CN108524910A - 一种治疗痛风的组合物及其制备方法 - Google Patents

一种治疗痛风的组合物及其制备方法 Download PDF

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CN108524910A
CN108524910A CN201810560318.3A CN201810560318A CN108524910A CN 108524910 A CN108524910 A CN 108524910A CN 201810560318 A CN201810560318 A CN 201810560318A CN 108524910 A CN108524910 A CN 108524910A
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马南行
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Abstract

本发明公开了一种治疗痛风的组合物，其活性成分包括酸樱桃提取物、肉桂提取物、人参提取物、党参提取物、菟丝子提取物、肉苁蓉提取物、干姜提取物、葵花盘提取物、鼠曲草提取物，西芹籽提取物，车前子提取物、木瓜提取物、桑枝提取物、杜仲提取物、鹅肌肽。本发明的组合物适用于痛风患者，有降低尿酸、缓解痛风症状的功效；制成膳食轻饮后，口感怡人，易于被患者所接受。

Description

一种治疗痛风的组合物及其制备方法
技术领域
本发明属于保健食品技术领域，涉及一种治疗痛风的组合物及其制备方法。
背景技术
痛风主要是由于嘌呤代谢紊乱导致尿酸生成增多所引起的。临床上表现为高尿酸血症、痛风性急性关节炎反复发作、痛风石沉积、特征性慢性关节炎和关节炎畸形，常常导致肾脏引起慢性间质性肾炎和肾尿酸结石形成，并可出现关节致残及肾功能不全。
随着人们生活水平的提高，饮食结构的变化，糖、蛋白、脂肪的摄入量明显增加，痛风的发病率逐年增高。因此，开发一种具有具有降尿酸作用的食用膳食组合物具有良好的市场前景。
发明内容
本发明的目的在于提供一种具有治疗痛风功效的组合物，尤其是一种具有治疗痛风功效的膳食轻饮。
本发明所采取的技术方案是：
一种治疗痛风的组合物，其活性成分包括酸樱桃提取物、肉桂提取物、人参提取物、党参提取物、菟丝子提取物、肉苁蓉提取物、干姜提取物、葵花盘提取物、鼠曲草提取物，西芹籽提取物，车前子提取物、 木瓜提取物、桑枝提取物、杜仲提取物、鹅肌肽。
作为优选的，所述的治疗痛风的组合物的活性成分包括酸樱桃提取物5-15份、肉桂提取物0.1-2、人参提取物1-5、党参提取物5-10、菟丝子提取物1-2、肉苁蓉提取物1-3份、干姜提取物1-10份、葵花盘提取物1-5份、鼠曲草提取物1-2份，西芹籽提取物5-10份，车前子提取物5-10份、 木瓜提取物1-5份、桑枝提取物5-15份、杜仲提取物1-5份、鹅肌肽5-15份。
进一步优选的，所述的治疗痛风的组合物的活性成分包括酸樱桃提取物5份、肉桂提取物1、人参提取物3、党参提取物5、菟丝子提取物1、肉苁蓉提取物2份、干姜提取物5份、葵花盘提取物2份、鼠曲草提取物1.5份，西芹籽提取物8份，车前子提取物10份、 木瓜提取物5份、桑枝提取物10份、杜仲提取物2份、鹅肌肽15份。
进一步优选的，上述组合物中还含有食用辅料。
上述治疗痛风的组合物，将各组分充分混合后，可制备成水剂、片剂、胶囊、粉剂、丸剂或颗粒剂。
一种治疗痛风的膳食轻饮的制备方法，包括如下步骤：
（1） 将组合物各组分混合均匀后，粉碎细度在20-100目；
（2） 步骤（1）的粉料加入10-40倍重量的水浸泡，添加葡萄糖和无机盐，调节pH至6.5-7.5，灭菌，得到发酵底物；
（3） 往发酵底物中接种体积百分比为0.5%的乳酸杆菌，30-35℃发酵20-24小时；当pH值将至4.2以下时，降低发酵液温度至25℃，继续发酵20-24小时；当发酵液pH值将至3.5时，结束发酵；
（4） 离心或过滤，除去残渣，添加低聚糖和可溶性膳食纤维，调配、灭菌，即得治疗痛风的膳食轻饮。
本发明的有益效果是：1、适用于痛风患者，有降低尿酸、缓解痛风症状的功效；2、制成膳食轻饮后，口感怡人，易于被患者所接受。
具体实施方式
以下实施例所用药材均可从中国药材集团公司购买得到，符合中华人民共和国药典2005版标准。其他原料均可通过市售购买获得。
实施例1
一种治疗痛风的组合物，活性成分包括：酸樱桃提取物5份、肉桂提取物0.1、人参提取物5、党参提取物10、菟丝子提取物2、肉苁蓉提取物1份、干姜提取物5份、葵花盘提取物1份、鼠曲草提取物2份，西芹籽提取物5份，车前子提取物10份、 木瓜提取物5份、桑枝提取物10份、杜仲提取物2份、鹅肌肽10份。
上述组合物可加入食用辅料，进一步制备成水剂、片剂、胶囊、粉剂、丸剂或颗粒剂。
实施例2
一种治疗痛风的组合物，活性成分包括：酸樱桃提取物15份、肉桂提取物2、人参提取物1、党参提取物5、菟丝子提取物1、肉苁蓉提取物3份、干姜提取物1份、葵花盘提取物5份、鼠曲草提取物1份，西芹籽提取物10份，车前子提取物5份、 木瓜提取物1份、桑枝提取物15份、杜仲提取物1份、鹅肌肽15份。
上述组合物可加入食用辅料，进一步制备成水剂、片剂、胶囊、粉剂、丸剂或颗粒剂。
实施例3
一种治疗痛风的组合物，活性成分包括：酸樱桃提取物5份、肉桂提取物1、人参提取物3、党参提取物5、菟丝子提取物1、肉苁蓉提取物2份、干姜提取物5份、葵花盘提取物2份、鼠曲草提取物1.5份，西芹籽提取物8份，车前子提取物10份、 木瓜提取物5份、桑枝提取物10份、杜仲提取物2份、鹅肌肽15份。
上述组合物可加入食用辅料，进一步制备成水剂、片剂、胶囊、粉剂、丸剂或颗粒剂。
实施例4
一种治疗痛风的膳食轻饮的制备方法，包括如下步骤：
（5） 将实施例1-3任一组的组合物各组分混合均匀后，粉碎细度在20-100目；
（6） 步骤（1）的粉料加入10-40倍重量的水浸泡，添加葡萄糖和无机盐，调节pH至6.5-7.5，灭菌，得到发酵底物；
（7） 往发酵底物中接种体积百分比为0.5%的乳酸杆菌，30-35℃发酵20-24小时；当pH值将至4.2以下时，降低发酵液温度至25℃，继续发酵20-24小时；当发酵液pH值将至3.5时，结束发酵；
（8） 离心或过滤，除去残渣，添加低聚糖和可溶性膳食纤维，调配、灭菌，即得治疗痛风的膳食轻饮。
临床试用观察：
寻痛风患者120名，随机分成3组，分别服用实施例1-3的膳食轻饮，早晚一袋，50ml/袋，连续服用2个月。
患者诊断标准：患者关节疼痛，夜间发作，难以入眠；血尿酸增高，男性高于6.0mg/dL，女性高于5.0 mg/dL；具有痛风石。
功效评定标准：
治愈：实验室检查血尿酸值正常，关节疼痛症状消失，痛风石去除；
好转：实验室检查血尿酸值降低，关节肿胀消退、疼痛缓解，痛风石明显缩小；
无效：实验室检查血尿酸值及症状无变化，痛风石无变化。
实验结果如下表所示：
组别 治愈 好转 无效
实施例1 2 32 8
实施例2 3 32 7
实施例3 12 26 2
以上实践表明，本发明的组合物适用于痛风患者，有降低尿酸、缓解痛风症状的功效；制成膳食轻饮后，口感怡人，易于被患者所接受。

Claims (6)

1.一种治疗痛风的组合物，其活性成分包括酸樱桃提取物、肉桂提取物、人参提取物、党参提取物、菟丝子提取物、肉苁蓉提取物、干姜提取物、葵花盘提取物、鼠曲草提取物，西芹籽提取物，车前子提取物、 木瓜提取物、桑枝提取物、杜仲提取物、鹅肌肽。
2.根据权利要求1所述的治疗痛风的组合物，按重量份计，其活性成分包括酸樱桃提取物5-15份、肉桂提取物0.1-2、人参提取物1-5、党参提取物5-10、菟丝子提取物1-2、肉苁蓉提取物1-3份、干姜提取物1-10份、葵花盘提取物1-5份、鼠曲草提取物1-2份，西芹籽提取物5-10份，车前子提取物5-10份、 木瓜提取物1-5份、桑枝提取物5-15份、杜仲提取物1-5份、鹅肌肽5-15份。
3.根据权利要求2所述的治疗痛风的组合物，按重量份计，其活性成分包括酸樱桃提取物5份、肉桂提取物1、人参提取物3、党参提取物5、菟丝子提取物1、肉苁蓉提取物2份、干姜提取物5份、葵花盘提取物2份、鼠曲草提取物1.5份，西芹籽提取物8份，车前子提取物10份、木瓜提取物5份、桑枝提取物10份、杜仲提取物2份、鹅肌肽15份。
4.根据权利要求1-3任一项所述的组合物，其特征在于，所述组合物中还含有食用辅料。
5.根据权利要求1-3任一项所述的组合物，其特征在于，将各组分充分混合后，可制备成水剂、片剂、胶囊、粉剂、丸剂或颗粒剂。
6.一种治疗痛风的膳食轻饮的制备方法，包括如下步骤：
（1）将权利要求1-3任一项所述的组合物各组分混合均匀后，粉碎细度在20-100目；
（2）步骤（1）的粉料加入10-40倍重量的水浸泡，添加葡萄糖和无机盐，调节pH至6.5-7.5，灭菌，得到发酵底物；
（3）往发酵底物中接种体积百分比为0.5%的乳酸杆菌，30-35℃发酵20-24小时；当pH值将至4.2以下时，降低发酵液温度至25℃，继续发酵20-24小时；当发酵液pH值将至3.5时，结束发酵；
（4）离心或过滤，除去残渣，添加低聚糖和可溶性膳食纤维，调配、灭菌，即得治疗痛风的膳食轻饮。
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