CN102643734B - Nourishing medicinal liquor and preparation process thereof - Google Patents
Nourishing medicinal liquor and preparation process thereof Download PDFInfo
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- CN102643734B CN102643734B CN201210103393.XA CN201210103393A CN102643734B CN 102643734 B CN102643734 B CN 102643734B CN 201210103393 A CN201210103393 A CN 201210103393A CN 102643734 B CN102643734 B CN 102643734B
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Abstract
The invention discloses a nourishing medicinal liquor and a preparation process thereof. The medicinal liquor consists of the root of pilose asiabell, poria cocos, white paeony root, teasel root, angelica, pseudo-ginseng, eucommia ulmoides leaf, prepared fleeceflower root, safflower, milkvetch root, the root of bidentate achyranthes, Chinese yam, moutan bark, oriental waterplantain rhizome, bighead atractylodes rhizome, prepared rehmannia root and ginseng; the seventeen clean medicinal materials are added into 70-alcohol content liquor, and are steeped for two times; pressure is applied to filter supernate, and filtrates are combined; and cane sugar is taken and dissolved into a moderate amount of hot purified water, activated carbon for sugar is added for decoloration, filtration is carried out, the filtrate is added into the liquor steeping liquid, uniformly mixed, sealed and kept still, and after filtration and filling, the nourishing medicinal liquor is obtained. The nourishing medicinal liquor is composed according to the monarch, minister, assistant and guide of the traditional Chinese medical science, so that the effects of the medicinal materials generate a synergistic effect, and therefore the nourishing medicinal liquor can effectively play a nourishing and health-care role.
Description
Technical field
The invention belongs to healthy medicated wine technical field, be specifically related to a kind of nourishing and healthcare medicated wine and preparation technology thereof.
Background technology
At present, market has multiple nourishing and healthcare medicated wine, but these nourishing and healthcare medicated wines are from the reasonableness of formula, or uses single Chinese medicinal material, or it is unreasonable to fill a prescription, and effect has limitation.From preparation technology, a lot of nourishing and healthcare medicated wine is all directly obtain after medicinal material being soaked a few days or for some time fairly simplely, and this mode can not make the abundant stripping of the effective constituent of Chinese medicinal materials, therefore can affect effect of medicinal liquor.The nourishing and healthcare medicated wine also had uses multiple Chinese medicinal materials, carries out simple processing treatment, and not even by the preparation of property of medicine compatibility, the security of the medicinal liquor obtained is without any guarantee.Therefore, there is formula irrationality in existing nourishing and healthcare medicated wine, both effectiveness difference, the shortcoming that security is not high, have impact on the result of use of product, adds the consumer cost of human consumer simultaneously.
Therefore, people still also exist demand to the better healthy medicated wine of curative effect, up to now, do not find the report of pharmaceutical composition of the present invention.The present inventor, through repeatedly studying, completes the present invention.
Goal of the invention
The object of the present invention is to provide a kind of scientific formula, rational technology, quality controllable, Be very effective nourishing and healthcare medicated wine.This nourishing and healthcare medicated wine prescription adopts medicine-food two-purpose medicinal material mostly, compatibility science, clear efficacy, and security is high, and technical process is reasonable, simple to operate, quality controllable, can suitability for industrialized production, and production cost is lower.
The present invention is made up of the raw material of following weight part: Radix Codonopsis 40g, Poria cocos 40g, root of herbaceous peony 48g, teasel root 48g, Radix Angelicae Sinensis 25g, pseudo-ginseng 3.2g, Folium Eucommiae 36g, Radix Polygoni Multiflori Preparata 40g, safflower 4g, Radix Astragali 100g, the root of bidentate achyranthes (stir-fry) 48g, Chinese yam (stir-fry) 25g, Tree Peony Bark (stir-fry) 13g, rhizoma alismatis (stir-fry) 16g, the bighead atractylodes rhizome (stir-fry) 16g, Radix Rehmanniae Preparata 264g, ginseng 8g.
The present invention selects Radix Codonopsis, Poria cocos, the root of herbaceous peony, teasel root, Radix Angelicae Sinensis, pseudo-ginseng, Folium Eucommiae, Radix Polygoni Multiflori Preparata, safflower, the Radix Astragali, the root of bidentate achyranthes, Chinese yam, Tree Peony Bark, rhizoma alismatis, the bighead atractylodes rhizome, Radix Rehmanniae Preparata, ginseng to carry out compatibility, these medicines and 70 degree of white wine are carried out combination make to produce synergy between medicine, effectively can play nourishing health function.
Wherein select Radix Codonopsis to put down, sweet, the micro-acid of taste, returns spleen, lung channel, invigorating the spleen and replenishing QI, and invigorating the spleen benefit lung, for the deficiency of vital energy, deficiency person fills blood.Poria cocos taste is sweet, light, property is put down, and has effect of promoting diuresis to eliminate damp pathogen, beneficial spleen and stomach, tranquillizing by calming the heart, can enhancing body immunologic function.The root of herbaceous peony is bitter, sour, is slightly cold, returns liver, the spleen channel, flat liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Teasel root is bitter, pungent, and tepor, returns liver, kidney channel, strengthening the muscles and bones, invigorating the liver and kidney, adjusts blood vessels.Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, relax bowel.Pseudo-ginseng has the hemostasis of the loose stasis of blood, effect of subduing swelling and relieving pain.Folium Eucommiae has invigorating the liver and kidney, strengthening the bones and muscles, hypotensive activity.Radix Polygoni Multiflori Preparata has invigorating the liver and kidney, benefiting essence-blood, black beard and hair, strengthening the bones and muscles.Safflower has promoting blood circulation to restore menstrual flow, goes stasis of blood pain relieving.The Radix Astragali has invigorating QI to consolidate the body surface resistance, sharp water detumescence, expelling pus and toxin by strengthening QI, myogenic effect.The Radix Astragali has enhancing body immunologic function, protects the liver, diuresis, anti-ageing, step-down and anti-microbial effect.Root of bidentate achyranthes invigorating the liver and kidney, strengthening the bones and muscles, promoting blood circulation to restore menstrual flow.Tree Peony Bark heat-clearing, cool blood, Li Shui, dries.It is cold in nature for rhizoma alismatis, has effect of promoting diuresis to eliminate damp pathogen.Bighead atractylodes rhizome invigorating the spleen and benefiting QI, eliminating dampness Li Shui, hidroschesis, antiabortive.Radix Rehmanniae Preparata, Chinese medicine name, has another name called cultivated land, and the property of medicine turns tepor by being slightly cold, and help strengthens, vigour in energy kidney tonifying.Ginseng invigorating premordial QI, multiple arteries and veins takes off admittedly, reinforces the spleen to benefit the lung, promotes the production of body fluid to quench thirst, intelligence development of calming the nerves.
Above medicine 70 degree of white wine 10000g divide double-steeping, each seven days; Pressurization leaching supernatant liquor, merging filtrate; Separately get sucrose 1500g, use appropriate hot water dissolving, add 0.2% craboraffin decolouring, filter, filtrate adds in above-mentioned medicinal liquor steeping fluid, adds water to 25000ml, stirs evenly, and room temperature lower seal stores more than three months, filters, filling, to obtain final product.
The present invention carries out antifatigue, anti-ageing, the test such as testosterone, hypoxia tolerance, acute toxicity, result shows, this product long-term drinking is nontoxic, can improve body immune, antifatigue and anti-power of suffocating, and has anti-ageing, nourishing liver and kidney, strengthening the muscles and bones, lengthens one's life and the effect such as to keep fit.Be applicable to old, after being ill the crowd that lacks of proper care take.
One, the present invention is to the hypoxia endurance test of small white mouse.
(1) laboratory animal: healthy Kun Ming mice, body weight 18g ~ 21g, in 8 week age, Henan Province's Experimental Animal Center provides;
(2) experimental technique: undertaken by herbal pharmacology experimental technique, gets healthy mice 40, male and female half and half, is divided into two groups at random, often organizes 20.One group is experimental group, every day, gavage gave health-care tonic wine 0.3ml/20g of the present invention, and another group compares with white wine, and gavage capacity gives for examination thing by 0.3ml/20g body weight every day, once a day, continuous 25 days, give after terminating for examination thing, respectively each group of small white mouse is put into separately the wide-necked bottle of the 250ml that sodica calx is housed, jam-pack bottle cap, observe and record small white mouse hypoxic exposure, and carrying out statistical procedures, the results are shown in Table 1.
Table 1 health-care tonic wine of the present invention is to the hypoxia endurance test of small white mouse
Conclusion: result shows, health-care tonic wine of the present invention has the resisting oxygen lack significantly increasing small white mouse.
Two, the present invention is to the anti-fatigue test of small white mouse.
(1) laboratory animal: healthy Kun Ming mice, body weight 18g ~ 21g, in 8 week age, Henan Province's Experimental Animal Center provides;
(2) experimental technique: undertaken by herbal pharmacology experimental technique, gets healthy mice 40, male and female half and half, random point two groups, often organizes 20.One group is experimental group, and every day, gavage gave health-care tonic wine 0.3ml/20g of the present invention, and another group compares with white wine, gavage capacity gives for examination thing by 0.3ml/20g body weight every day, once a day, continuous 20 days, give after terminating for examination thing, all small white mouse fasting 12 hours, then every tail always adds the load of 5%, puts into depth of water 30cm, forced swimming in the water vat that water temperature is 28 ~ 30 DEG C, record the swimming continuance time of every small white mouse, the results are shown in Table 2.
Table 2 health-care tonic wine of the present invention is to the anti-fatigue test of small white mouse
| Group | Number of animals (only) | Dosage | Approach | Number of days (d) | Swimming time (X ± SD) | P value |
| Control group | 20 | 0.3ml/20g | Gavage | 20 | 4’25”±1’20” | |
| Experimental group | 20 | 0.3ml/20g | Gavage | 20 | 7’33”±1’37” | ＜0.05 |
Conclusion: result shows, health-care tonic wine of the present invention has the antifatigue effect significantly increasing small white mouse.
Three, the present invention is to the test of the testosterone of small white mouse.
(1) laboratory animal: get healthy waster male rat 60, body weight 120g ~ 140g, provided by Henan Province's Experimental Animal Center, raises one week in laboratory animal room;
(2) experimental technique: animal is divided into three groups at random, often organizes 20, and presses LD
501/5 and 1/10, if height two dosage groups (4g/kg, 2g/kg) and negative control.The height other gavage of dosage component health-care tonic wine of the present invention, control group gives the distilled water of equivalent, every day gavage once, give continuously for examination thing 20 days.During this period, observe the activity of animal, appetite behavior, scale body weight once, and to adjust to the amount for examination thing according to body weight change weekly simultaneously.At the end of giving for examination thing, eye socket gets blood, and after leaving standstill, centrifuging and taking serum, measures testosterone with radio immunoassay, the results are shown in Table 3.
The healthy medicated wine that table 3 is invented is tested the impact of the testosterone of small white mouse
Through statistics, low dose group compares with control group, significant difference.High dose group compares with control group, difference highly significant.
Conclusion: health-care tonic wine of the present invention is to the effect of being significantly improved of rat male hormone.
Four, the present invention is to the acute toxicity test of small white mouse.
(1) laboratory animal: healthy Kun Ming mice, male and female half and half, body weight 18g ~ 21g, Henan Province's Experimental Animal Center provides;
(2) experimental technique: get small white mouse 50, be divided into five groups at random, often organize 10, male and female half and half, by geometric progression row design 5 dosage groups, maximal dose is 29.48g/kg, and adjacent doses ratio is 1: 0.80; Small white mouse is in fasting after 12 hours, and with a health-care tonic wine of the present invention gavage contamination, contaminate latter 14 days record toxicity symptoms, death time and death toll, calculate LD with karber's method
50and the fiducial limit of 95%;
(3) experimental result: after mice lavage, toxicity symptom shows as excitement, disorderly jump weak and feeble after dapping, creep, expiratory dyspnea, finally dies of exhaustion and dies, the animal overwhelming majority is dead in 24 hours, indivedual then dead in 48 hours, animal performs an autopsy on sb. one by one, and naked eyes do not find obvious pathology.Calculation result: LD
50=26.2g/kg; QLD
5095% be crediblely limited to 23.52g/kg ~ 29.24g/kg.
Conclusion: this health-care tonic wine is to human non-toxic, and security is good.
Embodiment
The present invention is made up of the raw material of following weight part: Radix Codonopsis 40g, Poria cocos 40g, root of herbaceous peony 48g, teasel root 48g, Radix Angelicae Sinensis 25g, pseudo-ginseng 3.2g, Folium Eucommiae 36g, Radix Polygoni Multiflori Preparata 40g, safflower 4g, Radix Astragali 100g, the root of bidentate achyranthes (stir-fry) 48g, Chinese yam (stir-fry) 25g, Tree Peony Bark (stir-fry) 13g, rhizoma alismatis (stir-fry) 16g, the bighead atractylodes rhizome (stir-fry) 16g, Radix Rehmanniae Preparata 264g, ginseng 8g.Take pharmaceutical decocting piece by recipe quantity, sheet block the greater pulverizer such as Poria cocos, Radix Polygoni Multiflori Preparata, Chinese yam (stir-fry), rhizoma alismatis (stir-fry), the bighead atractylodes rhizome (stir-fry), Radix Rehmanniae Preparata is broken into fritter.The clean medicinal material of 17 taste is added 70 degree of white wine 5000g, stirs evenly, sealing, floods 7 days, stirs 1 every day, pressurization leaching supernatant liquor; The dregs of a decoction add 70 degree of white wine 5000g again, stir evenly, and sealing, floods 7 days, stir 1 every day, pressurization leaching supernatant liquor, and merging filtrate is for subsequent use.Get sucrose 1500g, add the hot purified water of 3000g and make dissolving, add 3g craboraffin, stir 30 minutes, decolouring, filter, filtrate adds in above-mentioned filtered steeping fluid, adds water to 25000ml, stirs evenly, sealing, and room temperature leaves standstill more than three months.Get standing liquid, filter, filling, to obtain final product.
The above is only preferred embodiment of the present invention, therefore all equivalences done according to structure, feature and the principle described in patent claim of the present invention change or modify, and are included in patent claim of the present invention.
Claims (4)
1. a chartreuse, it is characterized in that being made up of the raw material of following weight: Radix Codonopsis 40g, Poria cocos 40g, root of herbaceous peony 48g, teasel root 48g, Radix Angelicae Sinensis 25g, pseudo-ginseng 3.2g, Folium Eucommiae 36g, Radix Polygoni Multiflori Preparata 40g, safflower 4g, Radix Astragali 100g, root of bidentate achyranthes 48g, Chinese yam 25g, Tree Peony Bark 13g, rhizoma alismatis 16g, bighead atractylodes rhizome 16g, Radix Rehmanniae Preparata 264g, ginseng 8g.
2. chartreuse according to claim 1, is characterized in that the described root of bidentate achyranthes, Chinese yam, Tree Peony Bark, rhizoma alismatis, the bighead atractylodes rhizome are fryings.
3. the preparation technology of chartreuse according to claim 1, it is characterized in that preparation technology takes pharmaceutical decocting piece by raw material dosage, the Poria cocos that sheet block is larger, Radix Polygoni Multiflori Preparata, Chinese yam, rhizoma alismatis, the bighead atractylodes rhizome, Radix Rehmanniae Preparata pulverizer are broken into fritter, the clean medicinal material of 17 taste is added 70 degree of white wine 5000g, stir evenly, sealing, floods 7 days, stir 1 every day, pressurization leaching supernatant liquor; The dregs of a decoction add 70 degree of white wine 5000g again, stir evenly, and sealing, floods 7 days, stir 1 every day, pressurization leaching supernatant liquor, and merging filtrate is for subsequent use; Get sucrose 1500g, add the hot purified water of 3000g and make dissolving, add 3g craboraffin, stir 30 minutes, decolouring, filter, filtrate adds in above-mentioned filtered steeping fluid, adds water to 25000ml, stirs evenly, sealing, room temperature leaves standstill more than three months, gets standing liquid, filters, filling.
4. the preparation technology of chartreuse according to claim 3, is characterized in that described Chinese yam, rhizoma alismatis, the bighead atractylodes rhizome are fryings.
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|---|---|---|---|---|
| CN1846764A (en) * | 2005-04-15 | 2006-10-18 | 张伟 | Health medicinal wine |
| CN101362998A (en) * | 2007-08-08 | 2009-02-11 | 毛宗芳 | Production method of nourishing wine |
| CN101857832A (en) * | 2010-06-01 | 2010-10-13 | 毛成艺 | Beautifying health-care wine |
| CN102260619A (en) * | 2011-06-04 | 2011-11-30 | 鹤壁市益寿酒业有限公司 | Health preserving wine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR100520703B1 (en) * | 2002-10-24 | 2005-10-17 | 주식회사 장생도라지 | Funtional alcoholic liquors comprising old platycodon extracts |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1846764A (en) * | 2005-04-15 | 2006-10-18 | 张伟 | Health medicinal wine |
| CN101362998A (en) * | 2007-08-08 | 2009-02-11 | 毛宗芳 | Production method of nourishing wine |
| CN101857832A (en) * | 2010-06-01 | 2010-10-13 | 毛成艺 | Beautifying health-care wine |
| CN102260619A (en) * | 2011-06-04 | 2011-11-30 | 鹤壁市益寿酒业有限公司 | Health preserving wine |
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Owner name: HENAN LINGYOU PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: HENAN LINGYOU PHARMACEUTICAL LTD. |
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Address after: 450008, No. 129, No. 1808, the Yellow River Road, Jinshui District, Henan, Zhengzhou, No. 18 Patentee after: HENAN LINGYOU PHARMACEUTICAL CO., LTD. Address before: 450008, No. 129, No. 1808, the Yellow River Road, Jinshui District, Henan, Zhengzhou, No. 18 Patentee before: Henan Lingyou Pharmaceutical Co., Ltd. |