CN108618142A - 一种复合牦牛骨髓冻干粉组合物及其制备方法 - Google Patents
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Abstract
本发明属于食品加工的技术领域，涉及一种复合牦牛骨髓冻干粉组合物，包括牦牛骨髓冻干粉70～85份，肉苁蓉提取物10～15份，覆盆子提取物5～15份，以上各组分合计为100份；本发明还涉及复合牦牛骨髓冻干粉组合物的制备方法，包括新鲜牦牛骨髓冷冻，冻干机干燥，粉碎机粉碎，肉苁蓉饮片浸提后制粉，覆盆子饮片浸提后制粉，各组分按比例混合后制成片剂或胶囊。本发明提供的复合牦牛骨髓冻干粉组合物，采用冻干法加工牦牛骨髓，防止了牦牛骨髓中活性蛋白质类的热变性，保留了牦牛骨髓中的所有活性成分，同时调入互补增效的药食两用成份，对增强人体免疫功能及改善人体性功能有一定的功效。
Description
技术领域
本发明属于食品加工的技术领域，涉及一种复合牦牛骨髓冻干粉组合物及其制备方法。
背景技术
牦牛是青藏高原特有畜种，生活在海拔3000米以上天然、无污染的草原上。其体魄健壮，心肺功能佳，体内红细胞、血红蛋白含量高于其它牛种，携氧能力强，抗疲劳耐高寒。体内铅、镉等重金属元素含量极低。
牦牛骨髓从牦牛棒骨中采集，是藏族人传统名贵食品之一，自古以来就有“壮筋骨,延年益寿”的记载。古医学认为：牦牛骨髓味辛、性温,归肝、肾经两经。主治肾精不足，虚劳赢瘦，骨痿无力及肺肾阴虚，多喘多咳，口渴多饮，皮肤干燥，手足皲裂等症。
现代科学分析表明，牦牛骨髓中含有丰富的蛋白质、氨基酸、Ca、P、Fe、Zn、Cu,以及软骨素、卵磷脂、多种维生素等营养成分,营养价值极高。具有补充机体营养成份和提高免疫力的作用。可预防幼儿佝偻病,促进骨骼和大脑发育；对成人有预防骨质疏松、牙齿松动、降低血脂、软化血管、增强造血机能等多种功效；牦牛骨髓对男性前列腺肥大及性功能减退，也具有显著改善作用。
现有牦牛骨髓粉的加工方法，是将牦牛骨髓用热处理的方法进行干燥加工，这种加工方法会造成牦牛骨髓中很多活性蛋白质类的热变性，其功能性遭到破坏。例如中国专利CN201710211300.8公开了“一种补肾益精的组合物及其制备方法”，该配方由牦牛骨髓粉等组成，其中牦牛骨髓粉采用的是“90℃，灭菌10min”的加工工艺，此方法会使牦牛骨髓的活性蛋白成分受到破坏，影响产品功效。
发明内容
本发明针对现有技术的不足，提供一种复合牦牛骨髓冻干粉组合物及其制备方法，使用冻干技术将新鲜牦牛骨髓在低温下脱水干燥制成牦牛骨髓冻干粉，然后调入互补增效的药食两用成份，做成制剂，此制剂保留了牦牛骨髓中所有活性成分，对增强人体免疫功能及改善人体性功能有一定的功效。
本发明的目的是通过以下技术方案来实现的：
一种复合牦牛骨髓冻干粉组合物，包括牦牛骨髓冻干粉70～85份，肉苁蓉提取物10～15份，覆盆子提取物5～15份，以上各组分合计为100份。
上述组合物为胶囊剂或片剂。
本发明还提供了一种牦牛骨髓冻干粉的制备方法，所述方法包括如下步骤：(1)将新鲜的牦牛骨髓消毒清洗，然后迅速将其冷冻至-18℃以下；
(2)将冻硬的牦牛骨髓用切片机切成1～2mm的薄片，铺设于冻干盘中，放入冻干机进行冷冻干燥，冻干至牦牛骨髓的含水率≤15％；
(3)将牦牛骨髓冻干片用低温粉碎机粉碎成细粉，贮于冷库备用；
上述消毒清洗使用75％的食用酒精溶液。
上述冻干机冷冻干燥的条件是：冷阱温度≤-50℃，真空度≤13Pa,蒸发温度-50～35℃，冻干时间为12～24小时。
上述细粉为60～120目。
本发明还提供了一种复合牦牛骨髓冻干粉组合物的制备方法，所述方法包括如下步骤：
(1)取肉苁蓉饮片，洗净，加入饮片质量10～15倍的水，在90～95℃下浸提30～50min,将提取液用喷雾干燥机制成粉状物，备用；
(2)取覆盆子饮片，洗净，加入饮片质量10～15倍的净水，在80～85℃下浸提15～30min,将提取液用喷雾干燥机制成粉状物，备用；
(3)将牦牛骨髓冻干粉，肉苁蓉提取物，覆盆子提取物，按配方称重，混合，压成片状，或套制成胶囊，包装后检验合格即为成品。
本发明相对于现有技术的有益效果如下：
1、本发明提供的复合牦牛骨髓冻干粉组合物，通过牦牛骨髓冻干粉与其它有辅助增效作用的药食两用成份的配伍，制成的产品具改善人体性功能，及强身健体的功效。
2、本发明采用冻干法加工牦牛骨髓，防止了牦牛骨髓中活性蛋白质类的热变性，保健功效更好。
3、本发明的配方设计合理，制作方法简单，产品质量稳定。
附图说明
图1是本发明的工艺流程图；
具体实施方式
下面通过具体实施方式的描述对本发明作进一步说明，但这并非是对本发明的限制，本领域技术人员根据本发明的基本思想，可以做出各种修改或者改进，但是只要不脱离本发明的基本思想，均在本发明的范围之内。
本发明实施例中所用的各种原料和试剂如无特别说明均为市售购买。
实施例1：牦牛骨髓冻干粉的制备
将新鲜的牦牛骨髓用75％的食用酒精溶液清洗，然后迅速将其冷冻至-18℃；将冻硬的牦牛骨髓用切片机切成1mm的薄片，将其铺设于冻干盘中，进入冻干机进行冷冻干燥。冻干机冷阱温度-50℃，真空度12Pa，蒸发温度-50～35℃，冻干时间为16小时，冻干结束时牦牛骨髓的含水率为12％；将牦牛骨髓冻干片用低温粉碎机粉碎成60目的细粉，贮于冷库备用。
实施例2：牦牛骨髓冻干粉的制备
将新鲜的牦牛骨髓用75％的食用酒精溶液清洗，然后迅速将其冷冻至-18℃；将冻硬的牦牛骨髓用切片机切成2mm的薄片，将其铺设于冻干盘中，进入冻干机进行冷冻干燥。冻干机冷阱温度-55℃，真空度11Pa，蒸发温度-50～35℃，冻干时间为24小时，冻干结束时牦牛骨髓的含水率为10％；将牦牛骨髓冻干片用低温粉碎机粉碎成120目的细粉，贮于冷库备用。
实施例3：牦牛骨髓冻干粉的制备
将新鲜的牦牛骨髓用75％的食用酒精溶液清洗，然后迅速将其冷冻至-18℃；将冻硬的牦牛骨髓用切片机切成1mm的薄片，将其铺设于冻干盘中，进入冻干机进行冷冻干燥。冻干机冷阱温度-50℃，真空度13Pa，蒸发温度-50～35℃，冻干时间为12小时，冻干结束时牦牛骨髓的含水率为15％；将牦牛骨髓冻干片用低温粉碎机粉碎成80目的细粉，贮于冷库备用。
实施例4：复方牦牛骨髓冻干粉组合物的制备
取肉苁蓉饮片，洗净，然后用15倍的净水，在93℃下提取35min,将提取液用喷雾干燥机制成粉状物，备用；
取覆盆子饮片，洗净，然后用10倍的净水，在80℃下提取20min,将提取液用喷雾干燥机制成粉状物，备用；
取牦牛骨髓冻干粉750克，肉苁蓉提取物150克，覆盆子提取物100克混合，套制成胶囊，包装后检验合格即为成品。
实施例5：复方牦牛骨髓冻干粉组合物的制备
取肉苁蓉饮片，洗净，然后用10倍的净水，在90℃下提取50min,将提取液用喷雾干燥机制成粉状物，备用；
取覆盆子饮片，洗净，然后用15倍的净水，在85℃下提取15min,将提取液用喷雾干燥机制成粉状物，备用；
取牦牛骨髓冻干粉700克，肉苁蓉提取物150克，覆盆子提取物150克混合，压制成片剂，包装后检验合格即为成品。
实施例6：复方牦牛骨髓冻干粉组合物的制备
取肉苁蓉饮片，洗净，然后用12倍的净水，在95℃下提取30min,将提取液用喷雾干燥机制成粉状物，备用；
取覆盆子饮片，洗净，然后用12倍的净水，在80℃下提取30min,将提取液用喷雾干燥机制成粉状物，备用；
取牦牛骨髓冻干粉850克，肉苁蓉提取物100克，覆盆子提取物50克，混合，套制成胶囊，包装后检验合格即为成品。
Claims (7)
1.一种复合牦牛骨髓冻干粉组合物，其特征在于，所述组合物包括牦牛骨髓冻干粉70～85份，肉苁蓉提取物10～15份，覆盆子提取物5～15份，以上各组分合计为100份。
2.根据权利要求1所述的复合牦牛骨髓冻干粉组合物，其特征在于，所述组合物为胶囊剂或片剂。
3.一种权利要求1所述的牦牛骨髓冻干粉的制备方法，其特征在于，所述方法包括如下步骤：
(1)将新鲜的牦牛骨髓消毒清洗，然后迅速将其冷冻至-18℃以下；
(2)将冻硬的牦牛骨髓用切片机切成1～2mm的薄片，铺设于冻干盘中，放入冻干机进行冷冻干燥，冻干至牦牛骨髓的含水率≤15％；
(3)将牦牛骨髓冻干片用低温粉碎机粉碎成细粉，贮于冷库备用。
4.根据权利要求3所述的牦牛骨髓冻干粉的制备方法，其特征在于，所述消毒清洗使用75％的食用酒精溶液。
5.根据权利要求3所述的牦牛骨髓冻干粉的制备方法，其特征在于，所述冻干机冷冻干燥的条件是：冷阱温度≤-50℃，真空度≤13Pa,蒸发温度-50～35℃，冻干时间为12～24小时。
6.根据权利要求3所述的牦牛骨髓冻干粉的制备方法，其特征在于，所述细粉为60～120目。
7.一种权利要求1所述的复合牦牛骨髓冻干粉组合物的制备方法，其特征在于，所述方法包括如下步骤：
(1)取肉苁蓉饮片，洗净，加入饮片质量10～15倍的水，在90～95℃下浸提30～50min,将提取液用喷雾干燥机制成粉状物，备用；
(2)取覆盆子饮片，洗净，加入饮片质量10～15倍的净水，在80～85℃下浸提15～30min,将提取液用喷雾干燥机制成粉状物，备用；
(3)将牦牛骨髓冻干粉，肉苁蓉提取物，覆盆子提取物，按配方称重，混合，压成片状，或套制成胶囊，包装后检验合格即为成品。
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| CN102839206A (zh) * | 2012-09-15 | 2012-12-26 | 闫利琴 | 一种促进人自体产生骨髓造血干细胞的制剂方法 |
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| CN105685969A (zh) * | 2016-01-29 | 2016-06-22 | 中国科学院西北高原生物研究所 | 一种复方牦牛骨髓口服液及其制备方法 |
| CN107854591A (zh) * | 2017-12-30 | 2018-03-30 | 赵赛 | 一种男士滋补汤 |
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| CN102839206A (zh) * | 2012-09-15 | 2012-12-26 | 闫利琴 | 一种促进人自体产生骨髓造血干细胞的制剂方法 |
| CN104687147A (zh) * | 2013-12-08 | 2015-06-10 | 哈尔滨升益生物科技开发有限公司 | 一种人参补肾虚强身汤料的配方及生产方法 |
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