CN108588025A - 人视网膜祖细胞的表型谱 - Google Patents

人视网膜祖细胞的表型谱 Download PDF

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Publication number
CN108588025A
CN108588025A CN201810203142.6A CN201810203142A CN108588025A CN 108588025 A CN108588025 A CN 108588025A CN 201810203142 A CN201810203142 A CN 201810203142A CN 108588025 A CN108588025 A CN 108588025A
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China
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cells
human
progenitor cells
retinal progenitor
cell population
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Pending
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CN201810203142.6A
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Chinese (zh)
Inventor
迈克尔·J·杨
彼得·Y·巴拉诺夫
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Schepens Eye Research Institute Inc
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Schepens Eye Research Institute Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Acoustics & Sound (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
CN201810203142.6A 2012-02-17 2013-02-15 人视网膜祖细胞的表型谱 Pending CN108588025A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261600288P 2012-02-17 2012-02-17
US61/600,288 2012-02-17
CN201380007641.3A CN104136601A (zh) 2012-02-17 2013-02-15 人视网膜祖细胞的表型谱

Related Parent Applications (1)

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CN201380007641.3A Division CN104136601A (zh) 2012-02-17 2013-02-15 人视网膜祖细胞的表型谱

Publications (1)

Publication Number Publication Date
CN108588025A true CN108588025A (zh) 2018-09-28

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CN201810203142.6A Pending CN108588025A (zh) 2012-02-17 2013-02-15 人视网膜祖细胞的表型谱
CN201380007641.3A Pending CN104136601A (zh) 2012-02-17 2013-02-15 人视网膜祖细胞的表型谱

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US (3) US10758572B2 (enExample)
EP (2) EP2814947B1 (enExample)
JP (2) JP6468843B2 (enExample)
KR (1) KR20140144680A (enExample)
CN (2) CN108588025A (enExample)
AU (3) AU2013221458B2 (enExample)
BR (1) BR112014019328A8 (enExample)
CA (1) CA2864818C (enExample)
ES (1) ES2700980T3 (enExample)
WO (1) WO2013123292A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2814947B1 (en) 2012-02-17 2018-11-21 Schepens Eye Research Institute Phenotype profile of human retinal progenitor cells
EP3047017B1 (en) 2013-10-09 2025-09-10 The Regents of the University of California Methods of mammalian retinal stem cell production and applications
KR101690759B1 (ko) * 2015-02-25 2016-12-30 연세대학교 산학협력단 전능성 줄기세포로부터 중간엽 줄기세포를 수득하는 방법
CN106323845B (zh) * 2015-06-23 2019-11-19 何伟 鉴定具有治疗视网膜退行性病变功能的视网膜祖细胞的方法
EP4001402A1 (en) * 2015-09-08 2022-05-25 FUJIFILM Cellular Dynamics, Inc. Macs-based purification of stem cell-derived retinal pigment epithelium
GB201615714D0 (en) * 2016-09-15 2016-11-02 Univ Of Sheffield The Otic progenitor identification and isolation
GB201703058D0 (en) * 2017-02-24 2017-04-12 Ucl Business Plc Biomarkers
WO2020190848A1 (en) * 2019-03-15 2020-09-24 The Schepens Eye Research Institute, Inc. Isolation, enrichment and expansion of cone progenitor cells and uses thereof
US20250276021A1 (en) * 2022-05-06 2025-09-04 The Schepens Eye Research Institute, Inc. Isolation, enrichment, and expansion of human rod progenitor cells and extracellular vesicles derived therefrom

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Publication number Publication date
CA2864818C (en) 2022-05-03
JP2015508656A (ja) 2015-03-23
US10758572B2 (en) 2020-09-01
KR20140144680A (ko) 2014-12-19
US20150017133A1 (en) 2015-01-15
JP2019013243A (ja) 2019-01-31
AU2018214122B2 (en) 2021-04-01
ES2700980T3 (es) 2019-02-20
EP2814947A1 (en) 2014-12-24
EP2814947B1 (en) 2018-11-21
AU2018214122A1 (en) 2018-08-30
EP3492586A1 (en) 2019-06-05
US20200345785A1 (en) 2020-11-05
US20250161366A1 (en) 2025-05-22
EP2814947A4 (en) 2015-08-12
BR112014019328A8 (pt) 2017-07-11
AU2021204404B2 (en) 2024-05-02
WO2013123292A1 (en) 2013-08-22
CN104136601A (zh) 2014-11-05
US11957719B2 (en) 2024-04-16
AU2018214122C1 (en) 2021-08-19
WO2013123292A9 (en) 2015-01-08
EP3492586B1 (en) 2024-04-17
AU2013221458B2 (en) 2018-08-30
BR112014019328A2 (enExample) 2017-06-20
AU2021204404A1 (en) 2021-07-22
AU2013221458A1 (en) 2014-08-07
JP6468843B2 (ja) 2019-02-13
CA2864818A1 (en) 2013-08-22

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