A kind of skin care compositions of eliminating chloasma and the preparation method and application thereof
Technical field
The invention belongs to cosmetic field, more particularly to a kind of skin care compositions of eliminating chloasma and preparation method thereof with
Using.
Background technology
Chloasma is also referred to as chloasma hepaticum, for the yellowish-brown pigmentation of face.Multipair title butterfly is distributed in cheek.It is more common in female
Property, estrogen level height is main cause in blood, and morbidity is related with gestation, Long-term Oral contraceptive, paramenia.
Chinese medicine thinks:Yin and yang imbalance in human body, one, because of stagnation of liver qi, causes blood stasis face;Two because weakness of the spleen and the stomach, and qi and blood is not
Can moisten face, and the damp and hot face that rises to forms spot;Three form chloasma because of the insufficiency of the kidney yang, yang-energy disperse, blood stasis face.
Present medicine thinks:Placenta secretion hero progestational hormone increases after pregnancy, so common symmetrical point of pregnant women Face and cheek
The chloasma of cloth, but after male Progesterone Secretion restores normal condition in vivo after producing, the spot of most people can nature mitigate or disappear
It loses;Some chronic diseases such as chronic hepatitis, tuberculosis etc. can cause junket hydracid enzymatic activity to enhance, and melanin, which generates, to be increased, and machine
The ability that body itself excludes melanin but weakens therewith, and melanin cannot once excrete in time, in the course of time also can be in face
Portion generates chloasma;In addition cosmetics improper use can also aggravate, accelerate the formation of chloasma, be many color spot origin causes of formation.
In conjunction with Chinese medicine and modern medicine, the present inventor starts with from liver,kidney,spleen is mended, and is verified by long-term experiment, multi-party to sieve
Choosing selects glycyrrhiza glabra root, eucommia bark, Herba Lamii albi, artemisia scoparia, the leaf of spinach prescription compounding and cosmetics is made, adjusts human body
State is used for eliminating chloasma.
Invention content
Researcher of the present invention by a large amount of experiment, provide a kind of stability is good, absorb fully, curative effect is high, stingless
Swash the skin care compositions of eliminating chloasma and the preparation method and application thereof of property.
The primary and foremost purpose of the present invention is to disclose a kind of skin care compositions of eliminating chloasma.
It is achieved through the following technical solutions:
A kind of skin care compositions of eliminating chloasma, by weight, be with 1-10 parts of glycyrrhiza glabra root, 2-8 parts of eucommia bark,
1-10 parts of Herba Lamii albi, 2-10 parts of artemisia scoparia, 0.5-5 parts of the leaf of spinach are prepared for raw medicinal material.
Further, the skin care compositions of the eliminating chloasma is by weight with 2-8 parts of glycyrrhiza glabra root, Du
Secondary bark 4-6 parts, 2-8 parts of Herba Lamii albi, 4-8 parts of artemisia scoparia, 1-4 parts of the leaf of spinach be prepared for raw medicinal material.
Wherein, the preparation method of skin care compositions is as follows:1) eucommia bark after taking formula ratio to dry and fresh the leaf of spinach,
Impurity is removed, 60-80 mesh is ground into, adds 6-10 times to measure water refluxing extraction 1-3 times, each 1-3 hours, filtering, merging filtrate subtracted
Pressure is condensed into thick paste, and it is 60-85% ethyl alcohol to be then added 3-5 times and measure volume fraction, stirs, stands 12-24 hours,
Relative density is the thick paste of 1.10-1.30 to get extract A when filtering, decompression filtrate recycling ethanol, and being condensed into 60 DEG C;
2) glycyrrhiza glabra root, Herba Lamii albi and artemisia scoparia after taking formula ratio to dry remove impurity, are ground into 60-80 mesh, are added
Boiling range is 60-90 DEG C of petroleum ether, the petroleum ether and glycyrrhiza glabra root, Herba Lamii albi, artemisia scoparia liquid ratio be 5-10ml/
G is put into processor for ultrasonic wave after mixing, regulation power 200-300W, 40-60 DEG C of temperature, is ultrasonically treated 20-
After 40min, solvent mixture and residue are detached, petroleum ether is recovered under reduced pressure, drying is to constant mass to get extract B; 3)It will
Extract A is obtained by mixing skin care compositions with extract B.
Further, application of the skin care compositions as cosmetic additive agent in cosmetics, additive amount account for cosmetics
The 1-10wt% of gross mass.
Further, the cosmetics can be eliminating chloasma Essence.
Further, eliminating chloasma Essence includes the component of following mass percentage:
Above-mentioned skin care compositions 1-10%, ring five dimethyl silicone polymer 1-3%, octyl polymethyl siloxane 1-3%, the octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester 1-5 Brazil souari(CARYOCAR BRASILIENSE)Fruit oil 1-3%, C14-22 alcohol 0.1-1%, C12-20
Alkyl glucoside 0.1-1%, PEG-100 stearate 0.1-0.5%, stearine 0.1-1%, 1,2- hexylene glycol 2-5%,
Xanthans 0.05-0.25%, acrylic acid(Ester)Class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.1-0.4%, allantoin
0.01-0.1%, arginine 0.1-0.4%, thermal water 0.1-5%, potassium sorbate 0.1-0.3%, magnesium aminosuccinate 0.001-0.01%,
Copper gluconate 0.001-0.01%, zinc gluconate 0.001-0.01%, propylene glycol 1-5%, Phenoxyethanol 0.1-0.3%, methyl hydroxybenzoate
0.1-0.3%, EDETATE SODIUM 0.01-0.05%, deionized water surplus.
Compared with prior art, beneficial effects of the present invention are:The present invention utilizes the root and root-like stock tissue of glycyrrhiza glabra
Into the cell there is the very strong depigmentation of skin of antioxygenic activity, the functional component lightened the stain, eucommia bark tonify the liver and kidney, and strengthening tendons are strong
The effect of the effect of bone, coordinating Chong and Conception Vessels, strengthen meridian and miscarriage prevention, Herba Lamii albi menstruation regulating, dampness removing, artemisia scoparia Yellow River harnessing epidemic disease hepatitis, clearing away damp-heat,
The effect of removing jaundice subcutaneous ulcer, arranges in pairs or groups the effect of the leaf of spinach enriching yin soothing the liver, can effectively eliminate pigment deposition, light spot U.S. face, make the product of acquisition
Availability higher, drug effect are more notable.
Specific implementation mode
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
The detailed description of step, embodiments of the present invention are not limited thereto, for not specifically specified parameter or condition, can refer to routine
Technology carries out.
The part raw material that the present invention uses are summarized as follows:
Glycyrrhiza glabra is Glycyrrhiza perennial herb, Classification system:Radix Glycyrrhizae Glabrae, root and root shape
Stem is used as medicine, nature and flavor:Sweet and neutral.The thoughts of returning home, lung, spleen, stomach.There is antioxygenic activities in the root of glycyrrhiza glabra, root-like stock histocyte
Very strong depigmentation of skin, the functional component lightened the stain, and be main component, i.e., glycyrrhiza glabra plain (Glabrene) and light fruit are sweet
Grass is fixed (Glabridin).Glycyrrhiza glabra is fixed and many components of cosmetics are fully inclusive and equitable, and compatibility is good, and it is anti-not will produce Antagonism
It answers.Major function is invigorated the spleen and benefited qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, burnout is weary
Power, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
Cortex Eucommiae also known as bakelite are Eucommiaceae Cortex Eucommiae platymiscium, Classification system:Eucommia ulmoides, bark enters
Medicine, it is sweet in flavor, it is warm-natured.Tonify the liver and kidney, strengthen muscles and bones, coordinating Chong and Conception Vessels, strengthen meridian and miscarriage prevention the effect of;Caused by kidney-yang deficiency being treated
Pain in waist and lower extremities or aching and limp inability, born of the same parents' tire caused by liver- qi invasion is not solid, the wet equal diseases of itching of scrotum.《Sheng Nong's herbal classic》In be listed in
Product.Modern study Cortex Eucommiae, which has, removes internal rubbish, reinforces human body cell metabolism, prevents muscle skeleton aging, balances people
Body blood pressure, decomposer inner cholesterol reduce body fat, restore blood vessel elasticity, diuresis heat-clearing, broad-spectrum antiseptic, excited maincenter god
Through improving white blood cell pharmacological action.
Herba Lamii albi, is a plant species under Labiatae lamium, and Classification system is:Lamium album, entirely
Grass is used as medicine, sweet in flavor, pungent, mild-natured, enters liver, kidney, bladder three and passes through.Herb is containing tannin, volatile oil, ascorbic acid, carrotene, saponin
Equal bioactive ingredients;With the scattered stasis of blood, disperse accumulation, menstruation regulating, dampness removing and other effects is used for traumatic injury, infantile malnutrition, leukorrhea, dysmenorrhoea,
Irregular menstruation, ephritis, cystitis.
Artemisia scoparia, nickname Artemisia capillaris, A Rong, artemisia scoparia, northeast Artemisia capillaris etc., composite family artemisia perennial herb or nearly one, two
Year sward sheet, Classification system:Artemisia scoparia WaldstEt Kit., nature and flavor:It is bitter, pungent, it is slightly cold.Returns spleen,
Stomach, liver, gallbladder channel.All herbal medicine, containing flavones, chromone, cumarin, volatile oil, organic acid, the ingredients such as terpene have anti-inflammatory sharp
Urine acts on, energy Yellow River harnessing epidemic disease hepatitis, clearing away damp-heat, removing jaundice subcutaneous ulcer.For jaundice oliguria, itchy sore;Infectious jaundice type hepatitis.
Spinach also known as Persian dish, red root vegetables, parrot dish etc., Classification system:Spinacia oleracea L., belong to Chenopodiaceae
Spinach category, annual herb plant.Whole herb with root is used as medicine, nature and flavor:It is sweet, it is cool.Channel tropism liver, stomach, large intestine, small intestinl channel.It is given birth to rich in dimension
Element and phosphorus, iron.Leaf contains 56~68 mgs/kg of zinc(Dry weight), 1.22 micro- gram gram of folic acid, amino acid and lutein, β-carrot
The carotenoid such as element, Neo-3-CaroteneB, new-beta carotene U, also contain hitodesterol, stigmastene -7- alcohol, cholesterine with
And sterol ester and sterol glycoside, patuletin, spinacetin.With enriching yin soothing the liver, cough-relieving ease constipation and other effects.
It is worth noting that, unless otherwise indicated, various components used in the present invention are this field current material, can
It is bought by commercial channel and obtains or be made by existing method.
Embodiment 1:It is prepared by skin care compositions
1) eucommia bark after taking 2 parts by weight to dry and the fresh the leaf of spinach of 4 parts by weight remove impurity, are ground into 60 mesh, add 10
Amount water refluxing extraction 1 time again, is extracted 3 hours, filtering, is concentrated under reduced pressure into thick paste, then 3 times of 85% ethyl alcohol of amount of addition, are fully stirred
It mixes uniformly, stands 12 hours, the thick paste that relative density is 1.10 when filtering, decompression filtrate recycling ethanol, and being condensed into 60 DEG C, i.e.,
Obtain extract A;
2)1 weight of glycyrrhiza glabra root point, 4 parts by weight of 10 parts by weight of Herba Lamii albi and artemisia scoparia after drying are taken, impurity, powder are removed
80 mesh are broken into, the petroleum ether that boiling range is 60 DEG C, the liquid material of the petroleum ether and glycyrrhiza glabra root, Herba Lamii albi, artemisia scoparia is added
Than for 10ml/g, being put into processor for ultrasonic wave after mixing, regulation power 200W, 40 DEG C of temperature, it is ultrasonically treated 40min
Afterwards, solvent mixture and residue are detached, petroleum ether is recovered under reduced pressure, drying is to constant mass to get extract B;
3)Extract A and extract B are obtained by mixing skin care compositions.
Embodiment 2:It is prepared by skin care compositions
1) fresh the leaf of spinach of eucommia bark and 0.5 parts by weight after taking 8 parts by weight to dry removes impurity, is ground into 80 mesh,
6 times are added to measure water refluxing extraction 3 times, 1 hour every time, filtering, merging filtrate was concentrated under reduced pressure into thick paste, and 5 times of amounts 60% are then added
Ethyl alcohol stirs, and stands 24 hours, and relative density is when filtering, decompression filtrate recycling ethanol, and being condensed into 60 DEG C
1.30 thick paste is to get extract A;
2)2 parts by weight of 10 parts by weight of glycyrrhiza glabra root, 1 parts by weight of Herba Lamii albi and artemisia scoparia after drying are taken, impurity, powder are removed
60 mesh are broken into, the petroleum ether that boiling range is 90 DEG C, the liquid material of the petroleum ether and glycyrrhiza glabra root, Herba Lamii albi, artemisia scoparia is added
Than for 5ml/g, being put into processor for ultrasonic wave after mixing, regulation power 300W, temperature 60 C, it is ultrasonically treated 20min
Afterwards, solvent mixture and residue are detached, petroleum ether is recovered under reduced pressure, drying is to constant mass to get extract B;
3)Extract A and extract B are obtained by mixing skin care compositions.
Embodiment 3:It is prepared by skin care compositions
1) fresh the leaf of spinach of eucommia bark and 5 parts by weight after taking 4 parts by weight to dry removes impurity, is ground into 70 mesh, adds 8
Amount water refluxing extraction 2 times again, 2 hours every time, filtering, merging filtrate was concentrated under reduced pressure into thick paste, is then added 4 times and measures 72% second
Alcohol stirs, and stands 18 hours, and relative density is 1.20 when filtering, decompression filtrate recycling ethanol, and being condensed into 60 DEG C
Thick paste to get extract A;
2)10 parts by weight of 8 parts by weight of glycyrrhiza glabra root, 2 parts by weight of Herba Lamii albi and artemisia scoparia after drying are taken, impurity, powder are removed
70 mesh are broken into, the petroleum ether that boiling range is 75 DEG C, the liquid material of the petroleum ether and glycyrrhiza glabra root, Herba Lamii albi, artemisia scoparia is added
Than for 7.5ml/g, being put into processor for ultrasonic wave after mixing, regulation power 250W, temperature 50 C, it is ultrasonically treated
After 30min, solvent mixture and residue are detached, petroleum ether is recovered under reduced pressure, drying is to constant mass to get extract B;
3)Extract A and extract B are obtained by mixing skin care compositions.
Embodiment 4:It is prepared by skin care compositions
1) fresh the leaf of spinach of eucommia bark and 1 parts by weight after taking 6 parts by weight to dry removes impurity, is ground into 65 mesh, adds 7
Amount water refluxing extraction 2 times again, 1.5 hours every time, filtering, merging filtrate was concentrated under reduced pressure into thick paste, is then added 3.5 times and measures
70% ethyl alcohol, stirs, and stands 15 hours, relative density when filtering, decompression filtrate recycling ethanol, and being condensed into 60 DEG C
For 1.15 thick paste to get extract A;
2)8 parts by weight of 2 parts by weight of glycyrrhiza glabra root, 8 parts by weight of Herba Lamii albi and artemisia scoparia after drying are taken, impurity, powder are removed
65 mesh are broken into, the petroleum ether that boiling range is 70 DEG C, the liquid material of the petroleum ether and glycyrrhiza glabra root, Herba Lamii albi, artemisia scoparia is added
Than for 6ml/g, being put into processor for ultrasonic wave after mixing, regulation power 220W, temperature 45 C, it is ultrasonically treated 25min
Afterwards, solvent mixture and residue are detached, petroleum ether is recovered under reduced pressure, drying is to constant mass to get extract B;
3)Extract A and extract B are obtained by mixing skin care compositions.
Embodiment 5:It is prepared by skin care compositions
1) fresh the leaf of spinach of eucommia bark and 2.5 parts by weight after taking 5 parts by weight to dry removes impurity, is ground into 75 mesh,
9 times are added to measure water refluxing extraction 2 times, 2.5 hours every time, filtering, merging filtrate was concentrated under reduced pressure into thick paste, and 4.5 times of amounts are then added
80% ethyl alcohol, stirs, and stands 20 hours, relative density when filtering, decompression filtrate recycling ethanol, and being condensed into 60 DEG C
For 1.25 thick paste to get extract A;
2)5 parts by weight of 5 parts by weight of glycyrrhiza glabra root, 5 parts by weight of Herba Lamii albi and artemisia scoparia after drying are taken, impurity, powder are removed
75 mesh are broken into, the petroleum ether that boiling range is 80 DEG C, the liquid material of the petroleum ether and glycyrrhiza glabra root, Herba Lamii albi, artemisia scoparia is added
Than for 8.5ml/g, being put into processor for ultrasonic wave after mixing, regulation power 280W, 55 DEG C of temperature, it is ultrasonically treated
After 35min, solvent mixture and residue are detached, petroleum ether is recovered under reduced pressure, drying is to constant mass to get extract B;
3)Extract A and extract B are obtained by mixing skin care compositions.
Embodiment 6:Eliminating chloasma Essence
It is added separately to the skin care compositions of embodiment 1-5 in following formulas, the Essence of eliminating chloasma is made, successively
It is calculated as Essence 1-5, wherein Essence 1-5 includes each component of following mass percentage, as shown in table 1:Table 1
Comparative example 7:Comparative example 1-5
Comparative example 1-5 includes each component of following mass percentage, as shown in table 2:
Table 2
Wherein, the extract in comparative example 1 is prepared by the following method:
22.5 weight of glycyrrhiza glabra root point after drying is taken, impurity is removed, is ground into 80 mesh, the oil that boiling range is 60 DEG C is added
The liquid ratio of ether, the petroleum ether and glycyrrhiza glabra root is 10ml/g, is put into processor for ultrasonic wave after mixing, and work(is adjusted
Rate is 200W, and 40 DEG C of temperature after being ultrasonically treated 40min, detaches solvent mixture and residue, petroleum ether is recovered under reduced pressure, drying is extremely
Constant mass is to get extract.
Wherein, the extract in comparative example 2 is prepared by the following method:
Eucommia bark after taking 22.5 parts by weight to dry removes impurity, is ground into 80 mesh, adds 6 times to measure water refluxing extraction 3 times, often
Secondary 1 hour, filtering, merging filtrate was concentrated under reduced pressure into thick paste, and 5 times of 60% ethyl alcohol of amount are then added, stirs, stands
24 hours, the thick paste that relative density is 1.30 when filtering, decompression filtrate recycling ethanol, and being condensed into 60 DEG C was to get extract.
Wherein, the extract in comparative example 3 is prepared by the following method:
22.5 parts by weight of Herba Lamii albi after drying are taken, impurity is removed, are ground into 70 mesh, the oil that boiling range is 75 DEG C is added
The liquid ratio of ether, the petroleum ether and Herba Lamii albi is 7.5ml/g, is put into processor for ultrasonic wave after mixing, is adjusted
Power is 250W, and temperature 50 C after being ultrasonically treated 30min, detaches solvent mixture and residue, petroleum ether is recovered under reduced pressure, dry
To constant mass to get extract.
Wherein, the extract in comparative example 4 is prepared by the following method:
22.5 parts by weight of artemisia scoparia after drying are taken, impurity is removed, are ground into 65 mesh, the petroleum ether that boiling range is 70 DEG C is added, it is described
The liquid ratio of petroleum ether and artemisia scoparia is 6ml/g, is put into processor for ultrasonic wave after mixing, regulation power 220W, temperature
45 DEG C, after being ultrasonically treated 25min, detach solvent mixture and residue, be recovered under reduced pressure petroleum ether, it is dry to constant mass to get
Extract.
Wherein, the extract in comparative example 5 is prepared by the following method:
It takes fresh the leaf of spinach of 22.5 parts by weight, removes impurity, be ground into 75 mesh, add 9 times of amount water refluxing extractions 2 times, every time 2.5
Hour, filtering, merging filtrate is concentrated under reduced pressure into thick paste, and 4.5 times of 80% ethyl alcohol of amount are then added, stirs, stands 20
Hour, the thick paste that relative density is 1.25 when filtering, decompression filtrate recycling ethanol, and being condensed into 60 DEG C is to get extract.
Prepared Essence, comparative example and its number are along in following experiment in the above various embodiments.
In order to better illustrate advantages of the present invention, the skin care compositions of eliminating chloasma provided by the invention is given below
The effect of product, tests:
1, eliminating chloasma Essence crowd tests:
Test method
550 patient with chloasma are randomly divided into 11 groups, Essence group, comparative example group and blank control group in embodiment 6, every group
50, average age 34.98 ± 5.23 years old, course of disease 2-10, the basic condition of 10 groups of subjects, age, the course of disease are without significantly
Sex differernce is comparable.
Above 10 groups of samples after daily face cleaning, are smeared given the test agent in face, are respectively used 1 time sooner or later, continuous use 30
It, pregnant and lying-in women, menorrhalgia person's disabling, subject stop using other nti-freckle products, blank control group not to make during medication
With any medicine for removing speckle.
Observe the size of pretherapy and post-treatment patch, the variation of color spot shade
With the tested front and back length and width of the same chloasma of tape measure, color spot area is calculated;According to Chinese Academy of Sciences's geography
Research institute's development and design, what Mapping Press published for 1992《Practical standard colour atla》(Y+M+BK is brown in (first edition)
Yellow+pinkish red+black folded color) colour atla be the chloasma depth criterion:I (15,20,5), II (30,40,10), III (40,
60、15)。
Freckle effect judges
(1) effective:Chloasma color obviously shoals, and area reduces > 1/3, does not generate new chloasma;
(2) effectively:Chloasma lighter, area reduce≤1/3, do not generate new chloasma;
(3) invalid:Chloasma color and area are without significant change.
Pretherapy and post-treatment curative effect index and adverse reaction are observed, and detects activity of SOD in serum and MDA contents.SOD is measured
Using yellow crash cry of certain animals enzymatic measurement, MDA, which is measured, uses thiobarbituricacidα- method.
Freckle effect test result, is shown in Table 3.
Table 3
The result shows that:Inventive samples are used continuously after 30 days in subject, and the color of facial chloasma obviously shoals until disappearing
It losing, color spot area is reduced significantly, and 76%(38/50*100%)Above subject's color spot area is reduced beyond primary colors spot area
1/3 or more, wherein the chloasma of 66% subject (i.e. 33 subjects) completely disappears, and do not observe that new chloasma goes out
Existing, total effective rate of the invention reaches 98.0%(That is 49/50*100% in Essence 1, Essence 2-5 are 100% effective)More than.
Compared with comparative example 1-5, effect of the present invention is more preferable;In addition, comparative example 1-5 is only to add glycyrrhiza glabra root, eucommia bark, short handle
One pack system extract in white dead nettle, artemisia scoparia and the leaf of spinach, effect is undesirable, only glycyrrhiza glabra root, eucommia bark, short handle open country sesame
Effect is just apparent when fiber crops, artemisia scoparia and the leaf of spinach share, and has the function of synergy.
In addition, during experiment, Essence 1-5 subject illustrates this hair without any allergic reaction and other adverse reactions
Bright extract has no adverse effects to human body.And it is subject's healthy looking, exquisiteness, ruddy glossy, illustrate the extract of the present invention
Has effects that nti-freckle, U.S. face.
2, product quality research
Essence 1-5 made from the scheme of Example 6, numbered samples 1-5, every group of 10 people of sample tests, with character matter
Sense, irritation, absorbability etc. are index, investigate the quality of product.
Experimental result is shown:After subject uses Essence, there is skin irritation, red after use in no one in 24 hours
It is swollen to wait adverse reactions;Product is fine and smooth mildly, tends to smear out absorption, non-greasy, and moistens degree satisfaction.
From the above data, extract of the present invention and its manufactured cosmetics, eliminating chloasma work well, and stingless
Swash property and toxicity, by investigations such as curative effect, safety, product qualities, corresponding index meets the expected requirements, and illustrates the present invention
It is formulated reasonable design, preparation method is simply controllable, has a good application prospect.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore
All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.