CN108498692A - It is a kind of to treat hemopathic Chinese medicine preparation and preparation method thereof - Google Patents

It is a kind of to treat hemopathic Chinese medicine preparation and preparation method thereof Download PDF

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CN108498692A
CN108498692A CN201810701806.1A CN201810701806A CN108498692A CN 108498692 A CN108498692 A CN 108498692A CN 201810701806 A CN201810701806 A CN 201810701806A CN 108498692 A CN108498692 A CN 108498692A
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parts
root
radix
prepared
chinese medicine
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荆凌华
刘松年
张曼
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First Affiliated Hospital of Henan University of Science and Technology
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First Affiliated Hospital of Henan University of Science and Technology
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Abstract

Hemopathic Chinese medicine preparation and preparation method thereof is treated the invention discloses a kind of, which is prepared by the raw material of following parts by weight：10 20 parts of Radix Astragali, 10 20 parts of Radix Angelicae Sinensis, 10 30 parts of Chinese actinidia root, 10 30 parts of the root of fangji, 10 30 parts of the Fructus Sophorae, 10 20 parts of madder, 5 10 parts of indigo naturalis, 5 10 parts of fritillaria thunbergii, 10 15 parts of Radix Ophiopogonis, 10 15 parts of Java brucea, 10 20 parts of ginseng, 5 10 parts of tortoise-shell glue, 10 20 parts of prepared rehmannia root, 10 20 parts of tree peony root, 10 15 parts of oldenlandia diffusa, 40 60 parts of psoralea corylifolia, 20 30 parts of dried human placenta.The bioactivity of multi-medicine drug resistance of leukaemia can be reversed in the Chinese medicine preparation of the present invention, and chemotherapy of acute leukemia toxicity can be mitigated, immune function of human body can also be adjusted simultaneously, improve natural killer cells and LAK activity, the effect for increasing anti-leukocythemia ability.

Description

It is a kind of to treat hemopathic Chinese medicine preparation and preparation method thereof
Technical field
The present invention relates to field of traditional Chinese, and in particular to a kind of to treat hemopathic Chinese medicine preparation and preparation method thereof.
Background technology
Blood disease be primary in the disease of hemopoietic system, or influence hemopoietic system occur together blood dyscrasia change, with anaemia, go out The disease that blood, fever are characterized.Hemopoietic system includes blood, one macrophage system of bone marrow mononuclear and lymphoid tissue, all to be related to Hemopoietic system pathology, physiology, and be the disease mainly showed with it, belong to blood disease scope.Currently, cause it is hemopathic because It is plain very much, such as：Chemical factor, physical factor, biological factor, heredity, immune, pollution etc. can become blood disease and fall ill Inducement or immediate cause, be much the product of recent decades modern industry for these reasons, to make hemopathic morbidity Rate has the tendency that increasing year by year, it may be said that blood disease is a kind of modern disease.Modern medicine swashs hemopathic treatment mostly application The methods of element, chemotherapy, but side effect is big, easily recurs.
Multidrug resistance is that leukaemia cell attacks most important cellular defence mechanisms from chemotherapeutics, is leukemia chemotherapy The main reason for failure and recurrence.For many years studies have shown that Chinese traditional medicine reverse leukaemia has obtained many achievements, from simple Obvious curative effects are had received to Chinese medicine compound prescription and drug combination.
Invention content
Hemopathic Chinese medicine preparation and preparation method thereof is treated the purpose of the present invention is to provide a kind of.
To achieve the above object, the technical solution that the present invention takes is：
It is a kind of to treat hemopathic Chinese medicine preparation, it is prepared by the raw material of following parts by weight：
10-20 parts of Radix Astragali, 10-20 parts of Radix Angelicae Sinensis, 10-30 parts of Chinese actinidia root, 10-30 parts of the root of fangji, 10-30 parts of the Fructus Sophorae, madder 10- 20 parts, 5-10 parts of indigo naturalis, 5-10 parts of fritillaria thunbergii, Radix Ophiopogonis 10-15 part, 10-15 parts of Java brucea, 10-20 parts of ginseng, tortoise-shell glue 5-10 Part, 10-20 parts of prepared rehmannia root, 10-20 parts of tree peony root, 10-15 parts of oldenlandia diffusa, 40-60 parts of psoralea corylifolia, 20-30 parts of dried human placenta.
Preferably, it is prepared by the raw material of following parts by weight：
10 parts of Radix Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of Chinese actinidia root, 10 parts of the root of fangji, 10 parts of the Fructus Sophorae, 10 parts of madder, 5 parts of indigo naturalis, bulb of thunberg fritillary 5 parts female, 10 parts of Radix Ophiopogonis, 10 parts of Java brucea, 10 parts of ginseng, 5 parts of tortoise-shell glue, 10 parts of prepared rehmannia root, 10 parts of tree peony root, oldenlandia diffusa 10 parts, 40 parts of psoralea corylifolia, 20 parts of dried human placenta.
Preferably, it is prepared by the raw material of following parts by weight：
20 parts of Radix Astragali, 20 parts of Radix Angelicae Sinensis, 30 parts of Chinese actinidia root, 30 parts of the root of fangji, 30 parts of the Fructus Sophorae, 20 parts of madder, 10 parts of indigo naturalis, bulb of thunberg fritillary 10 parts female, 15 parts of Radix Ophiopogonis, 15 parts of Java brucea, 20 parts of ginseng, 10 parts of tortoise-shell glue, 20 parts of prepared rehmannia root, 20 parts of tree peony root, oldenlandia 15 parts of grass, 60 parts of psoralea corylifolia, 30 parts of dried human placenta.
Preferably, it is prepared by the raw material of following parts by weight：
15 parts of Radix Astragali, 15 parts of Radix Angelicae Sinensis, 20 parts of Chinese actinidia root, 20 parts of the root of fangji, 20 parts of the Fructus Sophorae, 15 parts of madder, 7.5 parts of indigo naturalis, Zhejiang 7.5 parts of fritillaria, 12.5 parts of Radix Ophiopogonis, 12.5 parts of Java brucea, 15 parts of ginseng, 7.5 parts of tortoise-shell glue, 15 parts of prepared rehmannia root, 15 parts of tree peony root, 12.5 parts of oldenlandia diffusa, 50 parts of psoralea corylifolia, 25 parts of dried human placenta.
Preferably, it is prepared by the raw material of following parts by weight：
13 parts of Radix Astragali, 13 parts of Radix Angelicae Sinensis, 18 parts of Chinese actinidia root, 18 parts of the root of fangji, 18 parts of the Fructus Sophorae, 13 parts of madder, 6 parts of indigo naturalis, bulb of thunberg fritillary 6 parts female, 11 parts of Radix Ophiopogonis, 11 parts of Java brucea, 13 parts of ginseng, 6 parts of tortoise-shell glue, 13 parts of prepared rehmannia root, 13 parts of tree peony root, oldenlandia diffusa 11 parts, 48 parts of psoralea corylifolia, 13 parts of dried human placenta.
Preferably, it is prepared by the raw material of following parts by weight：
17 parts of Radix Astragali, 17 parts of Radix Angelicae Sinensis, 22 parts of Chinese actinidia root, 22 parts of the root of fangji, 22 parts of the Fructus Sophorae, 17 parts of madder, 9 parts of indigo naturalis, bulb of thunberg fritillary 9 parts female, 14 parts of Radix Ophiopogonis, 14 parts of Java brucea, 17 parts of ginseng, 9 parts of tortoise-shell glue, 17 parts of prepared rehmannia root, 17 parts of tree peony root, oldenlandia diffusa 14 parts, 52 parts of psoralea corylifolia, 27 parts of dried human placenta.
The present invention also provides a kind of above-mentioned preparation methods for treating hemopathic Chinese medicine preparation, include the following steps：
S1, each component is weighed by the above-mentioned formula stated；
S2, by the Chinese actinidia root weighed, the root of fangji, the Fructus Sophorae, madder, indigo naturalis, fritillaria thunbergii, Radix Ophiopogonis, Java brucea, ginseng, tortoise-shell glue, It after prepared rehmannia root, tree peony root, oldenlandia diffusa, dried human placenta mixing, crushes, the ethyl alcohol that the volume fraction that 5 times of amounts are added is 75% returns Stream 2 times, every time 1.5 hours；Merge secondary returning flow liquid, filtration recycles ethyl alcohol, obtains alcohol extract and the dregs of a decoction；
S3,60 DEG C of the alcohol extract of gained is concentrated under reduced pressure into relative density is 1.25, obtains thick medicinal extract, then with the positive fourth of water saturation Alcohol extracts extract 3 times, and recycling design obtains extract liquor；
S4, after mixing the dregs of a decoction of gained with the Radix Astragali, Radix Angelicae Sinensis, psoralea corylifolia weighed, add 8 times of amount water to decoct 1.5h, filter, After being mixed with extract liquor, spray drying to get.
The invention has the advantages that：
The Chinese medicine preparation of the present invention has apparent downward to act on the drug-resistant protein of height expression, and it is resistance to that leukaemia multiple medicine can be reversed The bioactivity of medicine, and chemotherapy of acute leukemia toxicity can be mitigated, improve quality of life during chemotherapy of patients.Simultaneously also Immune function of human body can be adjusted, natural killer cells and LAK activity is improved, increases anti-leukocythemia The effect of ability.
Specific implementation mode
In order to make objects and advantages of the present invention be more clearly understood, the present invention is carried out with reference to embodiments further It is described in detail.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to limit this hair It is bright.
Embodiment 1
A kind of preparation method for treating hemopathic Chinese medicine preparation, includes the following steps：
S1, it weighs by weight：10 parts of Radix Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of Chinese actinidia root, 10 parts of the root of fangji, 10 parts of the Fructus Sophorae, madder 10 Part, 5 parts of indigo naturalis, 5 parts of fritillaria thunbergii, 10 parts of Radix Ophiopogonis, 10 parts of Java brucea, 10 parts of ginseng, 5 parts of tortoise-shell glue, 10 parts of prepared rehmannia root, tree peony root 10 parts, 10 parts of oldenlandia diffusa, 40 parts of psoralea corylifolia, 20 parts of dried human placenta；
S2, by the Chinese actinidia root weighed, the root of fangji, the Fructus Sophorae, madder, indigo naturalis, fritillaria thunbergii, Radix Ophiopogonis, Java brucea, ginseng, tortoise-shell glue, It after prepared rehmannia root, tree peony root, oldenlandia diffusa, dried human placenta mixing, crushes, the ethyl alcohol that the volume fraction that 5 times of amounts are added is 75% returns Stream 2 times, every time 1.5 hours；Merge secondary returning flow liquid, filtration recycles ethyl alcohol, obtains alcohol extract and the dregs of a decoction；
S3,60 DEG C of the alcohol extract of gained is concentrated under reduced pressure into relative density is 1.25, obtains thick medicinal extract, then with the positive fourth of water saturation Alcohol extracts extract 3 times, and recycling design obtains extract liquor；
S4, after mixing the dregs of a decoction of gained with the Radix Astragali, Radix Angelicae Sinensis, psoralea corylifolia weighed, add 8 times of amount water to decoct 1.5h, filter, After being mixed with extract liquor, spray drying to get.
Embodiment 2
A kind of preparation method for treating hemopathic Chinese medicine preparation, includes the following steps：
S1, it weighs by weight：20 parts of Radix Astragali, 20 parts of Radix Angelicae Sinensis, 30 parts of Chinese actinidia root, 30 parts of the root of fangji, 30 parts of the Fructus Sophorae, madder 20 It is part, 10 parts of indigo naturalis, 10 parts of fritillaria thunbergii, 15 parts of Radix Ophiopogonis, 15 parts of Java brucea, 20 parts of ginseng, 10 parts of tortoise-shell glue, 20 parts of prepared rehmannia root, male 20 parts of red root, 15 parts of oldenlandia diffusa, 60 parts of psoralea corylifolia, 30 parts of dried human placenta；
S2, by the Chinese actinidia root weighed, the root of fangji, the Fructus Sophorae, madder, indigo naturalis, fritillaria thunbergii, Radix Ophiopogonis, Java brucea, ginseng, tortoise-shell glue, It after prepared rehmannia root, tree peony root, oldenlandia diffusa, dried human placenta mixing, crushes, the ethyl alcohol that the volume fraction that 5 times of amounts are added is 75% returns Stream 2 times, every time 1.5 hours；Merge secondary returning flow liquid, filtration recycles ethyl alcohol, obtains alcohol extract and the dregs of a decoction；
S3,60 DEG C of the alcohol extract of gained is concentrated under reduced pressure into relative density is 1.25, obtains thick medicinal extract, then with the positive fourth of water saturation Alcohol extracts extract 3 times, and recycling design obtains extract liquor；
S4, after mixing the dregs of a decoction of gained with the Radix Astragali, Radix Angelicae Sinensis, psoralea corylifolia weighed, add 8 times of amount water to decoct 1.5h, filter, After being mixed with extract liquor, spray drying to get.
Embodiment 3
A kind of preparation method for treating hemopathic Chinese medicine preparation, includes the following steps：
S1, it weighs by weight：15 parts of Radix Astragali, 15 parts of Radix Angelicae Sinensis, 20 parts of Chinese actinidia root, 20 parts of the root of fangji, 20 parts of the Fructus Sophorae, madder 15 Part, 7.5 parts of indigo naturalis, 7.5 parts of fritillaria thunbergii, 12.5 parts of Radix Ophiopogonis, 12.5 parts of Java brucea, 15 parts of ginseng, 7.5 parts of tortoise-shell glue, prepared rehmannia root 15 parts, 15 parts of tree peony root, 12.5 parts of oldenlandia diffusa, 50 parts of psoralea corylifolia, 25 parts of dried human placenta；
S2, by the Chinese actinidia root weighed, the root of fangji, the Fructus Sophorae, madder, indigo naturalis, fritillaria thunbergii, Radix Ophiopogonis, Java brucea, ginseng, tortoise-shell glue, It after prepared rehmannia root, tree peony root, oldenlandia diffusa, dried human placenta mixing, crushes, the ethyl alcohol that the volume fraction that 5 times of amounts are added is 75% returns Stream 2 times, every time 1.5 hours；Merge secondary returning flow liquid, filtration recycles ethyl alcohol, obtains alcohol extract and the dregs of a decoction；
S3,60 DEG C of the alcohol extract of gained is concentrated under reduced pressure into relative density is 1.25, obtains thick medicinal extract, then with the positive fourth of water saturation Alcohol extracts extract 3 times, and recycling design obtains extract liquor；
S4, after mixing the dregs of a decoction of gained with the Radix Astragali, Radix Angelicae Sinensis, psoralea corylifolia weighed, add 8 times of amount water to decoct 1.5h, filter, After being mixed with extract liquor, spray drying to get.
Embodiment 4
A kind of preparation method for treating hemopathic Chinese medicine preparation, includes the following steps：
S1, it weighs by weight：13 parts of Radix Astragali, 13 parts of Radix Angelicae Sinensis, 18 parts of Chinese actinidia root, 18 parts of the root of fangji, 18 parts of the Fructus Sophorae, madder 13 Part, 6 parts of indigo naturalis, 6 parts of fritillaria thunbergii, 11 parts of Radix Ophiopogonis, 11 parts of Java brucea, 13 parts of ginseng, 6 parts of tortoise-shell glue, 13 parts of prepared rehmannia root, tree peony root 13 parts, 11 parts of oldenlandia diffusa, 48 parts of psoralea corylifolia, 13 parts of dried human placenta；
S2, by the Chinese actinidia root weighed, the root of fangji, the Fructus Sophorae, madder, indigo naturalis, fritillaria thunbergii, Radix Ophiopogonis, Java brucea, ginseng, tortoise-shell glue, It after prepared rehmannia root, tree peony root, oldenlandia diffusa, dried human placenta mixing, crushes, the ethyl alcohol that the volume fraction that 5 times of amounts are added is 75% returns Stream 2 times, every time 1.5 hours；Merge secondary returning flow liquid, filtration recycles ethyl alcohol, obtains alcohol extract and the dregs of a decoction；
S3,60 DEG C of the alcohol extract of gained is concentrated under reduced pressure into relative density is 1.25, obtains thick medicinal extract, then with the positive fourth of water saturation Alcohol extracts extract 3 times, and recycling design obtains extract liquor；
S4, after mixing the dregs of a decoction of gained with the Radix Astragali, Radix Angelicae Sinensis, psoralea corylifolia weighed, add 8 times of amount water to decoct 1.5h, filter, After being mixed with extract liquor, spray drying to get.
Embodiment 5
A kind of preparation method for treating hemopathic Chinese medicine preparation, includes the following steps：
S1, it weighs by weight：17 parts of Radix Astragali, 17 parts of Radix Angelicae Sinensis, 22 parts of Chinese actinidia root, 22 parts of the root of fangji, 22 parts of the Fructus Sophorae, madder 17 Part, 9 parts of indigo naturalis, 9 parts of fritillaria thunbergii, 14 parts of Radix Ophiopogonis, 14 parts of Java brucea, 17 parts of ginseng, 9 parts of tortoise-shell glue, 17 parts of prepared rehmannia root, tree peony root 17 parts, 14 parts of oldenlandia diffusa, 52 parts of psoralea corylifolia, 27 parts of dried human placenta；
S2, by the Chinese actinidia root weighed, the root of fangji, the Fructus Sophorae, madder, indigo naturalis, fritillaria thunbergii, Radix Ophiopogonis, Java brucea, ginseng, tortoise-shell glue, It after prepared rehmannia root, tree peony root, oldenlandia diffusa, dried human placenta mixing, crushes, the ethyl alcohol that the volume fraction that 5 times of amounts are added is 75% returns Stream 2 times, every time 1.5 hours；Merge secondary returning flow liquid, filtration recycles ethyl alcohol, obtains alcohol extract and the dregs of a decoction；
S3,60 DEG C of the alcohol extract of gained is concentrated under reduced pressure into relative density is 1.25, obtains thick medicinal extract, then with the positive fourth of water saturation Alcohol extracts extract 3 times, and recycling design obtains extract liquor；
S4, after mixing the dregs of a decoction of gained with the Radix Astragali, Radix Angelicae Sinensis, psoralea corylifolia weighed, add 8 times of amount water to decoct 1.5h, filter, After being mixed with extract liquor, spray drying to get.
Test example
100 patients are received, the Chinese medicine preparation prepared using embodiment 3, take medicine 2g every time, 3 times a day, continuous to take medicine 6 months, wherein the physiochemical indice items numerical value of 78 patients reaches normal value, remaining 20 patient was slightly less than just except blood platelet value Constant value is in good condition hereinafter, other indices numerical stabilities, is belonging to recovery from illness scope, only two Platelets always below just Constant value, other indices numerical stabilities.Statistics is it is found that the present invention is used to treat hemopathic Chinese medicine composition to hemopathic Cure rate is efficient up to 100% up to 78%.Wherein, curative effect judging standard is：Effectively：Symptom mitigate, whole blood cells, red blood cell, Leucocyte reaches normal value, and the only insufficient normal value of one, blood platelet, integrality is good；It cures：Symptom disappears, physiochemical indice Every numerical value reaches normal value.
Toxic side effect
4 have slight gastrointestinal reaction in 100 patients for the treatment of group, periodic review hepatic and renal function in all patients follow-up, Only 3 there are AST raisings, are down to after being treated using hepatic normally, can adhere to treating.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, without departing from the principle of the present invention, it can also make several improvements and retouch, these improvements and modifications are also answered It is considered as protection scope of the present invention.

Claims (7)

1. a kind for the treatment of hemopathic Chinese medicine preparation, it is characterised in that：It is prepared by the raw material of following parts by weight：
10-20 parts of Radix Astragali, 10-20 parts of Radix Angelicae Sinensis, 10-30 parts of Chinese actinidia root, 10-30 parts of the root of fangji, 10-30 parts of the Fructus Sophorae, madder 10-20 Part, 5-10 parts of indigo naturalis, 5-10 parts of fritillaria thunbergii, Radix Ophiopogonis 10-15 part, 10-15 parts of Java brucea, 10-20 parts of ginseng, tortoise-shell glue 5-10 Part, 10-20 parts of prepared rehmannia root, 10-20 parts of tree peony root, 10-15 parts of oldenlandia diffusa, 40-60 parts of psoralea corylifolia, 20-30 parts of dried human placenta.
2. a kind of as described in claim 1 treat hemopathic Chinese medicine preparation, it is characterised in that：By the raw material of following parts by weight It is prepared：
10 parts of Radix Astragali, 10 parts of Radix Angelicae Sinensis, 10 parts of Chinese actinidia root, 10 parts of the root of fangji, 10 parts of the Fructus Sophorae, 10 parts of madder, 5 parts of indigo naturalis, fritillaria thunbergii 5 Part, 10 parts of Radix Ophiopogonis, 10 parts of Java brucea, 10 parts of ginseng, 5 parts of tortoise-shell glue, 10 parts of prepared rehmannia root, 10 parts of tree peony root, oldenlandia diffusa 10 Part, 40 parts of psoralea corylifolia, 20 parts of dried human placenta.
3. a kind of as described in claim 1 treat hemopathic Chinese medicine preparation, it is characterised in that：By the raw material of following parts by weight It is prepared：
20 parts of Radix Astragali, 20 parts of Radix Angelicae Sinensis, 30 parts of Chinese actinidia root, 30 parts of the root of fangji, 30 parts of the Fructus Sophorae, 20 parts of madder, 10 parts of indigo naturalis, fritillaria thunbergii 10 Part, 15 parts of Radix Ophiopogonis, 15 parts of Java brucea, 20 parts of ginseng, 10 parts of tortoise-shell glue, 20 parts of prepared rehmannia root, 20 parts of tree peony root, oldenlandia diffusa 15 Part, 60 parts of psoralea corylifolia, 30 parts of dried human placenta.
4. a kind of as described in claim 1 treat hemopathic Chinese medicine preparation, it is characterised in that：By the raw material of following parts by weight It is prepared：
15 parts of Radix Astragali, 15 parts of Radix Angelicae Sinensis, 20 parts of Chinese actinidia root, 20 parts of the root of fangji, 20 parts of the Fructus Sophorae, 15 parts of madder, 7.5 parts of indigo naturalis, fritillaria thunbergii 7.5 parts, 12.5 parts of Radix Ophiopogonis, 12.5 parts of Java brucea, 15 parts of ginseng, 7.5 parts of tortoise-shell glue, 15 parts of prepared rehmannia root, 15 parts of tree peony root, white flower 12.5 parts of HERBA HEDYOTIS DIFFUSAE, 50 parts of psoralea corylifolia, 25 parts of dried human placenta.
5. a kind of as described in claim 1 treat hemopathic Chinese medicine preparation, it is characterised in that：By the raw material of following parts by weight It is prepared：
13 parts of Radix Astragali, 13 parts of Radix Angelicae Sinensis, 18 parts of Chinese actinidia root, 18 parts of the root of fangji, 18 parts of the Fructus Sophorae, 13 parts of madder, 6 parts of indigo naturalis, fritillaria thunbergii 6 Part, 11 parts of Radix Ophiopogonis, 11 parts of Java brucea, 13 parts of ginseng, 6 parts of tortoise-shell glue, 13 parts of prepared rehmannia root, 13 parts of tree peony root, oldenlandia diffusa 11 Part, 48 parts of psoralea corylifolia, 13 parts of dried human placenta.
6. a kind of as described in claim 1 treat hemopathic Chinese medicine preparation, it is characterised in that：By the raw material of following parts by weight It is prepared：
17 parts of Radix Astragali, 17 parts of Radix Angelicae Sinensis, 22 parts of Chinese actinidia root, 22 parts of the root of fangji, 22 parts of the Fructus Sophorae, 17 parts of madder, 9 parts of indigo naturalis, fritillaria thunbergii 9 Part, 14 parts of Radix Ophiopogonis, 14 parts of Java brucea, 17 parts of ginseng, 9 parts of tortoise-shell glue, 17 parts of prepared rehmannia root, 17 parts of tree peony root, oldenlandia diffusa 14 Part, 52 parts of psoralea corylifolia, 27 parts of dried human placenta.
7. a kind of preparation method for treating hemopathic Chinese medicine preparation, it is characterised in that：Include the following steps：
S1, each component is weighed by claim 1-6 any one of them formulas；
S2, by the Chinese actinidia root weighed, the root of fangji, the Fructus Sophorae, madder, indigo naturalis, fritillaria thunbergii, Radix Ophiopogonis, Java brucea, ginseng, tortoise-shell glue, radix rehmanniae preparata It after Huang, tree peony root, oldenlandia diffusa, dried human placenta mixing, crushes, the alcohol reflux 2 that the volume fraction of 5 times of amounts is 75% is added It is secondary, 1.5 hours every time；Merge secondary returning flow liquid, filtration recycles ethyl alcohol, obtains alcohol extract and the dregs of a decoction；
S3,60 DEG C of the alcohol extract of gained is concentrated under reduced pressure into relative density is 1.25, obtains thick medicinal extract, then with water-saturated n-butanol pair Extract extracts 3 times, and recycling design obtains extract liquor；
S4, after mixing the dregs of a decoction of gained with the Radix Astragali, Radix Angelicae Sinensis, psoralea corylifolia weighed, 8 times of amount water is added to decoct 1.5h, filtration, with extraction Take liquid mix after, spray drying to get.
CN201810701806.1A 2018-06-30 2018-06-30 It is a kind of to treat hemopathic Chinese medicine preparation and preparation method thereof Pending CN108498692A (en)

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Application publication date: 20180907