CN108244128A - A kind of bactericidal composition containing fenbendazole and copper agent - Google Patents

A kind of bactericidal composition containing fenbendazole and copper agent Download PDF

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Publication number
CN108244128A
CN108244128A CN201810203101.7A CN201810203101A CN108244128A CN 108244128 A CN108244128 A CN 108244128A CN 201810203101 A CN201810203101 A CN 201810203101A CN 108244128 A CN108244128 A CN 108244128A
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copper
fenbendazole
active
agent
disease
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夏宝成
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Shaanxi Kanghelifeng Biotechnology Pesticide Co Ltd
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Shaanxi Kanghelifeng Biotechnology Pesticide Co Ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A01N37/04—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof polybasic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/04—Sulfonic acids; Derivatives thereof
    • A01N41/08—Sulfonic acid halides; alpha-Hydroxy-sulfonic acids; Amino-sulfonic acids; Thiosulfonic acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A01N59/20—Copper
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention discloses a kind of bactericidal composition containing fenbendazole and copper agent, effective active composition is active components A and active constituent B, and wherein active components A is fenbendazole, and active constituent B is selected from any one following copper agent：The gloomy copper of benziothiazolinone, thiophene, Thiodiazole-copper, nonylphenolsulfonate copper, copper 8-hydroxyquinolinate, tiger glue adipic acid copper, and active components A and the weight ratio of active constituent B are 1 ︰, 80~80 ︰ 1.The present composition has synergistic effect to the multiple diseases for endangering agricultural production, reduces pesticide usage amount, reduces residual quantity of the pesticide on crop, alleviate environmental pollution, to safety of human and livestock, Environmental compatibility is good, and disease is not likely to produce drug resistance.

Description

A kind of bactericidal composition containing fenbendazole and copper agent
Technical field
The invention belongs to technical field of pesticide, are related to a kind of bactericidal composition containing fenbendazole and copper agent in crops Application in disease.
Background technology
Fenbendazole (Fenbendazole), molecular formula：C15H13N3O2S, chemical name：(5- (thiophenyl) -1H- benzos Imidazoles -2- ylcarbamic acid methyl esters, fenbendazole is wide spectrum, novel benzimidazoles anthelmintic efficiently, less toxic.It is not only right Animal gastrointestinal tract nematode, adult, larva have height anthelmintic activity, and to net tail nematode, lance type two-chamber worm, fasciola and wash Worm also has preferable effect.Absorbed since Phenbendasol's solubility is low, thus when being taken to animal it is few, after absorption in animal body Majority forms metabolite, and such as in ruminant body, hydroxylating mainly occurs on phenyl ring, and de- carbethoxyl group also occurs in some Change acts on, and a large amount of metabolite is also formed in pig body or even some researchs also demonstrate, these metabolism in sheep body are produced Object, by after choleresis and the liver that can be expert at, intestines recycle.
The gloomy copper of benziothiazolinone, thiophene, Thiodiazole-copper, nonylphenolsulfonate copper, copper 8-hydroxyquinolinate, tiger glue adipic acid copper belong to copper agent, are widely used in In the disease of crops, in addition other copper agents such as Cupravit, copper acetate, copper rosinate, Kocide SD can also be with benzene sulphur miaow Azoles is compounded.
However, in the real process of agricultural production, controlling disease is easiest to generate the problem that the production of disease drug resistance It is raw.Different cultivars ingredient is compounded, and is to prevent the very common method of resistance disease.Heterogeneity is compounded, according to reality Application effect, to judge that certain compounding is synergy, adduction or antagonism.In most cases, the compounding effect of pesticide All it is additive effect, the compounding for really having synergistic effect is seldom, and especially synergistic effect is clearly, co-toxicity coefficient is very high answers With just less.Studied by inventor, find by fenbendazole and benziothiazolinone, the gloomy copper of thiophene, Thiodiazole-copper, nonylphenolsulfonate copper, copper 8-hydroxyquinolinate, Can generate good synergistic effect after tiger glue adipic acid copper compounding, and about fenbendazole and benziothiazolinone, the gloomy copper of thiophene, Thiodiazole-copper, The relevant report that nonylphenolsulfonate copper, copper 8-hydroxyquinolinate, tiger glue adipic acid copper compound not yet discloses.
Invention content
The purpose of the present invention is to propose to it is a kind of with synergistic function, use cost is low, preventive effect is good contains fenbendazole With the bactericidal composition of copper agent.
Bactericidal composition proposed by the present invention containing fenbendazole and copper agent contains active components A and active constituent B, living Property ingredient A and active constituent B weight ratios be 1 ︰, 80~80 ︰ 1, the active components A is fenbendazole, and active constituent B is selected from One of copper 8-hydroxyquinolinate, Cupravit, tiger glue adipic acid copper, copper acetate kind, active components A are 1 ︰ 60 with the preferred weight ratios of active constituent B ~60 ︰ 1；The weight ratio of more preferably fenbendazole and active constituent B is 1 ︰, 20~20 ︰ 1.
Bactericidal composition of the present invention containing fenbendazole and copper agent is used to prevent the purposes of disease on crops, The crops include cereal crops, legume crop, fibre crops, sugar crop, melon crop, fruits crop, dry fruit Class crop, hobby crop, root crop, oil crops, flower crop, medicinal crop, crop, green manure pasture crop； The disease is bacterial wilt, bacterial angular leaf spot, soft rot, canker, anthracnose, downy mildew, epidemic disease, rice blast, rice song It is disease, banded sclerotial blight, bakanae disease, powdery mildew, rust, leaf blight, gray mold, leaf spot, spot defoliation, anthrachose of grape, smut, withered Wither disease, black spot, scab, ring spot, brown spot, root rot, sclerotiniose, droop or shot hole.
Active components A, the weight ratio of active constituent B are 1 ︰, 80~80 ︰ 1.The weight hundred of active component in usual composition Point content is the 0.1%~90% of total weight, preferably 5%~70%.According to different preparation types, active component content Range is different.In general, liquid preparation contains by weight 1%~70% active material, preferably 5%~50%； Solid pharmaceutical preparation contains by weight 5%~80% active material, preferably 10%~80%.
At least containing a kind of surfactant in the bactericidal composition of the present invention, so that active component is in water during application Dispersion.Surface-active contents are the 5%~30% of total formulation weight, and surplus is solid or liquid diluent.
The bactericidal composition of the present invention can be used through dilution or directly before use by user.Its preparation can be by usual Processing method known in those skilled in the art prepare, i.e., after active material is mixed with liquid flux or solid carrier, Add one kind in surfactant such as dispersant, stabilizer, wetting agent, binding agent, antifoaming agent, disintegrant, antifreeze It is or several.
The bactericidal composition of the present invention, can be processed into acceptable dosage form in any sterilization, wherein it is preferred that agent on demand Type is wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent or microcapsule suspension-outstanding Floating agent.
Comprising following constituent content when wettable powder is made in composition：Active components A 0.1%~80%, active constituent B0.1%~80%, dispersant 2%~10%, wetting agent 2%~10%, filler surplus.
Composition includes following constituent content when water dispersible granules are made：Active components A 0.1%~80%, active constituent B0.1%~80%, dispersant 3%~12%, wetting agent 1%~8%, disintegrant 1%~10%, binding agent 0~8%, filler Surplus.
Composition includes following constituent content when suspending agent is made：Active components A 0.1%~50%, active constituent B0.1%~50%, antifreeze 0~8%, antifoaming agent 0.01%~2%, wetting agent 1.0%~3.0%, dispersant 1.0%~ 8.0%th, deionized water adds to 100%.
Composition includes following constituent content when suspension emulsion is made：Active components A 0.1%~50%, active constituent B0.1%~50%, dispersant 2%~10%, antifoaming agent 0.01%~2%, solvent 1%~15%, thickener 0~2%, breast Agent 2%~12%, antifreeze 0~8%, deionized water add to 100%.
Comprising following constituent content when aqueous emulsion is made in composition：Active components A 0.1%~50%, active constituent B0.1%~50%, solvent 1%~30%, emulsifier 1%~15%, antifreeze 0~8%, thickener 0~2%, antifoaming agent 0.01%~2%, deionized water supplies surplus.
Comprising following constituent content when microemulsion is made in composition：Active components A 0.1%~50%, active constituent B0.1%~50%, emulsifier 3%~25%, antifreeze 0~8%, antifoaming agent 0.01%~2%, is gone solvent 1%~30% Ionized water supplies surplus.
Composition includes following constituent content when microcapsule suspending agent is made：Active components A 0.1%~50%, active constituent B0.1%~50%, macromolecule cyst material 2%~10%, dispersant 1%~10%, solvent 1%~10%, emulsifier 1% ~7%, antifoaming agent 0.01%~2%, pH adjusting agent 0.01%~5%, deionized water add to 100%.
Composition includes following constituent content when processing microcapsule suspension-suspendinagent agent is made：Active components A 0.1%~50%, Active constituent B0.1%~50%, macromolecule cyst material 2%~10%, dispersant 1%~12%, wetting agent 1%~8%, Organic solvent 1%~15%, emulsifier 1%~6%, antifoaming agent 0.01%~2%, thickener 0~2%, pH adjusting agent 0.01%~5%, deionized water adds to 100%.
The wettable powder the key technical indexes of the present invention：
The water dispersible granules the key technical indexes of the present invention：
The suspending agent the key technical indexes of the present invention：
The suspension emulsion the key technical indexes of the present invention：
The aqueous emulsion the key technical indexes of the present invention：
The microemulsion the key technical indexes of the present invention：
The microcapsule suspending agent the key technical indexes of the present invention：
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention：
The advantage of the invention is that：
(1) fenbendazole is with after active constituent B compoundings, having apparent synergy and lasting effect；(2) to cereal crops, Legume crop, fibre crops, sugar crop, melon crop, fruits crop, dry fruit crop, hobby crop, tubers are made Object, oil crops, flower crop, medicinal crop, crop, the disease on green manure pasture crop have greater activity；(3) subtract Pesticide usage amount is lacked, has reduced residual quantity of the pesticide on crop, alleviate environmental pollution；(4) to safety of human and livestock, environment phase Capacitive is good；And preparation adhesion strength enhances, resistance of rainwater washing against.
Specific embodiment
With reference to embodiment to further instruction of the present invention, the percentage in embodiment is weight percentage, but The present invention is not limited thereto.
Application Example one
1~18 wettable powder of embodiment
Fenbendazole, active constituent B, dispersant, wetting agent, filler are mixed, are uniformly mixed in mixed cylinder, through air-flow Pulverizer remixes uniformly after crushing, you can wettable powder product of the present invention is made.Specifically it is shown in Table 1.
1 embodiment of table, 1~18 each component and content
19~36 water dispersible granules of embodiment
By fenbendazole, active constituent B, dispersant, wetting agent, binding agent (can add can be not added with), disintegrant, filler together The grain size needed through air-flow crushing obtains granulation materials.Item is quantified and is sent into fluidized bed granulating dryer by system After grain and drying, water dispersible granules product of the present invention is made.Specifically it is shown in Table 2.
2 embodiment of table, 19~36 each component and content
37~54 suspending agent of embodiment
By dispersant, wetting agent, antifoaming agent, thickener (can add can be not added with), antifreeze (can add can be not added with), by a high speed Shear-mixed is uniform, adds in fenbendazole, active constituent B, ball milling 2~3 hours, make diameter of particle all in 5 μ in the ball mill M is hereinafter, surplus is supplied with deionized water, you can suspending agent product of the present invention is made, is specifically shown in Table 3.
3 embodiment of table, 37~54 each component and content
55~58 suspension emulsion of embodiment
By dispersant, antifoaming agent, thickener (can add can be not added with), antifreeze (can add can be not added with), warp in above-mentioned formulation material It is uniform to cross high speed shear-mixed, adds in fenbendazole, ball milling 2~3 hours in the ball mill, make diameter of particle all 5 μm with Under, fenbendazole suspending agent is made, it is then that active constituent B, solvent, emulsifier and various auxiliary agents is directly newborn with high speed agitator Change into suspending agent, suspension emulsion product of the present invention is made.Specifically it is shown in Table 4.
4 embodiment of table, 55~58 each component and content
59~70 aqueous emulsion of embodiment
Fenbendazole, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase；Active constituent B, by deionized water, Antifreeze (can add can be not added with), thickener (can add can be not added with), antifoaming agent mix, into uniform water phase.In high-speed stirred Under, water phase is added in into oil phase, aqueous emulsion product of the present invention is made.Specifically it is shown in Table 5.
5 embodiment of table, 59~70 each component and content
By the gloomy copper of person's nonylphenolsulfonate copper, tiger glue adipic acid copper, copper 8-hydroxyquinolinate, benziothiazolinone, Thiodiazole-copper, thiophene or tiger glue adipic acid copper in table 1~5 It exchanges, novel formulation can be made.
82~84 microemulsion of embodiment
Fenbendazole, active constituent B are dissolved in the homogenizer equipped with solvent, by emulsifier, antifreeze, (can add can not Add), antifoaming agent be added in the homogenizer equipped with above-mentioned solution, give after supplying surplus with deionized water strongly mixing and it is even Change, finally obtain the transparent microemulsion product of the present invention of clear appearance.Specifically it is shown in Table 6.
6 embodiment of table, 71~73 each component and content
The embodiment of the present invention is the method being combined using Toxicity Determination and field trial.First pass through indoor virulence survey Calmly, the synergy ratio after clear and definite two kinds of medicaments compound by a certain percentage
(SR), SR ＜ 0.5 are antagonism, and 0.5≤SR≤1.5 are summation action, and SR ＞ 1.5 are synergistic effect, herein On the basis of, then carry out field trial.
Test method：After prerun determines the effective inhibition concentration range of each medicament, medicament sets 5 respectively by active constituent content A dosage processing, if clear water compares.Reference《Farm-chemical indoor determination test rule fungicide》It carries out, speed is grown using mycelia Rate method measures virulence of the medicament to crop germ.Colony diameter is measured with crossing method after 72h, calculates the net growth of each processing Amount, mycelial growth inhibition rate.Net growth (mm)=measurement colony diameter -5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) is converted into logarithm (x), with minimum Square law acquires virulence regression equation (y=a+bx), and thus calculates the EC50 values of each medicament.Simultaneously according to Wadley methods Two medicament different ratio synergy ratios (SR) are calculated, SR ＜ 0.5 are antagonism, and 0.5≤SR≤1.5 are summation action, SR ＞ 1.5 are synergistic effect.Calculation formula is as follows：
Wherein：A, b is respectively fenbendazole, the ratio shared by active constituent B；
Application Example two：
For trying disease：Bacterial wilt of tomato；Test medicine is provided by Shaanxi Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd.
Experimental design：The effective of fenbendazole and nonylphenolsulfonate copper active compound and the two different ratio mixture is determined by pilot study Inhibition concentration range.
Toxicity test result
7 fenbendazole of table compounds the toxicity test analysis of results table to bacterial wilt of tomato with nonylphenolsulfonate copper
As shown in Table 7, fenbendazole is matched with nonylphenolsulfonate copper 80:1~1:To the synergy ratio SR of bacterial wilt of tomato when 80 1.5 are all higher than, illustrates the two 80:1~1:Mixture shows synergistic effect in the range of 80, when fenbendazole and nonylphenolsulfonate copper Proportioning is 20:1~1:When 20, synergistic effect is more prominent, and synergy ratio founds rich biological section more than 2.25, through Shaanxi Kang He The experiment of skill pharmaceutcal corporation, Ltd finds that when fenbendazole and nonylphenolsulfonate copper weight ratio be 1:Synergy ratio is maximum when 3, and synergistic effect is most It is apparent.
Application Example three：
For trying disease：Cucumber downy mildew；Test medicine is provided by Shaanxi Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd.
Experimental design：The effective of fenbendazole and copper 8-hydroxyquinolinate active compound and the two different ratio mixture is determined by pilot study Inhibition concentration range.
Toxicity test result
8 fenbendazole of table is with oxine-copper composite to the toxicity test analysis of results table of cucumber downy mildew
As shown in Table 8, fenbendazole is matched with copper 8-hydroxyquinolinate 80:1~1:To the synergy ratio SR of cucumber downy mildew when 80 1.5 are all higher than, illustrates the two 80:1~1:Mixture shows synergistic effect in the range of 80, when fenbendazole and copper 8-hydroxyquinolinate Proportioning is 20:1~1:When 20, synergistic effect is more prominent, and synergy ratio founds rich biological section more than 2.25, through Shaanxi Kang He The experiment of skill pharmaceutcal corporation, Ltd finds that when fenbendazole and copper 8-hydroxyquinolinate weight ratio be 1:Synergy ratio is maximum when 2, and synergistic effect is most It is apparent.
Application Example four：
For trying disease：Soft rot of cabbage；Test medicine is provided by Shaanxi Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd.
Experimental design：The effective of fenbendazole and benziothiazolinone active compound and the two different ratio mixture is determined by pilot study Inhibition concentration range.
Toxicity test result
9 fenbendazole of table compounds the toxicity test analysis of results table to soft rot of cabbage with benziothiazolinone
As shown in Table 9, fenbendazole is matched with benziothiazolinone 80:1~1:To the synergy ratio SR of soft rot of cabbage when 80 1.5 are all higher than, illustrates the two 80:1~1:Mixture shows synergistic effect in the range of 80, when fenbendazole and benziothiazolinone Proportioning is 20:1~1:When 20, synergistic effect is more prominent, and synergy ratio founds rich biological section more than 2.20, through Shaanxi Kang He The experiment of skill pharmaceutcal corporation, Ltd finds that when fenbendazole and benziothiazolinone weight ratio be 2:Synergy ratio is maximum when 1, and synergistic effect is most It is apparent.
Application Example five：
For trying disease：Citrus scab；Test medicine is provided by Shaanxi Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd.
Experimental design：The effective of fenbendazole and Thiodiazole-copper active compound and the two different ratio mixture is determined by pilot study Inhibition concentration range.
Toxicity test result
10 fenbendazole of table compounds the toxicity test analysis of results table to citrus scab with Thiodiazole-copper
As shown in Table 10, fenbendazole is matched with Thiodiazole-copper 80:1~1:To the synergy ratio SR of citrus scab when 80 1.5 are all higher than, illustrates the two 80:1~1:Mixture shows synergistic effect in the range of 80, when fenbendazole and Thiodiazole-copper Proportioning is 20:1~1:When 20, synergistic effect is more prominent, and synergy ratio founds rich biological section more than 2.25, through Shaanxi Kang He The experiment of skill pharmaceutcal corporation, Ltd finds that when fenbendazole and Thiodiazole-copper weight ratio be 1:Synergy ratio is maximum when 2, and synergistic effect is most It is apparent.
Application Example six：
For trying disease：Bacterial wilt of tomato；Test medicine is provided by Shaanxi Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd.
Experimental design：The effective of fenbendazole copper active compound gloomy with thiophene and the two different ratio mixture is determined by pilot study Inhibition concentration range.
Toxicity test result
11 fenbendazole of table copper compounding gloomy with thiophene is to the toxicity test analysis of results table of bacterial wilt of tomato
As shown in Table 11, fenbendazole copper proportioning gloomy with thiophene is 80:1~1:To the synergy ratio SR of bacterial wilt of tomato when 80 1.5 are all higher than, illustrates the two 80:1~1:Mixture shows synergistic effect in the range of 80, when fenbendazole and the gloomy copper of thiophene Proportioning is 20:1~1:When 20, synergistic effect is more prominent, and synergy ratio founds rich biological section more than 2.20, through Shaanxi Kang He The experiment of skill pharmaceutcal corporation, Ltd finds that when fenbendazole and the gloomy weight of copper ratio of thiophene be 1:Synergy ratio is maximum when 2, and synergistic effect is most It is apparent.
Application Example seven：
For trying disease：Cucumber bacterial angular leaf spot；Test medicine founds the rich limited public affairs of biotechnology medicine company by Shaanxi Kang He Department provides.
Experimental design：Fenbendazole and tiger glue adipic acid copper active compound and the two different ratio mixture are determined by pilot study Effective inhibition concentration range.
Toxicity test result
12 fenbendazole of table compounds the toxicity test analysis of results table to cucumber bacterial angular leaf spot with tiger glue adipic acid copper
As shown in Table 12, fenbendazole is matched with tiger glue adipic acid copper 80:1~1:To cucumber bacterial angular leaf spot when 80 Synergy ratio SR is all higher than 1.5, illustrates the two 80:1~1:Mixture shows synergistic effect in the range of 80, works as fenbendazole Proportioning with tiger glue adipic acid copper is 20:1~1:When 20, synergistic effect is more prominent, and synergy ratio is more than 2.20, through Shaanxi The experiment of Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd finds that when fenbendazole and tiger glue adipic acid copper weight ratio be 1:Synergic ratio when 5 Value is maximum, and synergistic effect is the most apparent.
While it is found through experiment that：Fenbendazole, active constituent B compounding after in various crop bacterial wilt, bacillary angle Pinta, soft rot, canker, anthracnose, downy mildew, epidemic disease, rice blast, false smut, banded sclerotial blight, bakanae disease, powdery mildew, rust Disease, leaf blight, gray mold, leaf spot, spot defoliation, anthrachose of grape, smut, droop, black spot, scab, ring spot, The prevention of brown spot, root rot, sclerotiniose, droop or shot hole has apparent synergistic effect, and synergy ratio SR is all higher than 1.5。
Effect experiment part：Test medicine is researched and developed by Shaanxi Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd, provided, control 30% fenbendazole suspending agent (purchased in market) of medicament, 30% nonylphenolsulfonate copper microemulsion (purchased in market), 33.5% copper 8-hydroxyquinolinate suspending agent (purchased in market), 5% benziothiazolinone suspending agent (purchased in market), 30% Thiodiazole-copper suspending agents (purchased in market), the gloomy copper suspending agent of 20% thiophene, 30% tiger glue adipic acid copper Suspending agent.
Eight fenbendazole of Application Example, active constituent B and its compounding prevention cucumber disease test of pesticide effectiveness.
This test arrangement investigates cucumber state of an illness radix, total number of sheets, the sick number of sheets and disease before Xi'an City, Shanxi Province Changan District, medicine Leaf series, in early stage dispenser, every dispenser in 7 days is primary, and dispenser 3 times, 10 days after last dispenser, investigates the state of an illness in 30 days respectively altogether Index simultaneously calculates preventive effect.Experimental result is as follows：
13 fenbendazole of table, active constituent B and its compounding prevention cucumber disease test of pesticide effectiveness
As can be seen from Table 13, cucumber disease can be effectively prevented after fenbendazole, active constituent B and its compounding, through Shaanxi The experiment of Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd can also effectively be prevented after finding fenbendazole, active constituent B and its compounding Cucumber anthracnose, downy mildew, epidemic disease, powdery mildew, scab are controlled, control effect is above 97%, better than the preventive effect of single dose, and it is anti- The effect phase is long.It has no adverse effects in experiment scope of medication to target crop.
Nine fenbendazole of Application Example, active constituent B and its compounding prevention tomato test of pesticide effectiveness.
This test arrangement investigates tomato state of an illness radix, total number of sheets, the sick number of sheets and disease before Shaanxi Province Weinan City Dali County, medicine Leaf series, in early stage dispenser, every dispenser in 7 days is primary, and dispenser 3 times, 10 days after last dispenser, investigates the state of an illness in 30 days respectively altogether Index simultaneously calculates preventive effect.Experimental result is as follows：
14 fenbendazole of table, active constituent B and its compounding prevention tomato disease test of pesticide effectiveness
As can be seen from Table 14, tomato disease can be effectively prevented after fenbendazole, active constituent B and its compounding, through Shaanxi The experiment of Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd can also effectively be prevented after finding fenbendazole, active constituent B and its compounding Tomato blight, anthracnose are controlled, control effect is above 97%, and better than the preventive effect of single dose, and preventive effect phase is long.In experiment scope of medication It is interior to have no adverse effects to target crop.
Ten fenbendazole of Application Example, active constituent B and its compounding prevention citrus disease test of pesticide effectiveness.
This test arrangement investigates citrus state of an illness radix, total number of sheets, the sick number of sheets and sick leaf grade before Shaanxi Province Chenggu County, medicine Number, in early stage dispenser, every dispenser in 7 days is primary, and dispenser 3 times, 10 days after last dispenser, investigates disease index in 30 days respectively altogether And calculate preventive effect.Experimental result is as follows：
15 fenbendazole of table, active constituent B and its compounding prevention citrus disease test of pesticide effectiveness
As can be seen from Table 15, citrus disease can be effectively prevented after fenbendazole, active constituent B and its compounding, through Shaanxi The experiment of Kang He Li Feng biotechnologies pharmaceutcal corporation, Ltd can also effectively be prevented after finding fenbendazole, active constituent B and its compounding Citrus anthracnose is controlled, control effect is above 97%, and better than the preventive effect of single dose, and preventive effect phase is long.It is right in experiment scope of medication Target crop has no adverse effects.
11 fenbendazole of Application Example, active constituent B and its compounding prevention rice disease test of pesticide effectiveness.
This test arrangement investigates rice state of an illness radix, total number of sheets, the sick number of sheets and sick leaf grade before Shaanxi Province's Hanzhong City, medicine Number, in early stage dispenser, every dispenser in 7 days is primary, and dispenser 3 times, 10 days after last dispenser, investigates disease index in 30 days respectively altogether And calculate preventive effect.Experimental result is as follows：
16 fenbendazole of table, active constituent B and its compounding prevention rape disease test of pesticide effectiveness
As can be seen from Table 16, rice disease, prevention effect can be effectively prevented after fenbendazole, active constituent B and its compounding Fruit is above 97%, and better than the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects in experiment scope of medication to target crop.
Ten diphenyl sulfide imidazoles of Application Example, active constituent B and its compounding prevention Chinese cabbage disease test of pesticide effectiveness.
This test arrangement investigates ornamental flower state of an illness radix, total number of sheets, the sick number of sheets before Xi'an City, Shanxi Province Changan District, medicine And sick leaf series, in early stage dispenser, every dispenser in 7 days is primary, and dispenser 3 times, 10 days after last dispenser, is investigated for 30 days respectively altogether Disease index simultaneously calculates preventive effect.Experimental result is as follows：
17 fenbendazole of table, active constituent B and its compounding prevention Chinese cabbage disease test of pesticide effectiveness
As can be seen from Table 17, Chinese cabbage disease, prevention effect can be effectively prevented after fenbendazole, active constituent B and its compounding Fruit is above 97%, and better than the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects in experiment scope of medication to target crop.
The experiment by different places throughout the country obtains afterwards, to a variety of after fenbendazole, active constituent B and its compounding Bacterial wilt, bacterial angular leaf spot on crop, soft rot, canker, anthracnose, downy mildew, epidemic disease, rice blast, false smut, line Blight, bakanae disease, powdery mildew, rust, leaf blight, gray mold, leaf spot, spot defoliation, anthrachose of grape, smut, droop, The preventive effect of the Common Diseases such as black spot, scab, ring spot, brown spot, root rot, sclerotiniose, droop or shot hole exists More than 97%, better than single dose preventive effect, synergistic effect is apparent.

Claims (6)

1. a kind of bactericidal composition containing fenbendazole and copper agent, effective active composition is active components A and active constituent B, It is characterized in that：Active components A is 1 ︰, 80~80 ︰ 1 with active constituent B weight ratios, and the active components A is fenbendazole, Active constituent B is selected from one of benziothiazolinone, the gloomy copper of thiophene, Thiodiazole-copper, nonylphenolsulfonate copper, copper 8-hydroxyquinolinate, tiger glue adipic acid copper kind.
2. the bactericidal composition according to claim 1 containing fenbendazole and copper agent, it is characterised in that：Active components A Weight ratio with active constituent B is 1 ︰, 60~60 ︰ 1.
3. the bactericidal composition according to claim 2 containing fenbendazole and copper agent, it is characterised in that：Fenbendazole with The weight ratio of active constituent B is 1 ︰, 20~20 ︰ 1.
4. the bactericidal composition according to any one of claim 1 to 3 containing fenbendazole and copper agent, feature exist In：Wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent or micro- is made in composition Capsule suspension-suspending agent.
5. the bactericidal composition according to claim 4 containing fenbendazole and copper agent is used to prevent disease on crops Purposes.
6. purposes according to claim 5, it is characterised in that：The disease is bacterial wilt, bacterial angular leaf spot, soft corruption Disease, canker, anthracnose, downy mildew, epidemic disease, rice blast, false smut, banded sclerotial blight, bakanae disease, powdery mildew, rust, leaf blight, Gray mold, leaf spot, spot defoliation, anthrachose of grape, smut, droop, black spot, scab, ring spot, brown spot, root Maize ear rot, sclerotiniose, droop or shot hole.
CN201810203101.7A 2018-03-13 2018-03-13 A kind of bactericidal composition containing fenbendazole and copper agent Pending CN108244128A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108849948A (en) * 2018-08-01 2018-11-23 浙江东风化工有限公司 A kind of bactericidal composition containing captan Yu the gloomy copper of thiophene
CN110881476A (en) * 2018-09-07 2020-03-17 刘力 High-efficiency broad-spectrum low-toxicity environment-friendly agricultural new compound and composition thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103704234A (en) * 2014-01-07 2014-04-09 中国农业科学院植物保护研究所 Composite for preventing and controlling agricultural bacterial disease
CN107094775A (en) * 2017-04-25 2017-08-29 中国农业科学院植物保护研究所 A kind of composition for preventing and treating agricultural disease and the spiral shell that goes out

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103704234A (en) * 2014-01-07 2014-04-09 中国农业科学院植物保护研究所 Composite for preventing and controlling agricultural bacterial disease
CN107094775A (en) * 2017-04-25 2017-08-29 中国农业科学院植物保护研究所 A kind of composition for preventing and treating agricultural disease and the spiral shell that goes out

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108849948A (en) * 2018-08-01 2018-11-23 浙江东风化工有限公司 A kind of bactericidal composition containing captan Yu the gloomy copper of thiophene
CN110881476A (en) * 2018-09-07 2020-03-17 刘力 High-efficiency broad-spectrum low-toxicity environment-friendly agricultural new compound and composition thereof

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Application publication date: 20180706