CN105106888A - Pharmaceutical composition capable of enhancing immunity and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition capable of enhancing immunity and preparation method of pharmaceutical composition Download PDFInfo
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- CN105106888A CN105106888A CN201510566731.7A CN201510566731A CN105106888A CN 105106888 A CN105106888 A CN 105106888A CN 201510566731 A CN201510566731 A CN 201510566731A CN 105106888 A CN105106888 A CN 105106888A
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Abstract
The invention relates to the field of traditional Chinese medicines, and discloses a pharmaceutical composition capable of enhancing the immunity. The pharmaceutical composition is prepared from the following components in parts by weight: 200-300 parts of Chinese yam, 100-150 parts of hawthorns, 100-160 parts of processed polygonum multiflorum, 120-220 parts of codonopsis pilosula, 20-100 parts of rhizoma atractylodis macrocephalae, 1-50 parts of poria cocos, 1-50 parts of rhizoma zingiberis, 1-100 parts of angelica sinensis, 1-150 parts of cassia twig, 1-100 parts of liquorice, 1-80 parts of white peony roots, 1-100 parts of radix ophiopogonis, 80-200 parts of radix rehmanniae praeparata and 3-500 parts of a sweetening agent. Through synergistic action of the raw materials, the pharmaceutical composition has the effects that the pharmaceutical composition has the functions of reinforcing qi, nourishing blood and regulating the spleen and stomach, and is clinically applied to senile asthenia, weakness after illness, fatigue weakness, loss of appetite, pain and numbness of limbs, insomnia and dreaminess and the like at present. The invention further discloses a preparation method. The preparation method is simple to operate, environment-friendly, economic, efficient and nontoxic, and has a wide application prospect.
Description
Technical field
The present invention relates to the field of Chinese medicines, relate to the pharmaceutical composition of enhancing immunity, particularly relate to the preparation method of the pharmaceutical composition of enhancing immunity.
Background technology
The pressure of present social people all grows with each passing day, and also immediately, people more and more focus on the immunity strengthening self to sub-health status.And the health product of existing a lot of enhancing immunity, be much the dangerous of industry manufacture, also there is toxic and side effects.
Summary of the invention
The present invention is directed to the shortcoming of prior art, provide the pharmaceutical composition of enhancing immunity, also provide the preparation method of the pharmaceutical composition of enhancing immunity.
In order to solve the problems of the technologies described above, the present invention is solved by following technical proposals:
The pharmaceutical composition of enhancing immunity, in following weight proportion, each component and content is, 200 ~ 300 portions of Rhizoma Dioscoreaes, 100 ~ 150 portions of Fructus Crataegis, 100 ~ 160 parts of Radix Polygoni Multiflori Preparatas, 120 ~ 220 parts of Radix Codonopsis, 20 ~ 100 parts of Rhizoma Atractylodis Macrocephalaes, 1 ~ 50 part of Poria, 1 ~ 50 portion of Rhizoma Zingiberis, 1 ~ 100 part of Radix Angelicae Sinensis, 1 ~ 150 part of Ramulus Cinnamomi, 1 ~ 100 portion of Radix Glycyrrhizae, 1 ~ 80 portion of Radix Paeoniae Alba, 1 ~ 100 part of Radix Ophiopogonis, 80 ~ 200 parts of Radix Rehmanniae Preparata, 3 ~ 500 parts of sweeting agents.
The present invention is the pharmaceutical composition of the enhancing immunity that Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata, sweeting agent etc. obtain.Find through clinical trial, a few taste synergism, has following effect: have benefiting QI and nourishing blood, the function of function of spleen and stomach regulating, at present clinically for old weak, body void, fatigue and weak, loss of appetite, acroesthesia numbness, insomnia and dreamful sleep etc. after being ill.Modern study shows, Radix Polygoni Multiflori contains the effective ingredient such as stilbene glucoside.Wherein 2; 3; 5; 4 ＇-tetrahydroxystilbene-2-O-β-D-Glucose glycosides (stilbene glucoside) is main chemical compositions and the active component of Radix Polygoni Multiflori, has defying age, neurocyte protection, adjustment immunity of organism, scavenging free radicals, raising memory, blood fat reducing, vasodilator suppress atherosclerosis, antitumor, the pharmacological action such as to protect the liver.And safety of the present invention is high, toxic and side effects is little.
As preferably, sweeting agent comprises one or more in stevioside, xylitol, dihydrochalcone, cyclamate, protein sugar.
As preferably, also comprise 1 ~ 20 part of antioxidant, antioxidant comprises one or more in vitamin C, vitamin E, sodium sulfite, sodium D-isoascorbate.The present invention, by increasing antioxidant, protects composition perishable in medicine, the effect of the aspects such as the defying age of product, scavenging free radicals is enhanced.
As preferably, also comprise 0.1 ~ 10 part of clarifier, clarifier comprises one or more in tannic acid, gelatin, Ovum Gallus domesticus album, chitosan, Bentonite.Clarifier removes impurity, and product is not precipitated.
As preferably, also comprise 0.1 ~ 10 portion of antiseptic, antiseptic comprises one or more in benzoic acid, sorbic acid, dehydroactic acid, propanoic acid, diacetic acid, lactic acid, parabens.
The preparation method of the pharmaceutical composition of enhancing immunity, comprises the following steps,
A. take Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata, sweeting agent are for subsequent use;
B. Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi are soaked, with hydrodistillation distillation, collect volatile oil, extract volatile oil, collect the aqueous solution after distillation; Volatile oil be a class can volatilize at normal temperatures, can with vapor distillation, with the immiscible oily liquids of water, there is biologic activity widely.Through research repeatedly, Rhizoma Zingiberis, Radix Angelicae Sinensis are extracted in discovery, Ramulus Cinnamomi obtains volatile oil makes the better ideal of medical effect.Steam distillation is a kind of method comparatively effectively extracting traditional medicine volatile oil.Steam distillation is passed into by steam insoluble or is insoluble in water but has in certain volatile organic substance, makes this organic substance lower than at the temperature of 100 DEG C, along with steam distills together.Due to its have that equipment is simple, handling safety, free from environmental pollution, cost is low, avoid organic solvent residual in leaching process, to features such as oil impact, is the important method effectively extracting traditional medicine volatile oil.
C. the medicinal residues after extraction volatile oil and Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata are decocted with water secondary, 2 ~ 5 hours first times, second time 2 ~ 4 hours, collecting decoction, filter, be condensed into runny plaste;
D. add the ethanol that concentration is 20 ~ 95% in runny plaste, the volume adding ethanol is 1 ~ 3 times of runny plaste volume, leaves standstill, and filters, and concentrates and obtains concentrated solution;
E. concentrated solution adds water, and the volume adding water is 1 ~ 4 times of concentrated solution volume, mixing, and filter, filtrate is for subsequent use; Add the aqueous solution after the volatile oil and distillation that the lysate, the steps A that are dissolved with sweeting agent obtain in filtrate, stir, add water, filter, obtain the pharmaceutical composition of enhancing immunity.
As preferably, in step e, concentrated solution adds water, and the volume adding water is 1 ~ 4 times of concentrated solution volume, mixing, and filter, filtrate is for subsequent use; Add the lysate being dissolved with sweeting agent and antiseptic in filtrate, boil, let cool, add the aqueous solution after the volatile oil and distillation that the lysate, the steps A that are dissolved with antioxidant obtain, stir, add water, filter, obtain the pharmaceutical composition of enhancing immunity.
As preferably, in step e, concentrated solution adds water, and the volume adding water is 1 ~ 2 times of concentrated solution volume, and clarifier is mixed with homogeneous dispersion, mixing, 30 ~ 70 DEG C of heating 2 minutes, and place, cold preservation 20 ~ 48 hours, filter, filtrate is for subsequent use; Add the aqueous solution after the volatile oil and distillation that the lysate, the steps A that are dissolved with sweeting agent obtain in filtrate, stir, add water, filter, obtain the pharmaceutical composition of enhancing immunity.Clarifier removes impurity, and product is not precipitated.
The present invention is the pharmaceutical composition of the enhancing immunity that Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata, sweeting agent etc. obtain.Find through clinical trial, a few taste synergism, has following effect: have benefiting QI and nourishing blood, the function of function of spleen and stomach regulating, at present clinically for old weak, body void, fatigue and weak, loss of appetite, acroesthesia numbness, insomnia and dreamful sleep etc. after being ill.Modern study shows, Radix Polygoni Multiflori Preparata contains the effective ingredient such as stilbene glucoside.Wherein 2; 3; 5; 4 ＇-tetrahydroxystilbene-2-O-β-D-Glucose glycosides (stilbene glucoside) is main chemical compositions and the active component of Radix Polygoni Multiflori Preparata, has defying age, neurocyte protection, adjustment immunity of organism, scavenging free radicals, raising memory, blood fat reducing, vasodilator suppress atherosclerosis, antitumor, the pharmacological action such as to protect the liver.And safety of the present invention is high, toxic and side effects is little.
Because Chinese medicine ingredients is complicated, some ingredient stability is bad, and place a period of time, active constituent content can decline.Some composition is impurity, dissolubility is little, place a period of time, easy precipitation, traditional handicraft will add a large amount of sucrose in medicinal liquid, prevents the precipitation that effective ingredient declines and precipitates, and sucrose is not suitable for diabetic to take, therefore, need to improve, use the sweeting agent such as stevioside, xylitol, cyclamate, protein sugar that diabetes patient can take instead.And use these sweeting agents instead, just need to refine medicinal liquid, and add suitable antioxidant.
The present invention is suitable for the preparation method of suitability for industrialized production, and the pharmaceutical composition avoiding enhancing immunity prepared by existing preparation method contains a large amount of sucrose, is not suitable for the phenomenon of diabetic to take.The pharmaceutical composition steady quality of enhancing immunity prepared by the present invention, controlled, homogeneous, and simple to operate, with short production cycle, without the need to special equipment, cost is low, yield is high, is suitable for suitability for industrialized production.In addition, preparation method of the present invention, environmental protection, economy, efficient, nontoxic, have broad application prospects.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1
The pharmaceutical composition of enhancing immunity, in following weight proportion, each component and content is, 200 portions of Rhizoma Dioscoreaes, 100 portions of Fructus Crataegis, 100 parts of Radix Polygoni Multiflori Preparatas, 120 parts of Radix Codonopsis, 20 parts of Rhizoma Atractylodis Macrocephalaes, 1 part of Poria, 1 portion of Rhizoma Zingiberis, 1 part of Radix Angelicae Sinensis, 1 part of Ramulus Cinnamomi, 1 portion of Radix Glycyrrhizae, 1 portion of Radix Paeoniae Alba, 1 part of Radix Ophiopogonis, 80 parts of Radix Rehmanniae Preparata, 3 parts of sweeting agents.
The preparation method of the pharmaceutical composition of enhancing immunity, comprises the following steps,
A. take Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata, sweeting agent are for subsequent use;
B. Ramulus Cinnamomi is soaked, with hydrodistillation distillation, collect volatile oil, extract volatile oil, collect the aqueous solution after distillation;
C. the medicinal residues after extraction volatile oil and Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata are decocted with water secondary, 2 hours first times, second time 2 hours, collecting decoction, filter, be condensed into runny plaste;
D. add the ethanol that concentration is 20% in runny plaste, the volume adding ethanol is 1 times of runny plaste volume, leaves standstill, and filters, and concentrates and obtains concentrated solution;
E. concentrated solution adds water, and the volume adding water is 1 times of concentrated solution volume, mixing, and filter, filtrate is for subsequent use; Add the aqueous solution after the volatile oil and distillation that the lysate, the steps A that are dissolved with sweeting agent obtain in filtrate, stir, add water, filter, obtain the pharmaceutical composition of enhancing immunity.
Embodiment 2
The pharmaceutical composition of enhancing immunity, in following weight proportion, each component and content is, 300 portions of Rhizoma Dioscoreaes, 150 portions of Fructus Crataegis, 160 parts of Radix Polygoni Multiflori Preparatas, 220 parts of Radix Codonopsis, 100 parts of Rhizoma Atractylodis Macrocephalaes, 50 parts of Poria, 50 portions of Rhizoma Zingiberiss, 100 parts of Radix Angelicae Sinensis, 150 parts of Ramulus Cinnamomi, 100 portions of Radix Glycyrrhizaes, 80 portions of Radix Paeoniae Albas, 100 parts of Radix Ophiopogonis, 200 parts of Radix Rehmanniae Preparata, 500 parts of sweeting agents.
Sweeting agent comprises stevioside.Also comprise 20 parts of antioxidants, antioxidant comprises vitamin C.Also comprise 10 portions of antiseptic, antiseptic comprises benzoic acid.
The preparation method of the pharmaceutical composition of enhancing immunity, comprises the following steps,
A. take Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata, sweeting agent are for subsequent use;
B. Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi are soaked, with hydrodistillation distillation, collect volatile oil, extract volatile oil, collect the aqueous solution after distillation;
C. the medicinal residues after extraction volatile oil and Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata are decocted with water secondary, 5 hours first times, second time 4 hours, collecting decoction, filter, be condensed into runny plaste;
D. add the ethanol that concentration is 95% in runny plaste, the volume adding ethanol is 3 times of runny plaste volume, leaves standstill, and filters, and concentrates and obtains concentrated solution;
E. concentrated solution adds water, and the volume adding water is 4 times of concentrated solution volume, mixing, and filter, filtrate is for subsequent use; Add the lysate being dissolved with sweeting agent and antiseptic in filtrate, boil, let cool, add the aqueous solution after the volatile oil and distillation that the lysate, the steps A that are dissolved with antioxidant obtain, stir, add water, filter, obtain the pharmaceutical composition of enhancing immunity.
Embodiment 3
The pharmaceutical composition of enhancing immunity, in following weight proportion, each component and content is, 260 portions of Rhizoma Dioscoreaes, 120 portions of Fructus Crataegis, 120 parts of Radix Polygoni Multiflori Preparatas, 130 parts of Radix Codonopsis, 80 parts of Rhizoma Atractylodis Macrocephalaes, 45 parts of Poria, 25 portions of Rhizoma Zingiberiss, 80 parts of Radix Angelicae Sinensis, 120 parts of Ramulus Cinnamomi, 80 portions of Radix Glycyrrhizaes, 60 portions of Radix Paeoniae Albas, 80 parts of Radix Ophiopogonis, 100 parts of Radix Rehmanniae Preparata, 50 parts of sweeting agents.
Sweeting agent comprises stevioside, xylitol, dihydrochalcone.Also comprise 10 parts of antioxidants, antioxidant comprises the mixture of sodium sulfite, sodium D-isoascorbate.Also comprise 8 portions of antiseptic, antiseptic comprises the mixture of sorbic acid, dehydroactic acid, propanoic acid, diacetic acid, lactic acid, parabens.
Also comprise 1 part of clarifier, clarifier comprises the mixing of tannic acid, gelatin, Ovum Gallus domesticus album, chitosan, Bentonite.
The preparation method of the pharmaceutical composition of enhancing immunity, comprises the following steps,
A. take Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata, sweeting agent are for subsequent use;
B. Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi are soaked, with hydrodistillation distillation, collect volatile oil, extract volatile oil, collect the aqueous solution after distillation;
C. the medicinal residues after extraction volatile oil and Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata are decocted with water secondary, 3 hours first times, second time 3 hours, collecting decoction, filter, be condensed into runny plaste;
D. add the ethanol that concentration is 25% in runny plaste, the volume adding ethanol is 2 times of runny plaste volume, leaves standstill, and filters, and concentrates and obtains concentrated solution;
E. concentrated solution adds water, and the volume adding water is 1.5 times of concentrated solution volume, and clarifier is mixed with homogeneous dispersion, mixing, and 35 DEG C are heated 2 minutes, place, cold preservation 25 hours, and filter, filtrate is for subsequent use; Add the aqueous solution after the volatile oil and distillation that the lysate, the steps A that are dissolved with sweeting agent obtain in filtrate, stir, add water, filter, obtain the pharmaceutical composition of enhancing immunity.
Embodiment 4
The pharmaceutical composition of enhancing immunity, in following weight proportion, each component and content is, 210 portions of Rhizoma Dioscoreaes, 110 portions of Fructus Crataegis, 110 parts of Radix Polygoni Multiflori Preparatas, 125 parts of Radix Codonopsis, 25 parts of Rhizoma Atractylodis Macrocephalaes, 5 parts of Poria, 5 portions of Rhizoma Zingiberiss, 3 parts of Radix Angelicae Sinensis, 6 parts of Ramulus Cinnamomi, 6 portions of Radix Glycyrrhizaes, 5 portions of Radix Paeoniae Albas, 2 parts of Radix Ophiopogonis, 85 parts of Radix Rehmanniae Preparata, 8 parts of sweeting agents.
Sweeting agent comprises the mixture in dihydrochalcone, cyclamate, protein sugar.Also comprise 1 part of antioxidant, antioxidant comprises vitamin C, vitamin E.Also comprise 0.1 part of clarifier, clarifier comprises tannic acid.Also comprise 0.1 portion of antiseptic, antiseptic comprises benzoic acid.
The preparation method of the pharmaceutical composition of enhancing immunity, comprises the following steps,
A. take Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata, sweeting agent are for subsequent use;
B. Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi are soaked, with hydrodistillation distillation, collect volatile oil, extract volatile oil, collect the aqueous solution after distillation;
C. the medicinal residues after extraction volatile oil and Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata are decocted with water secondary, 2.5 hours first times, second time 2.4 hours, collecting decoction, filter, be condensed into runny plaste;
D. add the ethanol that concentration is 25% in runny plaste, the volume adding ethanol is 2 times of runny plaste volume, leaves standstill, and filters, and concentrates and obtains concentrated solution;
E. concentrated solution adds water, and the volume adding water is 1 times of concentrated solution volume, and clarifier is mixed with homogeneous dispersion, mixing, and 30 DEG C are heated 2 minutes, place, cold preservation 20 hours, and filter, filtrate is for subsequent use; Add the aqueous solution after the volatile oil and distillation that the lysate, the steps A that are dissolved with sweeting agent obtain in filtrate, stir, add water, filter, obtain the pharmaceutical composition of enhancing immunity.
Embodiment 5
The pharmaceutical composition of enhancing immunity, in following weight proportion, each component and content is, 290 portions of Rhizoma Dioscoreaes, 145 portions of Fructus Crataegis, 155 parts of Radix Polygoni Multiflori Preparatas, 210 parts of Radix Codonopsis, 90 parts of Rhizoma Atractylodis Macrocephalaes, 40 parts of Poria, 40 portions of Rhizoma Zingiberiss, 90 parts of Radix Angelicae Sinensis, 140 parts of Ramulus Cinnamomi, 90 portions of Radix Glycyrrhizaes, 70 portions of Radix Paeoniae Albas, 90 parts of Radix Ophiopogonis, 190 parts of Radix Rehmanniae Preparata, 480 parts of sweeting agents.
Sweeting agent comprises the mixture of cyclamate, protein sugar.Also comprise 20 parts of antioxidants, antioxidant comprises the mixture of vitamin C, vitamin E.Also comprise 10 parts of clarifiers, clarifier comprises the mixture of Ovum Gallus domesticus album, chitosan.Also comprise 10 portions of antiseptic, antiseptic comprises the mixture of propanoic acid, diacetic acid, lactic acid.
The preparation method of the pharmaceutical composition of enhancing immunity, comprises the following steps,
A. take Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata, sweeting agent are for subsequent use;
B. Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi are soaked, with hydrodistillation distillation, collect volatile oil, extract volatile oil, collect the aqueous solution after distillation;
C. the medicinal residues after extraction volatile oil and Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata are decocted with water secondary, first time 2.5 hours, second time 2 hours, collecting decoction, filters, is condensed into runny plaste;
D. add the ethanol that concentration is 20% in runny plaste, the volume adding ethanol is 1 times of runny plaste volume, leaves standstill, and filters, and concentrates and obtains concentrated solution;
E. concentrated solution adds water, and the volume adding water is 2 times of concentrated solution volume, and clarifier is mixed with homogeneous dispersion, mixing, and 70 DEG C are heated 2 minutes, place, cold preservation 48 hours, and filter, filtrate is for subsequent use; Add the aqueous solution after the volatile oil and distillation that the lysate, the steps A that are dissolved with sweeting agent obtain in filtrate, stir, add water, filter, obtain the pharmaceutical composition of enhancing immunity.
In a word, the foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to the covering scope of patent of the present invention.
Claims (8)
1. the pharmaceutical composition of enhancing immunity, it is characterized in that: in following weight proportion, each component and content is, 200 ~ 300 portions of Rhizoma Dioscoreaes, 100 ~ 150 portions of Fructus Crataegis, 100 ~ 160 parts of Radix Polygoni Multiflori Preparatas, 120 ~ 220 parts of Radix Codonopsis, 20 ~ 100 parts of Rhizoma Atractylodis Macrocephalaes, 1 ~ 50 part of Poria, 1 ~ 50 portion of Rhizoma Zingiberis, 1 ~ 100 part of Radix Angelicae Sinensis, 1 ~ 150 part of Ramulus Cinnamomi, 1 ~ 100 portion of Radix Glycyrrhizae, 1 ~ 80 portion of Radix Paeoniae Alba, 1 ~ 100 part of Radix Ophiopogonis, 80 ~ 200 parts of Radix Rehmanniae Preparata, 3 ~ 500 parts of sweeting agents.
2. the pharmaceutical composition of enhancing immunity according to claim 1, is characterized in that: sweeting agent comprises one or more in stevioside, xylitol, dihydrochalcone, cyclamate, protein sugar.
3. the pharmaceutical composition of enhancing immunity according to claim 1, is characterized in that: also comprise 1 ~ 20 part of antioxidant, antioxidant comprises one or more in vitamin C, vitamin E, sodium sulfite, sodium D-isoascorbate.
4. the pharmaceutical composition of enhancing immunity according to claim 1, is characterized in that: also comprise 0.1 ~ 10 part of clarifier, clarifier comprises one or more in tannic acid, gelatin, Ovum Gallus domesticus album, chitosan, Bentonite.
5. the pharmaceutical composition of enhancing immunity according to claim 1, it is characterized in that: also comprise 0.1 ~ 10 portion of antiseptic, antiseptic comprises one or more in benzoic acid, sorbic acid, dehydroactic acid, propanoic acid, diacetic acid, lactic acid, parabens.
6. the preparation method of the pharmaceutical composition of enhancing immunity, is characterized in that: comprise the following steps,
A. take Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata, sweeting agent are for subsequent use;
B. Rhizoma Zingiberis, Radix Angelicae Sinensis, Ramulus Cinnamomi are soaked, with hydrodistillation distillation, collect volatile oil, extract volatile oil, collect the aqueous solution after distillation;
C. the medicinal residues after extraction volatile oil and Rhizoma Dioscoreae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Ophiopogonis, Radix Rehmanniae Preparata are decocted with water secondary, 2 ~ 5 hours first times, second time 2 ~ 4 hours, collecting decoction, filter, be condensed into runny plaste;
D. add the ethanol that concentration is 20 ~ 95% in runny plaste, the volume adding ethanol is 1 ~ 3 times of runny plaste volume, leaves standstill, and filters, and concentrates and obtains concentrated solution;
E. concentrated solution adds water, and the volume adding water is 1 ~ 4 times of concentrated solution volume, mixing, and filter, filtrate is for subsequent use; Add the aqueous solution after the volatile oil and distillation that the lysate, the steps A that are dissolved with sweeting agent obtain in filtrate, stir, add water, filter, obtain the pharmaceutical composition of enhancing immunity.
7. the preparation method of the pharmaceutical composition of enhancing immunity according to claim 6, it is characterized in that: in step e, concentrated solution adds water, and the volume adding water is 1 ~ 4 times of concentrated solution volume, mixing, and filter, filtrate is for subsequent use; Add the lysate being dissolved with sweeting agent and antiseptic in filtrate, boil, let cool, add the aqueous solution after the volatile oil and distillation that the lysate, the steps A that are dissolved with antioxidant obtain, stir, add water, filter, obtain the pharmaceutical composition of enhancing immunity.
8. the preparation method of the pharmaceutical composition of enhancing immunity according to claim 6, it is characterized in that: in step e, concentrated solution adds water, and the volume adding water is 1 ~ 2 times of concentrated solution volume, and clarifier is mixed with homogeneous dispersion, mixing, 30 ~ 70 DEG C are heated 2 minutes, place, cold preservation 20 ~ 48 hours, filter, filtrate is for subsequent use; Add the aqueous solution after the volatile oil and distillation that the lysate, the steps A that are dissolved with sweeting agent obtain in filtrate, stir, add water, filter, obtain the pharmaceutical composition of enhancing immunity.
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| CN (1) | CN105106888A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108048370A (en) * | 2018-01-27 | 2018-05-18 | 北京中科润之农业科技发展有限公司 | A kind of zymotechnique of bacillus subtilis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1240589A (en) * | 1998-06-30 | 2000-01-12 | 肖树恩 | Health-care crunchy candy |
-
2015
- 2015-09-08 CN CN201510566731.7A patent/CN105106888A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1240589A (en) * | 1998-06-30 | 2000-01-12 | 肖树恩 | Health-care crunchy candy |
Non-Patent Citations (2)
| Title |
|---|
| 中华人民共和国卫生部药典委员会: "《中华人民共和国卫生部 药品标准 中药成方制剂第十三册》", 31 December 1997 * |
| 李瑶卿等: "《小病上药店 国家非处方中成药简明手册》", 31 August 2002 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108048370A (en) * | 2018-01-27 | 2018-05-18 | 北京中科润之农业科技发展有限公司 | A kind of zymotechnique of bacillus subtilis |
| CN108048370B (en) * | 2018-01-27 | 2020-05-26 | 北京中科润之农业科技发展有限公司 | Fermentation process of bacillus subtilis |
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Address after: 321071 No. 1 Taikang Road, Kaihua County Industrial Park, Quzhou City, Zhejiang Province Applicant after: ZHEJIANG TAIKANG PHARMACEUTICAL GROUP CO., LTD. Address before: 324300 No. 46 Zhongshan Road, Kaihua County, Quzhou City, Zhejiang Province Applicant before: ZHEJIANG TAIKANG PHARMACEUTICAL GROUP CO., LTD. |
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