |
| CN112826918A (en) * | 2021-03-08 | 2021-05-25 | 郭宝叶 | A Chinese and western medicinal composition for improving cerebral blood supply, supplementing nutrition and improving arteriosclerosis, and its preparation method |
| CN116103219A (en) * | 2022-10-25 | 2023-05-12 | 山东益衡元健康科技有限公司 | Preparation method of saussurea involucrata stem cell powder and prepared bacteriostatic agent thereof |
| CN116103219B (en) * | 2022-10-25 | 2023-07-04 | 山东益衡元健康科技有限公司 | Preparation method of saussurea involucrata stem cell powder and prepared bacteriostatic agent thereof |
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| CN108671002B (en) | 2021-06-01 |
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