CN108567873A - Chinese yam is fresh to carry spray-dried granules medicine materical crude slice - Google Patents
Chinese yam is fresh to carry spray-dried granules medicine materical crude slice Download PDFInfo
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- CN108567873A CN108567873A CN201810733297.0A CN201810733297A CN108567873A CN 108567873 A CN108567873 A CN 108567873A CN 201810733297 A CN201810733297 A CN 201810733297A CN 108567873 A CN108567873 A CN 108567873A
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- Prior art keywords
- chinese yam
- fresh
- materical crude
- medicine materical
- crude slice
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of " Chinese yam is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that:Chinese yam harvest after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, granulation, whole grain, vacuum packaging.The water content of granule pieces is less than 10%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter in capsule, tablet, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of Chinese yam medicine materical crude slice.
Background technology
Traditional Chinese medicine Chinese yam is Dioscoreaceae plant Chinese yamDioscotea oppositaThunb. dry rhizome has tonifying spleen
Nourishing the stomach, engender liquid and benefic lung, effect of the puckery essence of kidney tonifying.This product is mainly used for spleen eating less, endless diarrhea, and the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency,
Under band, frequent micturition, abnormal heat is quenched one's thirst the treatments of equal diseases, is a herb common on tcm clinical practice.The processing method of traditional Chinese yam is:
It is excavated after winter cauline leaf is withered, cuts root head, cleaned, remove crust and fibrous root, it is dry, it practises and claims " hair yam slice ";Or it removes outer
Skin takes advantage of fresh-cut sheet, dry, referred to as " yam slice ";Also there is the loose straight drying Chinese yam of selection, set in clear water, be dipped into without dry
The heart, it is bored, both ends are trimmed, are twisted into plank cylindric, are dried, polishing, practises and claims " light yam ".Thus obtained Chinese yam medicine materical crude slice body
Product is big, and Hygienic Standard is poor, is easy to make moist, is mildew, infested, being unfavorable for taking care of, storage and transportation cost are high.In addition, such
Prepared slice quality stability is poor, and clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Therefore, a kind of stable quality is developed
Reliably, storage/transportation it is at low cost, conducive to keeping, carry and easy to use, rapid-action novel Chinese yam medicine materical crude slice, it is imperative.Mesh
Preceding market Chinese yam medicine materical crude slice, other than traditional medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but both
It is using traditional medicine materical crude slice as raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve asking for medicinal material pollution
Topic;Concentrated granular can only extract water-soluble components.
Invention content
The invention discloses a kind of " Chinese yam is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that:It is harvested in Chinese yam
Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm
Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, medicine
Slag presses extracting juice.50 ~ 70 DEG C of water of 5 ~ 10 times of weight are added in the gained dregs of a decoction, stirring at low speed 10 ~ 30 minutes filters while hot,
The dregs of a decoction are squeezed the juice again, collect concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, is concentrated into
The concentrate that relative density is 1.02 ~ 1.10.Gained concentrate leaves and takes 1% ~ 3% spare, remaining spray drying.By the spray drying of collection
Powder and spare concentrate mixing granulation, dry to be less than 10% to water content, whole grain is vacuum-packed to get finished product.Chinese yam particle
Prepared slice quality is stablized, good fluidity, and clinical general usage amount is 1 ~ 5g.Such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, also can be straight
It accesses in capsule and tablet, to substantially increase the convenience and compliance of Clinical practice, is conducive to controlling for clinical acute disease
It treats.
The present invention solve traditional Chinese yam medicine materical crude slice is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after yam medicinal material is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.50 ~ 70 DEG C of pure water of 8 times of weight are added into the above-mentioned dregs of a decoction again, stirring at low speed is extracted for 20 minutes, filtering, medicine
Slag is squeezed the juice again, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and being concentrated into relative density is
1.05.The concentrate of gained is left and taken into 3% spare, remaining spray drying.Spray powder is collected, system is mixed with spare concentrate
Particle, it is 10% that 80 DEG C, which are dried under vacuum to water content, and whole grain is vacuum-packed to get finished product.
Claims (2)
1. a kind of Chinese yam is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that:It after Chinese yam harvests, cleans, removes in time
The impurity such as silt and dis-medicinal part are added 1 ~ 5 times in the piece for taking advantage of using fresh herb tap water in 24 hours and cleaning and being cut into 2 ~ 5mm thickness
The water that 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice;5 ~ 10 are added in the gained dregs of a decoction
The water of times 50 ~ 70 DEG C of weight is stirred 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects concoction;Merge above-mentioned concoction,
60 ~ 100 mesh sieve is crossed, is concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density;Gained concentrate is left and taken
1% ~ 3% is spare, remaining spray drying;By the spray powder of collection and spare concentrate mixing granulation, drying to water content is less than
10%, whole grain is vacuum-packed to get finished product.
2. Chinese yam according to claim 1 is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that:Clinic generally uses
Amount is 1 ~ 5g, this medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810733297.0A CN108567873A (en) | 2018-07-06 | 2018-07-06 | Chinese yam is fresh to carry spray-dried granules medicine materical crude slice |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810733297.0A CN108567873A (en) | 2018-07-06 | 2018-07-06 | Chinese yam is fresh to carry spray-dried granules medicine materical crude slice |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108567873A true CN108567873A (en) | 2018-09-25 |
Family
ID=63573801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810733297.0A Withdrawn CN108567873A (en) | 2018-07-06 | 2018-07-06 | Chinese yam is fresh to carry spray-dried granules medicine materical crude slice |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108567873A (en) |
-
2018
- 2018-07-06 CN CN201810733297.0A patent/CN108567873A/en not_active Withdrawn
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180925 |
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WW01 | Invention patent application withdrawn after publication |