CN108653530A - It is a kind of to treat burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite - Google Patents

It is a kind of to treat burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite Download PDF

Info

Publication number
CN108653530A
CN108653530A CN201810957856.6A CN201810957856A CN108653530A CN 108653530 A CN108653530 A CN 108653530A CN 201810957856 A CN201810957856 A CN 201810957856A CN 108653530 A CN108653530 A CN 108653530A
Authority
CN
China
Prior art keywords
parts
chinese
herb
root
leaf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810957856.6A
Other languages
Chinese (zh)
Inventor
朱桂珍
韩加栋
韩加艳
韩雯竹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Han Jiahui
Original Assignee
Han Jiahui
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Han Jiahui filed Critical Han Jiahui
Priority to CN201810957856.6A priority Critical patent/CN108653530A/en
Publication of CN108653530A publication Critical patent/CN108653530A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • A61K36/12Filicopsida or Pteridopsida
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264Aristolochia (Dutchman's pipe)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/37Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/58Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/59Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/758Zanthoxylum, e.g. pricklyash
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Insects & Arthropods (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Burning is treated the invention discloses a kind of,It scalds,Chinese medicine amber cream of frostbite and preparation method thereof,The amber cream of the present invention is by poly- algae,Frankincense,Vaiante spleenwort herb,Chinese prickly ash,Ji fern,Yellow wax,Chinese wax,Hair mouth label,Chinese yam,Rough brake herb,Greyhair cipadessa root or leaf,Chinese fevervine fruit,Uvarialeaf wendlandia leaf and root,Pale bittersweet leaf,Chinese cassia tree,Sinomenium acutum,Hairless rockvine herb,Showy jasmine root,Made of spurless columbine root or herb and vegetable oil,Amber cream is the method using Chinese traditional treatment theory and orthogonal test and subjective appreciation,Determine rational formula and processing technology,Amber cream pure Chinese medicinal preparation,It has no toxic side effect,It is not damaged to normal skin mucous membrane,Analgesic is fast,Antibacterial anti-inflammatory power is strong,Control exudation,Blood activating and promoting tissue regeneration,The effect that forms a scab is good,It is not required to make skin graft,Preventing from scar,Normal beautiful and daily life is not influenced,It is that the ideal topical drug of scald, frostbite is burnt in treatment,With conventional treatment,Method is simple,Cure rate is high,Curative effect is reliable.

Description

It is a kind of to treat burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite
Technical field
The present invention relates to external-use skin care technical fields, more particularly, to a kind of Chinese medicine amber for treating burn, scald, frostbite Cream and preparation method thereof.
Background technology
Burn is a kind of damage caused by human body, such as flame, scorching hot gas, liquid or solid due to thermodynamic activity Human body can be damaged.Scald is a kind of specific type of burn, mainly caused by scorching hot liquid effects are in human body.It burns Situations such as wound can betide in daily life, can also betide contingency, scientific experiment, war environment.Burn the state of an illness compared with Weight in addition to causing human body pain to patient, can also cause different degrees of hurt in spirits after facial burn.According to relevant information Statistics burns most of generation at home, and about 80% or so.The burn that accidental burns in family occur with scald in more industrial Probability is up to 15 times.Common burn heating power source has:1. heating power:It is most commonly seen with flame burn and hot water scald.Such as gasoline, coal The effects that gas, natural gas, thermos bottle, stove, boiling water, boiling soup, can cause different degrees of burn after human body.In general, The burn of children is mostly to scald within 3 years old, mostly due to knocking thermos bottle, hot water cup over or falling medium in hot soup.The burning of adult Wound is then more common in contingency, such as house catches fire, the explosion of coal gas, natural gas bottle, smoking is caught fire in bed;2. electric burn:Packet It includes body surface and is in direct contact power supply causes electric arc caused by topical burn, arc discharge to hinder, thunder and lightning is burnt etc.;3. chemical substance:With Highly basic and strong acid are common, cause chemical burn after acting on human body;4. radiogen is burnt:It is relatively rare.Mostly due to radiation Matter leakage causes.
To the severity of burn, three degree of quarterings are mostly used at present and are judged:
I degree(It is erythematous):Part is like erythema, and mild redness, no blister is dry, no infection.Skin burns sample pain.General 2 Resolution of symptoms in~3 days fully recovers in 3~5 days, does not stay spot.
II degree(It is vesiculovirus):It is divided into Superficial bums and deepⅱdegreeburn.
Superficial bums:There are larger bubble, oedema not to be complicated by infection such as, be cured within 2 weeks or so with severe pain, dermal sensation allergy It closes, does not stay scar, in a short time visible pigmentation.
Deepⅱdegreeburn:Bubble is smaller, oedema, and dermal sensation is blunt.It generally needs fully recover within 3~4 weeks, has scar after healing.
III degree(Eschar):Ochrodermia or sallow charing, dry, hide-like, dermal sensation is blunt, pain unobvious. Wound healing is slower, and majority needs to make skin graft, and there are scar or deformities after healing.
Slight scald epidermis occurs red and swollen, cusalgia or gets blister;Serious scald, due to damaging the skin and skin of people Undertissue, fiery poison injure internal yin-fluid, inside fire attack internal organs, impairment of yin damage sun, frequently result in fluid and electrolyte balance imbalance in human body, Shock, the serious consequences such as skin histology is red and swollen, festers, infects.If being not treated in time the surface of a wound, the long disunion of infection meeting leads to scar The generation of trace, influences limb function.
The method of western medical treatment burn and scald is typically to use debridement, disinfection, wrapping and operation, and the course for the treatment of is long, and healing is slow, takes With height, and more after there are scars.Chinese medicine has the effect of certain swelling and pain relieving in the application using Chinese medicine treatment, but all has wound The disadvantage of face healing time length.The first symptom of burn and scald is in great pain, this is because microcirculation is destroyed, vasopermeability Increase, microcirculation thrombosis, occur in be solidification, in be stasis, be outside hyperemia phenomenon caused by.The maximum danger of burn and scald Danger is infection.Due to surface of a wound Microembolization, wound site, antibody, blood is not achieved clinically by blood circulation conveying antibiotic The immune substances such as cell cannot supply the surface of a wound in time, thus anti-infection effect is undesirable.Therefore burnt degree therapeutic effect will make The wound of patient heals completely, the sick and wounded restore the function of body kinematics to the maximum extent, also to restore each system, each internal organs Function, while also to restore shape as possible.This is the boundary that modern burn rehabilitation technology is pursued.
Currently, there are many drug for the treatment of burn and scald in the market, but to I ° of burn and scald, II ° of burn and scald, III ° of burn and scald Treatment etc..Burn and scald (I °, II °) treatment of small area is ideal, but controlling to the burn and scald of III ° of larger area It treats, effect unobvious, this is must to carry out skin grafting, and larger pain and financial burden are caused to patient's body and mind.Have in the market Patent of invention technical data in containing alcohol etc. stimulate drug.
Nowadays the drug for being used to treat scald on the market is very more, and each drug generally can effectively be treated by scalding Caused pain, oedema, wound wound after most of drug is applied to wound, relieve pain speed although its effect is relatively good It is relatively slow, it cannot palliate the agonizing sufferings at once for patient, and it is possible to will appear and disturb gargalesthesia feel, or purulence can occur at scald position Packet, drug side-effect is generally bigger, and wound after being healed by drug therapy or even will appear this tool of hyperplastic scar There is permanent wound, brings great inconvenience to the normal life of patient, it is also necessary to which subsequent medical supplementary means is to scar Further treatment is carried out, treatment cost is virtually increased, different degrees of injury can be also caused to the soul of patient.
Frostbite is the frequently-occurring disease of cold district or cold season, it is under certain condition since low-temperature cold acts on people The damage of body, caused part or even whole body.The whole body or part of cold service below freezing in human body, can cause frostbite, The central temperature of entire body is too low referred to as numb with cold.Numb with cold is systemic Cold water stress, and metabolism and function reduce or inhibit, Jelly is eventually led to die and be difficult to recover.The property freezed damage refers to being exposed to extremely low temperature or long period exposure the body short time In 0 DEG C or less low temperature, the property freezed pathological change is organized(Ice crystal is formed), cause damaged membrane, permeability to increase, cell Dehydration, albuminous degeneration, and then dysbolism, tissue necrosis.Non-freezing damage refers to body and is exposed to 0~10 DEG C of low temperature for a long time Frostbite caused by wet environment organizes the not property freezed pathological change, vasopermeability to increase, and shaped components in blood is poly- Collection, microvascular corrosion cast cause dyshaemia, tissue necrosis.Systemic resistance power lowly as hungry, malnutritive, fatigue, shock and Wound, it is easier to lead to frostbite.Such as the mankind, when Heart temperature is less than 22~28 DEG C, heart can stop bounce in diastole or There is room to quiver, this temperature limits for Hypothermia.Healthy People causes catechu at low ambient temperatures, by skin vasoconstriction, shiver with cold Phenol amine discharges, and makes the momentary increase of oxygen consumption to ensure that body temperature is normal, and increased heart rate, blood pressure increase at this time, but for heart patient, Before central body temperature can be made to decline sudden arrest of heart beat just occurs for this mechanism.Be exposed in cold for a long time, defense mechanism finally by Limitation.When center, temperature decline reaches 30~35 DEG C, or else shiver with cold and vessel retraction etc. can prevent body temperature from further declining, disease People enters the inhibition phase, and blood pressure declines, shiver with cold stops, muscle arthrosis hardens.Further decline(30 DEG C or less), then it is absorbed in paralysis, Clouding of consciousness, Muscle tensility declines, and arteries and veins is slow and weak, may occur in which arrhythmia cordis.With temperature decline, brain and Whole body oxygen consumption, the heart Output quantity, blood pressure, heart rate, minute output, microcirculation, brain blood flow and electrical activity of brain decline.Hypothermia to heart damage most Greatly, but because brain metabolic rate declines brain is protected.
According to the range and degree of frostbite, frostbite is clinically divided into two kinds of whole body frostbite and part frozen.Systemic jelly Wound may occur in which that shiver with cold, cold limbs or cyanosis, body temperature gradually decline, and stolidity is in a certain state of delirium, slow in reacting, and severe patient can Stupor is until dead.It is three degree that part frozen, which is divided into,:1. once:Damage is happened at epidermis, and red swelling of the skin is congested, conscious heat, Itch, cusalgia.If do not continued to endure cold, it can disappear after the symptom a few days, not stay scar;2. two degree:Damage reaches skin corium, except redness is filled There is bubble outside blood, sharp ache is insensitive, and bubble is absorbable after 1~2 day, heals within about 2~3 weeks, does not stay scar;3. three Degree:Damage reaches full cortex, and severe patient is as deep as subcutaneous tissue, muscle, bone or even entire limb necrosis.Whiteness of skin when beginning, Gradually become brown later until black, tissue necrosis.It, can there are ulcer not to recover for a long time after slough falls off.
The cause of disease of Chinese medicine frostbite:Pernio is commonly called as " rotten trick ", belongs to the scopes such as " being frozen rotten sore ", " frost mark ", motherland's medicine is to freezing The discussion of sore is more early, Chao Yuanfang (550-630 A.D.)《The General Treatise on the Cause and Symptoms of Diseases》There is cloud:" moon in severe winter the gas for emitting the cold poison of wind and snow is touched, is hindered in skin, qi and blood It stops up stagnant, becomes pernio or even skin and flesh festers, severe one podomere Sui falls ".《Surgery is authentic》Day:" muscle cold pole, qi and blood is not all right, from the beginning of Purple plague purpura, long then blackening, rots to make purulence.Control suitable warming yang for dispelling cold, harmonizing yingfen and weifen ".《Surgery opens profound》It points out:It " by its cold, causes to enable Face, ear, hand, the first pain of foot, it is secondary swollen, purulence blood is broken out, chance is warm then to generate heat;Also the people that has vigour weak has it intolerant to its cold person ".
Traditional medicine to the therapy of pernio mainly based on external used medicine, common formulations mainly have paste, tincture, Aqua, prescription for oral administration is less, in addition there are powder, spray and other tcm characteristic therapies.
Exterior-applied formulation is rapid-action, significant in efficacy, easy to use, quick and easy to spread.According to incompletely statistics, in each doctor Institute, in use, paste, ingredients are more, general curative effect is preferable, more welcome;Other exterior-applied formulations, such as spray, plastics Deng, although cost of manufacture is higher and more popular dosage form,
Medicine mostly uses at this stage:
Snake oil ointment:It is the fat used in snake abdomen, ten pleasant impression Chinese herbal medicines is added, then be made after special process is handled.Specially control burn; Scald, pernio (bleed stream flow purulence);Chapped skin (i.e. ice mouth) rough to skin has special efficacy etc..Resistance infection is strong, relieves pain Soon, it can fully recover within general 3-7 days.However preparation method complexity is of high cost, the coming year can recur to the cold after healing in short term.
Safflower oil:This product is orthopedics and traumatology soft tissue strain and contusion class non-prescribed medicine drug.Major function:Promoting blood circulation wind dispelling, relaxing muscles and tendons Analgesic.For treating rheumatic ostealgia, extremity numbness, traumatic injury, bite by mosquitos.Safflower oil, which cannot be used for scratch, incised wound etc., skin The mucous membranes such as damaged wound, or contact eyes, oral cavity, and there is also easily recurred with the rear coming year.
The Western medicine of the treatment all symptoms of frostbite at present, much certain toxic side effect can be all brought during patient's use, Curative effect is little, can't resolve the practical slight illness of patient, as a result makes status of patient worse, and quality of life declines, threat to life;Generally Biological agent therapeutic effect repeatedly, drug dependence is big, is damaged to liver and gall big, and long-time service easily leads to body damage, immune Power decline etc., causes various complication to generate, cannot preferably palliate the agonizing sufferings for patient;Also the formula for having a small number of drug effects relatively good And at agent, but patent medicine takes mode drug effect absorption difference, and the purpose effectively treated is not achieved.
Invention content
Burning, boiling hot, frostbite Chinese medicine amber cream and preparation method thereof are treated the purpose of the present invention is to provide a kind of, it can be treated Burn and scald can treat the Chinese medicine amber cream of frostbite again, and Chinese medicine frankincense plays the role of analgesic, detumescence, myogenic, and Chinese prickly ash has anti-inflammatory analgetic, The effect of Chinese cassia tree has an analgesic warming meridian, and sore is restrained, it can adjust the immune system of people to Chinese yam, and anti-inflammatory is antibacterial, has anesthesia Analgesic activity, yellow wax, Chinese wax, vegetable oil, they can play the role of anti-inflammatory, sterilize, moisturize, and the present invention has analgesic, changes corruption The effect of myogenic, dissipating bind, therapeutic effect is notable, is the ideal drug for the treatment of burn, scald, frostbite.
What the object of the invention was achieved through the following technical solutions:
It is a kind of to treat burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite, it is made of the raw material of following weight ratio:
Poly- algae 30-60 parts, 20-30 parts of frankincense, 20-50 parts of vaiante spleenwort herb, 20-30 parts of Chinese prickly ash, 20-40 parts of Ji fern, yellow wax 30-40 Part, 30-40 parts of Chinese wax, 10-20 parts of hair mouth label, 30-45 parts of Chinese yam, 10-30 parts of rough brake herb, 20-35 parts of greyhair cipadessa root or leaf, Chinese Fevervine Herb 15-35 parts of fruit, 10-20 parts of uvarialeaf wendlandia leaf and root, 10-20 parts of pale bittersweet leaf, 10-15 parts of Chinese cassia tree, sinomenium acutum be 20-30 parts sub-, hairless rockvine herb 15- 35 parts, 10-15 parts of showy jasmine root, 10-30 parts of spurless columbine root or herb, 60-80 parts of vegetable oil;The vegetable oil includes sesame oil, peanut oil One or two.
The present invention is a kind of to be treated burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite, in preferred embodiment, institute Amber cream is stated to be made of the raw material of following parts by weight:Poly- algae 30-40 parts, 20-25 parts of frankincense, 20-40 parts of vaiante spleenwort herb, Chinese prickly ash 20- 25 parts, 20-30 parts of Ji fern, 30-35 parts of yellow wax, 30-35 parts of Chinese wax, 10-15 parts of hair mouth label, 30-40 parts of Chinese yam, rough brake herb 10-20 parts, 20-30 parts of greyhair cipadessa root or leaf, 15-30 parts of Chinese fevervine fruit, 10-15 parts of uvarialeaf wendlandia leaf and root, 10-15 parts of pale bittersweet leaf, Chinese cassia tree 10-12 Part, sinomenium acutum is 20-25 parts sub-, 15-30 parts of hairless rockvine herb, 10-12 parts of showy jasmine root, 10-20 parts of spurless columbine root or herb, 60-70 parts of vegetable oil;Institute The vegetable oil stated includes the one or two of sesame oil, peanut oil.
The present invention is a kind of to be treated burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite, in preferred embodiment, institute Amber cream is stated to be made of the bulk pharmaceutical chemicals of following parts by weight:Poly- algae 40-60 parts, 25-30 parts of frankincense, 30-50 parts of vaiante spleenwort herb, Chinese prickly ash 25-30 parts, 25-40 parts of Ji fern, 35-40 parts of yellow wax, 35-40 parts of Chinese wax, 15-20 parts of hair mouth label, 35-45 parts of Chinese yam, shaft mouth side 20-30 parts careless, 25-35 parts of greyhair cipadessa root or leaf, 25-35 parts of Chinese fevervine fruit, 15-20 parts of uvarialeaf wendlandia leaf and root, 15-20 parts of pale bittersweet leaf, Chinese cassia tree 12- 15 parts, sinomenium acutum is 25-30 parts sub-, 25-35 parts of hairless rockvine herb, 12-15 parts of showy jasmine root, 20-30 parts of spurless columbine root or herb, 70-80 parts of vegetable oil; The vegetable oil includes the one or two of sesame oil, peanut oil.
The present invention is a kind of to be treated burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite, in preferred embodiment, institute Amber cream is stated to be made of the bulk pharmaceutical chemicals of following parts by weight:60 parts of poly- algae, 20 parts of frankincense, 20 parts of vaiante spleenwort herb, 20 parts of Chinese prickly ash, Ji fern 40 Part, 30 parts of yellow wax, 30 10 parts of part, mao mouth label of Chinese wax, 30 parts of Chinese yam, 10 parts of rough brake herb, 20 parts of greyhair cipadessa root or leaf, Chinese fevervine fruit 15 Part, 10 parts of uvarialeaf wendlandia leaf and root, 10 parts of pale bittersweet leaf, 15 parts of Chinese cassia tree, 30 parts of sinomenium acutum, 15 parts of hairless rockvine herb, 10 parts of showy jasmine root, spurless columbine root or herb 10 parts, 80 parts of vegetable oil;The vegetable oil includes the one or two of sesame oil, peanut oil.
The present invention is a kind of to be treated burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite, in preferred embodiment, institute Amber cream is stated to be fabricated to by the bulk pharmaceutical chemicals of following parts by weight:40 parts of poly- algae, 25 parts of frankincense, 35 parts of vaiante spleenwort herb, 25 parts of Chinese prickly ash, Ji fern 30 parts, 35 parts of yellow wax, 35 15 parts of part, mao mouth label of Chinese wax, 35 parts of Chinese yam, 20 parts of rough brake herb, 25 parts of greyhair cipadessa root or leaf, Chinese fevervine fruit 25 Part, 15 parts of uvarialeaf wendlandia leaf and root, 15 parts of pale bittersweet leaf, 12 parts of Chinese cassia tree, 25 parts of sinomenium acutum, 25 parts of hairless rockvine herb, 12 parts of showy jasmine root, spurless columbine root or herb 20 parts, 70 parts of vegetable oil;The vegetable oil includes the one or two of sesame oil, peanut oil.
On the other hand, it a kind for the treatment of burning the present invention provides described, scalds, the Chinese medicine amber cream and preparation method thereof of frostbite:
The amber cream is to be prepared from the following steps:
Step 1, stock, cleaning, removal of impurities:
A, it stocks up:Good poly- algae, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, white is weighed by above-mentioned raw materials parts by weight proportioning Wax, hair mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, Showy jasmine root, spurless columbine root or herb, vegetable oil are spare;
B, cleaning, removal of impurities:The poly- algae of Chinese medicine material that step a is obtained, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, Chinese wax, hair Mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, little Liu It turns, cleaned in spurless columbine root or herb merging bubbling -cleaning equipment, is fitted into after removal of impurities spare in sterile chamber;
Step 2 prepares extract:30min will be impregnated in frankincense that step b is obtained, Chinese prickly ash, Chinese cassia tree, Chinese yam merging water, after immersion Merging decocts 30-60min in the drug-decocting equipment equipped with boiling water, and filtrate is obtained after filtering;Filtrate is placed in distiller, water flowing is steamed The oil water mixture distilled out is collected in steam distillation, and the oil water mixture distilled out is detached, and is retained oil reservoir, is used anhydrous slufuric acid Oil reservoir is dried in sodium, is obtained after filtering in mixed extract A merging sterilization containers, spare;
Step 3, ethyl alcohol extraction:By the poly- algae of step 2, vaiante spleenwort herb, Ji fern, yellow wax, Chinese wax, hair mouth label, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, sinomenium acutum, hairless rockvine herb, showy jasmine root, spurless columbine root or herb are crushed with medicinal herb grinder, cross 100 After mesh sieve, the ethyl alcohol that 2~9 times of weight 70-95% are added impregnates 60~120min, and 5~15 times of weight 70-95% are added after immersion Ethyl alcohol heating and refluxing extraction 7~10 times, extract 60~300min every time, mistake in each extracting solution merging ultrafiltration membrance filter equipment Filter, merges filtered ethanol extract, obtains extracting solution B, is placed in sterilization container, spare;
Step 4 is condensed into cream:Step 3 is obtained extracting solution B ethyl alcohol is recovered under reduced pressure to be concentrated into relative density under room temperature being 0.10- 1.50, medicinal extract is made;The extract A that step 2 obtains is added in vegetable oil, is stirred evenly, medicinal extract is added in vegetable oil 85 DEG C of heating for dissolving of temperature, continue to stir, be uniformly mixed, mixing time 30-60min, condense up to amber cream.
Step 5, sealed packaging, ultra-high pressure sterilization, vanning:The amber cream that step 4 obtains is sealed packaging, will be dispensed In amber cream merging ultra-high pressure sterilization equipment after sealing, the tissue of mould, bacterium is destroyed to keep product using super-pressure The principle of freshness sterilizes, and without heating, does not interfere with the active ingredient of raw material, is refrigerated after sterilizing, obtains a kind for the treatment of burning The Chinese medicine amber cream of wound, scald, frostbite.
The pharmacological action of each raw material is as follows:
Frankincense, warm-natured, acrid flavour, hardship, thoughts of returning home warp, the spleen channel, Liver Channel, can regulating qi and activating blood, analgesic therapy, detumescence, myogenic, with controlling the qi and blood stasis of blood Stagnant, trusted subordinate's pain, ulcerative carbuncle pyogenic infections, traumatic injury, arthralgia pain due to rheumatism, dysmenorrhoea, postpartum blood stasis stabbing pain.
Chinese prickly ash, warm-natured, acrid flavour, converge to the spleen channel, stomach, kidney channel, can warm in pain, desinsection it is antipruritic, with controlling coldness and pain in the epigastrium, vomiting Diarrhea, abdominal pain due to enterositosis, ascariasis etc.;Eczema itch are controlled in external application.
Yellow wax has inducing astrigency, sore, myogenic, analgesic effect.
Chinese wax leaf, warm-natured, acrid flavour, can menstruation regulating, hemostasia and promoting granulation.
Hair mouth label, it is cool in nature, it is mildly bitter flavor, puckery, can be clearing heat and detoxicating, astringing to arrest bleeding is red with burn and scald, traumatic hemorrhage, boil is controlled Swollen, eczema, ulcerative carbuncle is festered:Stem, leaf levigation adjust tea oil to apply outside.
Chinese yam, mild-natured, sweet in flavor, converge to the spleen channel, lung channel, kidney channel, can tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying, with controlling spleen deficiency Deficiency of food, endless diarrhea, the deficiency syndrome of the lung breath with cough, under emission due to the kidney deficiency, band, frequent micturition, abnormal heat quench one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney, with controlling spleen Empty deficiency of food, diarrhea loose stool, leukorrhea.
Rough brake herb, it is cool in nature, it is sweet in flavor, light, can clearing heat and promoting diuresis, hemostasia and promoting granulation, removing toxicity for detumescence, main diarrhea, dysentery, jaundice, Stranguria, oedema, hemoptysis, hematuria, have blood in stool, knife wound bleeding, treating swelling and pain by traumatic injury, sore carbuncle, scald.
Vaiante spleenwort herb, it is cool in nature;Taste micro-puckery, can activating blood circulation and reducing swelling, hemostasia and promoting granulation.Operator is hindered, fracture, sore fester, burn and scald.
Poly- algae, it is cold in nature, it is sweet in flavor, light;Can heat-clearing, cool blood, removing toxic substances, cure mainly pyreticosis polydipsia, dysentery, erysipelas, boil, scald Wound.
Greyhair cipadessa root or leaf, slightly warm in nature, acrid flavour, hardship, can wind-dispelling dampness elimination, promoting qi circulation and relieving pain cures cold, arthralgia pain due to rheumatism, dysentery, malaria, Abdominal pain, scald, pruitus.
Ji fern, it is cool in nature, it is bitter, pungent, can be clearing heat and detoxicating, convergence analgesic cures mainly burn and scald, traumatic hemorrhage.
Chinese fevervine fruit, it is distributed in lung channel, it can detoxify and cure the wound.Cure mainly snake venom sting;Frostbite.
Uvarialeaf wendlandia leaf and root, cool in nature, mildly bitter flavor, can dispelling wind and eliminating dampness, eliminating stasis to subdue swelling, hemostasia and promoting granulation, be used for rheumatic arthritis, bruise Damage, traumatic hemorrhage, sore festers not to close up long.
Pale bittersweet leaf, mild-natured, acrid flavour return kidney channel, the spleen channel, the heart channel of Hang-Shaoyin, Liver Channel;Can hemostasia and promoting granulation, control knife wound, mends fire supporing yang, Guiding fire to origin, eliminating cold to stop pain, warming meridian, be used for impotence Gong Leng, waist and knee crymodynia, deficiency of the kidney and dyspnea, deficient yang with upper manifestation, dizziness hot eyes, Trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold hernia stomachache, dysmenorrhoea Amenorrhea.
Sinomenium acutum son, cool in nature, mildly bitter flavor, can clearing away damp-heat, myogenic of drawing out the pus.
Hairless rockvine herb, cold in nature, puckery, slight bitter, can synthetism myogenic, hemostasis and anti-inflammation.
Showy jasmine root, warm-natured, mildly bitter flavor is puckery, can myogenic, convergence.Control knife wound.
Spurless columbine root or herb, mild-natured, sweet in flavor, myogenic detoxification.
Beneficial effects of the present invention:The amber cream of the present invention is by poly- algae, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, white Wax, hair mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, Made of showy jasmine root, spurless columbine root or herb and vegetable oil, wherein the vegetable oil raw materials include sesame oil, peanut oil, and amber cream is to adopt With Chinese traditional treatment theory and the method for orthogonal test and subjective appreciation, rational formula and processing technology are determined, during amber cream is pure Medicine preparation, has no toxic side effect, not damaged to normal skin mucous membrane, and analgesic is fast, and antibacterial anti-inflammatory power is strong, control exudation, blood activating and promoting tissue regeneration, The effect that forms a scab is good, is not required to make skin graft, preventing from scar, does not influence normal beautiful and daily life, amber cream and cures mainly:1, it is various burn, scald, Frostbite, such as:Burn, scald, electric injury, oils scald, pitch scald, trauma infection contamination, long disunion;2, weather frostbite, change Product freon frostbite;Amber cream is that the ideal topical drug of scald, frostbite is burnt in treatment, and compared with conventional treatment, method is simple, Cure rate is high, and curative effect is reliable.
Amber cream of the present invention achievees the purpose that treat frostbite by being directly applied to affected part, with easy to use, curative effect Define, have no toxic side effect, drug safety the features such as.Simultaneously by Preliminary pharmacological, toxicological experiment, the results showed that drug action Obviously, estimated total effective rate is up to 90% or more.
Following experimental examples and embodiment further prove but are not limited to the present invention.
Influence of the experimental example 1 to part frozen rat whole blood viscosity, factor I, hematocrit and Plasma Viscosity;
Take rat 32, be randomly divided into normal group, model group, amber cream group and Chinese fevervine fruit frostbite cream group, 4 groups each 8.First exist Laboratory adapts to 1 week, then with the intraperitoneal injection of 1% yellow Jackets in anesthesia shape.By the double metapedes of rat in addition to normal group Ankle-joint immerses 5min in -25 DEG C of ethyl alcohol with lower portion, causes the cold-injury models.6h starts grouping administration after moulding, and model group is removed Daily to replace outside gauze, no any other processing, amber cream group uses the amber cream prepared by 5 method of embodiment, Chinese fevervine fruit Frostbite cream group is used presses Chinese fevervine fruit cream prepared by 5 method of embodiment by main ingredient of Chinese fevervine fruit, in locally embrocating frostbite cream, often It 3 times, broken end takes blood examination to test after successive administration 48h, 52h:Whole blood viscosity (uses NEX.1 type cone-plate formula blood viscosities meter);Blood Specific volume of cell and Plasma Viscosity (the capillary viscosmeter for using 1.5 × 75mm), the results are shown in Table 1.
Average ± the s of testing result N=6, x of 1. each group frostbite rat whole blood viscosity of table, plasma viscosity, hematocrit
Note:Compared with normal group, * 1P < 0.01;Compared with model group, * 2P < 0.01, * 3P < 0.05
The experimental results showed that 3 model group whole blood viscosity, hematocrit and Plasma Viscosity levels are all remarkably higher than normal group, and The indices of two administration groups be significantly lower than model group, and amber cream group result compared with Chinese fevervine fruit frostbite cream group effect compared with It is good.
Therapeutic effect of the experimental example 2 to rabbit moderate frostbite
Take regular grade new zealand rabbit 50, half male and half female is randomly divided into normal group, model group, amber cream group is (by 5 side of embodiment It is prepared by method), pernio cold cream group and Chinese fevervine fruit frostbite cream group (being main ingredient by the preparation of 5 method of embodiment using Chinese fevervine fruit), 5 groups Each 10.By the double metapedes cropping of new zealand rabbit, after local ethanol disinfection, it is cold that its biped is dipped in the constant temperature equipped with -25 DEG C of ethyl alcohol But it is freezed in slot, natural rewarming at room temperature after freezing.6h starts grouping administration after moulding, and model group is replaced except daily Outside gauze, no any other processing.Therapeutic component is using pernio cold cream, amber cream and Chinese fevervine fruit frostbite cream group, in jelly Start within the 1st day after wound the volume (using drainage) after 2,3,5,7 days measurement rabbit foot frostbite.Calculate each time segment body Changing value is accumulated, value × 100% is become up to volume change percentage (value is in terms of 100% before freezing) with volume before volume changes value/jelly Change percentage as its swelling rate, the results are shown in Table 2.
2 each group moderate frostbite rabbit of table freezes the area average ± s of swelling rate testing result %, x, n=10
Group 1st day 2nd day 3rd day 5th day 7th day
Normal group —— —— —— —— ——
Model group 226.7±33.1 222.6±34.2 206.5±36.1 188.3±28.1 162.7±30.2
Chinese fevervine fruit frostbite cream group 225.3±32.5 224.1±27.2 212.7±22.1 176.3±30.4 146.4±22.4
Amber cream 220.9±26.4 212.3±28.1 178.7±27.5 142.2±29.2 102.5±18.5
Pernio cold cream 223.5±15.2 221.7±26.3 200.6±25.2 169.5±22.1 137.6±27.3
Note:Compared with model group, * 1P < 0.01, * 2P < 0.05.
The experimental results showed that the swelling degree variation of model group and three administration groups 2d before the treatment are little, opened from the 3rd day Beginning, the swelling rate of three administration groups starts drastically to decline, until the 7th day, amber cream group starts portion of tissue loss occur (before freezing just Constant value), it is with obvious effects better than pernio cold cream group, Chinese fevervine fruit frostbite cream group.
Area is deposited in the work that the areas treatment Hou Tuzudong are started medication with image analyzer measurement, and is calculated work and deposited area percentage Than the results are shown in Table 3.In the areas each group Tu Dong live and deposit the testing result of area, it can be seen that the preceding 2 days therapeutic effects for the treatment of are unknown Aobvious, the 3rd, 5,7 day, two areas administration group Tu Dong, which live, deposited that area and model group comparing difference be significant or pole conspicuousness.
3 each group moderate frostbite rabbit of table jelly area, which lives, deposits area detecting result %, x average ± s, n=10
Group 1st day 2nd day 3rd day 5th day 7th day
Model group 18.7±2.1 19.2±3.2 19.5±2.6 20.8±2.8 22.2±3.2
Chinese fevervine fruit frostbite cream group 19.1±1.9 20.2±3.2 22.7±3.1 30.3±4.4 38.9±7.5
Amber cream 19.9±3.4 21.3±4.1 31.2±4.4 46.5±7.2 69.3±8.5
Pernio cold cream 19.5±2.2 20.7±3.3 26.6±2.7 36.9±3.1 51.6±7.3
Note:Compared with model group, * 1P < 0.01, * 2P < 0.05.
3 compound ganoderma frostbite cream of experimental example (being prepared by 5 method of embodiment) preliminary skin irritation test
New zealand rabbit 20, weight 3kg or so, half male and half female is taken to slough outer hair at left and right sides of buttocks with depilatory agent, on a left side The hairless position in side applies matrix (3 centimetres or so of diameter), and the hairless place in right side applies amber cream (diameter is identical), twice daily, continuous 15 Day.
Experimental result finds that coating is showed no the stimulate the reactions such as redness with matrix position, all grows virgin wool.
The 4 antifreeze experiment of amber cream of the present invention of experimental example
Antifreeze experiment:It is index to be investigated by the appearance, stretchability and centrifugal test to amber cream, is transferred in -20 DEG C of conditions It sets 24 hours.The result shows that:Amber cream with indistinction before placement, and is packed into centrifuge tube by amber cream appearance and stretchability In, it under the conditions of 2500r/min, centrifuges 30 minutes, observation amber cream is without water-oil separating phenomenon.Separately take 10 ointment in -20 After being placed 30 days under the conditions of DEG C, observes its appearance, stretchability and meet regulation, and do not occur solidification phenomenon.
Study on the stability:By to prepared amber cream according to《Chinese Pharmacopoeia》Version requirement in 2010, has carried out accelerating examination It tests, influence factor experiment, using check items such as appearance, stretchability, index contents as index.Investigate the result shows that, the prescription prescription Rationally, as a result meet regulation, compared with product index of correlation is not placed, there was no significant difference.
Specific implementation mode
Pass through the following implementation technical solution that present invention be described in more detail.It should be pointed out that following explanation Only to claimed technical solution for example, not to any restrictions of these technical solutions.This hair Bright protection domain be subject to the appended claims record content.
Embodiment 1
It is a kind of to treat burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite, it is made of the raw material of following weight ratio:
60 parts of poly- algae, 20 parts of frankincense, 50 parts of vaiante spleenwort herb, 30 parts of Chinese prickly ash, 40 parts of Ji fern, 30 parts of yellow wax, 30 part, mao mouth label 10 of Chinese wax Part, 30 parts of Chinese yam, 10 parts of rough brake herb, 20 parts of greyhair cipadessa root or leaf, 35 parts of Chinese fevervine fruit, 10 parts of uvarialeaf wendlandia leaf and root, 10 parts of pale bittersweet leaf, Chinese cassia tree 15 parts, sinomenium acutum son 20 parts, 35 parts of hairless rockvine herb, 10 parts of showy jasmine root, 30 parts of spurless columbine root or herb, 80 parts of vegetable oil;The vegetable oil packet Include the one or two of sesame oil, peanut oil.
The amber cream is to be prepared from the following steps:
Step 1, stock, cleaning, removal of impurities:
A, it stocks up:Good poly- algae, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, white is weighed by above-mentioned raw materials parts by weight proportioning Wax, hair mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, Showy jasmine root, spurless columbine root or herb, vegetable oil are spare;
B, cleaning, removal of impurities:The poly- algae of Chinese medicine material that step a is obtained, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, Chinese wax, hair Mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, little Liu It turns, cleaned in spurless columbine root or herb merging bubbling -cleaning equipment, is fitted into after removal of impurities spare in sterile chamber;
Step 2 prepares extract:30min will be impregnated in frankincense that step b is obtained, Chinese prickly ash, Chinese cassia tree, Chinese yam merging water, after immersion Merging decocts 60min in the drug-decocting equipment equipped with boiling water, and filtrate is obtained after filtering;Filtrate is placed in distiller, water flowing steam Distillation, collects the oil water mixture distilled out, and the oil water mixture distilled out is detached, and retains oil reservoir, uses anhydrous sodium sulfate Oil reservoir is dried, is obtained after filtering in mixed extract A merging sterilization containers, it is spare;
Step 3, ethyl alcohol extraction:By the poly- algae of step 2, vaiante spleenwort herb, Ji fern, yellow wax, Chinese wax, hair mouth label, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, sinomenium acutum, hairless rockvine herb, showy jasmine root, spurless columbine root or herb are crushed with medicinal herb grinder, cross 100 After mesh sieve, the ethyl alcohol that 8 times of weight 90% are added impregnates 80min, and the ethyl alcohol heating and refluxing extraction of 7 times of weight 90% is added after immersion 7 times, 240min is extracted every time, is filtered in each extracting solution merging ultrafiltration membrance filter equipment, merges filtered ethanol extract, Extracting solution B is obtained, is placed in sterilization container, it is spare;
Step 4 is condensed into cream:Step 3 is obtained extracting solution B ethyl alcohol is recovered under reduced pressure to be concentrated into relative density under room temperature being 0.10- 1.50, medicinal extract is made;The extract A that step 2 obtains is added in vegetable oil, is stirred evenly, medicinal extract is added in vegetable oil 85 DEG C of heating for dissolving of temperature, continue to stir, be uniformly mixed, mixing time 60min, condense up to amber cream.
Step 5, sealed packaging, ultra-high pressure sterilization, vanning:The amber cream that step 4 obtains is sealed packaging, will be dispensed In amber cream merging ultra-high pressure sterilization equipment after sealing, the tissue of mould, bacterium is destroyed to keep product using super-pressure The principle of freshness sterilizes, and without heating, does not interfere with the active ingredient of raw material, is refrigerated after sterilizing, obtains a kind for the treatment of burning The Chinese medicine amber cream of wound, scald, frostbite.
Embodiment 2
In a preferred embodiment in accordance with this invention, the amber cream is made of the raw material of following parts by weight:
30 parts of poly- algae, 20 parts of frankincense, 20 parts of vaiante spleenwort herb, 25 parts of Chinese prickly ash, 20 parts of Ji fern, 30 parts of yellow wax, 30 part, mao mouth label 10 of Chinese wax Part, 30 parts of Chinese yam, 10 parts of rough brake herb, 20 parts of greyhair cipadessa root or leaf, 15 parts of Chinese fevervine fruit, 10 parts of uvarialeaf wendlandia leaf and root, 10-15 parts of pale bittersweet leaf, 10 parts of Chinese cassia tree, 25 parts of sinomenium acutum, 15 parts of hairless rockvine herb, 10 parts of showy jasmine root, 15 parts of spurless columbine root or herb, 65 parts of vegetable oil;The plant Oil includes the one or two of sesame oil, peanut oil.
The amber cream is to be prepared from the following steps:
Step 1, stock, cleaning, removal of impurities:
A, it stocks up:Good poly- algae, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, white is weighed by above-mentioned raw materials parts by weight proportioning Wax, hair mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, Showy jasmine root, spurless columbine root or herb, vegetable oil are spare;
B, cleaning, removal of impurities:The poly- algae of Chinese medicine material that step a is obtained, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, Chinese wax, hair Mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, little Liu It turns, cleaned in spurless columbine root or herb merging bubbling -cleaning equipment, is fitted into after removal of impurities spare in sterile chamber;
Step 2 prepares extract:30min will be impregnated in frankincense that step b is obtained, Chinese prickly ash, Chinese cassia tree, Chinese yam merging water, after immersion Merging decocts 50min in the drug-decocting equipment equipped with boiling water, and filtrate is obtained after filtering;Filtrate is placed in distiller, water flowing steam Distillation, collects the oil water mixture distilled out, and the oil water mixture distilled out is detached, and retains oil reservoir, uses anhydrous sodium sulfate Oil reservoir is dried, is obtained after filtering in mixed extract A merging sterilization containers, it is spare;
Step 3, ethyl alcohol extraction:By the poly- algae of step 2, vaiante spleenwort herb, Ji fern, yellow wax, Chinese wax, hair mouth label, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, sinomenium acutum, hairless rockvine herb, showy jasmine root, spurless columbine root or herb are crushed with medicinal herb grinder, cross 100 After mesh sieve, the ethyl alcohol that 5 times of weight 80% are added impregnates 100min, and the ethyl alcohol that 12 times of weight 80% are added after immersion is heated to reflux and carries It takes 9 times, extracts 150min every time, filtered in each extracting solution merging ultrafiltration membrance filter equipment, merge filtered ethyl alcohol extraction Liquid obtains extracting solution B, is placed in sterilization container, spare;
Step 4 is condensed into cream:Step 3 is obtained extracting solution B ethyl alcohol is recovered under reduced pressure to be concentrated into relative density under room temperature being 1.0, system Obtain medicinal extract;The extract A that step 2 obtains is added in vegetable oil, is stirred evenly, 85 DEG C of temperature in vegetable oil is added in medicinal extract It dissolves by heating, continues to stir, be uniformly mixed, mixing time 35min, condense up to amber cream.
Step 5, sealed packaging, ultra-high pressure sterilization, vanning:The amber cream that step 4 obtains is sealed packaging, will be dispensed In amber cream merging ultra-high pressure sterilization equipment after sealing, the tissue of mould, bacterium is destroyed to keep product using super-pressure The principle of freshness sterilizes, and without heating, does not interfere with the active ingredient of raw material, is refrigerated after sterilizing, obtains a kind for the treatment of burning The Chinese medicine amber cream of wound, scald, frostbite.
Embodiment 3
In a preferred embodiment of the present invention, the amber cream is made of the bulk pharmaceutical chemicals of following parts by weight:
40 parts of poly- algae, 25 parts of frankincense, 30 parts of vaiante spleenwort herb, 25 parts of Chinese prickly ash, 25 parts of Ji fern, 35 parts of yellow wax, 35 part, mao mouth label 15 of Chinese wax Part, 35 parts of Chinese yam, 20 parts of rough brake herb, 25 parts of greyhair cipadessa root or leaf, 25 parts of Chinese fevervine fruit, 15 parts of uvarialeaf wendlandia leaf and root, 15 parts of pale bittersweet leaf, Chinese cassia tree 12 parts, sinomenium acutum son 25 parts, 25 parts of hairless rockvine herb, 12 parts of showy jasmine root, 20 parts of spurless columbine root or herb, 70 parts of vegetable oil;The vegetable oil packet Include the one or two of sesame oil, peanut oil.
The amber cream is to be prepared from the following steps:
Step 1, stock, cleaning, removal of impurities:
A, it stocks up:Good poly- algae, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, white is weighed by above-mentioned raw materials parts by weight proportioning Wax, hair mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, Showy jasmine root, spurless columbine root or herb, vegetable oil are spare;
B, cleaning, removal of impurities:The poly- algae of Chinese medicine material that step a is obtained, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, Chinese wax, hair Mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, little Liu It turns, cleaned in spurless columbine root or herb merging bubbling -cleaning equipment, is fitted into after removal of impurities spare in sterile chamber;
Step 2 prepares extract:30min will be impregnated in frankincense that step b is obtained, Chinese prickly ash, Chinese cassia tree, Chinese yam merging water, after immersion Merging decocts 50min in the drug-decocting equipment equipped with boiling water, and filtrate is obtained after filtering;Filtrate is placed in distiller, water flowing steam Distillation, collects the oil water mixture distilled out, and the oil water mixture distilled out is detached, and retains oil reservoir, uses anhydrous sodium sulfate Oil reservoir is dried, is obtained after filtering in mixed extract A merging sterilization containers, it is spare;
Step 3, ethyl alcohol extraction:By the poly- algae of step 2, vaiante spleenwort herb, Ji fern, yellow wax, Chinese wax, hair mouth label, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, sinomenium acutum, hairless rockvine herb, showy jasmine root, spurless columbine root or herb are crushed with medicinal herb grinder, cross 100 After mesh sieve, the ethyl alcohol that 2 times of weight 70% are added impregnates 60min, and the ethyl alcohol heating and refluxing extraction of 5 times of weight 70% is added after immersion 7 times, 60min is extracted every time, is filtered in each extracting solution merging ultrafiltration membrance filter equipment, merges filtered ethanol extract, Extracting solution B is obtained, is placed in sterilization container, it is spare;
Step 4 is condensed into cream:Step 3 is obtained extracting solution B ethyl alcohol is recovered under reduced pressure to be concentrated into relative density under room temperature being 1.50, Medicinal extract is made;The extract A that step 2 obtains is added in vegetable oil, is stirred evenly, temperature 85 in vegetable oil is added in medicinal extract It DEG C dissolves by heating, continues to stir, be uniformly mixed, mixing time 30min, condense up to amber cream.
Step 5, sealed packaging, ultra-high pressure sterilization, vanning:The amber cream that step 4 obtains is sealed packaging, will be dispensed In amber cream merging ultra-high pressure sterilization equipment after sealing, the tissue of mould, bacterium is destroyed to keep product using super-pressure The principle of freshness sterilizes, and without heating, does not interfere with the active ingredient of raw material, is refrigerated after sterilizing, obtains a kind for the treatment of burning The Chinese medicine amber cream of wound, scald, frostbite.
Embodiment 4
In another preferred embodiment of the present invention, the amber cream is made of the bulk pharmaceutical chemicals of following parts by weight:
60 parts of poly- algae, 20 parts of frankincense, 20 parts of vaiante spleenwort herb, 20 parts of Chinese prickly ash, 40 parts of Ji fern, 30 parts of yellow wax, 30 part, mao mouth label 10 of Chinese wax Part, 30 parts of Chinese yam, 10 parts of rough brake herb, 20 parts of greyhair cipadessa root or leaf, 15 parts of Chinese fevervine fruit, 10 parts of uvarialeaf wendlandia leaf and root, 10 parts of pale bittersweet leaf, Chinese cassia tree 15 parts, sinomenium acutum son 30 parts, 15 parts of hairless rockvine herb, 10 parts of showy jasmine root, 10 parts of spurless columbine root or herb, 80 parts of vegetable oil;The vegetable oil packet Include the one or two of sesame oil, peanut oil.
The amber cream is to be prepared from the following steps:
Step 1, stock, cleaning, removal of impurities:
A, it stocks up:Good poly- algae, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, white is weighed by above-mentioned raw materials parts by weight proportioning Wax, hair mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, Showy jasmine root, spurless columbine root or herb, vegetable oil are spare;
B, cleaning, removal of impurities:The poly- algae of Chinese medicine material that step a is obtained, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, Chinese wax, hair Mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, little Liu It turns, cleaned in spurless columbine root or herb merging bubbling -cleaning equipment, is fitted into after removal of impurities spare in sterile chamber;
Step 2 prepares extract:30min will be impregnated in frankincense that step b is obtained, Chinese prickly ash, Chinese cassia tree, Chinese yam merging water, after immersion Merging decocts 60min in the drug-decocting equipment equipped with boiling water, and filtrate is obtained after filtering;Filtrate is placed in distiller, water flowing steam Distillation, collects the oil water mixture distilled out, and the oil water mixture distilled out is detached, and retains oil reservoir, uses anhydrous sodium sulfate Oil reservoir is dried, is obtained after filtering in mixed extract A merging sterilization containers, it is spare;
Step 3, ethyl alcohol extraction:By the poly- algae of step 2, vaiante spleenwort herb, Ji fern, yellow wax, Chinese wax, hair mouth label, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, sinomenium acutum, hairless rockvine herb, showy jasmine root, spurless columbine root or herb are crushed with medicinal herb grinder, cross 100 After mesh sieve, the ethyl alcohol that 9 times of weight 95% are added impregnates 120min, and the ethyl alcohol that 15 times of weight 95% are added after immersion is heated to reflux and carries It takes 10 times, extracts 200min every time, filtered in each extracting solution merging ultrafiltration membrance filter equipment, merge filtered ethyl alcohol extraction Liquid obtains extracting solution B, is placed in sterilization container, spare;
Step 4 is condensed into cream:Step 3 is obtained extracting solution B ethyl alcohol is recovered under reduced pressure to be concentrated into relative density under room temperature being 0.10, Medicinal extract is made;The extract A that step 2 obtains is added in vegetable oil, is stirred evenly, temperature 85 in vegetable oil is added in medicinal extract It DEG C dissolves by heating, continues to stir, be uniformly mixed, mixing time 60min, condense up to amber cream.
Step 5, sealed packaging, ultra-high pressure sterilization, vanning:The amber cream that step 4 obtains is sealed packaging, will be dispensed In amber cream merging ultra-high pressure sterilization equipment after sealing, the tissue of mould, bacterium is destroyed to keep product using super-pressure The principle of freshness sterilizes, and without heating, does not interfere with the active ingredient of raw material, is refrigerated after sterilizing, obtains a kind for the treatment of burning The Chinese medicine amber cream of wound, scald, frostbite.
Embodiment 5
In a preferred embodiment of the present invention, the amber cream is fabricated to by the bulk pharmaceutical chemicals of following parts by weight:
40 parts of poly- algae, 25 parts of frankincense, 35 parts of vaiante spleenwort herb, 25 parts of Chinese prickly ash, 30 parts of Ji fern, 35 parts of yellow wax, 35 part, mao mouth label 15 of Chinese wax Part, 35 parts of Chinese yam, 20 parts of rough brake herb, 25 parts of greyhair cipadessa root or leaf, 25 parts of Chinese fevervine fruit, 15 parts of uvarialeaf wendlandia leaf and root, 15 parts of pale bittersweet leaf, Chinese cassia tree 12 parts, sinomenium acutum son 25 parts, 25 parts of hairless rockvine herb, 12 parts of showy jasmine root, 20 parts of spurless columbine root or herb, 70 parts of vegetable oil;The vegetable oil packet Include the one or two of sesame oil, peanut oil.
A kind of preparation method of Chinese medicine amber cream that treating burn, scald, frostbite:
The amber cream is to be prepared from the following steps:
Step 1, stock, cleaning, removal of impurities:
A, it stocks up:Good poly- algae, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, white is weighed by above-mentioned raw materials parts by weight proportioning Wax, hair mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, Showy jasmine root, spurless columbine root or herb, vegetable oil are spare;
B, cleaning, removal of impurities:The poly- algae of Chinese medicine material that step a is obtained, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, Chinese wax, hair Mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, little Liu It turns, cleaned in spurless columbine root or herb merging bubbling -cleaning equipment, is fitted into after removal of impurities spare in sterile chamber;
Step 2 prepares extract:30min will be impregnated in frankincense that step b is obtained, Chinese prickly ash, Chinese cassia tree, Chinese yam merging water, after immersion Merging decocts 40min in the drug-decocting equipment equipped with boiling water, and filtrate is obtained after filtering;Filtrate is placed in distiller, water flowing steam Distillation, collects the oil water mixture distilled out, and the oil water mixture distilled out is detached, and retains oil reservoir, uses anhydrous sodium sulfate Oil reservoir is dried, is obtained after filtering in mixed extract A merging sterilization containers, it is spare;
Step 3, ethyl alcohol extraction:By the poly- algae of step 2, vaiante spleenwort herb, Ji fern, yellow wax, Chinese wax, hair mouth label, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, sinomenium acutum, hairless rockvine herb, showy jasmine root, spurless columbine root or herb are crushed with medicinal herb grinder, cross 100 After mesh sieve, the ethyl alcohol that 5 times of weight 85% are added impregnates 90min, and the ethyl alcohol that 10 times of weight 85% are added after immersion is heated to reflux and carries It takes 8 times, extracts 120min every time, filtered in each extracting solution merging ultrafiltration membrance filter equipment, merge filtered ethyl alcohol extraction Liquid obtains extracting solution B, is placed in sterilization container, spare;
Step 4 is condensed into cream:Step 3 is obtained extracting solution B ethyl alcohol is recovered under reduced pressure to be concentrated into relative density under room temperature being 0.10, Medicinal extract is made;The extract A that step 2 obtains is added in vegetable oil, is stirred evenly, temperature 85 in vegetable oil is added in medicinal extract It DEG C dissolves by heating, continues to stir, be uniformly mixed, mixing time 40min, condense up to amber cream.
Step 5, sealed packaging, ultra-high pressure sterilization, vanning:The amber cream that step 4 obtains is sealed packaging, will be dispensed In amber cream merging ultra-high pressure sterilization equipment after sealing, the tissue of mould, bacterium is destroyed to keep product using super-pressure The principle of freshness sterilizes, and without heating, does not interfere with the active ingredient of raw material, is refrigerated after sterilizing, obtains a kind for the treatment of burning The Chinese medicine amber cream of wound, scald, frostbite.
The major function and therapeutic domain of drug of the present invention:
1, major function:
Not damaged to normal skin mucous membrane, analgesic is fast, and antibacterial anti-inflammatory power is strong, and control exudation, blood activating and promoting tissue regeneration, incrustation effect is good, no It needs to make skin graft, preventing from scar does not influence normal beautiful and daily life, is that the ideal topical drug of scald, frostbite is burnt in treatment.
2, usage and dosage
Patient injury, first part cleaning wipe, and row is broken at blistering, removes Beancurd sheet, locally scrubs, and is applied with amber cream, The exposure surface of a wound, I degree, II degree of patient this medicine is used alone, without any oral intravenous administration method, III degree of patient compliance suits the medicine to the illness Fluid infusion, calmness, therapies, the patient such as sleeping is supported to be all made of Local out dressing, without wrapping, covering treatment daily dressing 2-3 times is not Deng, less serious case from the topical application of drug, severe one medical staff assists.
3, the clinical observation of drug of the present invention:
(1)General information
From 2003 ----2018 years, patient 148, wherein empyrosis patient populations 96, male 106 female 42, age Between 2-80 Sui, the cause of disease includes:Boiling water scald, fire wound, pitch scald, chemicals caustic trauma, electric injury, burn degree:I degree 48, II degree 40, III degree 8, burn and scald area is between 2%-25%.Frostbite patient 52, man 35, female 17, wound Feelings:Weather frostbite, a few peoples' chemicals frostbite, degree:Face blistering swelling is festered.
Method is local diagnosis foundation:With reference to People's Republic of China's traditional Chinese medicine industry standard《Chinese medical disease diagnoses curative effect mark It is accurate》In diagnostic criteria:
(2)Criterion of therapeutical effect:With reference to People's Republic of China's traditional Chinese medicine industry standard《Chinese medical disease Standardization of diagnosis and curative effect》In scald Wound, wound efficacy assessment standard:
Recovery from illness:Symptom disappears, and sign is normal;
It is effective:Symptom mitigates, and sign is improved;
Effectively:Symptom is mitigated, and sign is without being clearly better;
In vain:Symptom is without improvement, and sign is without improvement.
Therapeutic effect:In the clinical observation case, affected part of exterior coating 2-5 weeks is fully recovered 135, effective 148, and effective 148 Example;There is no any toxic side effect to generate during treatment.
Model case 1:
Lee, man, people from Heilongjiang Province, 45 years old, because head, face, skin coke black are wounded in electric welding, hair was burnt, and is diagnosed as III Spend electric injury, affected part clean with clear water, outer painting amber cream, recovery from illness in 15 days, more after without scar.
Model case 2:
Liu, man 5 years old, people from Bin County of Heilongjiang Province, because falling into accidentally in hot congee pot, scald is seen a doctor after 13 hours, left hand and wrist Still pale asphyxia, left lumbar region pale asphyxia and arm are in atropurpureus, and major part skin and flesh is downright bad at scald, are diagnosed as 3 grades of scalds, use Amber cream applies outside, relieves pain at that time, and 4 days fully recover, and rear discharge continues to outer painting, pays a return visit within subsequent 2 years, affected part surfacing is seen not Go out any scar, pigment deposition restores normal, recovery from illness.
Model case 3:
Poplar, female, 24 years old, right crus of diaphragm, leg, knee split enlargement in coke, were diagnosed as 3 degree of burns, saw a doctor after four days, external application amber cream, and 7 After it, surface skin, which festers, to be clearly better, affected part redness unobvious, continues two treatments of ointment for applying the present invention outside Journey, skin surface healing, has no that apparent scar, local skin have pigment deposition, exhorts that it continues to apply outside using this product, 28 days Recovery from illness, without scar, affected part surface does not see that any scar, pigment deposition restore normal for no skin-grafting.
Typical case falls ill 4:
Zhang, female, when opening refrigerator-freezer, the right hand peels off bubble external application amber cream, daily timing by the freon frostbite in refrigerator-freezer, blistering Dressing, after 3 days, wound surface infection part significantly improves, its wound is fully recovered after being continuing with 7 days, and surface is without apparent Scar.
Typical case falls ill 5:
Zhang, man, 55 years old, by carriage water tank scald hand and and shoulder, shirtfront were periodically changed daily through amber pasting exterior-applied therapeutic Medicine, after 5 days, the fever caused by wound infection is not eaten food and is controlled, and its wound surface infection part is significantly changed Kind, after being continuing with 15 days, wound recovery from illness, surface is without apparent scar.
Typical case falls ill 6:
Lee, female 55 years old, in May, 2013 petrol burn, limbs upper left quarter, front burn, II degree at the condition of the injury, close to III degree, use Amber cream be applied with, 15 days fully recover, more after without scar.
The content of present invention merely illustrates some claimed specific embodiments, one of them or more skill Recorded technical characteristic can be combined with arbitrary one or more technical solutions in art scheme, these are combined and obtain Technical solution also in the application protection domain, technical solution is disclosed in the present invention just as obtained from these are combined It is specifically recorded in content the same.

Claims (6)

1. a kind for the treatment of burning, scalding, the Chinese medicine amber cream of frostbite, it is characterised in that:It is made of the raw material of following weight ratio:
Poly- algae 30-60 parts, 20-30 parts of frankincense, 20-50 parts of vaiante spleenwort herb, 20-30 parts of Chinese prickly ash, 20-40 parts of Ji fern, yellow wax 30-40 Part, 30-40 parts of Chinese wax, 10-20 parts of hair mouth label, 30-45 parts of Chinese yam, 10-30 parts of rough brake herb, 20-35 parts of greyhair cipadessa root or leaf, Chinese Fevervine Herb 15-35 parts of fruit, 10-20 parts of uvarialeaf wendlandia leaf and root, 10-20 parts of pale bittersweet leaf, 10-15 parts of Chinese cassia tree, sinomenium acutum be 20-30 parts sub-, hairless rockvine herb 15- 35 parts, 10-15 parts of showy jasmine root, 10-30 parts of spurless columbine root or herb, 60-80 parts of vegetable oil;The vegetable oil includes sesame oil, peanut oil One or two.
It a kind for the treatment of burning 2. according to claim 1, scalding, the Chinese medicine amber cream of frostbite, it is characterised in that:The amber cream It is made of the raw material of following parts by weight:
Poly- algae 30-40 parts, 20-25 parts of frankincense, 20-40 parts of vaiante spleenwort herb, 20-25 parts of Chinese prickly ash, 20-30 parts of Ji fern, yellow wax 30-35 Part, 30-35 parts of Chinese wax, 10-15 parts of hair mouth label, 30-40 parts of Chinese yam, 10-20 parts of rough brake herb, 20-30 parts of greyhair cipadessa root or leaf, Chinese Fevervine Herb 15-30 parts of fruit, 10-15 parts of uvarialeaf wendlandia leaf and root, 10-15 parts of pale bittersweet leaf, 10-12 parts of Chinese cassia tree, sinomenium acutum be 20-25 parts sub-, hairless rockvine herb 15- 30 parts, 10-12 parts of showy jasmine root, 10-20 parts of spurless columbine root or herb, 60-70 parts of vegetable oil;The vegetable oil includes sesame oil, peanut oil One or two.
It a kind for the treatment of burning 3. according to claim 1, scalding, the Chinese medicine amber cream of frostbite, it is characterised in that:The amber cream It is made of the bulk pharmaceutical chemicals of following parts by weight:
Poly- algae 40-60 parts, 25-30 parts of frankincense, 30-50 parts of vaiante spleenwort herb, 25-30 parts of Chinese prickly ash, 25-40 parts of Ji fern, yellow wax 35-40 Part, 35-40 parts of Chinese wax, 15-20 parts of hair mouth label, 35-45 parts of Chinese yam, 20-30 parts of rough brake herb, 25-35 parts of greyhair cipadessa root or leaf, Chinese Fevervine Herb 25-35 parts of fruit, 15-20 parts of uvarialeaf wendlandia leaf and root, 15-20 parts of pale bittersweet leaf, 12-15 parts of Chinese cassia tree, sinomenium acutum be 25-30 parts sub-, hairless rockvine herb 25- 35 parts, 12-15 parts of showy jasmine root, 20-30 parts of spurless columbine root or herb, 70-80 parts of vegetable oil;The vegetable oil includes sesame oil, peanut oil One or two.
It a kind for the treatment of burning 4. according to claim 1, scalding, the Chinese medicine amber cream of frostbite, it is characterised in that:The amber cream It is made of the bulk pharmaceutical chemicals of following parts by weight:
60 parts of poly- algae, 20 parts of frankincense, 20 parts of vaiante spleenwort herb, 20 parts of Chinese prickly ash, 40 parts of Ji fern, 30 parts of yellow wax, 30 part, mao mouth label 10 of Chinese wax Part, 30 parts of Chinese yam, 10 parts of rough brake herb, 20 parts of greyhair cipadessa root or leaf, 15 parts of Chinese fevervine fruit, 10 parts of uvarialeaf wendlandia leaf and root, 10 parts of pale bittersweet leaf, Chinese cassia tree 15 parts, sinomenium acutum son 30 parts, 15 parts of hairless rockvine herb, 10 parts of showy jasmine root, 10 parts of spurless columbine root or herb, 80 parts of vegetable oil;The vegetable oil packet Include the one or two of sesame oil, peanut oil.
It a kind for the treatment of burning 5. according to claim 1, scalding, the Chinese medicine amber cream of frostbite, it is characterised in that:The amber cream It is fabricated to by the bulk pharmaceutical chemicals of following parts by weight:
40 parts of poly- algae, 25 parts of frankincense, 35 parts of vaiante spleenwort herb, 25 parts of Chinese prickly ash, 30 parts of Ji fern, 35 parts of yellow wax, 35 part, mao mouth label 15 of Chinese wax Part, 35 parts of Chinese yam, 20 parts of rough brake herb, 25 parts of greyhair cipadessa root or leaf, 25 parts of Chinese fevervine fruit, 15 parts of uvarialeaf wendlandia leaf and root, 15 parts of pale bittersweet leaf, Chinese cassia tree 12 parts, sinomenium acutum son 25 parts, 25 parts of hairless rockvine herb, 12 parts of showy jasmine root, 20 parts of spurless columbine root or herb, 70 parts of vegetable oil;The vegetable oil packet Include the one or two of sesame oil, peanut oil.
6. treating burning, the preparation method of boiling hot, frostbite Chinese medicine amber cream according to claim 1-5 any one of them is a kind of:Its It is characterized in that:
The amber cream is to be prepared from the following steps:
Step 1, stock, cleaning, removal of impurities:
A, it stocks up:Good poly- algae, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, white is weighed by above-mentioned raw materials parts by weight proportioning Wax, hair mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, Showy jasmine root, spurless columbine root or herb, vegetable oil are spare;
B, cleaning, removal of impurities:The poly- algae of Chinese medicine material that step a is obtained, frankincense, vaiante spleenwort herb, Chinese prickly ash, Ji fern, yellow wax, Chinese wax, hair Mouth label, Chinese yam, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, Chinese cassia tree, sinomenium acutum, hairless rockvine herb, little Liu It turns, cleaned in spurless columbine root or herb merging bubbling -cleaning equipment, is fitted into after removal of impurities spare in sterile chamber;
Step 2 prepares extract:30min will be impregnated in frankincense that step b is obtained, Chinese prickly ash, Chinese cassia tree, Chinese yam merging water, after immersion Merging decocts 30-60min in the drug-decocting equipment equipped with boiling water, and filtrate is obtained after filtering;Filtrate is placed in distiller, water flowing is steamed The oil water mixture distilled out is collected in steam distillation, and the oil water mixture distilled out is detached, and is retained oil reservoir, is used anhydrous slufuric acid Oil reservoir is dried in sodium, is obtained after filtering in mixed extract A merging sterilization containers, spare;
Step 3, ethyl alcohol extraction:By the poly- algae of step 2, vaiante spleenwort herb, Ji fern, yellow wax, Chinese wax, hair mouth label, rough brake herb, greyhair cipadessa root or leaf, Chinese fevervine fruit, uvarialeaf wendlandia leaf and root, pale bittersweet leaf, sinomenium acutum, hairless rockvine herb, showy jasmine root, spurless columbine root or herb are crushed with medicinal herb grinder, cross 100 After mesh sieve, the ethyl alcohol that 2~9 times of weight 70-95% are added impregnates 60~120min, and 5~15 times of weight 70-95% are added after immersion Ethyl alcohol heating and refluxing extraction 7~10 times, extract 60~300min every time, mistake in each extracting solution merging ultrafiltration membrance filter equipment Filter, merges filtered ethanol extract, obtains extracting solution B, is placed in sterilization container, spare;
Step 4 is condensed into cream:Step 3 is obtained extracting solution B ethyl alcohol is recovered under reduced pressure to be concentrated into relative density under room temperature being 0.10- 1.50, medicinal extract is made;The extract A that step 2 obtains is added in vegetable oil, is stirred evenly, medicinal extract is added in vegetable oil 85 DEG C of heating for dissolving of temperature, continue to stir, be uniformly mixed, mixing time 30-60min, condense up to amber cream;
Step 5, sealed packaging, ultra-high pressure sterilization, vanning:The amber cream that step 4 obtains is sealed packaging, by sealed packaging In amber cream merging ultra-high pressure sterilization equipment afterwards, the tissue of mould, bacterium is destroyed to keep product freshness using super-pressure Principle sterilize, without heating, do not interfere with the active ingredient of raw material, refrigerated after sterilizing, obtain a kind of burn, boiling hot for the treatment of The Chinese medicine amber cream of wound, frostbite.
CN201810957856.6A 2018-08-22 2018-08-22 It is a kind of to treat burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite Pending CN108653530A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810957856.6A CN108653530A (en) 2018-08-22 2018-08-22 It is a kind of to treat burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810957856.6A CN108653530A (en) 2018-08-22 2018-08-22 It is a kind of to treat burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite

Publications (1)

Publication Number Publication Date
CN108653530A true CN108653530A (en) 2018-10-16

Family

ID=63789140

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810957856.6A Pending CN108653530A (en) 2018-08-22 2018-08-22 It is a kind of to treat burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite

Country Status (1)

Country Link
CN (1) CN108653530A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101313929A (en) * 2008-07-14 2008-12-03 陈安平 Purplish red chilblain plaster
CN102309536A (en) * 2010-07-06 2012-01-11 北京协和药厂 Ointment for treating frostbite and rahagades and preparation method of ointment
CN104225106A (en) * 2014-09-19 2014-12-24 绵阳市春鹏种畜养殖有限责任公司 No-scar scald ointment suitable for people and livestocks and preparation method of no-scar scald ointment

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101313929A (en) * 2008-07-14 2008-12-03 陈安平 Purplish red chilblain plaster
CN102309536A (en) * 2010-07-06 2012-01-11 北京协和药厂 Ointment for treating frostbite and rahagades and preparation method of ointment
CN104225106A (en) * 2014-09-19 2014-12-24 绵阳市春鹏种畜养殖有限责任公司 No-scar scald ointment suitable for people and livestocks and preparation method of no-scar scald ointment

Similar Documents

Publication Publication Date Title
CN102091203B (en) External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof
CN102048894B (en) Traditional Chinese medicine composition for treating burn and preparation method thereof
CN104367911B (en) Treat Chinese medicine composition of rheumatism and rheumatoid arthritis and preparation method thereof
CN102327478B (en) Pharmaceutical composition for treating burns and scalds and preparation method thereof
CN104857312A (en) Traditional Chinese medicine composition for preventing and controlling wound infection and promoting wound repair
CN106491769A (en) The Traditional Chinese medicine compound gel agent for the treatment of wound, preparation method and applications
CN104689066A (en) Traditional Chinese medicine composition for treating burns and preparation method thereof
CN108042770A (en) Treat Chinese medicine fuming-lotion, its preparation method and the application method of ephritis
CN104825941B (en) A kind of herbal composite and preparation method thereof for treating tinea pedis
CN103690807A (en) Traditional Chinese medicine for treating uremia
CN103211894A (en) Medicine for treating knife wound and preparation method thereof
CN109966364A (en) A kind of Chinese medicine composition and preparation method thereof for treating skin trauma
CN105998795A (en) Inflammation-diminishing and pain-relieving formula for treating scalds
CN108653530A (en) It is a kind of to treat burning, scalding, the Chinese medicine amber cream and preparation method thereof of frostbite
CN105250685A (en) Traditional Chinese medicine composition for treating burns and preparation method of traditional Chinese medicine composition
CN101596258A (en) A kind of Chinese medicine preparation for the treatment of burn and scald
CN104225256A (en) Chinese medicine for treating fire toxin invagination type burning and preparation method
CN107753670A (en) A kind of traditional Chinese medicinal ointment for treating burn and scald
CN110478421A (en) A kind of Chinese materia medica preparation and preparation method thereof for treating goat
CN102451249B (en) Drug for treating burn and scald, and application thereof
CN106421410A (en) Traditional Chinese medicine composition for treating diabetic foot
CN101085255A (en) Traditional Chinese medicine preparation for treating acute nephritis
CN107440089A (en) Jujube of integration of drinking and medicinal herbs for treating lung cancer and preparation method thereof
CN105596770A (en) Externally-used ointment for promoting bone fracture healing and preparation method thereof
CN105232650A (en) Unguent for treating scalds and preparation and application methods thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20181016