CN1085543A - 有药理活性的α-[叔-氨基甲基]-苯甲醇衍生物 - Google Patents

有药理活性的α-[叔-氨基甲基]-苯甲醇衍生物 Download PDF

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Publication number
CN1085543A
CN1085543A CN93108986A CN93108986A CN1085543A CN 1085543 A CN1085543 A CN 1085543A CN 93108986 A CN93108986 A CN 93108986A CN 93108986 A CN93108986 A CN 93108986A CN 1085543 A CN1085543 A CN 1085543A
Authority
CN
China
Prior art keywords
methyl
phenylcarbinol
compound
dimethylamino
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN93108986A
Other languages
English (en)
Chinese (zh)
Inventor
N·-E·韦尔曼
B·C·H·西约格伦
L·G·诺
G·L·佩森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Kabi Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia AB filed Critical Kabi Pharmacia AB
Publication of CN1085543A publication Critical patent/CN1085543A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/70—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN93108986A 1992-07-22 1993-07-22 有药理活性的α-[叔-氨基甲基]-苯甲醇衍生物 Pending CN1085543A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9202218A SE9202218D0 (sv) 1992-07-22 1992-07-22 Pharmacologically active alfa-(tertiary-aminomethyl)-benzenemethanol derivatives, pharmaceutical composition containing them, therapeutical use thereof and processes for their preparation
SE9202218 1992-07-22

Publications (1)

Publication Number Publication Date
CN1085543A true CN1085543A (zh) 1994-04-20

Family

ID=20386825

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93108986A Pending CN1085543A (zh) 1992-07-22 1993-07-22 有药理活性的α-[叔-氨基甲基]-苯甲醇衍生物

Country Status (22)

Country Link
US (1) US5527821A (enExample)
EP (1) EP0651735B1 (enExample)
JP (1) JPH07509699A (enExample)
KR (1) KR950702522A (enExample)
CN (1) CN1085543A (enExample)
AT (1) ATE166339T1 (enExample)
AU (1) AU672989B2 (enExample)
BR (1) BR9306870A (enExample)
CA (1) CA2140781C (enExample)
CZ (1) CZ13395A3 (enExample)
DE (1) DE69318715D1 (enExample)
FI (1) FI950209A0 (enExample)
HU (1) HUT72632A (enExample)
MX (1) MX9304403A (enExample)
NO (1) NO301760B1 (enExample)
NZ (1) NZ254309A (enExample)
RU (1) RU2111205C1 (enExample)
SE (1) SE9202218D0 (enExample)
SK (1) SK7695A3 (enExample)
TW (1) TW261605B (enExample)
WO (1) WO1994002442A1 (enExample)
ZA (1) ZA935045B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101108809B (zh) * 2003-06-13 2010-07-14 施万制药 作为毒蕈碱性受体拮抗剂的1-(烷氨基烷基-吡咯烷-/哌啶基)-2,2-二苯基乙酰胺衍生物

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe
DE69830728T2 (de) * 1997-04-11 2006-05-18 Nippon Shinyaku Co., Ltd. Arzneimittel zur behandlung von häufigem wasserlassen und harninkontinenz
US6008412A (en) * 1997-10-14 1999-12-28 Eli Lilly And Company Process to make chiral compounds
US6323231B1 (en) 2000-02-17 2001-11-27 Abbott Laboratories Use of α1A adrenoceptor agonists with α1B and α1D antagonism for the treatment of stress urinary incontinence
US6503190B1 (en) 2000-09-29 2003-01-07 Ethicon Endo-Surgery, Inc. Vaginal pessary
DE10059412A1 (de) * 2000-11-30 2002-06-13 Gruenenthal Gmbh Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie der Harninkontinenz
DE10146275A1 (de) * 2001-09-18 2003-04-24 Gruenenthal Gmbh Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE210031C (enExample) *
US4349549A (en) * 1981-05-18 1982-09-14 Syntex (U.S.A.) Inc. Anti-hypertensive 1-substituted spiro(piperidine-oxobenzoxazine)s
PL140232B1 (en) * 1982-07-05 1987-04-30 Warszawskie Zaklady Farma Method of obtaining derivatives of 1-aryl-2-aminoestanole
EP0103830A3 (de) * 1982-09-22 1985-07-31 Bayer Ag Wachstumsfördernde Phenylethylamin-Derivate
EP0213108A3 (de) * 1985-06-26 1987-07-15 Kurt Dr. Burghart Pharmazeutische Zubereitung mit einem Antihypotonikum als wirksames Mittel
PH30083A (en) * 1991-02-25 1996-12-27 Lilly Co Eli Treatment of lower urinary tract disorders

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101108809B (zh) * 2003-06-13 2010-07-14 施万制药 作为毒蕈碱性受体拮抗剂的1-(烷氨基烷基-吡咯烷-/哌啶基)-2,2-二苯基乙酰胺衍生物

Also Published As

Publication number Publication date
BR9306870A (pt) 1998-12-08
NO950177D0 (no) 1995-01-17
ZA935045B (en) 1994-02-07
AU672989B2 (en) 1996-10-24
DE69318715D1 (de) 1998-06-25
RU95104934A (ru) 1997-04-10
JPH07509699A (ja) 1995-10-26
MX9304403A (es) 1994-04-29
NO950177L (no) 1995-01-17
HUT72632A (en) 1996-05-28
HU9500175D0 (en) 1995-03-28
WO1994002442A1 (en) 1994-02-03
CZ13395A3 (en) 1995-11-15
NO301760B1 (no) 1997-12-08
CA2140781A1 (en) 1994-02-03
SK7695A3 (en) 1995-07-11
EP0651735B1 (en) 1998-05-20
CA2140781C (en) 1998-09-29
RU2111205C1 (ru) 1998-05-20
US5527821A (en) 1996-06-18
ATE166339T1 (de) 1998-06-15
FI950209L (fi) 1995-01-18
AU4595093A (en) 1994-02-14
KR950702522A (ko) 1995-07-29
FI950209A7 (fi) 1995-01-18
NZ254309A (en) 1996-08-27
SE9202218D0 (sv) 1992-07-22
FI950209A0 (fi) 1995-01-18
TW261605B (enExample) 1995-11-01
EP0651735A1 (en) 1995-05-10

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Address after: Stockholm

Applicant after: Pharmacia AB

Address before: Sweden Sara Appleton

Applicant before: Kabi Pharmacia AB

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Free format text: CORRECT: APPLICANT; FROM: KABI PHARMACIA AB TO: FAMERSIA PHARMACY CORP.

C01 Deemed withdrawal of patent application (patent law 1993)