CN108477171A - A kind of efficient bactericidal composite containing fenbendazole - Google Patents
A kind of efficient bactericidal composite containing fenbendazole Download PDFInfo
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- CN108477171A CN108477171A CN201810347635.7A CN201810347635A CN108477171A CN 108477171 A CN108477171 A CN 108477171A CN 201810347635 A CN201810347635 A CN 201810347635A CN 108477171 A CN108477171 A CN 108477171A
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- fenbendazole
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
- A01N43/52—1,3-Diazoles; Hydrogenated 1,3-diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/10—Animals; Substances produced thereby or obtained therefrom
Abstract
The invention discloses a kind of efficient bactericidal composites containing fenbendazole, the bactericidal composition containing active constituent fenbendazole Yu active constituent B, and the weight ratio of fenbendazole and active constituent B are 1 ︰, 80~80 ︰ 1.The present composition has greater activity to the multiple diseases in various crop, and has apparent synergistic effect, expands fungicidal spectrum, and the small, resistance of rainwater washing against with dosage, the apparent feature of synergy.
Description
Technical field
The invention belongs to technical field of pesticide, it is related to a kind of efficient bactericidal composite containing fenbendazole in crop disease
Application.
Technical background
Fenbendazole (Fenbendazole), molecular formula：C15H13N3O2S, chemical name：(5- (thiophenyl) -1H- benzos
Imidazoles -2- ylcarbamic acid methyl esters, fenbendazole are wide spectrum, novel benzimidazoles anthelmintic efficiently, less toxic.It is not only right
Animal gastrointestinal tract nematode, adult, larva have height anthelmintic activity, and to net tail nematode, lance type two-chamber worm, fasciola and wash
Worm also has preferable effect.Absorbed since Phenbendasol's solubility is low, thus when being taken to animal it is few, after absorption in animal body
Majority forms metabolite and hydroxylating mainly occurs on phenyl ring such as in ruminant body, and de- carbethoxyl group also occurs in some
Change acts on, and a large amount of metabolite is also formed in pig body or even some researchs also demonstrate, these metabolism in sheep body are produced
Object, by after choleresis and the liver that can be expert at, intestines recycle.
In the real process of agricultural production, the problem of controlling disease most easily produces is the generation of disease drug resistance.No
It is compounded with kind ingredient, is to prevent the very common method of resistance disease.Heterogeneity is compounded, and is imitated according to practical application
Fruit, to judge that certain compounding is synergy, adduction or antagonism.In most cases, the compounding effect of pesticide is all to add
And effect, really have the compounding of synergistic effect seldom, especially synergistic effect clearly, the very high compounding of synergy ratio just more
It is few.It is studied by inventor, discovery mutually compounds fenbendazole and active constituent B, there is good increasing in a certain range
Effect acts on, and in relation to fenbendazole compounding related to active constituent B's, at present at home and abroad there is not yet relevant report.
Invention content
The purpose of the present invention is to propose to a kind of with synergistic function, use cost is low, preventive effect is good contains fenbendazole
Efficient bactericidal composite.
The present invention is achieved through the following technical solutions：
A kind of efficient bactericidal composite containing fenbendazole, containing fenbendazole and active constituent B, fenbendazole with work
Property ingredient B weight range be 1 ︰, 80~80 ︰ 1；Preferably fenbendazole with the weight range of active constituent B be 1 ︰ 60~
60 ︰ 1；More preferably fenbendazole is 1 ︰, 20~20 ︰ 1 with the weight range of active constituent B, active constituent B be polyoxin,
Kasugarnycin, Ningnanmycin, Zhongshengmycin, antibiotic in pyrimidine nucleoside class, antibiotic in pyrimidine nucleoside class are also pesticide corrosion 120.
The bactericidal composition containing fenbendazole is used to prevent the application of the disease of crop, and the crop includes grain
Food crop, legume crop, fibre crops, sugar crop, melon crop, fruits crop, dry fruit crop, hobby crop, root
Stem class crop, oil crops, flower crop, medicinal crop, crop, green manure pasture crop.
The bactericidal composition containing fenbendazole is used to prevent the application of the disease of crop, and the disease includes water
Rice rice blast, anthracnose of peach, Pear black spot, anthrax leaf blight, apple brown rot, capsicum black rot, early blight, damping-off, root
Maize ear rot, downy mildew, spot defoliation, epidemic disease, gray mold, powdery mildew, virosis.
The amount of application when content of active constituent depends on being used alone in the present composition, also depends on a kind of chemical combination
The mixed ratio and synergistic effect degree of object and another compound, at the same it is also related with target disease.In usual composition
The weight percentage of active constituent is the 1%~90% of total weight, preferably 5%~80%.According to different preparation classes
Type, active component content range are different.In general, liquid preparation contains by weight 1%~60% active material, preferably
Ground is 5%~50%；Solid pharmaceutical preparation contains by weight 5%~80% active material, preferably 10%~80%.
The present invention bactericidal composition at least contain a kind of surfactant, in favor of application when active constituent in water
Dispersion.Surface-active contents are the 2%~30% of total formulation weight, and surplus is solid or liquid diluent.
Surfactant selected by the bactericidal composition of the present invention is known in those skilled in the art：It can be selected from
One or more of dispersant, wetting agent, thickener or antifoaming agent.According to different dosage forms, this field can also be contained in preparation
Stabilizer, antifreeze well known to technical staff etc..
The bactericidal composition of the present invention can used before through dilution or directly by user.Its preparation can be by ability
Prepared by the processing method well known to field technique personnel, i.e., after mixing active constituent with liquid flux or solid carrier, add
One or more of surfactant such as dispersant, stabilizer, wetting agent, binder, antifoaming agent etc..
The bactericidal composition of the present invention, can be processed into any dosage form pesticide-acceptable on demand.Wherein preferred agent
Type is wettable powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, aqua.
Composition includes following component and content when wettable powder is made：Fenbendazole 0.01%~80%, activity at
Divide B 0.01%~50%, dispersant 1%~12%, wetting agent 1%~8%, filler surplus.
Composition includes following component and content when water dispersible granules are made：Fenbendazole 0.01%~80%, activity at
Point B 0.01%~50%, dispersant 1%~12%, wetting agent 1%~8%, disintegrant 1%~10%, binder 0~8%,
Filler surplus.
Composition includes following component and content when suspending agent is made：Fenbendazole 0.01%~50%, active constituent B
0.01%~50%, dispersant 1%~10%, wetting agent 1%~10%, antifoaming agent 0.01%~2%, thickener 0~2%,
Antifreeze 0~8%, deionized water add to 100%.
Composition includes following component and content when suspension emulsion is made：Fenbendazole 0.01%~50%, active constituent B
0.01%~50%, emulsifier 1%~10%, dispersant 1%~10%, solvent 1%~20%, antifoaming agent 0.01%~2%,
Thickener 0~2%, antifreeze 0~8%, deionized water add to 100%.
Composition includes following constituent content when aqua is made：Fenbendazole 0.01%~50%, active constituent B
0.01%~50%, cosolvent 2%~6%, wetting agent 1%-10%, antifreeze 0~8%, deionized water add to 100%.
Composition includes following component and content when aqueous emulsion is made：Fenbendazole 0.01%~50%, active constituent B
0.01%~50%, solvent 1%~20%, emulsifier 1%~12%, antifreeze 0~8%, antifoaming agent 0.01%~2%, increasing
Thick dose 0~2%, deionized water add to 100%.
Composition includes following component and content when microemulsion is made：Fenbendazole 0.01%~50%, active constituent B
0.01%~50%, emulsifier 3%~25%, solvent 1%~10%, antifreeze 0~8%, antifoaming agent 0.01%~2%, go
Ionized water adds to 100%.
The wettable powder the key technical indexes of the present invention：
The water dispersible granules the key technical indexes of the present invention：
The suspending agent the key technical indexes of the present invention：
The suspension emulsion the key technical indexes of the present invention：
The aqua the key technical indexes of the present invention：
The aqueous emulsion the key technical indexes of the present invention：
The microemulsion the key technical indexes of the present invention：
The advantage of the invention is that：
(1) present composition has good synergy and lasting effect, preventive effect to be higher than single dose in a certain range；(2) agriculture
Medicinal dose is reduced, and is reduced residual quantity of the pesticide on crop, is mitigated environmental pollution；(3) fungicidal spectrum is expanded, to multiple diseases
Such as rice blast, bacterial wilt, soft rot, bacterial angular leaf spot, shot hole, anthracnose of peach, Pear black spot, anthrax leaf blight,
Apple brown rot, capsicum black rot, damping-off, root rot, downy mildew, spot defoliation, epidemic disease, gray mold, powdery mildew, virus
Disease has greater activity.
Specific implementation mode
With reference to embodiment to further instruction of the present invention, the percentage in embodiment is weight percentage, but
The present invention is not limited thereto.
Application Example one
1~15 wettable powder of embodiment
Fenbendazole, active constituent B, dispersant, wetting agent, filler are mixed, are uniformly mixed in mixed cylinder, through air-flow
Pulverizer remixes uniformly after crushing, you can wettable powder product of the present invention is made.Specifically it is shown in Table 1.
1 embodiment of table, 1~15 each component and content
16~25 water dispersible granules of embodiment
Fenbendazole, active constituent B, dispersant, wetting agent, disintegrant, filler are needed through air-flow crushing together
Grain size, add other auxiliary agents such as binder (can add can be not added with), obtain granulation materials.Item is quantified into the fluid bed system of feeding
In grain drying machine after granulation and drying, water dispersible granules product of the present invention is made.Specifically it is shown in Table 2.
2 embodiment of table, 16~25 each component and content
26~35 suspending agent of embodiment
By dispersant, wetting agent, thickener (can add can be not added with), antifoaming agent, antifreeze (can add can be not added with) by high speed
Shear-mixed is uniform, and fenbendazole, active constituent B is added, supplies surplus with deionized water, ball milling 2~3 is small in the ball mill
When, make diameter of particle all at 5 μm hereinafter, suspending agent product of the present invention is made.Specifically it is shown in Table 3.
3 embodiment of table, 26~35 each component and content
36~37 suspension emulsion of embodiment
By dispersant, antifoaming agent, thickener (can add can be not added with), antifreeze (can add can be not added with), deionized water through excessively high
Fast shear-mixed is uniform, fenbendazole is added, in the ball mill ball milling 2~3 hours, makes diameter of particle all at 5 μm hereinafter, system
Fenbendazole suspending agent is obtained, then active constituent B, solvent, emulsifier and various auxiliary agent high speed agitators are directly emulsified and arrived
In suspending agent, suspension emulsion product of the present invention is made.Specifically it is shown in Table 4.
4 embodiment of table, 36~37 each component and content
38~47 aqueous emulsion of embodiment
Fenbendazole, active constituent B, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase；By deionized water,
Antifreeze (can add can be not added with), thickener (can add can be not added with), antifoaming agent mix, at uniform water phase.In high-speed stirred
Under, oil phase is added in water phase, aqueous emulsion product of the present invention is made.Specifically it is shown in Table 5.
5 embodiment of table, 38~47 each component and content
48~50 aqua of embodiment
Fenbendazole, active constituent B, wetting agent, antifreeze (can add can be not added with), solvent, deionized water etc. are mixed together
It closes, the aqua product of the present invention is made.Specifically it is shown in Table 6.
6 embodiment of table, 48~50 each component and content
63~65 microemulsion of embodiment
Fenbendazole, active constituent B are dissolved in the homogenizer equipped with solvent, by emulsifier, antifreeze, (can add can not
Add), antifoaming agent be added in the homogenizer equipped with above-mentioned solution, give after supplying surplus with deionized water strongly mixing and it is even
Change, finally obtains the transparent microemulsion product of the present invention of clear appearance.Specifically it is shown in Table 6.
6 embodiment of table, 63~65 each component and content
The embodiment of the present invention is the method being combined using Toxicity Determination and field trial.First pass through indoor virulence survey
It is fixed, the synergy ratio (SR) after two kinds of medicaments compound by a certain percentage is defined, SR ＜ 0.5 are antagonism, 0.5≤SR≤1.5
For summation action, SR ＞ 1.5 are synergistic effect, on this basis, then carry out field trial.
Test method：After prerun determines the effective inhibition concentration range of each medicament, medicament sets 5 respectively by active constituent content
A dosage processing, if clear water compares.Reference《Farm-chemical indoor determination test rule fungicide》It carries out, speed is grown using mycelia
Rate method measures virulence of the medicament to crop germ.Colony diameter is measured with crossing method after 72h, calculates the net growth of each processing
Amount, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter -5
Application Example two：
For trying disease：Wheat scab；Test medicine：By Shaanxi, Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd carries
For；Experimental design：Effective suppression of fenbendazole and active constituent B active compounds and the two different ratio mixture is determined by pilot study
Concentration range processed.
Toxicity test result
7 fenbendazole of table compounds the toxicity test analysis of results table to wheat scab with polyoxin
As shown in Table 7, fenbendazole and polyoxin compounding prevention wheat scab are in fenbendazole and polyoxin
Weight ratio is that 1 ︰ 80~80 ︰ 1, synergy ratio SR are all higher than 1.5, illustrate the weight ratio of fenbendazole and polyoxin be 1 ︰ 80~
Mixture shows synergistic effect in 80 ︰, 1 ranges；When the proportioning of fenbendazole and polyoxin is in 1 20~20 ︰ 1 of ︰, synergy
Effect is more prominent, and synergy ratio is 2.25 or more, preferably matching through applicant's experiment discovery fenbendazole and polyoxin
Than being 20:1、15:1、10:1、9:1、8:1、7:1、6:1、5:1、4:1、3:1、2:1、1：1、1：2、1：3、1：4、1：5、1：6、1：
7、1：8、1：9、1：10、1：15、1：20, especially when fenbendazole and polyoxin weight ratio are 1：Synergy ratio is maximum when 1,
Synergistic effect is the most apparent.
Application Example three：
For trying disease：Rice blast；Test medicine：By Shaanxi, Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd carries
For；Experimental design：Effective suppression of fenbendazole and kasugarnycin active compound and the two different ratio mixture is determined by pilot study
Concentration range processed.
Toxicity test result
8 fenbendazole of table compounds the toxicity test analysis of results table to rice blast with kasugarnycin
As shown in Table 8, fenbendazole and kasugarnycin compounding prevention rice blast are in fenbendazole and kasugarnycin
Weight ratio is that 1 ︰ 80~80 ︰ 1, synergy ratio SR are all higher than 1.5, illustrates that the two is in the weight ratio of fenbendazole and kasugarnycin
Mixture shows synergistic effect in 1 ︰, 80~80 ︰, 1 ranges；When the proportioning of fenbendazole and kasugarnycin is in 1 ︰, 20~20 ︰ 1
When, synergistic effect is more prominent, and synergy ratio is tested through applicant 2.25 or more and finds fenbendazole and kasugarnycin
Optimum ratio is 20:1、15:1、10:1、9:1、8:1、7:1、6:1、5:1、4:1、3:1、2:1、1：1、1：2、1：3、1：4、1：5、
1：6、1：7、1：8、1：9、1：10、1：15、1：20, especially when fenbendazole and kasugarnycin weight ratio are 2：Synergic ratio when 1
Value is maximum, and synergistic effect is the most apparent.
Application Example four：
For trying disease：Bacterial wilt of tomato；Test medicine：By Shaanxi, Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd carries
For；Experimental design：Effective suppression of fenbendazole and zhongshengmycin bulk drug and the two different ratio mixture is determined by pilot study
Concentration range processed.
Toxicity test result
9 fenbendazole of table compounds the toxicity test analysis of results table to bacterial wilt of tomato with Zhongshengmycin
As shown in Table 9, fenbendazole and Zhongshengmycin compounding control of plant bacterial wilt are in fenbendazole and Zhongshengmycin
Weight ratio is that 1 ︰ 80~80 ︰ 1, synergy ratio SR are all higher than 1.5, illustrates that the two is in the weight ratio of fenbendazole and Zhongshengmycin
Mixture shows synergistic effect in 1 ︰, 80~80 ︰, 1 ranges；When the proportioning of fenbendazole and Zhongshengmycin is in 1 ︰, 20~20 ︰ 1
When, synergistic effect is more prominent, and synergy ratio is tested through applicant 2.25 or more and finds fenbendazole and Zhongshengmycin
Optimum ratio is 20:1、15:1、10:1、9:1、8:1、7:1、6:1、5:1、4:1、3:1、2:1、1：1、1：2、1：3、1：4、1：5、
1：6、1：7、1：8、1：9、1：10、1：15、1：20, especially when fenbendazole and Zhongshengmycin weight ratio are 1：Synergic ratio when 1
Value is maximum, and synergistic effect is the most apparent.
Application Example five：
For trying disease：Tomato virus disease；Test medicine：By Shaanxi, Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd carries
For；Experimental design：Effective suppression of fenbendazole and Ningnanmycin active compound and the two different ratio mixture is determined by pilot study
Concentration range processed.
Toxicity test result
10 fenbendazole of table compounds the toxicity test analysis of results table to tomato virus disease with Ningnanmycin
As shown in Table 10, fenbendazole and Ningnanmycin compounding prevention tomato virus disease are in fenbendazole and Ningnanmycin
When weight ratio is 1 80~80 ︰ 1 of ︰, synergy ratio SR is all higher than 1.5, both illustrates the weight ratio in fenbendazole and Ningnanmycin
Synergistic effect is shown for mixture in 1 ︰, 80~80 ︰, 1 ranges；When the proportioning of fenbendazole and Ningnanmycin is in 1 ︰, 20~20 ︰ 1
When, synergistic effect is more prominent, and synergy ratio is tested through applicant 2.20 or more and finds fenbendazole and Ningnanmycin
Optimum ratio is 20:1、15:1、10:1、9:1、8:1、7:1、6:1、5:1、4:1、3:1、2:1、1：1、1：2、1：3、1：4、1：5、
1：6、1：7、1：8、1：9、1：10、1：15、1：20, especially when fenbendazole and Ningnanmycin weight ratio are 1：Synergic ratio when 1
Value is maximum, and synergistic effect is the most apparent.
Application Example six：
For trying disease：Soft rot of cabbage；Test medicine：By Shaanxi, Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd carries
For；Experimental design：Effective inhibition of fenbendazole and pesticide corrosion 120 active compound and the two different ratio mixture is determined by pilot study
Concentration range.
Toxicity test result
11 fenbendazole of table compounds the toxicity test analysis of results table to soft rot of cabbage with pesticide corrosion 120
As shown in Table 11, fenbendazole compounds the weight for preventing soft rot of cabbage in fenbendazole and pesticide corrosion 120 with pesticide corrosion 120
When amount is than being 1 80~80 ︰ 1 of ︰, synergy ratio SR is all higher than 1.5, illustrates that the two is in the weight ratio of fenbendazole and pesticide corrosion 120
Mixture shows synergistic effect within the scope of when 1 80~80 ︰ 1 of ︰；When the proportioning of fenbendazole and pesticide corrosion 120 is in 1 ︰, 20~20 ︰ 1
When, synergistic effect is more prominent, and synergy ratio is tested through applicant 2.20 or more and finds fenbendazole and pesticide corrosion 120
Optimum ratio is 20:1、15:1、10:1、9:1、8:1、7:1、6:1、5:1、4:1、3:1、2:1、1：1、1：2、1：3、1：4、1：5、
1：6、1：7、1：8、1：9、1：10、1：15、1：20, especially when fenbendazole and pesticide corrosion 120 weight ratio are 2：Synergy ratio when 1
Maximum, synergistic effect are the most apparent.
Seven fenbendazole of Application Example and active constituent B and its compounding prevention rice blast test of pesticide effectiveness
For this test arrangement in Anhui Province Fuyang City Yingshang County, it is limited that test medicine by Shaanxi Kang He founds rich biotechnology medicine company
Company research and development, provide, 30% fenbendazole suspending agent (autogamy) of comparison medicament, 3% Zhongshengmycin wettable powder (purchased in market),
2% kasugarnycin aqua (purchased in market), 10% Wettable polyoxin powder (purchased in market), 8% Ningnanmycin aqua (purchased in market), 2%
Pesticide corrosion 120 aqua (purchased in market).
The rice blast state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days is primary, altogether dispenser 2 times.
7 days after last dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
12 fenbendazole of table and active constituent B and its compounding prevention rice blast test of pesticide effectiveness
As can be seen from Table 12, rice blast, control effect can effectively be prevented after fenbendazole and active constituent B compoundings
It is superior to the preventive effect of single dose, and preventive effect phase is long, and rice leaf blight, damping-off can be prevented, control effect is up to after 14 days
97% or more.It has no adverse effects to target crop in experiment scope of medication.
Eight fenbendazole of Application Example and active constituent B and its compounding prevention apple brown rot test of pesticide effectiveness
For this test arrangement in Xianyang, Shanxi province city Liquan County, it is limited that test medicine by Shaanxi Kang He founds rich biotechnology medicine company
Company research and development, provide, 30% fenbendazole suspending agent (autogamy) of comparison medicament, 3% Zhongshengmycin wettable powder (purchased in market),
2% kasugarnycin aqua (purchased in market), 10% Wettable polyoxin powder (purchased in market), 8% Ningnanmycin aqua (purchased in market), 2%
Pesticide corrosion 120 aqua (purchased in market).
The apple brown rot state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days is primary, altogether dispenser 2 times.
7 days after last dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
13 fenbendazole of table and active constituent B and its compounding prevention apple brown rot test of pesticide effectiveness
As can be seen from Table 13, apple brown rot, control effect can effectively be prevented after fenbendazole and active constituent B compoundings
It is superior to the preventive effect of single dose, and preventive effect phase is long, and alternaria leaf spot of apple, powdery mildew, anthrax leaf blight can be prevented, 14 days
Control effect is up to 97% or more afterwards.It has no adverse effects to target crop in experiment scope of medication.
Nine fenbendazole of Application Example and active constituent B and its compounding prevention tomato virus disease test of pesticide effectiveness
For this test arrangement in Shaanxi Province Weinan City Dali County, it is limited that test medicine by Shaanxi Kang He founds rich biotechnology medicine company
Company research and development, provide, 30% fenbendazole suspending agent (autogamy) of comparison medicament, 3% Zhongshengmycin wettable powder (purchased in market),
2% kasugarnycin aqua (purchased in market), 10% Wettable polyoxin powder (purchased in market), 8% Ningnanmycin aqua (purchased in market), 2%
Pesticide corrosion 120 aqua (purchased in market).
The tomato virus disease state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days is primary, altogether dispenser 2 times.
7 days after last dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
14 fenbendazole of table and active constituent B and its compounding prevention tomato virus disease test of pesticide effectiveness
As can be seen from Table 14, tomato virus disease, control effect can effectively be prevented after fenbendazole and active constituent B compoundings
Be superior to the preventive effect of single dose, and preventive effect phase is long, and graw mold of tomato can be prevented, after 14 days control effect be up to 97% with
On.It has no adverse effects to target crop in experiment scope of medication.
Ten fenbendazole of Application Example and active constituent B and its compounding prevention anthracnose of peach test of pesticide effectiveness
For this test arrangement in the Xianyang, Shanxi province city towns Bei Du, it is limited that test medicine by Shaanxi Kang He founds rich biotechnology medicine company
Company research and development, provide, 30% fenbendazole suspending agent (autogamy) of comparison medicament, 3% Zhongshengmycin wettable powder (purchased in market),
2% kasugarnycin aqua (purchased in market), 10% Wettable polyoxin powder (purchased in market), 8% Ningnanmycin aqua (purchased in market), 2%
Pesticide corrosion 120 aqua (purchased in market).
The anthracnose of peach state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days is primary, altogether dispenser 2 times.End
7 days after secondary dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
15 fenbendazole of table and active constituent B and its compounding prevention anthracnose of peach test of pesticide effectiveness
As can be seen from Table 15, anthracnose of peach can be effectively prevented after fenbendazole and active constituent B compoundings, control effect is equal
Better than the preventive effect of single dose, and preventive effect phase is long, and control effect is up to 97% or more after 14 days.Target is made in experiment scope of medication
Object has no adverse effects.
11 fenbendazole of Application Example and active constituent B and its compounding prevention cucumber downy mildew test of pesticide effectiveness
This test arrangement founds the rich limited public affairs of biotechnology medicine company in Xian District, Shanxi Province suburban area, test medicine by Shaanxi Kang He
Department's research and development provide, 30% fenbendazole suspending agent (autogamy) of comparison medicament, 3% Zhongshengmycin wettable powder (purchased in market), 2%
Kasugarnycin aqua (purchased in market), 10% Wettable polyoxin powder (purchased in market), 8% Ningnanmycin aqua (purchased in market), 2% agriculture are anti-
120 aquas (purchased in market).
The cucumber downy mildew state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days is primary, altogether dispenser 2 times.
7 days after last dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
16 fenbendazole of table and active constituent B and its compounding prevention cucumber downy mildew test of pesticide effectiveness
As can be seen from Table 16, cucumber downy mildew, control effect can effectively be prevented after fenbendazole and active constituent B compoundings
It is superior to the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
Ten diphenyl sulfide imidazoles of Application Example and active constituent B and its compounding control of plant bacterial wilt disease test of pesticide effectiveness
For this test arrangement in Xi'an City, Shanxi Province Changan District, it is limited that test medicine by Shaanxi Kang He founds rich biotechnology medicine company
Company research and development, provide, 30% fenbendazole suspending agent (autogamy) of comparison medicament, 3% Zhongshengmycin wettable powder (purchased in market),
2% kasugarnycin aqua (purchased in market), 10% Wettable polyoxin powder (purchased in market), 8% Ningnanmycin aqua (purchased in market), 2%
Pesticide corrosion 120 aqua (purchased in market).
The bacterial wilt of tomato state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days is primary, altogether dispenser 2 times.
7 days after last dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
17 fenbendazole of table and active constituent B and its compounding control of plant bacterial wilt test of pesticide effectiveness
As can be seen from Table 17, fenbendazole with after active constituent B compounding can effective control of plant bacterial wilt, control effect
It is superior to the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
13 fenbendazole of Application Example and active constituent B and its compounding prevention soft rot of cabbage test of pesticide effectiveness
For this test arrangement in Shaanxi Province Weinan city Linwei district, it is limited that test medicine by Shaanxi Kang He founds rich biotechnology medicine company
Company research and development, provide, 30% fenbendazole suspending agent (autogamy) of comparison medicament, 3% Zhongshengmycin wettable powder (purchased in market),
2% kasugarnycin aqua (purchased in market), 10% Wettable polyoxin powder (purchased in market), 8% Ningnanmycin aqua (purchased in market), 2%
Pesticide corrosion 120 aqua (purchased in market).
The soft rot of cabbage state of an illness is investigated before medicine, in state of an illness first time at initial stage dispenser, every dispenser in 7 days is primary, altogether dispenser 2 times.
7 days after last dispenser, disease index is investigated respectively and calculates preventive effect within 14 days, 30 days.Experimental result is as follows：
18 fenbendazole of table and active constituent B and its compounding prevention soft rot of cabbage test of pesticide effectiveness
As can be seen from Table 18, soft rot of cabbage, control effect can effectively be prevented after fenbendazole and active constituent B compoundings
It is superior to the preventive effect of single dose, and preventive effect phase is long, preventive effect is 97% or more.To target crop without bad in experiment scope of medication
It influences.
The experiment by different places throughout the country obtains afterwards, to a variety of works after fenbendazole and active constituent B compoundings
Rice blast on object, bacterial wilt, soft rot, bacterial angular leaf spot, anthrax leaf blight, shot hole, anthracnose of peach, pears blackspot
Disease, apple brown rot, capsicum black rot, damping-off, root rot, downy mildew, spot defoliation, epidemic disease, gray mold, powdery mildew,
The preventive effect of the multiple diseases such as virosis 97% or more, is better than single dose preventive effect, and synergistic effect is apparent.
Claims (6)
1. a kind of efficient bactericidal composite containing fenbendazole, it is characterised in that effective active composition be fenbendazole with activity at
Point B, fenbendazole is 1 ︰, 80~80 ︰ 1 with the weight range of active constituent B, active constituent B be polyoxin, kasugarnycin,
Ningnanmycin, Zhongshengmycin, antibiotic in pyrimidine nucleoside class.
2. the efficient bactericidal composite according to claim 1 containing fenbendazole, it is characterised in that：Fenbendazole with work
Property ingredient B weight ratio be 1 ︰, 60~60 ︰ 1.
3. the efficient bactericidal composite according to claim 2 containing fenbendazole, it is characterised in that：The weight of fenbendazole
It is ranging from 1 ︰, 20~20 ︰ 1 with the weight ratio of active constituent B.
4. the efficient bactericidal composite according to any one of claims 1 to 3 containing fenbendazole, it is characterised in that：
Wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqua, aqueous emulsion, microemulsion is made in composition.
5. the efficient bactericidal composite according to claim 4 containing fenbendazole is used to prevent the application of crop disease.
6. application according to claim 5, it is characterised in that：The disease is rice blast, bacterial wilt, soft corruption
Disease, bacterial angular leaf spot, anthrax leaf blight, shot hole, anthracnose of peach, Pear black spot, apple brown rot, capsicum black rot are stood
Blight, root rot, downy mildew, spot defoliation, epidemic disease, gray mold, powdery mildew, virosis.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105211063A (en) * | 2012-09-13 | 2016-01-06 | 陕西美邦农药有限公司 | A kind of bactericidal composition containing dimoxystrobin and antibiotics |
| CN107041373A (en) * | 2017-05-09 | 2017-08-15 | 李洪军 | A kind of crops long-acting fungicide |
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2018
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105211063A (en) * | 2012-09-13 | 2016-01-06 | 陕西美邦农药有限公司 | A kind of bactericidal composition containing dimoxystrobin and antibiotics |
| CN107041373A (en) * | 2017-05-09 | 2017-08-15 | 李洪军 | A kind of crops long-acting fungicide |
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