CN108567848A - A kind of diabetes electuary and preparation method thereof - Google Patents
A kind of diabetes electuary and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a kind of diabetes electuaries and preparation method thereof, belong to Chinese medicine manufacturing field.A kind of diabetes electuary, it is characterised in that be made of the Chinese herbal medicine of following parts by weight：Raw 25 ~ 40 parts of Radix Astragali, 25 ~ 40 parts of Radix Rehmanniae, 10 ~ 20 parts of rhizoma atractylodis, 25 ~ 40 parts of ginseng, 10 ~ 20 parts grams of pueraria lobata, 25 ~ 40 parts of Radix Salviae Miltiorrhizae.The present invention diabetes electuary, it is not only easy to carry, drink conveniently, safety, mouthfeel is suitable, long-term consumption can treat diabetes, control blood glucose, reduce blood pressure, be antitumor, anti diar rhea, improve immunity, the effects that boosting metabolism.
Description
Technical field
The present invention relates to Chinese medicine manufacturing field, more particularly to a kind of diabetes electuary and preparation method thereof.
Background technology
Diabetes are one group of metabolic diseases characterized by hyperglycemia.Hyperglycemia be then due to defect of insulin secretion or
Its biological effect is impaired, or both have concurrently and cause.Long-standing hyperglycemia when diabetes, cause various tissues, especially eye,
Kidney, heart, blood vessel, the chronic lesion of nerve, dysfunction.
Currently, the method for the treatment of diabetes is treated by insulin injection or by oral drugs on the market.Note
Penetrate that insulin can cause to develop immunity to drugs and other toxic side effects also will produce although oral drugs can control blood glucose
Toxic side effect can only alleviate symptom, do not have the effect for the treatment of, also increase the injury of other organs of patient.
Invention content
It is an object of the invention to：In view of the above problems, a kind of diabetes electuary is provided, not only easy to carry,
Convenience, safety are drunk, mouthfeel is suitable, and long-term consumption can treat diabetes, control blood glucose, reduce blood pressure, is antitumor, anti-abdomen
The effects that rushing down, improving immunity, boost metabolism.The electuary of the present invention not only reconstitutes conveniently, and mouthfeel is suitable, absorbs soon, and
It has no toxic side effect.The present invention also provides a kind of production methods of diabetes electuary.
The technical solution adopted by the present invention is as follows：
A kind of diabetes electuary, it is characterised in that be made of the Chinese herbal medicine of following parts by weight：Raw 25 ~ 40 parts of Radix Astragali, Radix Rehmanniae 25 ~ 40
Part, 10 ~ 20 parts of rhizoma atractylodis, 25 ~ 40 parts of ginseng, 10 ~ 20 parts of pueraria lobata, 25 ~ 40 parts of Radix Salviae Miltiorrhizae.
Preferably, raw 30 ~ 35 parts of Radix Astragali, 30 ~ 35 parts of Radix Rehmanniae, 12 ~ 18 parts of rhizoma atractylodis, 30 ~ 35 parts of ginseng, 12 ~ 18 parts of pueraria lobata
Gram, 30 ~ 35 parts of Radix Salviae Miltiorrhizae.
Preferably, further include auxiliary material, the auxiliary material is Icing Sugar, beta-cyclodextrin, inorganic salts, wetting agent.
Preferably, the Icing Sugar is mixed by steviol glycoside and starch, mixed proportion 1：0.2.
Preferably, the wetting agent is purified water or ethyl alcohol.
Preferably, inorganic salts can be calcium carbonate or medicinal calcium carbonate.
A kind of preparation method of diabetes electuary, includes the following steps：
（1）The Chinese herbal medicine that the raw Radix Astragali, Radix Rehmanniae, rhizoma atractylodis, ginseng, pueraria lobata, Radix Salviae Miltiorrhizae mix by weight is put into 30 DEG C
30min is impregnated in~40 DEG C of warm water, Chinese herbal medicine draining is taken out, is put into container and adds water to cook secondary, the ratio of herbal medicine and water
Example is 1：3, heating time 1.5h~2h obtain decocting liquid, merge decocting liquid twice, and filtering concentrates the filtrate to defined relative density
Clear cream, add the wetting agent of equivalent, make its precipitation, take supernatant recycling ethyl alcohol and concentrate after, add 1.5 times of water, stir, it is quiet
Set 7h~10h, take supernatant concentration to the clear cream of proportion 1.38-1.40, qinghuo reagent, Icing Sugar, beta-cyclodextrin, be added wetting agent and
Inorganic salts are uniformly mixed, with fashion of extrusion by 14~22 mesh screens, dry wet particle are made；
（2）By step（1）Filter residue be sequentially placed into drying unit and dried, crush, fine drug powder obtained with screen filtration, be added
Icing Sugar, beta-cyclodextrin, wetting agent and inorganic salts are uniformly mixed, and with fashion of extrusion by 14~22 mesh screens, are made wet dry
Grain；
（3）By step（1）And step（2）Made dry wet particle is uniformly mixed, and is dried, is cooled down in time, is sieved, is made
Particle is uniform；
（4）Selection is not easy to breathe freely, the packaging material of moisture-inhibiting, by step（3）The particle of gained is carried out using automatic granular packaging machine
Packing, often packet particle is 10g, dry storage.
Preferably, the filtrate is concentrated into the clear cream of defined relative density, is the heat survey proportion at 80 DEG C~90 DEG C
It is 1.30~1.35.
Preferably, the drying temperature is 60 DEG C~80 DEG C, the clear cream, the mixed proportion of Icing Sugar, beta-cyclodextrin
It is 1：3：1.
Preferably, the drying temperature is 60 DEG C~80 DEG C, and the degree of drying of particle controls water content below 2%.
Above-mentioned formula, the effect of the Chinese herbal medicine and other components of the diabetes electuary respectively are as follows：
The effect of raw Radix Astragali and effect：Invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation.For treatment deficiency of vital energy weak, deficiency of food is just
It is half congealed, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, qi deficiency edema Radix Astragali disk, ulcer is difficult to burst, burst for a long time and does not holds back, blood
Empty impotence is yellow, Heat Diabetes.Effect：1, enhance immune function 2, to the effect 3 of interferon, enhancing body hypoxia-bearing and stress energy
Power 4 promotes organism metabolism 5, improves heart function 6, antihypertensive effect 7, hepatoprotective effect 8, adjusts blood glucose 9, anti-mattress and inhibit disease
Toxic action 10, hormone-like effect.
The effect of Radix Rehmanniae and effect：Clearing heat and promoting fluid, cool blood, hemostasis.For consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, spot dermexanthesis is spat
Blood, bleeding from five sense organs or subcutaneous tissue, abscess of throat.Radix rehmanniae recen clearing heat and cooling blood, yin-nourishing are promoted the production of body fluid.
The effect of rhizoma atractylodis and effect：There is hypoglycemic effect；For controlling wet soreness, burnout, gastral cavity ruffian abdominal distension, appetite is not
It shakes, vomits, diarrhea, dysentery, malaria, phlegm and retained fluid, oedema, feel cold, wind-cold-dampness arthralgia, atrophy, yctalopia.
The effect of ginseng and effect：It reinforces vital energy, veins takes off admittedly reinforces the spleen to benefit the lung, and promotes the production of body fluid to quench thirst, tranquilize the mind and promote the intelligence.It cures mainly：Labor
Hinder deficient, deficiency of food, burnout, regurgitation and emesis, stool lingering diarrhea, cough of deficient and syndrome characterized by dyspnea, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, impotence,
Frequent micturition is quenched one's thirst, woman uterine bleeding, infantile chronic fright and perennial and irrecoverable weakness, the card of all qi-blood-body fluid deficiencies.Central nervous system can be adjusted
System promotes utilization of the brain to energy matter, improves cardiac function, and hypoglycemic effect enhances the immune function of body, raising pair
The resilience of destructive stimulus can enhance the stress ability and adaptability of body, antitumor action, antioxidation.
The effect of pueraria lobata and effect：Expelling pathogenic factors from muscles and skin is brought down a fever；It delivers and examines；It promotes the production of body fluid to quench thirst；Shengyang Zhixie.Main fever caused by exogenous pathogens；Head term
Strong pain；Measles from the beginning of；Rash goes out unsmooth；Warm disease is thirsty；Diabete；Diarrhea；Dysentery；Hypertension；Coronary heart disease.Effect：Expansion blood vessel,
Hypoglycemic, lipoid and reducing blood pressure of dispelling, promotes the production of body fluid to quench thirst at antidiarrheal of quenching the thirst.
The effect of Radix Salviae Miltiorrhizae and effect：1. reinforcing myocardial contractive power, improving cardiac function, do not increase myocardial oxygen consumption.2. pair
Blood vessel function expands coronary artery, increases myocardial blood flow;Peripheral blood vessel is expanded, blood flow increases;Cerebral blood flow (CBF) declines.3. antithrombotic shape
At raising plasmin activity;Extend bleeding and cotting time;Inhibit platelet aggregation, improves hemorheological properties.4. improving micro- follow
Ring.
Steviol glycoside：Steviol glycoside has blood pressure lowering, strengthening body, controls the medical values such as chaff urine disease, weight-reducing, steviol glycoside master
There are treatment diabetes, control blood glucose, reduces blood pressure, is antitumor, anti diar rhea, improving immunity, the effects that boosting metabolism,
There is fine effect to obesity controlling disease, adjusting hydrochloric acid in gastric juice, recovery neural fatigue, also has notable treatment to heart disease, pediatric saprodontia etc.
Effect, it is most important that it can eliminate the side effect of sucrose.Steviol glycoside analog derivative also has antihypertensive, blood glucose, antitumor,
Improve diarrhea and improves the immunity of the human body.Steviol glycoside, which is added, in electuary of the present invention can make the inclined sweet tea of mouthfeel, cover medium-height grass
The bitter taste of medicine itself, allows patient preferably to receive.
Usage and dosage：3 times a day, it 1 wraps every time, half an hour warm water is taken after meal.Every 15 days as a treatment course.
The present invention diabetes electuary preparation method in, before water boiling first with warm water impregnate purpose be in order to make in
The pharmacological property of herbal medicine can be fully played, and the method for then using water boiling again obtains supernatant, and auxiliary material is added, particle is made,
It is crushed again after the filter residue of Chinese herbal medicine is dried, auxiliary material is added, particle is made, then all particles are uniformly mixed again and are done
It is dry, it is therefore an objective to which that Chinese herbal medicine is very expensive, and filter residue of Chinese herbal medicine itself yet has good drug effect, is made with the method for water boiling
Particle mixes, and Chinese medicinal herbs can be made adequately to be used, and the diabetes electuary of the present invention can also played more preferably
Therapeutic effect, fundamentally improve patient physical function, improve immunity of organisms, antibacterial anti-inflammatory, control allergy, from
And achieve the purpose that treating both manifestation and root cause of disease.
Steviol glycoside is mixed with starch can play moisture-proof, anti-bonding, anti-mildew effect.
Beneficial effects of the present invention：
（1）The essence of Chinese medicine is passed on, a kind of prescription pharmacology of diabetes electuary of the invention is：Adjust blood glucose, softening blood vessel, drop
Low blood fat, glucose in urine, antibacterial hemostasis, analgesia, nourishing Yin and promoting production of body fluid, nourishing yin and lessening fire kidney tonifying, qi and activate blood circulation nourish the liver to improve visual acuity, are antitumor, improving
Immunity, boost metabolism and other effects.The combination of ginseng, rhizoma atractylodis, pueraria lobata, raw Radix Astragali mainly first controls and adjusts diabetes
Blood glucose prevents from causing other symptom because blood glucose increases, and is promoted the production of body fluid to quench thirst by pueraria lobata, raw Radix Astragali, Radix Rehmanniae, diuretic and maintain drug, interior heat
Pharmacology of quenching one's thirst and other effects improves the malaise symptoms such as the thirsty of diabetes, urine is more, and rhizoma atractylodis improve the diseases such as spirit is indolent and listless, malaise
Shape, then filled blood by ginseng, Radix Salviae Miltiorrhizae pharmacology, invigorate blood circulation, calm the nerves, promoting human metabolism, immunity of organisms is improved, from entirety
The upper vital organs of the human body for adjusting patient are suitble to diabetic's long-term consumption, to play the effect for the treatment of.
（2）Inorganic salts are mainly used for absorbing the liquid in prescription.Icing Sugar, beta-cyclodextrin are mainly used for increasing the weight of tablet
Amount and volume.Wetting agent is that one kind does not have sticking liquid, effect to be moistening tablet materials and induce the viscosity of material in itself.
Particle made from this method passes through moistened surface, has granular mass good, and appearance looks elegant, wearability are compared with strong, compact property is good
The advantages of.
（3）Electuary made of Chinese herbal medicine can use mixing in water for oral taking, not only maintain the characteristic of decoction, but also decoction is overcome to decoct temporarily,
The shortcomings that being easy to go mouldy, and the bitter taste of drug can be covered, drug effect absorbs faster compared with solid pharmaceutical preparation, and better efficacy, safety is made without pair
With for the pregnant woman for having diabetes and good news, the formula also have cool blood tocolysis, solution in addition to that can treat diabetes
Malicious effect, therefore, formula adult, child, pregnant woman, diabetes, three high crowds are drinkable, both will not be because of solid pharmaceutical preparation
Used raw material cause hepar damnification, and the advantages that easy to carry, transport, use.
Specific implementation mode
Embodiment 1
A kind of diabetes electuary, it is characterised in that be made of the Chinese herbal medicine of following parts by weight：Raw 25 parts of Radix Astragali, 25 parts of Radix Rehmanniae, it is grey
10 parts of art, 25 parts of ginseng, 10 parts of pueraria lobata, 25 parts of Radix Salviae Miltiorrhizae.
Further include auxiliary material, the auxiliary material is Icing Sugar, beta-cyclodextrin, inorganic salts, wetting agent.
The Icing Sugar is mixed by steviol glycoside and starch, mixed proportion 1：0.2.
The wetting agent is purified water or ethyl alcohol.
The inorganic salts can be calcium carbonate or medicinal calcium carbonate.
Embodiment 2
A kind of diabetes electuary, it is characterised in that be made of the Chinese herbal medicine of following parts by weight：Raw 30 parts of Radix Astragali, 30 parts of Radix Rehmanniae, it is grey
30 parts of art, 30 parts of ginseng, 15 parts of pueraria lobata, 30 parts of Radix Salviae Miltiorrhizae.
Further include auxiliary material, the auxiliary material is Icing Sugar, beta-cyclodextrin, inorganic salts, wetting agent.
The Icing Sugar is mixed by steviol glycoside and starch, mixed proportion 1：0.2.
The wetting agent is purified water or ethyl alcohol.
The inorganic salts can be calcium carbonate or medicinal calcium carbonate.
Embodiment 3
A kind of diabetes electuary, it is characterised in that be made of the Chinese herbal medicine of following parts by weight：Raw 40 parts of Radix Astragali, 40 parts of Radix Rehmanniae, it is grey
20 parts of art, 40 parts of ginseng, 20 parts of pueraria lobata, 40 parts of Radix Salviae Miltiorrhizae.
Further include auxiliary material, the auxiliary material is Icing Sugar, beta-cyclodextrin, inorganic salts, wetting agent.
The Icing Sugar is mixed by steviol glycoside and starch, mixed proportion 1：0.2.
The wetting agent is purified water or ethyl alcohol.
The inorganic salts can be calcium carbonate or medicinal calcium carbonate.
Embodiment 4
The preparation method that above-described embodiment 1 to 3 is all made of, includes the following steps：
A kind of preparation method of diabetes electuary is provided, is included the following steps：
（1）The Chinese herbal medicine that the raw Radix Astragali, Radix Rehmanniae, rhizoma atractylodis, ginseng, pueraria lobata, Radix Salviae Miltiorrhizae mix by weight is put into 30 DEG C
30min is impregnated in~40 DEG C of warm water, Chinese herbal medicine draining is taken out, is put into container and adds water to cook secondary, the ratio of herbal medicine and water
Example is 1：3, heating time 1.5h~2h obtain decocting liquid, merge decocting liquid twice, and filtering concentrates the filtrate to defined relative density
Clear cream, add the wetting agent of equivalent, make its precipitation, take supernatant recycling ethyl alcohol and concentrate after, add 1.5 times of water, stir, it is quiet
Set 7h~10h, take supernatant concentration to the clear cream of proportion 1.38-1.40, qinghuo reagent, Icing Sugar, beta-cyclodextrin, be added wetting agent and
Inorganic salts are uniformly mixed, with fashion of extrusion by 14~22 mesh screens, dry wet particle are made；
（2）By step（1）Filter residue be sequentially placed into drying unit and dried, crush, fine drug powder obtained with screen filtration, be added
Icing Sugar, beta-cyclodextrin, wetting agent and inorganic salts are uniformly mixed, and with fashion of extrusion by 14~22 mesh screens, are made wet dry
Grain；
（3）By step（1）And step（2）Made dry wet particle is uniformly mixed, and is dried, is cooled down in time, is sieved, is made
Particle is uniform；
（4）Selection is not easy to breathe freely, the packaging material of moisture-inhibiting, by step（3）The particle of gained is carried out using automatic granular packaging machine
Packing, often packet particle is 10g, dry storage.
The quality examination of granule：
| Inspection item | As a result it describes |
| The type of granule | Sol particle |
| Appearance | Phenomena such as particle drying, uniform, color and luster is consistent, the no moisture absorption, softening, caking, deliquescence |
| Granularity | Cannot be by the 15% of the summation≤test sample amount for No.1 sieve+can be sieved by No. five, epigranular, appearance looks elegant, wearability are compared with strong, compact property is good |
| Loss on drying | Less loss weight≤test sample amount 2.0% |
| Melting | Soluble granule.It all dissolves under the defined conditions |
| Moisture | No more than 2.0% |
| Content uniformity | 10g is often wrapped, content uniformity limit is 3%, meets regulation |
Typical case：
1, Mrs Duan 40 years old, suffers from " type II diabetes ", on an empty stomach survey blood glucose 20mmol/L, glucose in urine 4+, and urine ketone bodies+, and with
Diuresis, dry, more drink, more foods are with the symptoms such as become thin, and after using the course for the treatment of of top 5 then, survey blood glucose 8mmol/L on an empty stomach, and glucose in urine+, urine
Ketoboidies, it is substantially back to normal, then take 5 course for the treatment of, diuresis, dry, more drinks, more foods disappear substantially, feel energetic, body
Body situation is clearly better.
2, certain is thanked, women 50 years old, suffers from " Type I diabetes ", and patient's body is fat, body weight is sleepy, god is tired weak, diuresis,
Dry.After 3 courses for the treatment of of the electuary, diuresis, dry symptom be eased, entire people appears to have energy.3 are taken again
A course for the treatment of is consolidated, the symptom disappearance of diuresis, dry, and the state of mind is good.
This Chongji for Treatment diabetic 86, what wherein blood glucose can be effectively controlled has 76, total effective rate
95.8%。
Claims (10)
1. a kind of diabetes electuary, it is characterised in that be made of the Chinese herbal medicine of following parts by weight：Raw 25 ~ 40 parts of Radix Astragali, Radix Rehmanniae 25 ~
40 parts, 10 ~ 20 parts of rhizoma atractylodis, 25 ~ 40 parts of ginseng, 10 ~ 20 parts grams of pueraria lobata, 25 ~ 40 parts of Radix Salviae Miltiorrhizae.
2. a kind of diabetes electuary according to claim 1, it is characterised in that be made of the Chinese herbal medicine of following parts by weight：It is raw
30 ~ 35 parts of Radix Astragali, 30 ~ 35 parts of Radix Rehmanniae, 12 ~ 18 parts of rhizoma atractylodis, 30 ~ 35 parts of ginseng, 12 ~ 18 parts grams of pueraria lobata, 30 ~ 35 parts of Radix Salviae Miltiorrhizae.
3. a kind of diabetes electuary according to claim 1 or 2, which is characterized in that further include auxiliary material, the auxiliary material is sugar
Powder, beta-cyclodextrin, inorganic salts, wetting agent.
4. a kind of diabetes electuary according to claim 3, which is characterized in that the Icing Sugar is by steviol glycoside and shallow lake
Powder mixes, mixed proportion 1：0.2.
5. a kind of diabetes electuary according to claim 3, which is characterized in that the wetting agent is purified water or second
Alcohol.
6. a kind of diabetes electuary according to claim 3, which is characterized in that inorganic salts can be calcium carbonate or carbo medicinalis
Sour calcium.
7. according to a kind of preparation method of diabetes electuary of claim 1 to 6, include the following steps：
（1）The Chinese herbal medicine that the raw Radix Astragali, Radix Rehmanniae, rhizoma atractylodis, ginseng, pueraria lobata, Radix Salviae Miltiorrhizae mix by weight is put into 30 DEG C
30min is impregnated in~40 DEG C of warm water, Chinese herbal medicine draining is taken out, is put into container and adds water to cook secondary, the ratio of herbal medicine and water
Example is 1：3, heating time 1.5h~2h obtain decocting liquid, merge decocting liquid twice, and filtering concentrates the filtrate to defined relative density
Clear cream, add the wetting agent of equivalent, make its precipitation, take supernatant recycling ethyl alcohol and concentrate after, add 1.5 times of water, stir, it is quiet
Set 7h~10h, take supernatant concentration to the clear cream of proportion 1.38-1.40, qinghuo reagent, Icing Sugar, beta-cyclodextrin, be added wetting agent and
Inorganic salts are uniformly mixed, with fashion of extrusion by 14~22 mesh screens, dry wet particle are made；
（2）By step（1）Filter residue be sequentially placed into drying unit and dried, crush, fine drug powder obtained with screen filtration, be added
Icing Sugar, beta-cyclodextrin, wetting agent and inorganic salts are uniformly mixed, and with fashion of extrusion by 14~22 mesh screens, are made wet dry
Grain；
（3）By step（1）And step（2）Made dry wet particle is uniformly mixed, and is dried, is cooled down in time, is sieved, is made
Particle is uniform；
（4）Selection is not easy to breathe freely, the packaging material of moisture-inhibiting, by step（3）The particle of gained is carried out using automatic granular packaging machine
Packing, often packet particle is 10g, dry storage.
8. a kind of preparation method of diabetes electuary according to claim 7, it is characterised in that：Step（1）Described in filtrate
The clear cream of relative density as defined in being concentrated into is that survey proportion in 80 DEG C~90 DEG C of heat be 1.30~1.35.
9. a kind of preparation method of diabetes electuary according to claim 7, it is characterised in that：Step（2）Described in drying
Temperature be 60 DEG C~80 DEG C, the clear cream, Icing Sugar, beta-cyclodextrin mixed proportion be 1：3：1.
10. a kind of preparation method of diabetes electuary according to claim 7, it is characterised in that：Step（3）The dry temperature
Degree is 60 DEG C~80 DEG C, and the degree of drying of particle controls water content below 2%.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110680886A (en) * | 2019-10-11 | 2020-01-14 | 江西新天地药业有限公司 | Chinese herbal medicine granules for improving immunity of livestock and poultry and preparation method thereof |
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2018
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110680886A (en) * | 2019-10-11 | 2020-01-14 | 江西新天地药业有限公司 | Chinese herbal medicine granules for improving immunity of livestock and poultry and preparation method thereof |
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