CN108653381A - A kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer - Google Patents
A kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Abstract
The invention discloses a kind of Chinese and western medicinal composition preparation methods for treating chronic gastric ulcer, include the following steps：Step 1：Take Cimetidine that the mixed solution of acetonitrile/water is added, stirring and dissolving, speed of agitator is 6 10r/min, mixing time is 8 14min, solubilizer is then sequentially added thereto, leaches adjuvant, continues to stir 12 16min, and desmodium doping Radix Astragali extractive solution, propolis is then added thereto again, continue to stir 4 10min, followed by suction filtration.The object of the present invention is to provide a kind of Chinese and western medicinal composition preparation methods for treating chronic gastric ulcer, which can cure gastric ulcer, while have health care curative effect, will not cause secondary injury to stomach, have higher use value and good application prospect.
Description
Technical field
The present invention relates to chronic gastric ulcer treatment technology fields, and in particular to a kind of Chinese and Western medicine group for treating chronic gastric ulcer
Close object preparation method.
Background technology
Chronic gastric ulcer using intermittent, recurrent exerbation rhythmicity epigastric pain as clinical characters, be often accompanied by heating, acid reflux,
The feelings such as scorching hot, noisy, in addition also Nausea and vomiting, spitting blood, have blood in stool, locally have round, oval chronic ulcer in stomach and intestine,
The inflammation of superficial gastritis is limited to the surface layer of foveolae gastricae and gastric mucosa, and epithelial cell denaturation, small recessed epithelial proliferation and gastric mucosa are solid
There is a layer inflammatory cell infiltration, cause mucous hyperemia, oedema, exudation, be mainly in antrum, there is a small amount of rotten to the corn and bleeding, part sometimes
Patient has more rotten to the corn stove in antrum, or with excipuliform protrusion, claims chronic erosion or gastritis verrucosa, since dietary structure changes
And excessive consumption of alcohol, enterogastritis is easily induced, enterogastritis makes stomach absorption function decline, and malnutritive, body immunity declines,
Influence people’s lives quality.
The mostly edible Omeprazole drug of existing chronic gastric ulcer patient, the entitled 5- methoxyl groups-of Omeprazole pharmaceutical chemistry
2- { [(4- Omeprazole Sodium methoxyl group -3,5- dimethyl -2- pyridyl groups)-methyl]-sulfinyl } -1H- benzimidazoles, the medicine
Though object is edible can to treat gastric ulcer, stomach injury is easily further resulted in.
Cimetidine is the treatment most common medication of stomach trouble, has the function of significantly inhibiting gastric acid secretion, can obviously press down
System basis and night gastric acid secretion, the structural formula of Cimetidine are：
Existing Chinese patent literature (publication number：CN106110144A a kind of Chinese medicine group for treating chronic gastric ulcer) is disclosed
Object is closed, a kind of Chinese medicine preparation is related to, to solve the problems, such as that fast using western medicine gastric ulcer curative effect but side effect is big, the present invention
The Chinese medicine composition of the treatment chronic gastric ulcer, includes the component of following parts by weight：2~4 parts of longan, 1~3 part of Rhizoma Atractylodis Macrocephalae,
2~4 parts of the bletilla striata, 2~5 parts of Cortex Magnoliae Officinalis, 1~4 part of galangal, 2~3 parts of the tuber of pinellia, 0.5~1.5 part of pepper, 1~2 part of Radix Codonopsis, in this
Though drug composition has treatment chronic gastric ulcer effect, withdrawal, illness that can rebound.
Chinese patent literature (publication number：CN108078951A a kind of Cimetidine combination for treating stomach trouble) is disclosed
Object includes the raw material of following parts by weight：42-46 parts of Cimetidine, 10-14 parts of bulking agent, 6-8 parts of wetting agent, disintegrant 11-13
Part, 6-10 parts of lubricant, 1-3 parts of corrigent, 12-18 parts of solvent, though the pharmaceutical composition can effectively treat stomach trouble, and it is long-term
It takes, causes secondary injury.
Invention content
In view of the drawbacks of the prior art, the object of the present invention is to provide a kind of Chinese and western medicinal compositions for treating chronic gastric ulcer
Preparation method, the drug can cure gastric ulcer, while have health care curative effect, will not cause secondary injury to stomach, have higher
Use value and good application prospect.
The present invention solves technical problem and adopts the following technical scheme that：
The present invention provides a kind of Chinese and western medicinal composition preparation methods for treating chronic gastric ulcer, include the following steps：
Step 1：Take Cimetidine be added acetonitrile/water mixed solution, stirring and dissolving, speed of agitator 6-10r/min,
Mixing time is 8-14min, then sequentially adds solubilizer thereto, leaches adjuvant, continues to stir 12-16min, then again
Desmodium doping Radix Astragali extractive solution, propolis are added thereto, continues to stir 4-10min, followed by suction filtration；
Filtrate in step 1 is down to 5 DEG C, the n-butyl ether of filtrate total amount 0.2-0.6% is slowly added dropwise, continues to drop by step 2
Warm crystallization, insulated and stirred is complete to crystallization, growing the grain, filters, and washes, dry, obtains white crystalline powder.
Preferably, the mass ratio that the Cimetidine, desmodium adulterate Radix Astragali extractive solution substance is 16：(82-86).
Preferably, the mass ratio that the Cimetidine, desmodium adulterate Radix Astragali extractive solution substance is 16：84.
Preferably, the desmodium doping astragalus extraction liquid and preparation method thereof is to clean desmodium, Radix Astragali, is drained, then
It is sent into drying box and is dried, drying temperature is 55-65 DEG C, and drying time 20-30min is then re-fed into pulverizer
It crushes, is crushed to 50-100 mesh, is subsequently placed in water and extracts 1-2h, 90-100 DEG C of water temperature uses absorbent gauze in leaching process
Filtering 1-3 times, merging filtrate adulterate Radix Astragali extractive solution to get desmodium.
Preferably, the desmodium adulterates desmodium in Radix Astragali extractive solution, the mass ratio of Radix Astragali substance is 6:4.
Preferably, the propolis amount is the 4-6% of reaction solution total amount in step 1.
Preferably, the acetonitrile, water volume ratio are (65-75)：30.
Preferably, the solubilizer is single month esters of silicon acis of diethylene glycol, ethylenediamine according to weight ratio 7:The mixing of 3 compositions
Object.
Preferably, the leaching adjuvant is tartaric acid.
Preferably, the cooling crystallization to temperature is -6 DEG C of crystallizations, rearing crystal time 120-240min.
Compared with prior art, the present invention has following advantageous effect：
(1) desmodium has effects that reducing fever and causing diuresis, wind-expelling pain-stopping, hemostasia and promoting granulation, eliminating inflammation and expelling toxin, Radix Astragali are supported with invigorating the spleen
The effect of stomach, but also have the effect of tonifying Qi, it is combined with Cimetidine, not only can effectively treat chronic gastric ulcer, together
When have nourishing the stomach effect, be suitble to take for a long time.
(2) propolis has antibacterial anti-inflammatory, repairing ulcer face, and the flavone compound in propolis has antibacterial, kills virus, disappears
Scorching, analgesic efficacy, can play cooperative effect with other raw materials.
(3) 3 drug of the embodiment of the present invention is taken, after taking 4 months, 23 illnesss are eliminated in 25 patients, and 2 illnesss subtract
Gently, 2 people are recurred after 2 years, are taken with Chinese patent literature (publication number：CN108078951A it) discloses a kind of for treating stomach trouble
Cimetidine composition medication medication, after taking 4 months, 20 illnesss are eliminated, and 5 illnesss mitigate, and 16 people are multiple after 2 years
Hair, it is known that the present invention can long-term treatment to chronic enterogastritis.
Specific implementation mode
With reference to specific embodiment, technical scheme in the embodiment of the invention is clearly and completely described, shows
So, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the reality in the present invention
Example is applied, every other embodiment obtained by those of ordinary skill in the art without making creative efforts all belongs to
In the scope of protection of the invention.
Embodiment 1.
A kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer of the present embodiment, includes the following steps：
Step 1：Take Cimetidine that the mixed solution of acetonitrile/water, stirring and dissolving, speed of agitator 6r/min, stirring is added
Time is 8min, then sequentially adds solubilizer thereto, leaches adjuvant, continues to stir 12min, then be added thereto again
Desmodium adulterates Radix Astragali extractive solution, propolis, continues to stir 4min, followed by suction filtration；
Filtrate in step 1 is down to 5 DEG C, the n-butyl ether of filtrate total amount 0.2% is slowly added dropwise by step 2, continues cooling analysis
Crystalline substance, insulated and stirred is complete to crystallization, growing the grain, filters, and washes, dry, obtains white crystalline powder.
The Cimetidine of the present embodiment, the mass ratio of desmodium doping Radix Astragali extractive solution substance are 16：82.
The desmodium doping astragalus extraction liquid and preparation method thereof of the present embodiment is to clean desmodium, Radix Astragali, drains, then send
Enter in drying box and be dried, drying temperature is 55 DEG C, and drying time 20min is then re-fed into pulverizer and crushes, and is crushed
It to 50 mesh, is subsequently placed in water and extracts 1h, 90 DEG C of water temperature is filtered 1 time in leaching process with absorbent gauze, merging filtrate, i.e.,
It obtains desmodium and adulterates Radix Astragali extractive solution.
The desmodium of the present embodiment adulterates desmodium in Radix Astragali extractive solution, the mass ratio of Radix Astragali substance is 6:4.
The propolis amount of the present embodiment is 4% of reaction solution total amount in step 1.
The acetonitrile, water volume ratio 75 of the present embodiment：30.
The solubilizer of the present embodiment is single month esters of silicon acis of diethylene glycol, ethylenediamine according to weight ratio 7:The mixture of 3 compositions.
The leaching adjuvant of the present embodiment is tartaric acid.
The cooling crystallization of the present embodiment to temperature is -6 DEG C of crystallizations, rearing crystal time 120min.
Embodiment 2.
A kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer of the present embodiment, includes the following steps：
Step 1：Take Cimetidine that the mixed solution of acetonitrile/water, stirring and dissolving is added, speed of agitator 10r/min is stirred
It is 14min to mix the time, then sequentially adds solubilizer thereto, leaches adjuvant, continues to stir 16min, then again thereto
Desmodium doping Radix Astragali extractive solution, propolis is added, continues to stir 10min, followed by suction filtration；
Filtrate in step 1 is down to 5 DEG C, the n-butyl ether of filtrate total amount 0.6% is slowly added dropwise by step 2, continues cooling analysis
Crystalline substance, insulated and stirred is complete to crystallization, growing the grain, filters, and washes, dry, obtains white crystalline powder.
The Cimetidine of the present embodiment, the mass ratio of desmodium doping Radix Astragali extractive solution substance are 16：86.
The desmodium doping astragalus extraction liquid and preparation method thereof of the present embodiment is to clean desmodium, Radix Astragali, drains, then send
Enter in drying box and be dried, drying temperature is 65 DEG C, and drying time 30min is then re-fed into pulverizer and crushes, and is crushed
To 100 mesh, it is subsequently placed in water and extracts 2h, 100 DEG C of water temperature is secondary with absorbent gauze filter 23 in leaching process, merging filtrate,
Radix Astragali extractive solution is adulterated up to desmodium.
The desmodium of the present embodiment adulterates desmodium in Radix Astragali extractive solution, the mass ratio of Radix Astragali substance is 6:4.
The propolis amount of the present embodiment is 6% of reaction solution total amount in step 1.
The acetonitrile, water volume ratio 75 of the present embodiment：30.
The solubilizer of the present embodiment is single month esters of silicon acis of diethylene glycol, ethylenediamine according to weight ratio 7:The mixture of 3 compositions.
The leaching adjuvant of the present embodiment is tartaric acid.
The cooling crystallization of the present embodiment to temperature is -6 DEG C of crystallizations, rearing crystal time 240min.
Embodiment 3.
A kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer of the present embodiment, includes the following steps：
Step 1：Take Cimetidine that the mixed solution of acetonitrile/water, stirring and dissolving, speed of agitator 8r/min, stirring is added
Time is 11min, then sequentially adds solubilizer thereto, leaches adjuvant, continues to stir 14min, then add thereto again
Enter desmodium doping Radix Astragali extractive solution, propolis, continues to stir 7min, followed by suction filtration；
Filtrate in step 1 is down to 5 DEG C, the n-butyl ether of filtrate total amount 0.4% is slowly added dropwise by step 2, continues cooling analysis
Crystalline substance, insulated and stirred is complete to crystallization, growing the grain, filters, and washes, dry, obtains white crystalline powder.
The Cimetidine of the present embodiment, the mass ratio of desmodium doping Radix Astragali extractive solution substance are 16：84.
The desmodium doping astragalus extraction liquid and preparation method thereof of the present embodiment is to clean desmodium, Radix Astragali, drains, then send
Enter in drying box and be dried, drying temperature is 60 DEG C, and drying time 25min is then re-fed into pulverizer and crushes, and is crushed
To 75 mesh, it is subsequently placed in water and extracts 1.5h, 95 DEG C of water temperature is filtered 2 times in leaching process with absorbent gauze, merging filtrate,
Radix Astragali extractive solution is adulterated up to desmodium.
The desmodium of the present embodiment adulterates desmodium in Radix Astragali extractive solution, the mass ratio of Radix Astragali substance is 6:4.
The propolis amount of the present embodiment is the 4-6% of reaction solution total amount in step 1.
The acetonitrile, water volume ratio 70 of the present embodiment：30.
The solubilizer of the present embodiment is single month esters of silicon acis of diethylene glycol, ethylenediamine according to weight ratio 7:The mixture of 3 compositions.
The leaching adjuvant of the present embodiment is tartaric acid.
The cooling crystallization of the present embodiment to temperature is -6 DEG C of crystallizations, rearing crystal time 180min.
Comparative example 1：
It is essentially identical with the material and preparation process of embodiment 3, it has only the difference is that being not added with desmodium doping Radix Astragali and carries
Take liquid.
Comparative example 2：
It is essentially identical with the material and preparation process of embodiment 3, it has only the difference is that in desmodium doping Radix Astragali extractive solution
It is not added with Radix Astragali.
Comparative example 3：
It is essentially identical with the material and preparation process of embodiment 3, it has only the difference is that being not added with propolis.
Clinical data：Select outpatient service that there is the chronic gastric ulcer 40 of typical clinical manifestations, man 20, female 20, age
20-65 Sui, -10 years April of the course of disease, the treatment chronic gastric ulcer medicine for 40 patients being used respectively embodiment 3 and comparative example 1-3 prepare
Compositions are tested.
Therapy
The drug of embodiment 3 and comparative example 1-3 preparations is taken, three times a day, once a grain, two groups for the treatment of times are 4 weeks.
Observation index
It cures：The sense that has a stomach-ache disappears, and gaseous distention is eliminated, and stool is normal, in no rebound phenomenon.
It is effective：Have a stomach-ache sensillary base this disappearance, and gaseous distention subsides substantially, and have a stomach-ache sense after 1 year, gaseous distention phenomenon unobvious.
Effectively：The sense that has a stomach-ache is reduced, and gaseous distention is reduced, and symptom mitigates after 1 year.
In vain：Sense, gaseous distention have a stomach-ache without improvement.
Embodiment 3 and comparative example 1-3 treatment results
The present invention is notable to chronic gastric ulcer therapeutic effect, therefore the present invention further carries out long-term experiment.
50 case same patients are selected in China, and patient suffers from chronic gastric ulcer, repeatedly takes conventional medicine
Without improving, therefore 25 patients are taken to the drug of the embodiment of the present invention 3, it is (open that 25 patients take Chinese patent literature
Number：CN108078951A a kind of drug for treating the Cimetidine composition of stomach trouble) is disclosed.
3 drug of the embodiment of the present invention is taken, after taking 4 months, 23 illnesss are eliminated in 25 patients, and 2 illnesss mitigate,
2 people are recurred after 2 years, are taken with Chinese patent literature (publication number：CN108078951A it) discloses a kind of for treating stomach trouble
The medication medication of Cimetidine composition, after taking 4 months, 20 illnesss are eliminated, and 5 illnesss mitigate, and 16 people are recurred after 2 years,
Understand that the present invention can long-term treatment to chronic enterogastritis.
Safety experiment
Embodiment 1, embodiment 2,3 sample of embodiment are configured to a concentration of 2mg/ respectively with 0.8% sodium chloride injection
The solution of ml, it is spare as test solution；
Healthy rabbits 24 are taken, are randomly divided into tetra- groups of A, B, C, D, every group 6；Wherein, A groups：1 sample of embodiment is for examination
Product solution, B groups：2 sample test solution of embodiment, C groups：3 sample test solution of embodiment, D groups：0.8% sodium chloride is noted
Liquid control group is penetrated, respectively with aseptic manipulation in the above-mentioned tetra- groups of injections of A, B, C, D of rabbit auricular vein instillation.
By multiple dosing, visually observing phenomenon is：A, B, C group rabbit react without struggling when vein slowly instils, and use
Portion of officina has no the symptoms such as hyperemia, redness, and blood vessel lines is very clear, and histopathologic slide's inspection result is visible：Auricular vein
Without endothelial denudation, Endothelial Structure is complete, and no thrombosis also has no other exceptions, compared with D groups, the results showed that this hair
The Chinese and western medicinal composition of bright treatment chronic gastric ulcer is safety drug.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiment being appreciated that.
Claims (10)
1. a kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer, which is characterized in that include the following steps：
Step 1：Take Cimetidine that the mixed solution of acetonitrile/water, stirring and dissolving, speed of agitator 6-10r/min, stirring is added
Time is 8-14min, then sequentially adds solubilizer thereto, leaches adjuvant, continues to stir 12-16min, then again to it
Middle addition desmodium doping Radix Astragali extractive solution, propolis, continue to stir 4-10min, followed by suction filtration；
Filtrate in step 1 is down to 5 DEG C, the n-butyl ether of filtrate total amount 0.2-0.6% is slowly added dropwise by step 2, continues cooling analysis
Crystalline substance, insulated and stirred is complete to crystallization, growing the grain, filters, and washes, dry, obtains white crystalline powder.
2. a kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer according to claim 1, which is characterized in that
The mass ratio that the Cimetidine, desmodium adulterate Radix Astragali extractive solution substance is 16：（82-86）.
3. a kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer according to claim 2, which is characterized in that
The mass ratio that the Cimetidine, desmodium adulterate Radix Astragali extractive solution substance is 16：84.
4. a kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer according to claim 3, which is characterized in that
The desmodium doping astragalus extraction liquid and preparation method thereof is to clean desmodium, Radix Astragali, drains, is subsequently sent to carry out in drying box
Dry, drying temperature is 55-65 DEG C, and drying time 20-30min is then re-fed into pulverizer and crushes, is crushed to 50-100
Mesh is subsequently placed in water and extracts 1-2h, 90-100 DEG C of water temperature, is filtered 1-3 times with absorbent gauze in leaching process, merges filter
Liquid adulterates Radix Astragali extractive solution to get desmodium.
5. a kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer according to claim 4, which is characterized in that
The desmodium adulterates desmodium in Radix Astragali extractive solution, the mass ratio of Radix Astragali substance is 6:4.
6. a kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer according to claim 1, which is characterized in that
The propolis amount is the 4-6% of reaction solution total amount in step 1.
7. a kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer according to claim 1, which is characterized in that
The acetonitrile, water volume ratio are（65-75）：30.
8. a kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer according to claim 1, which is characterized in that
The solubilizer is single month esters of silicon acis of diethylene glycol, ethylenediamine according to weight ratio 7:The mixture of 3 compositions.
9. a kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer according to claim 1, which is characterized in that
The leaching adjuvant is tartaric acid.
10. a kind of Chinese and western medicinal composition preparation method for treating chronic gastric ulcer according to claim 1, feature exist
In the cooling crystallization to temperature is -6 DEG C of crystallizations, rearing crystal time 120-240min.
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| CN107982274A (en) * | 2018-01-26 | 2018-05-04 | 湖南博隽生物医药有限公司 | A kind of pharmaceutical composition for treating nettle rash and preparation method thereof |
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2018
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|---|---|---|---|---|
| CN1243004A (en) * | 1998-06-11 | 2000-02-02 | 武田药品工业株式会社 | Enterogastric medicine for resisting activity of pyloric twining bacillus |
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Application publication date: 20181016 |