CN108452079A

CN108452079A - Slow down aging the method and composition for inhibiting growth of tumour cell and improvement microcirculation

Info

Publication number: CN108452079A
Application number: CN201810703893.4A
Authority: CN
Inventors: 傅金荣
Original assignee: Tianyuan Jiangxi Pharmaceutical Co Ltd
Current assignee: Tianyuan Jiangxi Pharmaceutical Co Ltd
Priority date: 2018-07-01
Filing date: 2018-07-01
Publication date: 2018-08-28
Anticipated expiration: 2038-07-01
Also published as: CN108452079B

Abstract

The present invention relates to the method and compositions for inhibiting growth of tumour cell and improvement microcirculation that slows down aging.The present composition selected from following substance by being made：8 parts by weight of ginseng, 4~8 parts by weight of Cordyceps militaris, 4~8 parts by weight of prepared rehmannia root, 4~8 parts by weight of Herba Epimedii, 1~3 parts by weight of Herba Cistanches, 1~3 parts by weight of cervus elaphus linnaeus and the acceptable carrier of optional physiology.The composition is typically in the form of oral solution.The invention further relates to the preparation method of above-mentioned composition and they prepare for slows down aging inhibit growth of tumour cell improvement cardiovascular and cerebrovascular microcirculation product in purposes.The present composition is excellent for slowing down aging, inhibiting growth of tumour cell, improvement cardiovascular and cerebrovascular microcirculation aspect to have the effect of, and the good excellent effect of active material high income, active material stability is presented in the present composition.

Description

Slow down aging the method and composition for inhibiting growth of tumour cell and improvement microcirculation

Technical field

The invention belongs to medicines and health protection product technical fields, are related to one kind and inhibit growth of tumour cell to change for slowing down aging The composition of mercy cerebrovascular microcirculation further relates to the preparation method of this composition and the purposes of their medical treatment, medicine, More particularly to one kind composition made of ginseng, Cordyceps militaris, prepared rehmannia root, Herba Epimedii, Herba Cistanches, cervus elaphus linnaeus.

Background technology

Aging, which refers to body, reduces the physiology and psychological fitness progressive of environment, gradual phenomenon deathward. Aging can be divided into two classes：Physiological aging and pathological seaility.The former refers to the physiological degenerative process occurred after the maturity period, the latter It is the senile variation caused by various foeign elements (including various diseases).Practical the two is difficult to distinguish.In short, aging It is the inevitable outcome of many pathology, physiology and noematic comprehensive function, is the biology of individual growth development final stage Psychology process.

Said from biologically, aging be biology over time, spontaneous necessary process, it is complicated naturally existing As showing as the retrogression of structure and the decline of function, adaptability and resistance decline.In a physiologically, aging is regarded as It is that old ontogeny is performed until since fertilized eggs.From pathology, aging is stress and to strain, damage and sense The result of dye, immune response decline, trophic disturbance, dysbolism and carelessness and drug abuse accumulation.In addition from sociology It sees, aging is that individual loses interest to fangle, detaches oneself from reality, likes missing old times or old friends.

Occur with life, a kind of activity in evolution, is body from constituting substance, institutional framework to physiological function Forfeiture and degenerative process.Aging course persistently occurs between fertilized eggs to death, has only arrived certain stage and has declined Old feature just displays obviously.Physiological change in human aging process be mainly reflected in body tissue cell and The forfeiture of substance is constituted, organism metabolism rate slows down, body and decreased organ function.Aging is inevitable, but delays to decline It is possible always.Reasonable diet, balanced nutrients are anti-aging, extend one of the important measures in service life.The feature master of aging Have：(1) dependence of having time；(2) the phenomenon that being all cells in organism, tissue, organ and whole generally existing； (3) it is by the endogeny variation caused by natural tendency.

The major physiological of aging is presented with：(1) metamorphosis.Including：1. cellular change.Be mainly shown as cell number by Step is reduced.2. the variation of tissue and organ.Since the cell quantity of internal organs and tissue is reduced, to which atrophy, weight occur Mitigate.3. overall variation.With advancing age, the bodily form and shape change, as hair bleaches；Skin elasticity reduces, and goes out , there is senile plaque in existing wrinkle；Tooth mobility falls off, and deafness, dim eyesight, hunchback, height are gradually shortened.(2) physiological function declines. Including：1. the decline of systema cariovasculare functional.Such as the gradual atrophy of cardiac muscle fibre, age pigment (lipofuscin) is heavy in cardiac muscle cell Product, heart valve becomes plump hardening, elasticity reduces etc..2. respiratory apparatus aging.Lung volume reduction is shown as, respiratory function is apparent Decline, compensatory capacity reduce.3. the variation of digestive system.Mainly oral cavity, gastrointestinal function weaken, and atrophy occurs for gum, tooth Property variation.4. muscle skeleton kinematic system changes.It is mainly manifested in and increases with the age, muscle fibre attenuates, elasticity reduces, convergent force Weaken；Organic component is reduced in bone, and inorganic salts increase, thus the toughness of the elasticity of bone is caused to reduce, easily fracture etc..5. nerve System change.It is mainly shown as the forfeiture to a certain degree of brain cell；Nerve conduction velocity reduces；The slow movement of the elderly, Reflect that flexibility weakens.(3) primary sensing organ's hypofunction.As vision, the sense of hearing, smell, the sense of taste, dermal sensation (including Tactile, the sense of heat, the pain sensation) decline.In addition, the elderly's psychokinesis reflection is also corresponding slow.

Aging itself has 6 big characteristics.1. generality：I.e. aging can all occur for all living things body.2. internality：Aging course It is necessary process spontaneous in organism, is that live in optimum environment also can gradual aging.3. progressive：Aging is The process continued to develop over time.4. harmfulness：Aging makes the physiological function of organism reduce, and increases sick With dead chance.5. individual difference：In same class biology, the process of aging is different between Different Individual, is especially existed The later stage of life, this otherness become apparent.Only the slower individual of those agings is possible to obtain long-lived.6. may interfere with Property：Although aging is the spontaneous process of inherence, but external condition can accelerate or delay the progress of this process.Such as environment temperature The service life of animal can be changed.Just because of this, people are possible to seek longevity by bettering people's living environment.Angle of physiology It sees, aging is as caused by metabolism decline.Metabolism is one of essential characteristic of vital movement, it includes synthesis generation It thanks and two aspect of catabolism.If the anabolism of body be higher than catabolism, people will growth and development, here it is boyhoods And the adolescence；If the speed of the two metabolic processes is in a basic balance, people has arrived midlife and mature stage, this period human body Variation it is smaller；If catabolism is higher than anabolism, people begins to aging, if metabolism once stops, the life of people Life activity also just finishes.People in life, above-mentioned variation is generally existing, therefore aging is inevitable.But People in life, due to inherent or external, so that aging course is occurred ahead of time, here it is early ageing.Early ageing is that pathology is old Change, it will influence the service life of people.Although people is easy to happen pathologic aging to the senescence phase, but not everyone must will send out It is raw.Therefore physiological aging to be inevitable the natural law, and what pathologic aging then can be prevented from and postpone.In order to same Aging is waged a struggle, and people once conducted extensive research the mechanism of aging.But up to now in relation to causing the machine of aging System not yet satisfies oneself.

Tumour cell essence is exactly tumour.Tumor tissues are made of essence and interstitial two parts, and tumor epithelial cell is that tumour is thin Born of the same parents are the main components of tumour, have tissue-derived specificity.It determines Biological characteristics and the spy of each tumour of tumour Different property.The tissue-derived of various tumours is identified generally according to the substantive form of tumour, carries out the classification, name and tissue of tumour Diagnosis is learned, and determines good pernicious and tumour the grade malignancy of tumour according to its differentiation and maturation degree and atypia size.It is swollen There are three oncocytes, and significant essential characteristic is：Immortality, migration and loses contact inhibition.In addition to this, tumour cell is also There are many physiology, biochemistry and the morphological features that are different from normal cell.

Tumour (tumor, neoplasm) is a kind of genopathy, but is not hereditary.It refers to cell in tumorigenesis factor Under effect, gene is changed, and is lost the normal regulation to growth, is led to paraplasm.It can be divided into benign and malignant swollen Tumor two major classes.The former is slow-growing, with surrounding tissue boundary clear, does not shift, little to human health damage.The latter gives birth to It is long rapid, other body parts are can be transferred to, harmful substance is also will produce, normal organ structure is destroyed, body function is made to lack of proper care, Life-threatening.Tumor tissues are made of essence and interstitial two parts, and tumor epithelial cell is tumour cell, are the main components of tumour, With tissue-derived specificity.The interstitial of tumour plays support and nutrition tumor epithelial cell, does not have specificity, generally by connective Tissue and blood vessel composition, can also there is lymphatic vessel sometimes.

There are three tumour cells, and significant essential characteristic is：Immortality, migration and lose contact inhibition.In addition to this, There are many more the physiology, biochemistry and the morphological features that are different from normal cell for cancer cell.Tumour cell size and form differs, and usually compares Its source cell volume is big, and the speed of growth is fast, and nucleocytoplasmic ratio is significantly higher than normal cell, up to 1：1, normal noble cells core Matter is than being only 1:4-6.Nuclear morphology differs, and may occur in which macronucleus, double-core or multinuclear phenomenon.Chromosome is in non-multiple state in core (aneuploidy), certain chromosome deficiencies, and some chromosome numbers increase.The abnormal variation of normal cell chromosome, Meeting active cell apoptotic process, but in cancer cell, the relevant signal path of Apoptosis generates obstacle, that is to say, that cancer cell With immortality.Mitochondria shows as different polymorphism, swelling, hyperplasia, such as mitochondria loose in acidophile adenoma It is tight to squeeze in the cell, occur giant mitochondria in liver cancer cells.Cytoskeleton is disorderly, and certain ingredients are reduced, and skeleton assembling is abnormal. Cell surface feature changes, and generates tumor-associated antibodies (tumorassociatedantigen).

It is generally believed that various tumours, disease hinders Tianjin and robs the moon, belongs to yin asthenia generating intrinsic heat more, therefore on dietetic regulation, it is scorching pungent-warm should to be avoided The food of attribute, stagnant greasy food also advocate to eat less；It is mostly asthenic symptoms in the middle and advanced stage of cancer, card of trembling with fear advocates warmly invigorating spleen and stomach on diet, The foodstuffs such as benefiting qi for promoting production of blood, and property belongs to cold and cool food, then should lack and eat or do not eat.In different diseases, cancer patient's diet Taboo is also different, if nasopharyngeal cancer patient is during radiotherapy, should avoid that pungent-warm is scorching, fried food roasting, avoid and eat dog meats, sheep Meat, pepper, fennel etc.；Patients with Gastric Cancer avoids eating pungent dry food, cassia bark, mustard, capsicum etc.；Patients With Carcinoma of Esophagus avoids old pork, old duck Meat；Hepatocarcinoma patient avoids sow meat, eats leek less.In short, dieting should suitably, blindly dieting will cause malnutritive, influence disease Rehabilitation.The maintenance of life, it is necessary to rely on the various nutrients in food.The most important problem of cancer patient is dystrophia, is changed The nutrition of kind patient is most important measure in anticancer therapy：(1) protein food for supplying absorption easy to digest, such as milk, fish Body against cancer power can be improved in class, egg, bean product etc..Wherein milk and egg can improve protein disorder after radiotherapy.(2) into Eat appropriate carbohydrate, additional heat.Large dosage of radiation therapy patient, the glycometabolism that its can be made internal are destroyed, glycogen drastically under It drops, lactic acid increases in blood, cannot recycle；And insulin function deficiency aggravates.So the effect of supplement glucose is preferable, In addition the abundant foods containing sugar such as honey, rice, face, potato of eating preferably with additional heat more.(3) eat the food of antitumaous effect more Object, such as soft-shelled turtle, mushroom, black fungus, garlic, seaweed, leaf mustard food.(4) patient of radiation and chemotherapy generally preferably feeds cool Food, cold drink, but have the patient of cold sense, then preferably feed hot food.(5) the study found that cordycepin contained by cordyceps sinensis can be effective Swallow tumour cell, effect is 4 times of selenium, moreover it is possible to enhance the ability that red blood cell sticks tumour cell, during chemotherapy of tumors with And it can play the role of preventing tumor recurrence, transfer after tumor operation.(6) it varies the diet, pays attention to color shape, promote disease People's appetite；The method that cooking food mostly uses steaming, boils, stewes, avoids eating heavy food, and taboo is drunk.(7) vitamin A and C have resistance Only malignant change of cell and diffusion increase the effect of epithelial cell stability, and vitamin C can also prevent the general symptom of radiation insult, And leucocyte level can be made to increase；Vitamin E can promote cell division, postpone cell ageing；Vitamin B1 can promote patient to eat It is intended to, mitigates symptom caused by radiotherapy.Therefore, should eat containing the abundant food of said vitamin more, as fresh vegetables, fruit, Sesame oil, cereal, beans and pluck etc..

Microcirculation disorder is the arch-criminal of cardiovascular and cerebrovascular.Cerebrovascular accident is that one kind seriously threatening the mankind, especially 50 Year old or more middle-aged and the old's health common disease, have rejuvenation trend at present, 40 years old or so sufferer gradually increases or even twenties Just there is mild disease in year, even if the treatment means that application is most advanced, perfect at present, can still there is 50% or more cerebrovascular accident good fortune The person of depositing can't take care of oneself！Only in China, annual nearly 3,000,000 people of cardiovascular and cerebrovascular patient is died of, daily about 8200 people, per hour about 340 people, about 6 people per minute.It can be seen that cardiovascular and cerebrovascular disease has become the big killer for endangering human health.Proverb It says：" microcirculation is logical, will not obtain apoplexy；Microcirculation is good, and myocardial infarction is few；Microcirculation is smooth, and whole body is all healthy." microcirculation is almost Origin of hundreds of diseases, sound microcirculation function are to ensure that internal vitals execute the primary premise of normal function.Microcirculation refers to Directly participate in the blood circulation between tissue, the arteriole and venule that iuntercellular antimetabolic agent exchanges.It is directly to thin Born of the same parents' blood supply, oxygen supply, for energy and related nutriment, while harmful metabolite is also discharged, such as creatine, breast Acid, carbon dioxide etc., such microcirculation are exactly the place of human metabolism, are the interior environment of human body, are the most basic of life Guarantee.It is conventionally believed that headstroke is the Other Risk Factors such as hypertension, heart disease, cerebral arteriovenous malformation, obesity Long term as a result, in fact, profound reason all has indivisible relationship with microcirculation in human body obstacle.Human body it is micro- Cycle directly participates in metabolism and the mass exchange of cell, directly to cell blood supply, oxygen supply, supply energy and related nutrients Matter, while also taking harmful metabolite such as creatine, lactic acid, carbon dioxide etc. in vitro out of.If in microcirculation The mutually viscous collection of blood platelet, leucocyte or fibrin forms microthrombus, as blood flows to whole body, or is deposited on endangium On, it will cause a series of symptoms after embolic leads to regional flow's obstacle.When microcirculation disorder occurs such as nervous system, brain is thin Born of the same parents cannot get enough nutrition and oxygen, while products of cellular metabolism cannot be completely exhausted out in vitro because of blood supply insufficiency, can lead to head Bitterly, dizziness, insomnia, dreaminess, memory loss；Apoplexy, hemiplegia, senile dementia, peripheral neuritis etc. occur for severe one.It is cardiovascular When microcirculation disorder occurs for system, cause uncomfortable in chest, nervous, angina pectoris, heart murmur, severe one that myocardial infarction occurs.Human body other Each system microcirculation disorder will appear corresponding symptom.

Microcirculation is the blood circulation in capillary between arteriole and venule, is the knot of circulatory system Zhong bases Structure and functional unit.It includes the body fluid circulatory in arteriole, venule, capillary lymph duct and tissue tract.The each device of human body Official, each histocyte are intended to provide oxygen, nutriment by microcirculation, transmit energy, and exchange of information excludes carbon dioxide and metabolism Waste.Microcirculation disorder is the change of blood physicochemical property, makes luminal stenosis, velocity of blood flow or is slowed down or thrombosis, and office is made The even necrosis of portion's tissue ischemia anoxic, causes a series of clinical symptoms, the unimpeded all kinds of diseases and ailments of microcirculation not to be given birth to, microcirculation disorder is all kinds of diseases and ailments Source.Sound microcirculation function is to ensure that internal important organ executes the primary premise of normal function, and medicine is proved：Human body Aging, the generation of tumour, hypertension, diabetes and many cardio-cerebrovascular diseases, mainly caused by microcirculation disorder, therefore Microcirculation normally whether, be human body whether health important symbol.Life style, diet, pressure, pollution now etc. are all made At the primary outer reason of microcirculation disorder.With advancing age, the cell of human body and blood can gradual aging, function also from It so degenerates therewith, this is to cause microcirculation disorder internal cause.Obstacle, which occurs, for microcirculation can make many people be in sub-health state, It can lead to other major diseases such as heart infarction or apoplexy when serious.

Those skilled in the art still expect to have new method to slow down aging, inhibit growth of tumour cell, improve heart and brain Blood vessel microcirculation；Especially expect have new composition as health care, medical treatment, medicine purposes, for slowing down aging, inhibiting tumour Cell growth improves cardiovascular and cerebrovascular microcirculation.

Invention content

The purpose of the present invention is to provide a kind of new methods to slow down aging, inhibit growth of tumour cell, improve heart and brain Blood vessel microcirculation；Another object of the present invention is to provide a kind of new drugs or health product to be used to slow down aging, press down Growth of tumour cell processed improves cardiovascular and cerebrovascular microcirculation.It has been unexpectedly discovered that prescription resulting composition of the present invention is presented Excellent anti-aging inhibits growth of tumour cell, improves the function of cardiovascular and cerebrovascular microcirculation, and presenting one or more excellent Good technique effect.It finds and is accomplished the present invention is based on this.

For this purpose, first aspect present invention provides a kind of inhibition growth of tumour cell improvement cardiovascular and cerebrovascular that is used to slow down aging The composition of microcirculation, by being made selected from following substance：Ginseng, Cordyceps militaris, prepared rehmannia root, Herba Epimedii, Herba Cistanches, red deer Young pilose antler and the acceptable carrier of optional physiology.

The inhibition growth of tumour cell that is used to slow down aging according to a first aspect of the present invention improves cardiovascular and cerebrovascular microcirculation Composition, by being made selected from following substance：8 parts by weight of ginseng, 4~8 parts by weight of Cordyceps militaris, 4~8 parts by weight of prepared rehmannia root, 4~8 parts by weight of Herba Epimedii, 1~3 parts by weight of Herba Cistanches, 1~3 parts by weight of cervus elaphus linnaeus and the acceptable load of optional physiology Body.

The inhibition growth of tumour cell that is used to slow down aging according to a first aspect of the present invention improves cardiovascular and cerebrovascular microcirculation Composition, by being made selected from following substance：8 parts by weight of ginseng, 5~7 parts by weight of Cordyceps militaris, 5~7 parts by weight of prepared rehmannia root, 5~7 parts by weight of Herba Epimedii, 1.5~2.5 parts by weight of Herba Cistanches, 1.5~2.5 parts by weight of cervus elaphus linnaeus and optional physiology can The carrier of receiving.

The inhibition growth of tumour cell that is used to slow down aging according to a first aspect of the present invention improves cardiovascular and cerebrovascular microcirculation Composition, by being made selected from following substance：8 parts by weight of ginseng, 6 parts by weight of Cordyceps militaris, 6 parts by weight of prepared rehmannia root, Herba Epimedii 6 Parts by weight, 2 parts by weight of Herba Cistanches, 2 parts by weight of cervus elaphus linnaeus and the acceptable carrier of optional physiology.

The ginseng of the present invention is the dry root and rhizome of Araliaceae ginseng Panax ginseng C.A.Mey..It is more than Autumn excavates, and cleans through drying or drying.Cultivation is commonly called as " garden ginsent "；Sow the title grown naturally under mountain forest wild state " ginseng under forest " is practised and being claimed in " seed sea ".The ginseng or its extract of the present invention or typical saponin(e packet in the compositions of the present invention Include ginsenoside Rg1 (C42H72O14), ginsenoside Re (C48H82O18), ginsenoside Rb1 (C54H92O23), above-mentioned three The assay of kind ginsenoside can refer to the side under the assay item of the one contained ginseng of page 8 of version Chinese Pharmacopoeia in 2015 What method measured.

The inhibition growth of tumour cell that is used to slow down aging according to a first aspect of the present invention improves cardiovascular and cerebrovascular microcirculation Composition, in the form of tablet or granule or oral solution.

The inhibition growth of tumour cell that is used to slow down aging according to a first aspect of the present invention improves cardiovascular and cerebrovascular microcirculation Composition, in the form of oral solution, the acceptable carrier of physiology includes xylitol.

The inhibition growth of tumour cell that is used to slow down aging according to a first aspect of the present invention improves cardiovascular and cerebrovascular microcirculation Composition, in the form of oral solution, in terms of every 8 parts by weight ginseng, the amount of xylitol is 6~10 parts by weight, such as 7~9 weights Measure part, such as 8 parts by weight.

The inhibition growth of tumour cell that is used to slow down aging according to a first aspect of the present invention improves cardiovascular and cerebrovascular microcirculation Composition, in the form of oral solution, per the 100ml oral solutions in the inventory of ginseng be 6~10g, such as 7~9g, such as 8g。

The inhibition growth of tumour cell that is used to slow down aging according to a first aspect of the present invention improves cardiovascular and cerebrovascular microcirculation Composition in the form of oral solution, and is prepared according to the method included the following steps：

(1) people is participated in 5~8 times of water boiling and extraction 1~1.5 hour, leaching filtrate；Filter residue adds 4~6 times of water decoctions to carry It takes 0.5~1 hour, leaching filtrate；Filter residue adds 4~6 times of water boiling and extractions 0.5~1 hour, leaching filtrate；Merging filtrate, concentration To one third volume, add ethyl alcohol to alcohol content up to 70~75%, be mixed, stands 24 hours；Take the filter of supernatant and deposit Liquid, recycle ethyl alcohol, be concentrated to density up to 1.25~1.30 (40 DEG C) clear cream, it is spare；

(2) make prepared rehmannia root, Herba Epimedii, Herba Cistanches, cervus elaphus linnaeus that 5~8 times of water be added to impregnate 12 hours, then decoct extraction 1 ~1.5 hours, leaching filtrate；Filter residue adds 4~6 times of water boiling and extractions 0.5~1 hour, leaching filtrate；Filter residue adds 4~6 times of decoctings Boil extraction 0.5~1 hour, leaching filtrate；Merging filtrate is concentrated into one third volume, add ethyl alcohol to alcohol content up to 70~ 75%, it is mixed, stands 24 hours；The filtrate of supernatant and deposit is taken, ethyl alcohol is recycled, is concentrated to density up to 1.25~1.30 The clear cream of (40 DEG C), it is spare；

(3) Cordyceps militaris is uniformly mixed with 2~3 times of weight xylitols and 3 times of weight waters, homogenate extremely can be by 120 mesh not Become rusty steel mesh, and slurries are set and placed 8~12 hours at 50 DEG C, then it is made to be mixed with clear cream obtained by step (1) and step (2), use prescription 30% water dissolution of amount, stirs evenly；

(4) the 20% water dissolution xylitol for using recipe quantity, is added mixed liquor obtained by step (3), and stirring and dissolving adds water to place Fang Liang is filtered, packing, and 120 DEG C of pressure sterilizings 20 minutes are to get in the composition of drink form.

The inhibition growth of tumour cell that is used to slow down aging according to a first aspect of the present invention improves cardiovascular and cerebrovascular microcirculation Composition, wherein the water of the recipe quantity refers to so that the inventory of ginseng is 6~10g in per the 100ml oral solutions, such as 7 ~9g, for example, the amount of 8g water.

Further, second aspect of the present invention provides a kind of prepare and improves for the inhibition growth of tumour cell that slows down aging The method of the composition of cardiovascular and cerebrovascular microcirculation, the composition in the form of oral solution, including：It is ginseng, Cordyceps militaris, ripe Glutinous rehmannia, Herba Epimedii, Herba Cistanches, cervus elaphus linnaeus and xylitol, this method comprises the following steps：

Method according to a second aspect of the present invention, wherein described inhibit growth of tumour cell to improve heart and brain for slowing down aging The composition of blood vessel microcirculation selected from following substance by being made：8 parts by weight of ginseng, 4~8 parts by weight of Cordyceps militaris, prepared rehmannia root 4~ 8 parts by weight, 4~8 parts by weight of Herba Epimedii, 1~3 parts by weight of Herba Cistanches, 1~3 parts by weight of cervus elaphus linnaeus and optional physiology can The carrier of receiving.

Method according to a second aspect of the present invention, wherein described inhibit growth of tumour cell to improve heart and brain for slowing down aging The composition of blood vessel microcirculation selected from following substance by being made：8 parts by weight of ginseng, 5~7 parts by weight of Cordyceps militaris, prepared rehmannia root 5~ 7 parts by weight, 5~7 parts by weight of Herba Epimedii, 1.5~2.5 parts by weight of Herba Cistanches, 1.5~2.5 parts by weight of cervus elaphus linnaeus, and optional The acceptable carrier of physiology.

Method according to a second aspect of the present invention, wherein described inhibit growth of tumour cell to improve heart and brain for slowing down aging The composition of blood vessel microcirculation selected from following substance by being made：8 parts by weight of ginseng, 6 parts by weight of Cordyceps militaris, 6 weight of prepared rehmannia root Part, 6 parts by weight of Herba Epimedii, 2 parts by weight of Herba Cistanches, 2 parts by weight of cervus elaphus linnaeus and the acceptable carrier of optional physiology.

Method according to a second aspect of the present invention, wherein the ginseng extracts to obtain ginseng extraction through aqueous extraction-alcohol precipitation technology Object, wherein containing ginsenoside Rg1 (C42H72O14), ginsenoside Re (C48H82O18), ginsenoside Rb1 (C54H92O23) Total amount be no less than 10.0%.

Method according to a second aspect of the present invention, wherein described inhibit growth of tumour cell to improve heart and brain for slowing down aging The composition of blood vessel microcirculation is in the form of oral solution, and in terms of every 8 parts by weight ginseng, the amount of xylitol is 6~10 parts by weight, example Such as 7~9 parts by weight, such as 8 parts by weight.

Method according to a second aspect of the present invention, wherein the water of the recipe quantity refers to so that in every 100ml oral solutions The inventory of ginseng is 6~10g, such as 7~9g, such as the water of the amount of 8g.

Further, third aspect present invention is provided by ginseng, Cordyceps militaris, prepared rehmannia root, Herba Epimedii, Herba Cistanches, red deer Composition made of the acceptable carrier of fine and soft and optional physiology inhibits growth of tumour cell preparing for slowing down aging Improve the purposes in the product of cardiovascular and cerebrovascular microcirculation.

Purposes according to a third aspect of the present invention, the composition selected from following substance by being made：8 parts by weight of ginseng, 4~8 parts by weight of Cordyceps militaris, 4~8 parts by weight of prepared rehmannia root, 4~8 parts by weight of Herba Epimedii, 1~3 parts by weight of Herba Cistanches, cervus elaphus linnaeus 1~ 3 parts by weight and the acceptable carrier of optional physiology.

Purposes according to a third aspect of the present invention, the composition selected from following substance by being made：8 parts by weight of ginseng, 5~7 parts by weight of Cordyceps militaris, 5~7 parts by weight of prepared rehmannia root, 5~7 parts by weight of Herba Epimedii, 1.5~2.5 parts by weight of Herba Cistanches, red deer Fine and soft 1.5~2.5 parts by weight and the acceptable carrier of optional physiology.

Purposes according to a third aspect of the present invention, the composition selected from following substance by being made：8 parts by weight of ginseng, 6 parts by weight of Cordyceps militaris, 6 parts by weight of prepared rehmannia root, 6 parts by weight of Herba Epimedii, 2 parts by weight of Herba Cistanches, 2 parts by weight of cervus elaphus linnaeus, Yi Jiren The acceptable carrier of physiology of choosing.

Purposes according to a third aspect of the present invention, wherein the ginseng extracts to obtain ginseng extraction through aqueous extraction-alcohol precipitation technology Object, wherein containing ginsenoside Rg1 (C42H72O14), ginsenoside Re (C48H82O18), ginsenoside Rb1 (C54H92O23) Total amount be no less than 10.0%.

Purposes according to a third aspect of the present invention, wherein described inhibit growth of tumour cell to improve heart and brain for slowing down aging The composition of blood vessel microcirculation, in the form of tablet or granule or oral solution.

Purposes according to a third aspect of the present invention, wherein described inhibit growth of tumour cell to improve heart and brain for slowing down aging The composition of blood vessel microcirculation is in the form of oral solution, and in terms of every 8 parts by weight ginseng, the amount of xylitol is 6~10 parts by weight, example Such as 7~9 parts by weight, such as 8 parts by weight.

Purposes according to a third aspect of the present invention, wherein described inhibit growth of tumour cell to improve heart and brain for slowing down aging The composition of blood vessel microcirculation in the form of oral solution, per the 100ml oral solutions in the inventory of ginseng be 6~10g, such as 7 ~9g, for example, the amount of 8g water.

Purposes according to a third aspect of the present invention, wherein described inhibit growth of tumour cell to improve heart and brain for slowing down aging The composition of blood vessel microcirculation in the form of oral solution is prepared according to the method included the following steps：

Purposes according to a third aspect of the present invention, wherein described inhibit growth of tumour cell to improve heart and brain for slowing down aging The composition of blood vessel microcirculation is in the form of oral solution, wherein the water of the recipe quantity refers to so that in every 100ml oral solutions The inventory of ginseng is 6~10g, such as 7~9g, such as the water of the amount of 8g.

In the method and step that describes of the present invention, although the specific steps of its description are in certain details or language description Step different from described in the upper and example of following detailed description part, however, those skilled in the art according to The detailed disclosure of full text of the present invention can summarize approach described above step completely.

Any embodiment of the either side of the present invention, can be combined with other embodiments, as long as they are not It will appear contradiction.In addition, in any embodiment of either side of the present invention, any technical characteristic can be adapted for other realities The technical characteristic in scheme is applied, as long as they are not in contradiction.

The invention will be further described below.

All documents recited in the present invention, their full content are incorporated herein by reference, and if these are literary When offering expressed meaning and the inconsistent present invention, it is subject to the statement of the present invention.In addition, the various terms that use of the present invention and Phrase has that well known to a person skilled in the art general senses, nonetheless, the present invention remain desirable at this to these terms and Phrase is described in more detail and explains, the term and phrase referred to is if any inconsistent with common art-recognized meanings, with institute's table of the present invention Subject to the meaning stated.

Ginseng (Panax ginseng C.A.Mey) is herbaceos perennial, and happiness is shady and cool, blade pore-free and fence group It knits, moisture can not be retained, temperature can burn higher than 32 degree of blades, canopy density 0.7-0.8.It blooms within usual 3 years, 5-6 annual bearings, flower Month phase 5-6, the fruiting period 6-9 months.It is grown on the theropencedrymion based on Korean pine of hundreds of meters of height above sea level between 33 degree -48 of north latitude degree Or broad leaved and deciduous broad leaved hayashishita, originate in Northeast China, Korea, South Korea, Japan, Russian east.The nickname of ginseng be kurarinone, Goblin, God grass, King of Herbs are one of well-known " northeast Triratnas ".Ginseng has huge economic value in terms of beauty.People Ginseng is described as the superfine product of " King of Herbs " " life is mended in enriching yin, is strengthened the body resistance to consolidate the constitution " from ancient times, can containing a variety of saponins and polysaccharide constituents, leachate By skin slow-absorbing and without pessimal stimulation, capillary of skin can be expanded, promotes skin blood cycle, increases skin-nourishing, The water and oil balance for adjusting skin prevents skin dehydration, hardening, corrugation, ginseng active material from inhibiting the reducing property of melanin, making Skin is pure white smooth, can enhance skin elasticity, so that cell is obtained newborn, is the superfine product improved looks.Ginseng is directly immersed in 50% glycerine, glycerine rubs face with the hands after 10 days, or ginseng is decocted into extract, and daily past face washing water a bit, is rubbed with the hands with the glycerine containing ginseng Face or ginseng water face-washing can allow skin quite to moisten.Ginseng has huge economic value at medicinal aspect.The fleshy root of ginseng For famous strong tonic, be suitable for adjustment blood pressure, restore cardiac function, neurasthenia and the diseases such as in poor health, also have eliminating the phlegm, Stomach invigorating, diuresis, excitement and other effects.The U.S., Northeast China, Radix Ginseng are can be divided by the place of production.Same kind due to weather difference, The former ginseng face band becomes apparent from than the latter, and import ginseng active constituent content is also higher.Nature and flavor：Sweet in flavor, slight bitter, it is warm-natured, flat. Returns spleen, lung channel, the heart channel of Hang-Shaoyin.Tonifying Qi, prevent prolapse are promoted the production of body fluid, and are calmed the nerves, intelligence development.Channel tropism：Enter spleen, lung, stomach.Effect：It reinforces vital energy, multiple arteries and veins Prevent prolapse reinforces the spleen to benefit the lung, and promotes the production of body fluid, and calms the nerves.It cures mainly：Physically weak to be taken off, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung breathes with cough, and injury thirst is interior Heat is quenched one's thirst, and prolonged illness void is thin, insomnia of palpitating with fear, impotence Gong Leng；Heart failure, cardiogenic shock.For dyspnea with shortness of breath, palpitation and amnesia, Thirsty hidrosis, deficiency of food are powerless, all acute and chronic diseases and caused shock, collapse after losing blood.It reinforces vital energy, prevent prolapse and engender liquid, peace God.It is deficient to control internal lesion caused by overexertion, deficiency of food, burnout, regurgitation and emesis, lingering diarrhea of defecating, cough of deficient and syndrome characterized by dyspnea, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness head Bitterly, impotence, frequent micturition are quenched one's thirst, woman uterine bleeding, infantile chronic fright and perennial and irrecoverable weakness, the card of all qi-blood-body fluid deficiencies.2, the heart is treated Vascular system disease：Ginseng has a timing to control high blood pressure, cardiac muscular dystrophy, coronary sclerosis, angina pectoris etc. Treatment acts on, and can mitigate various symptoms.Ginseng has corrective action to abnormal blood pressure, or thinks that different dosage can go out Existing different effect：Low dose can improve blood pressure, and large dosage can reduce blood pressure.3, to stomach and liver diseases：To chronic gastritis accompanied There are gastric anacidity or the too low person of hydrochloric acid in gastric juice, take visible stomach after ginseng and receive increase, symptom mitigates or disappears, but to gastric secretion and gastric juice Acidity has no significant effect.Also there is report to claim ginseng that chronic gastritis patient can be made to have a stomachache to disappear, appetite enhancing, stool is normal, gastric juice Total acidity increases.For acute infectious hepatitis, under the conditions of certain treatment, ginseng is taken for preventing from being changed into Chronic Liver Inflammation seemingly has certain positive effect.4, diabetes are treated：Ginseng can improve the ordinary circumstance of diabetes patient, but not change blood glucose mistake High degree.Or meaning ginseng can be such that levis diabetes patient's glucose in urine reduces, blood glucose reduces 40-50 milligrams of %, can still be tieed up after drug withdrawal It holds 2 weeks or more；In after isocratic diabetes patient takes ginseng, although reducing blood glucose acts on unobvious, most overall health of patients are changed It is kind, such as thirsty sense symptom disappears or mitigation；Certain patients take the dosage that insulin can be reduced after ginseng.5, for mental disease：People Ginseng is to asthenic type and inability-depressive psychosis, regardless of its cause of disease (essence caused by schizophrenia, poisoning or infectious disease Refreshing disease, degenerative psychosis etc.), seemingly there is therapeutic effect.Also have and think, ginseng is oral to be only capable of improving to organic neuropathy The general subjective symptom of patient, and without objective obvious therapeutic action.6, neurasthenia is treated：Ginseng has significantly nervous system Excitation, can improve body activities ability, reduce fatigue；There is certain treatment to different types of neurastheniac Effect, makes patient body weight increase, eliminates or mitigate the symptoms such as general weakness, headache, insomnia.7, impotence is treated：Ginseng is in Chinese medicine In, it is typically used as tonic, vigour can be taken a tonic or nourishing food to build up one's health；The research of person of modern times, it was demonstrated that it plays the role of enhancing sexual gland function.Ginseng tincture pair There is notable curative effect in paralysis, premature ejaculation type impotence, but invalid to spiritual type；To the cortex and ridge caused by neurasthenia Marrow impotence also has certain therapeutic effect.8, ginseng is also improved eyesight and enhances the effect of vision dark adaptation.9, with other medicines Object shares, and can also treat a variety of diseases.Ginseng has extensive pharmacological action.For example, the effect of its Central nervous system Aspect, ginseng Central nervous system have excitation.It can reinforce excitement and the process of inhibition of animal higher nervous activity.And Adaptability of the body to all nonspecific stimulations can be enhanced, capable of reducing feeling of fatigue, (root, stem, the leaf of ginseng can extend small The duration of white mouse swimming).

Ginseng can adjust central nervous system stimulant process and the balance of process of inhibition.By ginseng to animal electrical activity of brain The research of influence, the results showed that：It has an impact excited and two kinds of nerve processes of inhibition, but mainly reinforces corticocerebral emerging It puts forth energy process.Due to acting on process of inhibition simultaneously, therefore inhibition is made to tend to concentrate, differentiation is made to accelerate and more completely.Ginseng is adjustable Nervous function enables the nervous nerve process for causing disorder to restore.Ginsenoside Rb's class has a maincenter sedation, Rb1, Rb2, Rc mixing saponins have stable effect；Rg classes have central excitation effect.Influence of the panaxoside to maincenter is Small Dose Excitement, greatly Dosage inhibits.The spontaneous activity that can significantly reduce mouse is injected intraperitoneally in 5 gs/kg of ginseng flooding agent.Ginseng flooding agent also can be right It faints from fear caused by anti-cocaine, strychnine and pentylenetetrazol, and the convulsions death rate can be reduced.There is report to point out, the crude neutral soap of ginseng The existing calm stable effect of glucoside, also there is analgesia, flesh pine and cooling effect.

Influence of the ginseng to learning and memory has amphicheirality and Composition Dependence.Ginseng extract can prevent stress caused by it is small The decline of mouse learning ability.There is report to think, ginseng extract Memory acquisition caused by anisodine and yellow Jackets is bad There is antagonism, memory caused by memory consolidation obstacle caused by also capable of improving cycloheximide and sodium nitrite and 40% ethyl alcohol Reproduce defect.

Ginseng can prevent acute, the chronic plateau sickness of anoxic.Under the height anoxia condition of height above sea level 7000m, to acute The Changeement of brain tissue of rat cortex ultra microstructure under anoxia condition shows the ultra micro for having apparent protection cerebral cortical neuron Structure is acted on from Hypoxic；Experiment also once observed that panaxoside truly had apparent utilizing for inhibition endogenous glycogen to make With.Meanwhile it can enhance tissue respiration, promote anaerobic glycolysis, improve production capacity under anoxic conditions, reduce body oxygen consumption, So neuron and cardiovascular system can be protected to improve the tolerance to anoxic.Clinical verification ginsenoside prevention is acute, chronic Altitude sickness is effective.Ginseng can improve brain oxygen uptake capacity.Ginseng also has apparent influence to cerebral blood flow (CBF) and brain energy metabolism.Ginseng Preparation can increase the intake of rabbit brain glucose, while reduce the ratio of lactic acid, pyruvic acid and lactic acid/pyruvic acid, and can make grape The utilization of sugar is changed into aerobic metabolism from anaerobic metabolism approach.Ginseng can also be such that free Phos in cerebral cortex increases 25%.Herba Herminii saponin can improve brain oxygen uptake capacity.Ginsenoside, Effects of Ginseng Root Saponins are equal to cerebral ischemia/reperfusion injury There is protective effect.In short, ginseng can make animal brain more reasonably utilize energy matter glucose, production capacity is aoxidized, synthesis is more ATP be used for activities such as learning and memories.

Ginseng plateau mixture has the ability of anti-high altitude anoxia.It is tested by acute decompression hypoxia, it was demonstrated that close on ginseng plateau Agent can obviously lower the death rate of small white mouse, improve resistance to acute anoxia ability.The mechanism of ginseng plateau mixture anti anoxia need into One step research may improve the blood circulations such as the heart, brain, lung with it, improve myocardial metabolism, antithrombus formation, and thrombolysis improves blood Rheological characteristic and adaptive significances are related.The effect of ginseng plateau mixture needs to be put into clinic, examines its anti-high altitude anoxia.

Anti-Fatigue Effects of Panax ginseng, human experimentation prove：The mechanism of Anti-Fatigue Effects of Panax ginseng may increase blood fat and rush with it It is related into protein, RNA synthesis.Research shows that the antifatigue effect of panaxoside A is notable, neutral saponin (Rb1, Rb2, Rc Deng) without antifatigue effect.Remaining lipotropic component after panaxoside is isolated, the autogenic movement of mouse can be also increased, display is anti- Fatigue effect.Ginseng can make the availability of glycogen, energy-rich phosphate more economical, prevent the accumulation of lactic acid and pyruvic acid, and make Its metabolism is more complete.Ginseng can also prevent in tissue caused by rat prolonged exercise that cholesterol consumes in glycogen and adrenal gland It exhausts.Research shows that：There is ginseng maincenter to intend choline activity and quasi- catecholamine activity, can enhance choline system function, increase Ach Synthesis and release, while improving maincenter M- choline receptor density.

Experiments have shown that：Ginseng can promote the synthesis of protein, the synthesis of RNA and the synthesis of DNA.Ginseng easily changes the work of memory With may be mainly related with intracerebral nucleic acid and protein synthesis.Rg1 can be such that intracerebral protein content dramatically increases, and Rb1 then without This effect.There is report to think, stem and leaf of Radix Ginseng saponin can dramatically increase rna content in mouse brain.Stem and leaf of Radix Ginseng saponin, glycol group soap Glucoside and triol group saponin to the normal level of γ-aminobutyric acid in mouse brain without substantially changeing, but to the brain caused by isoniazid Interior γ-aminobutyric acid level reduction has obviously antagonism.

Ginseng can improve the adaptability of body.The reactivity of body can be changed in ginseng, with the phases such as wilsonii, fructus schisandrae Seemingly, there is " adapting to former " sample effect, respond of the body to various destructive stimulus can be enhanced, reinforce organism adaptation.Make For the conditioning agent of body function, stem and leaf of Radix Ginseng saponin and root saponin to physical (cold, overheat, aggravating activities, radioactive ray), (foreign serum, bacterium, the transplantation tumor) of biology, (poisonous substance, arcotic, hormone, anticarcinogen etc.) various thorns chemically Stress reaction has protective effect caused by swashing, and disorderly functional recovery can be made normal, and someone, which is called, adapts to immunogenic substance (one The substance of kind enhancing human body non-specificity resistivity).Dog is injected immediately when massive blood loss or asphyxia are in critically ill state Gen-seng can make the firm rise of the blood pressure for being down to very low level, extend animal survival time, or even animal is promoted to restore strong Health.Ginseng can prevent atrophy caused by adrenal gland loose and prednisone caused by ACTH；Prevent thyroid gland from being drawn by thyroxine Function caused by the hyperfunction risen and 6- methylthiouracils is insufficient；The hyperglycemia of Diet can be reduced, pancreas islet can be also increased Hypoglycemia caused by element；Leukocytosis caused by milk is subcutaneously injected can be allowed to decline, to white caused by dysentery endotoxin Leukopenia is then allowed to increase.The rabbit for taking ginseng for a long time, can prevent the exothermic reaction caused by intravenous injection vaccine.To dimension Symptom and anaphylactic shock caused by raw element B1, Vitamin B2 deficiency have certain good influences etc..But without apparent anti-adrenal gland The effect of element or antihistamine.Its action principle, may with ginseng to body reacting in " stress process ", especially to god Influence through-Pituitary Adrenalcortical system is related.There is report to point out, stem and leaf of Radix Ginseng saponin intraperitoneal injection can obviously reduce small The death rate of mouse under the conditions of high temperature (46 DEG C) and low temperature (- 9 DEG C), has the function of high temperature resistance and low-temperature resistance；With ginseng soap Glucoside is compared, and the two effect is similar.Cauline leaf saponin gastric infusion for three days on end, has protective effect to Scalding shock.Due to ginseng energy Reinforce body to the resistance of adverse factor, therefore, the treatment to many infectious diseases is of great significance.

In terms of ginseng is to the effect of cardiovascular system.1, to the effect of cardiac function：Heart of the ginseng to many animals Have it is first excited after inhibit, a small amount of excited, the effect largely inhibited.It is similar to cardiac glycoside to action of the heart, can improve the heart Myotility.It is large dosage of then weaken convergent force and reducing heart rate.Experiment shows：The alcohol extract and infusion of red ginseng are to the in vitro frog The heart can be such that it shrinks and reinforce, finally stop at the systole phase；To dog, rabbit, the cat heart in place, it can also be made to shrink enhancing, heart rate subtracts Slowly.Caused by the mainly directly excited cardiac muscle of these effects.Animal massive blood loss occurring acute circulatory failure, (heart rate is slow, the heart Power is weak), ginseng can be such that heartbeat amplitude increases extremely, and heart rate is significantly speeded.There is panaxoside stronger anti-barium chloride to induce Rat ventricular acts on, and has stronger role of correcting to generated tachycardia, the rhythm of the heart can be made to be restored to normal level.Have Report points out that panax ginseng fruit or ginseng saponin can be to Experimental Arrhythmias caused by antiadrenergic drug.Panaxoside is to cardiac muscle Intracellular cAMP and cGMP dual regulation containing measurer, therefore it is also to fight under stress situation to maintain the balance of cAMP and cGMP One factor of arrhythmia.Ginseng stem leaves general saponin has protective effect to the damage of rabbit experimental sinus node function.2, to cardiac muscle Effect：Ginseng has protective effect to cardiac muscle.Panaxoside can reduce mouse in severe depletion of oxygen brain and myocardium breast Acid content can restore content of cAMP/cGMP ratios when anoxic, and with protection heart muscle capillary endothelial cell and mitigate line grain The effect of bulk damage.The saponin extracted from positions such as gen-seng haulms, reed head, fruit and main roots, p-isopropyl adrenaline cause Rat heart muscle necrosis, have apparent myocardium protecting action, disease damage can be made to mitigate, especially with Herba Herminii saponin effect be preferred.People Join different parts saponin and is equipped with similar function and effect with gains in depth of comprehension.Ginseng rhizoma saponin can promote in vitro culture Neonatal myocardial thin The DNA of born of the same parents is synthesized, and the cardiac muscle cell to lacking sugared anoxia-induced apoptosis culture has certain protective effect.Research thinks, the total soap of ginseng The mechanism that glucoside resists myocardial ischemia with reperfusion injury is that cardiac muscle is promoted to generate and discharge prostaglandin, inhibits the life of thromboxane A2 At, and cardiac muscle cell is protected by antioxidant radical and lipoid peroxidization resistant.3, to the effect of blood vessel：Ginseng is to blood vessel Effect, it is considered that it is vasodilator agent, but also has low dose of contraction, large dosage expansion or first shrinks the report expanded afterwards It accuses.Ginseng shows difference to the effect of blood vessel because blood vessel type is different or fuselage state.After ginseng is to rabbit ear blood vessel and rat Limb blood vessel has contraction.But there is dilating effect to whole animal coronary artery, the cerebrovascular, optical fundus blood vessel.It is injected intravenously total soap Glucoside can reduce dog hind leg blood vessel and cerebral vascular resistance, but can increase rat renal vascular resistance.Panaxoside A, Re are to dog blood Guan Yicheng dilating effects, effect are respectively the 1/20 and 1/50 of papaverine, and the effect of Rc, Rb2 are very weak, and Rb1 is invalid.Ginseng shadow Ring vascular function active ingredient and mechanism of action research shows that：The dilating effect right and wrong of sanchinoside E1 and R0 to blood vessel Selectivity, and Rg1 only selects vessel retraction caused by sex resistance Ca++, mechanism of action still to need further to be studied.Someone Think, ginseng may be ginseng bidirectional modulation blood pressure to the different adjustment effects of blood vessel under different classes of, different physiological status The reason of.4, to the effect of blood pressure：Most of data shows：Animal reduces blood pressure in normal or hypertensive state, ginseng Effect, but also have and make the raised report of blood pressure.Ginseng is to the blood pressure of anesthetized animal, low dose boosting, large dosage decompression.Treatment Amount has no significant effect patient's blood pressure.The boosting of ginseng may be related with kidney, spleen volume-diminished, splanchnic vasoconstriction.And Decompression is then caused by discharging histamine.Anesthetized dog has tachylaxis to the antihypertensive effect of ginseng.Sanchinoside E1, Rb2, Rc, Rd, Re, Rf have the two-way function declined after first microlitre to blood pressure, most strong with Rg1, and whens Rb1 large dosages boosts.But It is not influenced the effect of blood pressure by atropine, diphenhydramine, phenol oxazoline and inderal.40 milligrams of ginseng ether extract/public affairs Jin intravenous injection can be such that the dog decreased heart rate of fluothane light anesthesia, central venous pressure reduces.It is worth noting that：Intravenous injection Radix Ginseng extractum can be such that breathing has stopped, the cat that blood pressure declines, reflection completely disappears recovers from moribund condition.It is generally believed that people Ginseng antihypertensive effect mechanism be：Ginseng has quasi- choline to act on；Red ginseng ether extract starts the of short duration antihypertensive effect occurred, with group Amine release is related, and the lasting buck effect then occurred belongs to other reasons；Ginseng can cause intravascular Ca++ to reduce, decompression Effect is that ginseng acts on vascular smooth muscle as a result, sanchinoside E1 has lasting buck effect；Due to cutting off animal brain Or with the antihypertensive effect that can eliminate ginseng after ganglionic block agents, the antihypertensive effect of old friend's ginseng may have nervous centralis and anti- Penetrate the participation of mechanism.5, to the effect of hypoxia-bearing capability：Ginseng or its extract, can significantly increase the energy of animal resist oxygen lack Power makes keto consumpting speed slow down, prolonged survival period, and can make atrium contraction time extension under anoxic conditions.Red ginseng improves resistance to The ability of anoxic is stronger than sun-dried ginseng.The mechanism of action that ginseng improves body's hypoxia tolerance may increase with reduction myocardial oxygen consumption Add coronary blood flow, increase by 2,3-DPG contents in red blood cell, adjusts cyclic nucleotide metabolism and glycometabolism of cardiac muscle etc. because being known as It closes.Experiments have shown that：10% Ginseng extract is injected to mouse peritoneal, can be significantly improved mouse normal pressure resistant anoxia ability, can also be carried The ability of the high resistance to sodium nitrite poisoning anoxic of mouse.Herba Herminii saponin can significantly reduce the oxygen demand of animal, and enhancing mouse is low Tolerance under the conditions of pressure and normobaric hypoxia, hence it is evident that the life of mouse when extending disturbance of cerebral circulation anoxic and histotoxic anoxia The time is deposited, this is consistent with the effect of ginseng.Ginseng still play the role of reduce myocardial oxygen consumption or increase coronary blood flow, this with The hypoxia-bearing capability for improving body also has certain relationship.Ginsenoside makes mouse in anoxic, and lactic acid content reduces in tissue, CAMP and cGMP contents reduce in cardiac muscle, and cAMP/cGMP ratios are close to normally.Ginsenoside can to Anoxia cardiac muscle cell Anerobic glycolysis is prevented, Glycogen synthesis is promoted, and is shielded to anoxic, scarce sugared cardiac muscle cell.6, to the effect of hematopoiesis function： Ginseng or its extract have protection and stimulation to the hematopoiesis function of marrow, can make normal and anaemia animal erythrocyte number, in vain Cell number and hemoglobin content increase.To anaemia patient also red blood cell number, hemoglobin and blood platelet can increase.Work as peripheral blood When Leukopenia or marrow are suppressed, the effect that ginseng increases peripheral blood cells number is more obvious.Ginseng is by increasing bone The synthesis of marrow DNA, RNA, protein and lipid promote bone marrow cell mitosis, stimulate hematopoiesis function.7, to blood platelet work( The effect of energy：Ginseng has the function of inhibiting platelet aggregation.Red ginseng powder 1.5g is taken orally on an empty stomach to health adult, and 1 and 3 is small after clothes When blood drawing measure platelet aggregation arachidonic acid, ADP, fibrin ferment and adrenaline etc. are lured as a result compared with before medication The platelet aggregation of hair has significant inhibiting effect, while the life of the blood platelet malonaldehyde by arachidonic acid and thrombin induction At being also suppressed.Compare 70% methanolic extract of red ginseng and white ginseng in vitro to the inhibiting effect of rabbit platelet aggregation, knot The effect of arnotto conopsea extraction is strong compared with white ginseng extract.By to ginseng inhibit platelet aggregation mechanism the study found that Panaxoside can be on excited platelet membrane adenyl cyclase and inhibit the activity of phosphodiesterase, make cAMP water in blood platelet It is flat to significantly improve.Since panaxoside inhibits the timeliness of ADP, arachidonic acid and collagen-induced platelet aggregation bent in vivo Line and the horizontal raised Time-activity-curves of cAMP is made in blood platelet to be consistent, therefore panaxoside makes cAMP levels liter in blood platelet It is high, it may be possible to which that panaxoside inhibits one of the mechanism of Platelet Aggregation in Rabbits.CAMP contains in the notable increased platelets counts of panaxoside Amount, but cGMP contents are not influenced.Experiment prompt, ginseng have direct effect, ginseng suppression to blood platelet epoxidase or TXA2 synzyme Platelet function processed is related with PG metabolism.Result of study shows：Ginseng or panaxoside truly have inhibiting effect to blood platelet.It is made It is related may to improve cAMP contents and the effects that Ca++ antagonisms in blood platelet with retardance PG metabolism with mechanism.8, reducing blood lipid and anti- Atherosclerosis：Ginseng especially panaxosideRb2 can improve blood fat, reduce blood cholesterol, triglycerides, raising Serum High Density Lipoprotein Cholesterol reduces atherogenic index, has treatment valence for hyperlipidemia, thrombosis and artery sclerosis Value.Panaxoside has facilitation to the lipid-metabolism of intact animal, can make the biosynthesis of lipoprotein in cholesterol and blood, divide Solution conversion, excretion accelerate, and can finally blood cholesterol be made to reduce, and when hypercholesterolemia occurs for animal, panaxoside is equal It can make its decline.Stem and leaf of Radix Ginseng saponin and panaxan also have effect for reducing blood fat to hyperlipidemia rats.Red ginseng powder, panaxoside Rb2, Rc, Rg1, Rb1, especially Rb2 make blood middle-high density lipoprotein cholesterol increase, and have preferable antiatherosclerosis to make With.Panaxoside also plays the role of preventing experimental atherosclerosis.PanaxosideRb2 feeds high cholesterol diet big Mouse can be such that its total cholesterol, free cholesterol, low density lipoprotein cholesterol reduces, and high-density lipoprotein cholesterol increases, and moves Arteries and veins hardenability value improves, once abdominal cavity injection, that is, effective, and multiple medication effect is more notable.Research has shown that panaxosideRb2 couple Cholesterol has dissimilation and promotes Excretion, then promotes it to be transferred in adipose tissue triglycerides.Ginseng is to Healthy People And high fat of blood has effect for reducing blood fat per capita.After red ginseng powder being taken orally to 5 Healthy Peoples and 6 hyperlipidemia patients 1 week, serum courage Sterol is without being substantially reduced, but serum High Density Lipoprotein Cholesterol obviously increases, and atherosclerosis index is remarkably decreased.To height Triglyceride patient can also be such that serum triglyceride is substantially reduced.9, ginseng has direct effect to cardiac muscle and blood vessel, generally It is excited in low dose, inhibit when large dosage of.10% ginseng immersion liquid, 1 milliliter/kilogram gives cat (or rabbit) gavage, has to amyocardia Certain improvement result.There is considerable degree of recovery during rewarming.Also there are antianaphylaxis shock and cardiac stimulant.Ginseng is to big Rat cardiomyocyte film ATPase activity has inhibiting effect.Antishock function：Ginseng can mitigate the mistake of guinea pig serum induction Quick property shock, and extend its life span.To Scalding shock mouse, its death of energy obvious postpone.To blood loss and asphyxiating Dog in critically ill state plays the role of promoting to restore normal activities.To blood loss acute circulatory failure animal, ginseng can make Heartbeat amplitude and heart rate dramatically increase.In heart failure, cardiac effect is more notable.Giving Herba Herminii saponin in advance can make The hemorrhagic shock dog time-to-live is obviously prolonged, and can prevent the sarolemma of haemorrhagic shock cardiac muscle cell, the damage of nuclear membrane, mitochondria Wound plays the role of protecting the shock animals heart, brain, kidney and liver.Herba Herminii saponin and ginseng bud saponin also have haemorrhagic shock Protect the effect of the tissues such as the heart, liver and lung.Ginseng extract (red ginseng, sugared ginseng, 20% ethanol percolation, 1:1 concentration) there is anti-pancreas islet Plain shock effect, and ginsenoside has promotion insulin shock effect.Shenmai injection (ginseng, Radix Ophiopogonis) treats mouse and big The experimental endotoxin shock of mouse has good effect, and diarrhea, heating paresthesia is made to mitigate, and peripheral hemogram and reticuloendothelial system function improve. It is a good reticuloendothelial system function activation agent to prompt it.Effect to liver：Ginseng can increase each object of liver metabolism The enzymatic activity of matter makes the detoxification ability of liver enhance, to enhance tolerance of the body to various chemical substances.Experiment shows： Ginseng can increase the activity of alcohol dehydrogenase in liver, can shorten anesthesia duration of the ethyl alcohol to rabbit and dog, make ethyl alcohol in rabbit blood Level reduces quickly.There is report to point out, ginseng can enhance the function of detoxification of liver, also there is anti-liver injury.Ginseng soap Glucoside has mitigation effect to hepatic injury transaminase mass formed by blood stasis caused by carbon tetrachloride.Also it has been reported that, panaxoside, which removes, can reduce by four chlorinations Carbon causes outside the active raising of rabbit anteserum glutamic-oxalacetic transaminease, to other poisonous substances, as thioacetamide causes liver in rabbit Variation, panaxoside can also be allowed to mitigate.The result of study of anti-liver toxicity and certain structures-effect relationship to panaxoside It was found that red ginseng is likely to have stronger anti-liver cytotoxic activity than white ginseng.Ginseng is fairly obvious to the detoxication of ethyl alcohol, it can not only Shorten the duration of ethyl alcohol anesthesia and accelerate to restore the normal time, moreover it is possible to reduce GOT, GPT, ALP and bilirubin in serum Equal size, and the activity of related with alcohol metabolism alcohol dehydrogenase and aldehyde dehydrogenase can be increased, while alcohol metabolism being produced Raw noxious material acetaldehyde promptly excretes, due also to excessive hydrogen participates in saponin synthesis to be effectively protected in ethyl alcohol The liver of poison.Effect to internal system.To hypophysis, adrenocortical effect：It is generally acknowledged that ginseng itself does not have skin Matter hormonal action, but also it has been proposed that it can excited adrenal cortex.Research shows that：Ginseng is to Pituitary Adrenalcortical system It is panaxoside to have stimulation, active ingredient.Various panaxosides make its stimulation also have because of its chemical constitution difference Institute is different.For the site of action of panaxoside more than pituitary level, panaxoside not directly acts on anterior pituitary secretion The biochemical process of ACTH, effect must could be realized by second messenger cAMP.Ginseng can make on normal and excision side kidney The adrenal gland of gland rat is loose；17-KS content reduces in so that cavy is urinated；Make rat eosinophilia, on kidney Vitamin C and cholesterol are reduced in gland cortex, and ACTH increases in urine.Under the stressed conditions such as hypobaric hypoxia state, ginseng can make Vitamin C content does not lower in adult rat adrenal tissue.Ginseng can improve the ability of mouse tolerance high temperature low temperature, but extract adrenal gland Afterwards, this effect disappears.A variety of panaxosides can increase cortex hormone of aadrenaline secretion activity in ginseng, wherein with panaxoside Rb is most strong.Penta bar of alpha-receptor antagonist phentolamine, receptor blocking agent inderal, nerve blocker Bistrium and somnifacient It is unable to antagonism than the intraperitoneal injection of appropriate sodium, to the blood that 7 milligrams of rats by intraperitoneal injection panaxoside/100 gram are caused after 30 minutes The raising of Corticosterone Level in slurry.Panaxoside stimulation adrenal cortex can be such that blood plasma inner cortex ketone level increases.It gives for a long time After panaxoside, adult rat adrenal tissue weight can be made to increase.Panaxoside mainly acts on adrenal cortex, and corticohyperplassia is made to become It is thick.Since glucocorticoid secretion increases, it can also make atrophy of thymus gland while adrenal gland weight increases.There is report to think, Panaxoside stimulation the increased mechanism of adrenal gland glucocorticoid secretion be：It is by releasing that panaxoside, which stimulates adrenal cortex function, Hypophysis ACTH is put, and ACTH must could realize adrenocortical stimulation by second messenger cAMP.Experiments have shown that：Kidney The increase of cAMP concentration and the dosage of panaxoside are related in upper gland.Give rats by intraperitoneal injection panaxoside, dosage 5 milligrams/ Kilogram or more when, cAMP concentration is apparently higher than control group in administration group animal adrenal gland.At the same time, 17- hydroxyls in rat plasma Corticosteroid concentration is also significantly raised, and adrenal gland inner cortex hormone is in then reduction trend, this may be cortin release Enter the result of blood.To further prove to after rats by intraperitoneal injection panaxoside, the variation of ACTH and cortisone in blood plasma Variation it is parallel.There is report to point out, the site of action of panaxoside is in hypophysis or hypophysis with upper bit.For cutting off pituitary Rat, influence of the ginseng to cAMP contents in ACTH in blood and adrenal gland be then not present.Panoxadiol and panaxoside Pd pair Rat plays the role of increasing adrenal gland cAMP levels, but panaxosideRb2 and panaxatriol are invalid, and pituitectomy can release Rd Influence with panoxadiol to adrenal gland cAMP contents.Ginseng has an antidiuretic activity to mouse, and in castration, hypophysectomize or kidney It is obviously reduced after upper gland, it is believed that ginseng acts on posterior pituitary access.The anti-profit of 20% alcohol extracting thing of ginseng and cauline leaf Urine acts on proportional relation approximate with having between dosage, removes hypophysis or pineal body or does not still lose anti-profit with yellow Jackets anesthetized animal Effect is urinated, but can be aldactone institute antagonism, it is believed that this effect is caused by promoting adrenocortical secretion mineralocorticoid； Also find have blood potassium significantly raised before antidiuretic activity occurs, thus it is speculated that it may be the knot for stimulating Aldosterone Secretion that blood potassium, which increases, Fruit.Influence to metabolism：1, experiments have shown that：Ginseng is to euglycemia and because Injection of Adrenaline and hypertonic glucose cause Hyperglycemia have inhibiting effect.To the alloxan diabetes of male rat, play the role of controlling blood glucose level, but not It can prevent its morbidity and death.It is also effective to the alloxan diabetes of mouse.To dog artificial diabetes hyperglycemia, have Certain inhibiting effect, but its dysbolism cannot be corrected completely.Also report points out, the different individual saponins of ginseng can be right Antiadrenergic drug, ACTH and glucagon effect and enhance influence of the insulin to glycometabolism.Experiment shows：Ginseng extracts There are hypoglycemic effect in object, panaxan, ginseng polypeptide, gen-seng haulms polysaccharide, the non-saponin part of ginseng, can be used for diabetes Treatment.Ginseng extract plays the role of reducing blood glucose value, reduces ketoboidies, promotion sugar absorption to alloxan diabetes.Ginseng 30 mgs/kg and 60 mgs/kg of polypeptide is injected to rabbit vein, can obviously reduce blood glucose and hepatic glycogen content.Ginseng stem 50 mgs/kg and 100 mgs/kg of leaf polyose is injected or is injected intravenously to mouse peritoneal, can obviously to antiadrenergic drug and The hypertension of alloxan.50 mgs/kg -200 mgs/kg of panaxan can cause blood to mouse peritoneal or hypodermic injection Sugar and hepatic glycogen content reduce, and epinephroectomy does not influence its effect.50 mgs/kg, 10 mgs/kg of ginseng polypeptide and 200 mgs/kg, to the primary intravenous injection of rat or the multiple subcutaneous administration of mouse, can reduce euglycemia and hepatic glycogen.Simultaneously There is inhibiting effect to hyperglycemia caused by adrenaline, alloxan and glucose, and adrenaline can be enhanced to hepatic glycogen Decomposition.To ginseng hypoglycemic mechanism the study found that Studies On The Hypoglycemic Effect of Ginseng Polypeptide promotes decomposition of glycogen or inhibition breast in addition to it Acid synthesis hepatic glycogen effect is outer, so that the aerobic oxidation of sugar is acted on mainly due to the activity that have stimulated succinate dehydrogenase and CCD and increases Strong reason.Panaxan can also be such that acetone acid content increases, and inhibit lactic acid dehydrogenase activity that lactic acid is made to reduce.Panaxan The activity of succinate dehydrogenase and cytochrome oxidase can also be enhanced.Ginseng can stimulate the free pancreas islet release insulin of mouse, And insulin synthesis amount can be made to obviously increase, the blood glucose of diabetic mice, insulin, glicentin water caused by steptozotozin It is flat to have no significant effect.Ginsenoside can stimulate isolated rat islets to discharge insulin, and caused by can promoting glucose Insulin releasing.Once pause to normal person and diabetes patient and take red ginseng powder 3-6g or saponin component, reduction trend occurs in blood glucose；Blood Middle gastrin increases；Cortex acetone number diabetes patient have decline and it is on the rise in normal person；Catechol amine value has decline to become Gesture.Adenyl cyclase on catecholaminergic active cell film, makes cAMP increase, and promotes gluconeogenesis, red ginseng that can make catechu Phenol amine content reduces, and to limit gluconeogenesis, leads to the adjusting to glycometabolism.Ginseng has bidirectional modulation work to glycometabolism With the blood glucose of the hyperglycemia of glucose can be made to reduce and make the blood glucose rise of hypoglycemia caused by insulin.This Outside, ginseng also has the function of the resistance for reinforcing body to adverse factor.

Prepared rehmannia root, original name：Glutinous rehmannia, also known as：Bosom celebrating glutinous rehmannia, radix rehmanniae preparata.Latin literary fame：Rehmannia glutinosa (Gaetn.) Libosch.ex Fisch.et Mey. Scrophulariaceaes, glutinous rehmannia platymiscium, it is close by the long pubescence of canescence many cells and gland Hair.Rhizome is medicinal.Chinese medicine prepared rehmannia root is the Preparation process product of radix rehmanniae recen, and surface is pitch-black glossy, and matter is soft and flexible, taste Sweet, slightly warm in nature has nourishing yin and supplementing blood, beneficial to spirit and marrow and other effects.The deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, osteopyrexia and fever, night sweat is cured mainly to lose The diseases such as essence, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, dizziness and tinnitus, poliosis.Radix rehmanniae recen is fumigated to black Profit is prepared rehmannia root, which is irregular blocky, and not of uniform size, inside and outside is pitch-dark color, glossy, and outer surface shrinkage is uneven.It is disconnected Face is moistened, the grease-like block of the visible light of central part, and viscosity is big, and matter is soft, and gas is micro-, sweet.Nine are steamed by nine to shine, with root tuber fertilizer Greatly, soft profit, inside and outside pitch-black glossy person are preferred.

In terms of meridian distribution of property and flavor.It is sweet in flavor；It is warm-natured.Return liver；Kidney channel.Effect：Enrich blood moist；Beneficial to spirit and marrow；For the deficiency of blood It is sallow；Dizziness palpitaition；Irregular menstruation；It collapses more than；Liver-kidney Yin deficiency；Hectic fever night sweat；Seminal emission impotence；Infertility；Irregular menstruation；It collapses Leak down blood；Soreness and weakness of waist and knees；Hiccough and deaf；It is dim-sighted；Poliosis；It quenches one's thirst；Constipation；Syndrome characterized by dyspnea.

Glutinous rehmannia has extensive pharmacological action.Syndrome effect is formed to Intravascular Thrombus about prepared rehmannia root and radix rehmanniae recen Drug effect relatively shows：In domestic pig gall shape thick prepared rehmannia root can strong inhibition liver hemorrhagic necrosis stove and pure it is bad Extremely.And the effect of prepared rehmannia root antithrombase is weaker.It is visited by plasminogen activation using fibrin plate method The activation to fibrinolytic system is begged for, it is found that radix rehmanniae preparata has activation, and radix rehmanniae recen is acted on without this.Also report thinks, ground Huang has an anastalsis before and after frying charcoal, and anastalsis and is not reinforced after glutinous rehmannia charcoal processing.To radix rehmanniae recen, prepared rehmannia root, fresh rehmannia charcoal, ripe The decocting liquid haemostatic effect of ground charcoal is analyzed, and as a result there was no significant difference.Experiment is found：Bosom celebrating prepared rehmannia root water decoction gavages, The weight loss of hyperthyroidism type deficiency of Yin rat can be enable to alleviate, 24 hours amounts of drinking water and urine volume significantly reduce, blood plasma T3, T4 concentration Level is significantly improved (i.e. T3 is reduced, T4 is increased) and AD (aldosterone in blood plasma) is horizontal significantly raised.It is relatively strong to prove that it truly has Nourishing yin effect.And be initially believed that, the effect of radix rehmanniae preparata enriching yin and nourishing kidney is related with internal AD levels are improved.

Prepared rehmannia root water decoction can obviously increase animal blood serum Glutathione Peroxidase (GSH-Px) to mouse gavaging Activity；Reduce the content of lipid peroxide in serum.The activity of superoxide dismutase in blood (SOD) can be made to have to a certain degree Raising, but without statistical meaning.On catalase activity in blood without influence.Prepared rehmannia root is to rat portions internal organs protein Metabolism has certain effect.Prepared rehmannia root is oral to have the inhibition mitotic effect of epithelial cell.Experiment shows：Based on prepared rehmannia root The Rehmanniae Decoction of Six Ingredients of medicine is to normal mouse in addition to it can put on weight, extend swimming time, outside enhancing muscle power, moreover it is possible to reduce N- nitrous The induction rate of mice model of forestomach squamous carcinoma caused by base sarcosine ethyl makes the animal spleen lymph nodule hair tonic for receiving chemical carcinogen Center active proliferation can enhance the phagocytic activity of Mononuclear phagocyte system at the initial stage of inoculation transplanted tumor, improve tumor animal The ratio of albumin and globulin in blood, can seemingly extend the time-to-live of tumor animal.(1) prepared rehmannia root delays the work of mice age With：The daily gavage 0.3ml of 20% decocting liquid of prepared rehmannia root totally 45 days, execution take blood, measure superoxide dismutase (SOD), peroxide Change the content of hydrogen enzyme (CAT), glutathione peroxidase (GSH-Px) vigor and lipid peroxide (LPO).As a result prepared rehmannia root GSH-Px activity can be enhanced and reduce the content of LPO in serum, be relatively respectively P compared with the control group<0.05 and P<0.01.(2) right The influence of hyperthyroidism type deficiency of Yin rat：Rat is given with triiodo thryonine (T3) to cause yin-deficient model and award prepared rehmannia root decocting Liquid 3ml (70% concentration), totally 6 days, then measures each data.As a result Normal group is compared with administration group, before and after medication no matter It is sign, weight change, 24 hours amounts of drinking water and urine volume and each associated hormone：T3, thyroxine (T4) and aldosterone (AD) Plasma concentration without significant difference (P>0.05).But after modeling, deficiency of Yin group is compared with normal group, then has highly significant change Change, such as excited bellicose, weight loss, 24 hours amounts of drinking water and drink amount increase, and T3 concentration increases, and T4, AD concentration reduce etc..And it is cloudy Empty rat gives above-mentioned symptom and indices after prepared rehmannia root and significantly improves, and tends to normal (being compared with deficiency of Yin group).Such as the deficiency of Yin Prepared rehmannia root group is added to be compared with deficiency of Yin group, plasma A D concentration significantly increases (P<0.05), twenty-four-hour urine amount substantially reduces (P<0.01), Prompt prepared rehmannia root has the function of that nourishing kidney yin is related with internal AD levels are improved.T3, T4 concentration are bright in deficiency of Yin administration group blood plasma It is aobvious to improve (T3 concentration reduces, and T4 concentration increases), and tend to be normal.Show that prepared rehmannia root can not only be by making systemic adjusting With, improvement deficiency of Yin symptom, and abnormal thyroxine state can be played regulatory role.In addition deficiency of Yin administration group and normal group phase Than in weight change, 24 hours amounts of drinking water, blood plasma T3, T4 concentration etc., being still significantly not up to normal level, having extremely aobvious Write difference (P<0.01).Although this shows that deficiency of Yin administration group is compared with deficiency of Yin group, indices are significantly improved and tend to just Often, it but is not completely recovered to normal.Illustrate that the effect of prepared rehmannia root still has limitation.(3) the experiment of prepared rehmannia root blood tonification effect is seen It examines：Raw, ripe bosom glutinous rehmannia is made 1：1 water decoction gavage awards mouse observation to blood loss anemia, candidate stem cell and the red system of marrow The influence that hematopoietic progenitor cells CFU-E is generated.As a result：Raw, ripe bosom glutinous rehmannia has apparent effect to blood loss mouse, after being administered 8 days, Especially prepared rehmannia root group restores very fast, restores substantially, and P values are respectively 0.001 He compared with the control group for RBC and Hb countings 0.01.Raw, prepared rehmannia root also has candidate stem cell certain proliferation, differentiation, like explainable glutinous rehmannia blood tonification effect and hematopoiesis Stem cell promotes the generation of haemocyte related.Generation to mouse bone marrow cells erythroid hematopoiesis group cell：Physiological saline group erythroid colonies (number) is 52.4 ± 18.41, and Radix Rehmanniae and radix rehmanniae preparata group are respectively 60.2 ± 19.44 and 125 ± 20.45 (P<0.05).Prompt ground Yellow blood tonification effect also plays the role of closely related with medulla hematopoietic system.(4) the influence after glutinous rehmannia stir-fry charcoal to anastalsis：To life Every 100ml decocting liquids 100g containing crude drug or 33g containing charcoal drug preparation is respectively prepared in glutinous rehmannia, fresh rehmannia charcoal, prepared rehmannia root, charred RADIX REHMANNIAE.Each sample Mouse is awarded by 0.8ml/20g dosage gavages, blood, statistics clotting time and and physiology salt are taken from left eye endocanthion, ball rear vein beard Water group is compared.As a result there are no significant difference (P>0.05), prompt glutinous rehmannia need not seemingly process for stopping blooding.

Herba Epimedii (scientific name：Epimedium brevicornu Maxim.) herbaceos perennial.It is Herba Epimedii acrid flavour, sweet, It is warm-natured, return liver and kidney channel, the light gas of body is male, and can rise can drop.Have effects that tonifying kidney and strengthening yang, dispelling wind and eliminating dampness, strong muscles and bones.Cure mainly kidney Empty impotence, premature ejaculation of passing out semen, cold sperm infertility, frequent micturition incontinence, dyspnea and cough due to deficiency of the kidney, soreness and weakness of waist and knees, muscles and bones contraction urgency, arthralgia pain due to rheumatism, numbness are arrested Contraction, hemiplegia, four limbs are meciless, climacteric hypertension, small leaching drip, breath with cough.Herba Epimedii has extensive pharmacological action.Enhancing Sex hormone is secreted, and men and women's sexual desire can be improved, and has establishing-Yang to promote the effect of sexual function.Medicinal material effect is as strong smart, strong medicinal. Also amnesia can be treated.Effect to sexual performance：Herba Epimedii can enhance inferior colliculus-pituitary-gonad axis and adrenal cortex axis, chest The secreting function of the internal systems such as gland axis can obviously increase anterior pituitary of rat, ovary, uterus weight.Urge excessive effect, be by In keeping gonopoiesis hyperfunction, after seminal vesicle is full of, sensation is neural and indirect excitation sexual desire, effect are better than hippocampus.Anti-aging Effect：D gal Aging models, the function of T and the B lymphocyte proliferation reaction of male wister rat can significantly be restored, and energy is bright The aobvious activity for improving the total SOD of mouse liver, reduces the formation of hepatic tissue lipid peroxide, reduces the lipofuscin shape of the tissues such as conscience At.Effect to immune system：There is dual regulation to body's immunity, its spleen weight can be made to obviously increase, and energy Promote the lymphopoiesis of antigenic activation.Effect to cardiovascular system：Have significantly to the coronary flow of extrasomatic rabbit heart Increasing action, and its resistance can be substantially reduced, also had antihypertensive effect, caused by peripheral vasodilation.Relieving cough and eliminating sputum and The effect relievingd asthma：Draw cough method with mouse sulfur dioxide, it was demonstrated that its extract has antitussive effect, is central.Also have to asthma Protective effect.Increase mouse sexual organ volume Ji Xue testis ketone contents：After male mice is to Shorthorned Epimedium P.E or decoction, forefront The weight of gland, seminal vesicle and levator ani increases, and Xue Jiang testis ketone contents increase the secretion of, testis hyperblastosis, testis and increase.Herba Epimedii Glucoside can promote the generation into the basal secretion and cAMP of cell plastid testis ketone between testis.After female rats are to Herba Epimedii decoction, hypophysis Frontal lobe, ovary and the weight in uterus obviously increase, and ovary HCG/LH receptor-specific binding forces significantly improve.Influence to sexual function Pharmacological action：Due to its QI invigorating effect with all worries set aside, Herba Epimedii is often used to releive pressure and fatigue.Folks of china doctor is often with red wine Herba Epimedii (100g-200g, 10 times of clinical dosage) and cuttlefish decoction is added to treat fatigue and body caused by overtax It is weak.It is to supply enough blood to brain that Herba Epimedii, which can treat fatigue and base system ill at ease and full of dread,.In addition, Herba Epimedii is that aphrodisiac wine is normal One of ingredient contained, it is even more history by long that Folium Epimedii decoction, which makees aphrodisiac purposes,.Increase antibody tormation：The excessive sheep of mouse subcutaneous injection Leaves of pulse plants general flavone, epimedium brevicornum polysaccharide and icariine can make sheep red blood cell (SRBC) (SRBC) and immune mouse blood hemolytic antibody horizontal Or spleen antibody tormation increases.Herba Epimedii adjusts the breeding of lymphocyte：Barren wort total chromocor or excessive is subcutaneously injected in mouse respectively Sheep leaves of pulse plants polysaccharide, once a day, successive administration seven days can remarkably promote lymphocyte transformation.Epimedium brevicornum polysaccharide can be such that mouse drenches Bar cell, which stimulates phytohemagglutin phytolectin (PHA), to be increased.50% Herba Epimedii ethanol extract can obviously inhibit a mitogen to induce Mouse lymphocyte proliferation response.It inhibits reaction to increase with drug concentration and reinforce.The super suitable dosage of Gei Huan Lin acyl pickling amine is exempted from Epidemic disease mouse subcutaneous injection epimedium brevicornum polysaccharide can promote the Ts cells of super suitable dosage Huan Lin amides induction to generate, enhance to receptor mouse The inhibition of antibody tormation.On the contrary, mouse subcutaneous injection icariine is immunized in the super suitable agent of Dang Huan Lin amides, Ts cells generate decrease, Receptor mouse antibody tormation level is set to increase.The intragastric administration on mice Herba Epimedii decoction that model of yang asthenia is caused to predniso lone acetate, can be bright The aobvious 3H-TdR incorporations for increasing lymphocyte and conversion, erythrocyte hemolysin and coagulation antibody titre.To antilymphocyte serum Caused by immunologic hypofunction intragastric administration on mice Herba Epimedii decoction, immunologic hypofunction mouse spleen lymphocyte quantity, spleen can be made Plaque forming cells's reacting recovery is to normal level.The red born of the same parents' phagocytic function of raising/recovery macrophage.Mouse subcutaneous injection Herba Epimedii is more Sugar or epimedium flavone, make abdominal cavity macrophage phagocytosis improve.The immunologic hypofunction mouse caused by antilymphocyte serum, it is excessive The sheep leaves of pulse plants can make the ability of its macrophage phagocytosis carbon granule be restored to normal level.IL-2 is stimulated to generate：Epimedium brevicornum polysaccharide is relatively low When concentration (100 μ g/mland1000 μ g/ml), the activity of the IL-2 of human lymphocyte generation can be enhanced.On the contrary, more highly concentrated When spending (2500 μ g/mland5000 μ g/ml), epimedium brevicornum polysaccharide has inhibiting effect to IL-2's.Add the DNA of bone marrow cell Generation and cell proliferation：Herba Epimedii decoction can significantly improve the breeding (72%) of deficiency of yang bone marrow cells in mice and DNA is generated (68%).Mitigate leukocyte cell and reduces symptom：The leukopenia patient 22 for having deficiency of vital energy symptom, takes Herba Epimedii electuary (15g/ packets), the 1st week daily 3 packet, daily 2 packet, adheres to pill taker 14 in treating 30-45 days, 22 altogether from the 2nd week, wherein Cure 3, effective 5, invalid 2.Improve Maintenance Hemodialysis Patients life quality：Dialysis patient is carried out with Herba Epimedii Treatment 4 months, patient's infection rate have downward trend, the activity of peripheral blood lymphocytes element 2 to be remarkably reinforced, and muscle power is slept The sexual function of dormancy, appetite and male patient makes moderate progress.Anti- asthma effect：One experiment discovery for making model with cat, Herba Epimedii Extract can be completely inhibited coughs as caused by electric current stimulates recurrence laryngeal nerve.Grinding for experimental model is made with cavy at another Study carefully display, Herba Epimedii can releive the asthma of histamine guiding.Chronic bronchitis is treated, treats 1066 with single Herba Epimedii ball, always Effective percentage is 74.6%.Antivirus action：Herba Epimedii has antibacterial and antitoxic action, and Herba Epimedii is to staphylococcus albus, golden yellow Staphylococcus, Nai Shi micrococcus catarrhalis, Diplococcus pneumopniae, haemophilus influenzae, poliomyelitis virus, echo, enteric cytopathogenic human orphan virus 6,9 types And Coxsackie virus A 9, B4, B5 type etc. have inhibiting effect.It is effective compared with vitamin C to treatment vital myocarditis：Use Herba Epimedii Medicinal extract piece, each 7-10 pieces 3 times a day, while being added 10% glucose solution 500ml internal jugular veins with vitamin C 3g and instiling, altogether Treatment 36, compared with 25 of vitamin C treatment are applied alone, the former obvious effective rate is 69.44%, and the latter 40%.In animal Antioxidation：The generation that Herba Epimedii Aqueous extracts are homogenized the rat heart, liver, brain and kidney lipid peroxide has significant inhibition to make With.Acute senescent mouse model gavage epimedium flavone is given, can significantly restore mouse T and B lymphocyte proliferation reaction, hence it is evident that carry High mouse liver total superoxide dismutase Xia Rising-of-clouds (SOD) activity, reduce the formation of hepatic tissue lipid peroxide, reduce the heart, liver The lipofuscin of equal tissues is formed.Other studies have shown that icariine tool catecholamines resist effect short of money.Hypoglycemic work in animal With：Normal rat or experimental hyperglycemia rat oral gavage Shorthorned Epimedium P.E, there is hypoglycemic effect.

In addition, Herba Epimedii has extensive clinical application.Herba Epimedii is for impotence and seminal emission, muscles and bones impotence, Bi condition, fiber crops The wooden contraction, climacteric hypertension disease and osteoporosis etc..Herba Epimedii cauline leaf contains icariine and volatile oil.It is verified, excessive sheep The leaves of pulse plants plays the role of male sex hormone sample, and effect is better than gekko and hippocampus.Clinic display, it makes seminal vesicle by promoting gonopoiesis After sperm, energy sensation is neural again in turn, and telotism is caused to excite sexual desire.Meanwhile Herba Epimedii can be with Inhibit vasomotor center, expand peripheral vessels, so that blood pressure is declined, and can antibechic, eliminating the phlegm, relieving asthma, to poliovirus, Staphylococcus albus, staphylococcus aureus etc. also have significant inhibiting effect.Herba Epimedii is given birth to clinically mainly used for treating It grows, Bones and joints, respiratory disease.Herba Epimedii compatibility radix rehmanniae preparata, Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae, matrimony vine, Cortex Eucommiae, thizoma curculiginis, Morinda officinalis, Fructus Corni, Frutus cnidii, semen allii tuberosi, Herba Cistanches, radix aconiti lateralis preparata, Chinese cassia tree referred to as " praise and educate pellet ", can control impotence, premature ejaculation.The Herba Epimedii compatibility root of Chinese clematis, The achene of Siberian cocklebur, Rhizoma Chuanxiong can control arthralgia.Herba Epimedii is regardless of how many, and decoction is gargled, and can control toothache.Take Herba Epimedii that ardisia japonica is added to decoct Soup is taken, and chronic bronchitis can be controlled, and eliminating phlegm and relieving cough plays a role clearly.Take Herba Epimedii and Radix Astragali, Radix Codonopsis, monkshood, asarum, The decoctions such as Chinese ephedra can control sick sinus syndrome and atrioventricular block with using.Herba Epimedii takes for treating infantile paralysis Each 1 gram of injection of every 2 milliliter contained is made in Herba Epimedii, Ramulus Taxilli equivalent.Acute stage, based on intramuscular injection, coordinates cave Position injection.2 milliliters every time of intramuscular injection, 2 times a day, continuous 20 days.Convalescence and sequela stage are based on acupoint injection therapy, cooperation Intramuscular injection.Acupoint injection therapy routinely acupoint selection, injects 1~2 milliliter per cave, the next day 1 time, continuous 20 days, rest half a month was further continued for Treatment.Each phase infantile paralysis totally 246, wherein patients during acute stage 34 are treated, is fully recovered 8, is almost recovered 16, significantly has Effect 7, effective 2, invalid 1；Reconvalescent 43 fully recovers 21, effective 15, progress 5, invalid 2；Sequelae Phase patient totally 169 fully recovers and is almost recovered 9, significantly effective and 129 effective, invalid 31.It has been observed that this product is to urgency Property the phase and the convalescence of having just enter into case it is significant in efficacy, restore very fast.Also there is certain effect to sequela stage, suffering limb is general after medication All over having a fever, the feelings such as energetically, the visible muscle of effective case gradually restores, suffering limb thickening；Wherein with crural paralysis person's curative effect Preferably, paralysis brachialis and older person's curative effect are poor.After medication in addition to having dry phenomenon, other side effects are had no.Herba Epimedii For treating neurasthenia, one penetrates method with 3% excessive sheep flower bud decocting liquid alien, and one time a day, 10~20 times as a treatment course.Minority is suffered from Person separately takes sedative.Observation 104 is fully recovered 22, marked improvement 21, progress 46, invalid 15.Course for the treatment of elder curative effect compared with It is good；After treatment symptom start improve it is more early, curative effect better, and treat 15 state of an illness still without improvement person, even if continual cure, curative effect Also not significantly, and do not consolidate.A small number of case treatment initial stages may occur in which that mild reaction or symptom temporarily aggravate, but continual cure, that is, fast Speed disappears.Two with 5 milliliters every time of 20% Herba Epimedii tincture, before meals 3 times a day, continuous 2~March.Treatment 50, there are about 80% trouble Person controls rear symptom eliminates or mitigation.Adverse reaction is had no during medication, but is not suitable for excited process dominance or sexual hyperesthesia, And hypertensive patient.Herba Epimedii observes more than 1000 examples for treating chronic bronchitis, with single Herba Epimedii ball, a course for the treatment of it is effective Rate is 74.6%, and control in the recent period and obvious effective rate are 22.1%.Ardisia japonica is such as coordinated to form compound treatment, curative effect increases. It was verified that the effect of simple form, better than type of panting, older person's curative effect is poor, but course of disease length and curative effect are without obvious relation； Eliminating the phlegm, antitussive effect are preferable, relieving asthma poor；Through controlling recent control of two course for the treatment of persons than course for the treatment of and obvious effective rate has and significantly carries It is high.Once to 110 progress follow-ups through controlling a course for the treatment of in observation, the effective percentage after as a result half a year is 59.1%, more originally curative effect Decline 26.1%.Preparation and usage：Herba Epimedii stem, leaf (dry product) are taken, extract is taken with the 80% of its total amount, 20% levigation, two Person is mixed into ball.Daily amount is equivalent to 1 liang of crude drug, twice sub-service.Once to be equivalent to 5 money of crude drug and 1.5 liang of dosage in treatment (daily dose), respectively observes some cases, as a result curative effect to take daily 1 both substantially similar.Some cases after medication There is minor response, is common with dry, nausea, is secondly abdominal distension, dizziness, can generally die away.

Cervus elaphus linnaeus, Cornu Cervi Pantotrichum also known as antler, eastern horse is fine and soft, western horse is fine and soft, the stag of animal red deer The young horn Cervidae of unossified dense fine hair, mainly inhabits high mountain forest grassland.By fine and soft shape, cervus elaphus linnaeus, which can be divided into, can be divided into lotus flower Fine and soft, three wooden forks young pilose antler, four wooden forks are fine and soft.The chemical analysis of cervus elaphus linnaeus：Containing acidic mucopolysaccharide, polyamines, a variety of amino acid etc..The nature and flavor of cervus elaphus linnaeus Channel tropism：It is warm-natured, it is sweet in flavor, salty.The major function of cervus elaphus linnaeus：Invigorating kidney yang, benefiting essence-blood, strengthening the bones and muscles adjust punching to appoint, torr sore poison.For sun Impotence involuntary emission, uterus cold infertile, win is thin, refreshing tired, chilly, dizziness, Hiccough and deaf, spinal column crymodynia, muscles and bones impotence, under uterine bleeding band, cloudy subcutaneous ulcer It does not hold back.The pharmacological action of cervus elaphus linnaeus：The coronary flow of isolated rat heart can be made to increase, the increasing of heart shrinkage amplitude, heart rate Slow down, there is cardiac effect；Induced by acute hemorrhagic low blood pressure can be made to restore to accelerate.In addition there are anti anoxia, increase intelligence, strong, promotion Glycolysis promotes the effects that nucleic acid and protein synthesis.

The health-care effect of cervus elaphus linnaeus is very strong, is good body-building antasthenic.Cervus elaphus linnaeus contains the ammonia more more rich than ginseng Base acid, lecithin, vitamin and trace element etc.；Cervus elaphus linnaeus is warm but not dry, has and rouses oneself and improve body function, to whole body Patient after weak, prolonged illness, there is preferable health-care effect.Cervus elaphus linnaeus can improve the cellular immunity and humoral immunity work(of body Can, promote the conversion of lymphocyte, has the function of immunopotentiating agent.It can increase body to extraneous defence capability, adjust Internal immunologic balance, to avoid disease from occurring and promote wound healing, sick body rehabilitation, to play strengthening body, resist The effect of aging.Effect of the cervus elaphus linnaeus to nervous system：Cervus elaphus linnaeus can enhance the tonicity of parasympathetic nerve tip, promote to restore The function of nervous system and improvement nerve, muscle systems, while also having excitation to sympathetic nerve.Cervus elaphus linnaeus is to cardiovascular system The effect of system：The cervus elaphus linnaeus of large dosage can reduce blood pressure, and heart contraction amplitude is made to become smaller, decreased heart rate, peripheral blood vessel expansion.In Equal dosage can cause heart contraction to significantly increase, and shrinkage amplitude becomes larger, increased heart rate, to make cardiac output increase；Cervus elaphus linnaeus It is especially especially pronounced to tired key role.Effect of the cervus elaphus linnaeus to sexual function：Cervus elaphus linnaeus extract can increase blood plasma Testosterone concentration, and interstitialcellstimulating hormone (ICSH) (LH) concentration can be made to increase.Therefore, cervus elaphus linnaeus strengthens old hebetic sex dysfunction The treatment of the atrophy of prostate disease of term is effective；It is good to treatment Menopause barrier effect.The strong effect of cervus elaphus linnaeus： Cervus elaphus linnaeus essence has stronger antifatigue effect, can enhance tolerance to cold, acceleration of wound healing and stimulation adrenal cortex function. Therefore cervus elaphus linnaeus is traditional tonic, for strong, kidney tonifying, Yiyang.Cervus elaphus linnaeus can be such that hemoglobin in blood increases, therefore right In the patient of the person of bleeding profusely and infectious disease latter stage, the treatment especially for aged people is extremely effective.Cervus elaphus linnaeus swashs property The effect of element：Animal experiment confirms, is subcutaneously injected with cervus elaphus linnaeus tincture, sees that prostate, seminal vesicle weights increase after a few days.Red deer Young pilose antler is nourishing superfine product, but not all people is suitable for being mended, and for Healthy People especially child, cervus elaphus linnaeus is not It can help yourself.Healthy child, which has eaten, is susceptible to interior heat, and nose is bleeding, body is extremely excited, or even mania occurs.Cervus elaphus linnaeus Effect to intestinal tube and uterus：Enhance the diuresis function of kidney：Cervus elaphus linnaeus is helpful to women and children, calcium, phosphorus contained by it, The inorganic elements such as magnesium participate in the metabolism of the calcium phosphorus and a variety of enzymes of body respectively, to promoting the absorption of calcium, the growth and enhancing of bone Heart, muscle function play the role of it is positive.Especially magnesium ion even more has the function of complexity, is that promote longevity must not The substance that can lack.This is to women because of palace cold infertility, irregular menstruation, the depauperation of children, the tooth because of caused by deficiency of kidney-QI Growth retardation, failure of closure of fontanel, bone are soft etc., there is preferable therapeutic effect.It is worth noting that with hypertension, ephritis, hepatitis And fire excess from yin deficiency, liver-yang hyperactivity the patient described in Chinese medicine, it should not take.Effect of the cervus elaphus linnaeus to treatment wound：Cervus elaphus linnaeus It is known as " strengthening the bones and muscles " function, for treating " disliking wound carbuncle swells ".Experiment proves that cervus elaphus linnaeus to not being cured and newborn undesirable ulcer for a long time The ability for having enhancing regeneration with wound promotes the healing of fracture.Oral, external application cervus elaphus linnaeus can make wound, especially suppurate Wound heals rapidly.Other effects of cervus elaphus linnaeus：Some active ingredients can inhibit the activity of MAO-B in cervus elaphus linnaeus, therefore have anti-ageing Old effect；Cervus elaphus linnaeus has antioxidation, enhancing gastrointestinal peristalsis and promotion secreting function；In addition, cervus elaphus linnaeus essence can also enhance The immune function etc. of body.

In the present invention, Cordyceps militaris is Ascomycota, meat seat mesh, Clavicipitaceae, Cordyceps type sepecies.Scientific name is Cordyceps militaris (L.ex Fr.) Link. Cordyceps militaris is called northern Chinese caterpillar Fungus, and Cordceps militaris, abbreviation pupa is careless, generally The Cordceps militaris of live body worm pupa culture is called Cordyceps militaris, the two is fungi of the same race, but content difference is larger in nutritional ingredient.Pupa The worldwide distribution of cordyceps sinensis, natural resources quantity are seldom.Nineteen fifty, Germany scientist Cunningham are observed by Cordyceps militaris parasitism Insect tissue it is not perishable, and then therefrom isolate a kind of antibacterial material, 3'-Deoxyadenosine is named as cordycepin.Pupa worm Grass, the pupas for infecting lepidopterous insects, by stroma (i.e. careless part, also known as fructification) and sclerotium (i.e. the corpse part of insect) two more The complex of part composition is exactly in simple terms the combination of polypide and grass.Chinese medicine thinks, can tonifying lung is cloudy and kidney-replenishing, Cure mainly kidney deficiency, impotence and seminal emission, soreness of waist and knee joint, eak after being ill, chronic cough is weak, phthisical cough phlegm blood, spontaneous sweating etc., be it is a kind of can be simultaneously Balance, the Chinese medicine for adjusting negative and positive.The morphological feature of Cordyceps militaris：Stroma list is raw or several together from the head of parasitic pupal cell or section portion It grows, color is orange or Chinese red, and 2-8 centimetres of overall length, pupal cell color is purple, is about 1.5~2 centimetres.Mycelium：Pupa Cordyceps sinensis is a kind of sac fungus, and zoogamy is carried out by heterothallism.Its phorozoon is that pupa draws up mould.After its fructification maturation Ascospore (reproduction unit) can be formed, spore is propagated with the wind after distributing, and spore is fallen on suitable polypide, just starts to sprout shape At mycelium.Mycelium one side is constantly developed, and starts to spread into polypide on one side, and then pupa worm will be fungi-infected, point The tissue in pupal cell is solved, the matter and energy source using the nutrition in pupal cell as its growth and development finally will be complete inside pupal cell It is complete to decompose.Fructification：The general mycelia when Cordyceps militaris in pupal cell various tissues and after organ decomposes, hyphostoma development Also a new stage is entered, form that the top of crocus or Chinese red slightly expands is in rodlike stroma (fructification).

Cordyceps militaris found that, by identification, it and cordyceps sinensis are the same categories in China for the first time in 1958 in Jilin Province, It names as Cordyceps militaris.Main product is in Yunnan (Kunming, peacefulness, river and mountain), Jilin (Antu, Yongji), Liaoning (Shenyang), the Inner Mongol (wise man Li Mu alliances), it is born in needle, broad-leaf forest or mixed forest surface soil layer on the pupal cell of lepidopterous insects.Cordyceps militaris compared with cordyceps sinensis, Have the advantages that several incomparable：First, Cordyceps militaris is the type sepecies of Cordyceps, widely distributed, by countries in the world, scholar recognizes Know and receives；Second is that Cordyceps militaris has been bred as complete stroma under artificial condition；Third, Cordyceps militaris contains cordycepin and cordyceps sinensis Polysaccharide, unique pharmacological action have increasingly caused the great attention of pharmacy circle.Since Cordyceps militaris has the advantages that above, become cordyceps sinensis Outstanding person in category in medicinal Cordyceps Militaris.In fact, under normal circumstances, specific organism has specific biochemistry anti- It answers, specific biochemical reaction could generate specific biological substance.For cordyceps sinensis, various nutritional ingredients are only logical The biological chemistry action that the organism of aweto absorbs, synthesizes is crossed, it is more to be just formed simultaneously cordycepin, cordycepic acid and cordyceps sinensis The various bioactivators such as sugar, other biological method or artificial chemistry method cannot reach simultaneously.Artificial chemistry method It can synthesize one such and be difficult to simultaneously synthesizing a variety of.Aweto is a kind of bioreactor, no matter what is used Method produces, and the bioactive substance of synthesis is the same.The health care of these bioactive substances is identical with medical value.Worm Careless element, cordycepic acid and Cordyceps sinensis polysaccharide are the distinctive substances of aweto, are the leading indicators of cordyceps sinensis special efficacy.And it is proper Just it is these indexs, the Cordyceps militaris content grown under the conditions of artificial environment is affluent can be grown higher than life under natural endowment. Protein, amino acid, the vitamin equal size of the Cordyceps militaris manually cultivated meet or exceed the level of natural cordyceps.Though So individual nutritional ingredients in the Cordyceps militaris manually cultivated are slightly below natural cordyceps level, but these nutritional ingredients be can be with It is improved by research.Cordyceps sinensis and ginseng, cervus elaphus linnaeus are eponymous to have won fame both at home and abroad for three big tonics of Chinese tradition, Domestic and international many experts are to Cordyceps militaris nutrient chemistry composition, the research of pharmacology and clinical effectiveness, all substantially with cordyceps sinensis phase Together, mainly have and protect lung kidney-nourishing, hemostasis and phlegm adjusts physical function, cures mainly pulmonary tuberculosis hemoptysis, impotence and seminal emission, soreness of waist and knee joint, beauty Skin care, psychasthenia, diabetes rise white blood cell, and anti-cancer, anticancer are also very big to Chemotherapy.The Cordyceps militaris of artificial cultivation is medicinal The effect of effect is with wild Chinese caterpillar fungus is very nearly the same, and the medical performance of some aspects is even better than wild Chinese caterpillar fungus.Medicine, pharmacology and face Bed is experiments have shown that Cordyceps militaris completely can be as the substitute of cordyceps sinensis.It is had shown that through research, the Cordyceps militaris medicine manually cultivated Clinical effectiveness, it is identical as natural cordyceps sinensis, it can equally adjust whole body function, improve immunocompetence, enhancing macrophage Phagocytic function, promote the formation of antibody, mainly have and protect lung kidney-nourishing nourishing the liver, relieving cough and asthma eliminating the phlegm, the wrinkle resistant anti-aging of moisturizing, antibacterial It is anti-inflammatory, calm, expansion blood vessel, reduce blood pressure, reduce blood glucose, is antifatigue, resist oxygen lack the effects that.Artificial Chinese caterpillar fungus cures mainly：Consumptive disease Hemoptysis, soreness of waist and knee joint, impotence and seminal emission, neurasthenia, palpitation and insomnia, night sweat, arrhythmia cordis, loss of appetite, nasopharyngeal carcinoma, lung qi The diseases such as Neuroleptic Leukocytopenia after swollen, pulmonary tuberculosis, tracheitis, asthma, hepatitis, ephritis, kidney deficiency, diabetes, frequent micturition and Radiotherapy chemotherapy.

Contain a large amount of cordycepin in Cordyceps militaris, the special medical healthcare function of cordycepin has caused domestic and international expert's Pay much attention to, has much launch such as the health products based on cordycepin, health food, cosmetics, drug.In China The new drug of the treatment leukaemia synthesized by cordycepin is entered into phase clinic trial.The healthcare function ingredient of Cordyceps militaris not only has worm Careless element, also Cordyceps sinensis polysaccharide are the generally acknowledged human immunity reinforcing agents of International Medical.Chinese medicine thinks that it serves and strengthens the body resistance to consolidate the constitution, to old Year property chronic bronchitis, cor pulmonale have significant curative effect, can improve liver detoxification ability, play liver protection effect, improve body Body is antiviral and capability of resistance to radiation.Cordycepic acid, that is, PEARLITOL 25C is the essential drugs for treating cardiovascular and cerebrovascular disease, has and removes certainly By base, effect expansion blood vessel, reduced blood pressure.Nucleotide, which has, to be inhibited platelet aggregation, prevents heart and brain thrombosis, is eliminated yellow Foxiness, senile plaque, whelk, anti-ageing wrinkle resistant, skin maintenance etc..The pure fructification for the Cordyceps militaris manually cultivated is used as food In human body, it is overall safety through research, can be widely used for health food, health diet and other nourishing based foods.People simultaneously The fruiting bodies of cordyceps militaris that work is cultivated, lovely luster, pure in smell, highly practical, commodity value is high, is suitble to a variety of different crowds It uses.Cordyceps militaris can also have therapeutic effect with some drug matchings to some diseases.It is generated during artificial culture Cordyceps militaris Culture medium residue can in the raw material of soy sauce brewing add 5%~10% culture medium residue, the soy sauce taste brewed It is pure, it is full of nutrition, there is strong cordyceps sinensis fragrance.

The biological effectiveness of Cordyceps militaris mainly has：1. righting QI invigorating improves immune and hematopoiesis function.2. tonifying lung is relievingd asthma, change Kind respiratory system.3. improve and adjust heart and brain system.4. adjusting internal blood fat.5. having invigorating the lung and the kidney, immunity, brain memory are improved The effect of power.6. spleen-benefiting mind-tranquilizing has good therapeutic effect for insomnia and dreamful sleep, neurasthenia.The chemical analysis master of Cordyceps militaris Have：N6- [β-(acetamide formyl) oxygen ethyl] adenosine；Cordyceps sinensis cyclic peptide A；Nucleosides；Ergosterol peroxide；Cordycepin, worm Oxalic acid, Cordyceps sinensis polysaccharide and cordyceps sinensis SOD.The medical value of the various bioactivators such as Cordyceps sinensis polysaccharide and SOD is the most notable.Cordyceps sinensis Sour (mannitol) can significantly decrease cranium pressure, promote body metabolism, thus cerebral hemorrhage and cerebral thrombosis disease is made to be delayed Solution.Cordycepin is a kind of nucleosides material with antibacterial activity, has very strong inhibiting effect to nuclear polyadenylic acid polymerase. Make mRNA dysmaturities during DNA transcript mRNAs, inhibits the growth of cancer cell.And play the role of hypoglycemic.Cordyceps sinensis polysaccharide It is a kind of highly branched galactomannans, it can promote lymphocyte transformation, improve the antibody content and body of serum IgG Immune function, enhancing body itself anticancer suppression cancer ability.SOD (superoxide dismutase) can eliminate in body super oxygen from By base, have the function of anti-aging, anticancer suppression cancer.In addition, Cordyceps militaris also contain abundant selenium (Se), it is this trace element by Acknowledged is the essential trace elements of the human body, is the activated centre of glutathione peroxidase, in the form of selenocystein It is connected on the peptide chain of zymoprotein, protects the normal permeability of the stability of cell membrane, and stimulate immunoglobulin and antibody Generation, enhance immunity of organism and oxidation resistance.Meanwhile a large amount of scientific practice proves that selenium can significantly inhibit cancer cell Growth.Cordycepin (cordycepin) has following effect：Antiviral, antibacterial obviously inhibits tumour growth, interference human body RNA and DNA synthesis.Cordycepic acid (PEARLITOL 25C) has following effect：Prophylactic treatment cerebral thrombus, cerebral hemorrhage, renal failure, profit Urine.Adenosine has following effect：Antiviral, antibacterial, prophylactic treatment cerebral thrombus, cerebral hemorrhage inhibit the anti-tampon of Platelet congregation It is formed, eliminates face spot, it is anti-ageing wrinkle resistant.Cordyceps sinensis polysaccharide has following effect：：Immunity is improved, slows down aging, strengthens the body resistance to consolidate the constitution, is protected Shield heart is dirty, liver, anti-convulsion.Ergosterol has following effect：Anticancer, health care, attenuation.Superoxide dismutase (SOD) has Following effect：Suppress or eliminate the superoxide radical formation for urging people's aging and anticancer, health care, attenuation.Selenium (Se) has following make With：For the Anticancer Element Selenium that international medical community is generally acknowledged, it is also important antioxidant, can be enhanced human immunity.

In the present invention, Herba Cistanches (scientific name：Cistanche deserticola Ma), alias boundary rue, very little rue, desert cistanche, It is sub- (Mongolian) to look into dry announcement, belongs to endangered species.Tall and big draft, 40-160 centimetres high, mostly lower life.The month at florescence 5-6, fruiting period 6-8 Month.Main product is also distributed in Xinjiang, Alashan Area, inner Mongolia Autonomous Region alliance, Gansu, Ningxia.Herba Cistanches are that one kind colonizing in desert trees sacsaoul The parasitic plant of root draws nutrient and moisture from sacsaoul host.It is known as the good reputation of " desert ginseng ", is had high medicinal Value, is the rare traditional Chinese medicine of Chinese tradition.The Herba Cistanches just treasure by Western Regions various countries as Shang Gong imperial court in history, and One of highest help drug of usage frequency in successive dynasties tonifying kidney and strengthening yang class prescription.Fleshy stem (cistanoside) containing boschnialoside A, B, C, H, Syring vulgaris phenol glucoside (acteoside), 2- acetyl group Syring vulgaris phenol glucosides (2-acetylacteoside), echinacosid (echinacoside) seven kinds of benzyl carbinol glucoside ingredients, also glucoside containing Liriodendron (lirio-dendrin), 8- table vomiting nuts glucoside acid (8- Epiloganic acid), Daucosterol (daucos-terol), glycine betaine (betaine), cupreol (β- Sitosterol), mannitol (mannitol), N, N- dimethyl are sweet by sour methyl esters (N, N-dimethylglycinemethyl Ester) and phenylalanine (phenylalanine), valine (valine), leucine (leucine), isoleucine (isoleacine), lysine (lysine), 15 kinds of amino acid such as threonine (serine) and succinic acid (succinic Acid), triacontanol (TCMLIBiacontanol), polysaccharide.Herba Cistanches are warm-natured, sweet in flavor, salty；Return kidney, large intestine channel.Herba Cistanches Major function be：Kidney-replenishing；Benefiting essence-blood；Ease constipation road.Main decline of kidney-YANG；The impotence of asthenia of essence and blood；Seminal emission；Gonorrhoea；More than frequent micturition Drip；Pain in the back flaccidity of lower limbs；Tinnitus mesh is spent；Menstruation is spread out the phase；Fertility；Dry constipation of intestines.Since the 1980s, both at home and abroad to meat The ingredient of desert cistanche has carried out numerous studies, wherein Japan's starting is more early, with the rapid development of separation and Extraction and detection technique, A plurality of types of substances are isolated, benzyl carbinol glycoside, iridoids, lignanoids, polysaccharide, ten several amino are can be divided mainly into Sour, a variety of alkaloids etc., rich in needed by human body trace element, wherein phenylethanoid glycosides are main actives in Herba Cistanches, tool It is improved male's sexual, treatment woman fertility, anti-oxidant, anti-aging, improves the functions such as immunity, enhancing memory.

The pharmacological action of Herba Cistanches is mainly reflected in the above.Improve immunity：Cistanche deserticola excited can hang down in a kind of Body, adrenal cortex have similar adrenocortical hormones fuction, adjust the rare medicinal herbs of body's immunity, polysaccharide is at it Extraction species content is higher, and the immunological enhancement of polysaccharide component may play master in the strong and help effectiveness of Herba Cistanches The influence wanted.Effect to immune system：Herba Cistanches aqueous extract 50mg/kg, 100mg/kg can be dramatically increased to intragastric administration on mice The weight of spleen and thymus gland, and the phagocytic activity of peritoneal macrophage can be remarkably reinforced, increase hemolysin and PFC values, improves leaching Bar cell transformation rate and delayed type hypersensitivity, DTH index, also can increase cAMP levels, it is horizontal to reduce cGMP, makes cAMP/cGMP ratios Value increases, this may be one of the reason of it enhances Peritoneal Macrophage Phagocytosis.Desertliving cistanche alcohol extract 1.25g/kg, 2.5g/kg (being equivalent to crude drug 5.61g/kg, 11.21g/kg) gives intragastric administration on mice, continuous 8 days, is caused with sheep red blood cell (SRBC) within the 5th day It is quick, it can obviously inhibit the plaque number in splenocyte.Cistanche extracts and barren wort total chromocor are to promoting immune suppressed mouse to drench Turning aspect has summation action, can enhance the immunocompetence of model mice.Anti-aging effects：" Herba Cistanches have a degree of anti-ageing Old effect.Herba Cistanches can be such that the activity of mouse red blood cell superoxide dismutase (SOD) is remarkably reinforced, and make mouse cardiac muscle lipofuscin Content is substantially reduced.Also it can extend average life span, median lethal number of days and the maximum life span of drosophila.Herba Cistanches water decoction 8g/kg To intragastric administration on mice, can significantly increase erythrocyte membrane Na+, K+-ATP enzymatic activitys, this may be one of mechanism of its benefiting action. 1993, news item can be gone out cruelly in the annual meeting of Geneva in International Medical：Chinese Alashan League looks into dry uncommon heat and ranks among world's longevity Township.Immediately, dry uncommon heat is looked into hot spot of people's attention.The survey team being made of China and foreign countries expert do not stint with 4 months when Between investigate looking into dry uncommon heat.They have found that there is 4 people of centenarian in dry uncommon hot (loud, high-pitched sound is looked into) village that looks into of only 139 people, per capita the longevity Life 87.5 years old；The incidence of the common diseases such as hypertension, stomach trouble, nephrosis, hypertrophy of the prostate is extremely low.Expert group finds local resident's Dietary structure is related, wherein 2 points be exactly here people's mutton ginseng and astragali casserole custom be put into Herba Cistanches, also drink the cistanche deserticola wine from home-brew. Improve impotence and premature ejaculation：The Tang Dynasty《Bencao Shiyi》In once recorded：" three money of Herba Cistanches, three decoct a system, and hot drink takes it, and penis is all the life not It declines ".Modern medicine has also confirmed this point, contains a large amount of amino acid, cystine, the rare battalion of vitamin and mineral in Herba Cistanches Nourishing ingredients are supported, has great help effect to sexual organs such as male's kidney, testis, penis, cavernous bodies, can also effectively improve essence Sub- vigor and quality.It is antifatigue：Kidney storing essence, main bone give birth to marrow, are the congenital foundation, are motive power and source that muscle power generates.When long Between move, it is spend body locomitivity when fatigues can cause testosterone to decline and decline and the extended principal element of recovery process more.Meat Desert cistanche can prevent testosterone caused by movement and reduce, and promote the secretion of hypophysis gonadal hormone, accelerate fatigue recovery, improve movement energy Power.After fixed quantitative load can also moved, blood lactase acid accumulation is reduced, and is removed and is accelerated, and body acid-fast ability improves.Protect liver：Meat Desert cistanche have protection ischemic myocardium, reducing blood lipid, antiatherosclerosis and antithrombus formation, reduce peripheral vascular resistance, decompression, Anti-fatty liver and a variety of pharmacological activity such as antitumor.Herba Cistanches can promote Synthesis of DNA, Herba Cistanches decoction (0.5g/ml) 0.5ml/ gavage, " deficiency of yang " mouse caused by Dichlorodiphenyl Acetate hydrocortisone, can increase its liver, spleen deoxyribose The synthesis of nucleic acid.It adjusts endocrine, promote metabolism and strong effect：Liver and spleen nucleic acid of the Herba Cistanches to the deficiency of yang and yin vacuity animals Content declines and raising has corrective action；Play the role of activating adrenal gland, release cortin.Its mechanism of action may be enhancing Hypothalamus-Pituitary-Ovaries promote luteal function, this to act on point for being not due to their direct Stimulation of Pituitary Gland metakentrin It secretes, but improves reactivity of the hypophysis to the reactivity of LRH and ovary to LH.The major significance of prompt Kidney-supplementing is to improve Regulation mechanism in body, by body built-in function itself is restored from positive therapeutic effect, by Herba Cistanches to " sun It is empty " effect of animal DNA synthetic ratio the study found that hydroxycarbamide inhibits nucleotide in the reduction reaction of diphosphate level because of it And leading to the reduction of DNA synthetic ratios, protein, energetic supersession disorder cause " deficiency of yang "；Herba Cistanches may contain a kind of activation nucleosides The bioactie agent of sour reductase, thus " deficiency of yang " animal DNA synthetic ratio can be significantly increased, promote the synthesis of RNA；It improves The nucleic acid metabolism of albumen；Raising rat in drinking-water is added with its Diluted Alcohol extract, there is enhancing development effect.Protect heart and brain Blood vessel：Many people are easy trick and feel cold, and four limbs chilly, one spends late autumn, is especially apparent.Active ingredient phenylethanoid glycosides in Herba Cistanches There are improvement microcirculation, softening blood vessel to increase the heart, brain and outer four limbs peripheral vessel cycle, reaches the protection blood cerebrovascular and nerveous system The effect of system.Runchang detoxification：Chinese medicine thinks that Herba Cistanches enter kidney and large intestine channel, tonifies the kidney and support yang with moistening dryness for relaxing bowels.Herba Cistanches class drug Water decoction there is apparent defecating feces excretion, enterocinesia can be improved, inhibit the moisture absorption of large intestine, shorten defecation time.To old Year people habitual constipation, physically weak constipation and puerpera's puerperal constipation are significant in efficacy.Other effects：Water-leach liquor, the ethyl alcohol-of Herba Cistanches Water-leach liquor and alcohol leaching liquid have antihypertensive effect Herba Cistanches to have promotion salivary secretion to mouse and exhale anesthetized dog, cat, rabbit etc. Paralysis effect is inhaled, it is certain organic acid sample substance to promote the ingredient of salivary secretion, and the ingredient of respiratory paralysis may be glucoside.

Prepare the present invention composition during, had now surprisingly been found that, in step (3) by Cordyceps militaris with A small amount of xylose alcohol and water is then postponed in 50 DEG C through homogenate everywhere together, and the adenosine content in gained oral solution is than it in without this The higher that mode is handled, step (4) filters gained filter cake (although filter cake amount is non-after the processing of above-mentioned steps (3) method after measured Often few, weight is approximately the 2.3~3.1% of Cordyceps militaris inventory, and this filter cake should not be entirely due to be generated by Cordyceps militaris) In adenosine content it is lower, this show through above-mentioned steps (3) method processing after residual volume of the adenosine in filter cake it is significantly lower. The method of the adenosine content in various materials is measured with reference to version in 2015《Chinese Pharmacopoeia》One contained cordyceps sinensis of page 115 【Assay】Method carries out.Specific experiment is as follows：Respectively refer to 1~embodiment of embodiment 5, different be only in step (3) not Xylitol is added, 5 batches of oral solutions that can be referred to as to supplement example 1~supplement example 5 are obtained；For each sample, it is measured In contained adenosine content account in its Cordyceps militaris inventory the percentage of theoretical adenosine content, as the adenosine rate of recovery, the results show that The adenosine rate of recovery of 1~embodiment of embodiment 5 supplements the adenosine recycling of example 1~supplement example 5 in 96.7~99.3% ranges Rate is in 86.2~89.5% ranges；In addition, measuring 1~embodiment of embodiment 5 and supplement example 1~supplement example 5 in step (4) Adenosine amount after filtering in gained filter cake calculates the adenosine loss late caused by filtering filter cake retention, as a result, embodiment 1~reality The adenosine loss late of example 5 is applied in 0.6~3.5% range, and supplement the adenosine loss late of example 1~supplement example 5 10.1~ In 13.3% range.These results indicate that the adenosine rate of recovery is high after step (3) processing through the invention.

In the present compositions, it has had now surprisingly been found that, a small amount of sodium tartrate energy is added in oral solution The stability that wherein important activity ingredient three-type-person joins saponin(e is enough significantly improved, and it is found through experiment that three-type-person joins the steady of saponin(e Qualitative may be to be influenced by added sugar alcohol.This specific method for improving three-type-person's ginseng saponin(e stability and result are as follows： 1~embodiment of embodiment 5 is respectively referred to, different is only in step (1), in the ginseng extract clear cream obtained by step (1) In also add sodium tartrate (each example additive amount is respectively equivalent to 10%, 15%, 5%, 12%, the 8% of ginseng extract weight), Obtain 5 batches of oral solutions that can be referred to as to supplement example a1~supplement example a5；Make 1~embodiment of embodiment, 5 oral solution and benefit It fills an a1~supplement example a5 oral solutions to be placed at 40 DEG C of temperature up to 6 months, uses version in 2015《Chinese Pharmacopoeia》One institute of page 8 Manned ginseng【Assay】Method measures three-type-person of each batch of oral solution at 0 month and when June in oral solution and joins saponin(e total content； Its saponin(e total content remnants percentage is calculated as follows for each sample：Saponin(e total content remnants percentages=June saponin(e 0 month saponin(e total content × 100% of total content ÷；As a result, the saponin(e total content percentage of 1~embodiment of embodiment, 5 oral solution is 88.7%~90.3%, the saponin(e total content remnants percentages of supplement example a1~supplement example a5 oral solutions are 97.4%~ 99.0%, the latter, which shows, is higher than the former, shows that the important physiological activator ginsenoside in the latter's oral solution is obviously more stable； In addition, respectively referring to 1~embodiment of embodiment 5, different is only that xylitol is not added in prescription, and obtaining 5 batches can be referred to as respectively To supplement the oral solution of example b1~supplement example b5, so that this five batches of oral solutions is carried out disposition in 40 DEG C-June with above method, measure simultaneously Saponin(e total content remnants percentages when calculating June, as a result percentage is 96.8%~98.3% more than their saponin(e total content.This It may be to be adversely affected by xylitol to show in 1~embodiment of embodiment 5 that saponin(e total content is substantially reduced, and this unfavorable shadow Sound can be overcome by adding this field conventional pharmaceutical adjuvants sodium tartrate.Therefore, according to either side of the present invention, wherein also adding Add sodium tartrate.In one embodiment, the additive amount of wherein sodium tartrate be equivalent to ginseng extract weight 5%~ 15%.In one embodiment, sodium tartrate adds in gained ginseng extract clear cream.

The present invention's uses people for the composition for inhibiting growth of tumour cell to improve cardiovascular and cerebrovascular microcirculation that slows down aging Ginseng, Cordyceps militaris, prepared rehmannia root, Herba Epimedii, Herba Cistanches, cervus elaphus linnaeus are made.The combination biological effectiveness of these medicinal materials is presented, especially Having effects that significantly to slow down aging inhibits growth of tumour cell to improve cardiovascular and cerebrovascular microcirculation.For example, being directed to symptoms include aging 45~50 years old male 18 and 48~53 years old male 15, give 1 resulting composition 30ml of the embodiment of the present invention for each person every day, Divide and take twice sooner or later, after taking a season, spirit is obviously shone compared with taking the present composition before, face wrinkles It significantly reduces, this shows that composition of the invention has the effect of excellent anti-aging.In another example benign swollen for 26 Tumor patient gives 1 resulting composition 30ml of the embodiment of the present invention for each person every day, and a point morning and evening takes twice, after taking half a year, with clothes It is substantially improved compared to apparent energetic, sleep with before the present composition, may be related with growth of tumour cell is inhibited, This shows that composition of the invention has the effect of excellent inhibition growth of tumour cell.In another example for 28 long-term existence The patient of cerebrovascular microcirculatory disorders puzzlement, gives 1 resulting composition 30ml of the embodiment of the present invention for each person every day, and point morning and evening is twice It takes, after taking half a year, compared with taking the present composition before, various perplex obviously subtracts caused by cerebrovascular microcirculation Few, this shows that composition of the invention has the effect of excellent improvement cardiovascular and cerebrovascular microcirculation.

In addition, based on the present invention for the composition for inhibiting growth of tumour cell to improve cardiovascular and cerebrovascular microcirculation that slows down aging In various medicinal materials physiologic properties, completely it is expected that the present invention for slow down aging inhibit growth of tumour cell improve the heart The composition of cerebrovascular microcirculation can present these medicinal materials respectively or combination generate biological effect.Such as the present invention is used for The composition for inhibiting growth of tumour cell to improve cardiovascular and cerebrovascular microcirculation that slows down aging can be endowed ginseng, Cordyceps militaris, radix rehmanniae preparata Huang, Herba Epimedii, Herba Cistanches, cervus elaphus linnaeus respective canonical biometric effect as described above.Therefore, the use of third aspect present invention Way further includes the purposes involved by these above-mentioned treatment/preventive effects.

Specific implementation mode

The present invention can be further described by the following examples, however, the scope of the present invention and unlimited In following embodiments.One of skill in the art, can be with it is understood that under the premise of without departing substantially from the spirit and scope of the present invention Various change and modification are carried out to the present invention.The present invention carries out the material and test method that are arrived used in experiment general And/or specific description.Although to realize the present invention many materials and operating method used in purpose be it is known in the art that But the present invention is still described in detail as far as possible herein.

Every batch of total amount of feeding is 10 kilograms in following compositions.

Embodiment 1：Prepare oral solution composition

Formula：8 parts by weight of ginseng, 6 parts by weight of Cordyceps militaris, 6 parts by weight of prepared rehmannia root, 6 parts by weight of Herba Epimedii, 2 weight of Herba Cistanches Part, 2 parts by weight of cervus elaphus linnaeus, 8 parts by weight of xylitol, water are measured, in right amount, makes the gained oral solution be per the inventory of ginseng in 100ml 8g。

Preparation method：(1) people is participated in 6 times of water boiling and extraction 1.25 hours, leaching filtrate；Filter residue adds 5 times of water boiling and extractions 0.75 hour, leaching filtrate；Filter residue adds 5 times of water boiling and extractions 0.75 hour, leaching filtrate；Merging filtrate, it is concentrated into three/ One volume adds ethyl alcohol to alcohol content up to 70%, is mixed, and stands 24 hours；The filtrate of supernatant and deposit is taken, ethyl alcohol is recycled, Be concentrated to density up to 1.25~1.30 (40 DEG C) clear cream, it is spare；(2) prepared rehmannia root, Herba Epimedii, Herba Cistanches, cervus elaphus linnaeus is made to add 7 times Water impregnate 12 hours, then decoct extraction 1.25 hours, leaching filtrate；Filter residue adds 5 times of water boiling and extractions 0.75 hour, leaching Filtrate；Filter residue adds 5 times of water boiling and extractions 0.75 hour, leaching filtrate；Merging filtrate is concentrated into one third volume, adds ethyl alcohol It to alcohol content up to 70%, is mixed, stands 24 hours；The filtrate of supernatant and deposit is taken, ethyl alcohol is recycled, is concentrated to density and reaches The clear cream of 1.25~1.30 (40 DEG C), it is spare；(3) Cordyceps militaris is uniformly mixed with 2.5 times of weight xylitols and 3 times of weight waters, Homogenate can extremely be set at 50 DEG C by 120 mesh stainless (steel) wires, slurries places 10 hours, then makes itself and step (1) and step (2) gained Clear cream mixes, and with 30% water dissolution of recipe quantity, stirs evenly；(4) the 20% water dissolution xylitol for using recipe quantity, is added step (3) gained mixed liquor, stirring and dissolving adds water to recipe quantity, filters, packing, and 120 DEG C of pressure sterilizings 20 minutes are to get in oral The composition of liquid form.Per bottled 100ml.

Embodiment 2：Prepare oral solution composition

Formula：8 parts by weight of ginseng, 8 parts by weight of Cordyceps militaris, 4 parts by weight of prepared rehmannia root, 8 parts by weight of Herba Epimedii, 1 weight of Herba Cistanches Part, 3 parts by weight of cervus elaphus linnaeus, 6 parts by weight of xylitol, water are measured, in right amount, makes the gained oral solution be per the inventory of ginseng in 100ml 10g。

Preparation method：(1) people is participated in 8 times of water boiling and extraction 1 hour, leaching filtrate；Filter residue adds 6 times of water boiling and extractions 0.5 Hour, leaching filtrate；Filter residue adds 4 times of water boiling and extractions 1 hour, leaching filtrate；Merging filtrate is concentrated into one third volume, Add ethyl alcohol to alcohol content up to 75%, be mixed, stands 24 hours；The filtrate of supernatant and deposit is taken, ethyl alcohol is recycled, is concentrated to close The clear cream up to 1.25~1.30 (40 DEG C) is spent, it is spare；(2) make prepared rehmannia root, Herba Epimedii, Herba Cistanches, cervus elaphus linnaeus that 5 times of water be added to impregnate 12 hours, then decoct extraction 1.5 hours, leaching filtrate；Filter residue adds 4 times of water boiling and extractions 1 hour, leaching filtrate；Filter residue adds 6 Times water boiling and extraction 0.5 hour, leaching filtrate；Merging filtrate is concentrated into one third volume, and ethyl alcohol to alcohol content is added to reach 75%, it is mixed, stands 24 hours；The filtrate of supernatant and deposit is taken, ethyl alcohol is recycled, is concentrated to density up to 1.25~1.30 The clear cream of (40 DEG C), it is spare；(3) Cordyceps militaris is uniformly mixed with 3 times of weight xylitols and 3 times of weight waters, homogenate can extremely pass through 120 mesh stainless (steel) wires, slurries are set and are placed 8 hours at 50 DEG C, then it is made to be mixed with clear cream obtained by step (1) and step (2), use 30% water dissolution just measured, stirs evenly；(4) mixing obtained by step (3) is added in the 20% water dissolution xylitol for using recipe quantity Liquid, stirring and dissolving add water to recipe quantity, filter, packing, and 120 DEG C of pressure sterilizings 20 minutes are to get in the combination of drink form Object.Per bottled 100ml.

Embodiment 3：Prepare oral solution composition

Formula：8 parts by weight of ginseng, 4 parts by weight of Cordyceps militaris, 8 parts by weight of prepared rehmannia root, 4 parts by weight of Herba Epimedii, 3 weight of Herba Cistanches Part, 1 parts by weight of cervus elaphus linnaeus, 10 parts by weight of xylitol, water are measured, in right amount, makes the gained oral solution be per the inventory of ginseng in 100ml 6g。

Preparation method：(1) people is participated in 5 times of water boiling and extraction 1.5 hours, leaching filtrate；Filter residue adds 4 times of water boiling and extractions 1 Hour, leaching filtrate；Filter residue adds 6 times of water boiling and extractions 0.5 hour, leaching filtrate；Merging filtrate is concentrated into one third body Product, adds ethyl alcohol to alcohol content up to 70%, is mixed, and stands 24 hours；The filtrate of supernatant and deposit is taken, ethyl alcohol, concentration are recycled It is spare to density up to the clear cream of 1.25~1.30 (40 DEG C)；(2) prepared rehmannia root, Herba Epimedii, Herba Cistanches, cervus elaphus linnaeus is made to add 8 times of water It impregnates 12 hours, then decocts extraction 1 hour, leaching filtrate；Filter residue adds 6 times of water boiling and extractions 0.5 hour, leaching filtrate；Filter Slag adds 4 times of water boiling and extractions 1 hour, leaching filtrate；Merging filtrate is concentrated into one third volume, and ethyl alcohol to alcohol content is added to reach 70%, it is mixed, stands 24 hours；The filtrate of supernatant and deposit is taken, ethyl alcohol is recycled, is concentrated to density up to 1.25~1.30 The clear cream of (40 DEG C), it is spare；(3) Cordyceps militaris is uniformly mixed with 2 times of weight xylitols and 3 times of weight waters, homogenate can extremely pass through 120 mesh stainless (steel) wires, slurries are set and are placed 12 hours at 50 DEG C, then it is made to be mixed with clear cream obtained by step (1) and step (2), use 30% water dissolution of recipe quantity, stirs evenly；(4) mixing obtained by step (3) is added in the 20% water dissolution xylitol for using recipe quantity Liquid, stirring and dissolving add water to recipe quantity, filter, packing, and 120 DEG C of pressure sterilizings 20 minutes are to get in the combination of drink form Object.Per bottled 100ml.

Embodiment 4：Prepare oral solution composition

Formula：8 parts by weight of ginseng, 7 parts by weight of Cordyceps militaris, 5 parts by weight of prepared rehmannia root, 7 parts by weight of Herba Epimedii, Herba Cistanches 1.5 Parts by weight, 2.5 parts by weight of cervus elaphus linnaeus, 7 parts by weight of xylitol, water make gained oral solution feed intake per ginseng in 100ml in right amount Amount is 9g.

Preparation method：(1) people is participated in 7 times of water boiling and extraction 1.1 hours, leaching filtrate；Filter residue adds 4.5 times of water boiling and extractions 0.9 hour, leaching filtrate；Filter residue adds 4.5 times of water boiling and extractions 0.6 hour, leaching filtrate；Merging filtrate, it is concentrated into three/ One volume adds ethyl alcohol to alcohol content up to 75%, is mixed, and stands 24 hours；The filtrate of supernatant and deposit is taken, ethyl alcohol is recycled, Be concentrated to density up to 1.25~1.30 (40 DEG C) clear cream, it is spare；(2) prepared rehmannia root, Herba Epimedii, Herba Cistanches, cervus elaphus linnaeus is made to add 7 times Water impregnate 12 hours, then decoct extraction 1.5 hours, leaching filtrate；Filter residue adds 6 times of water boiling and extractions 0.6 hour, leaching filter Liquid；Filter residue adds 4.5 times of water boiling and extractions 1 hour, leaching filtrate；Merging filtrate is concentrated into one third volume, adds ethyl alcohol to containing Alcohol amount is mixed up to 75%, stands 24 hours；Take the filtrate of supernatant and deposit, recycle ethyl alcohol, be concentrated to density up to 1.25~ The clear cream of 1.30 (40 DEG C), it is spare；(3) Cordyceps militaris is uniformly mixed with 2.8 times of weight xylitols and 3 times of weight waters, homogenate is extremely It can be set at 50 DEG C and be placed 9 hours by 120 mesh stainless (steel) wires, slurries, then keep it mixed with clear cream obtained by step (1) and step (2) It closes, with 30% water dissolution of recipe quantity, stirs evenly；(4) the 20% water dissolution xylitol for using recipe quantity, is added step (3) institute Mixed liquor, stirring and dissolving adds water to recipe quantity, filters, packing, and 120 DEG C of pressure sterilizings 20 minutes are to get in drink form Composition.Per bottled 100ml.

Embodiment 5：Prepare oral solution composition

Formula：8 parts by weight of ginseng, 5 parts by weight of Cordyceps militaris, 7 parts by weight of prepared rehmannia root, 5 parts by weight of Herba Epimedii, Herba Cistanches 2.5 Parts by weight, 1.5 parts by weight of cervus elaphus linnaeus, 9 parts by weight of xylitol, water make gained oral solution feed intake per ginseng in 100ml in right amount Amount is 7g.

Preparation method：(1) people is participated in 6 times of water boiling and extraction 1.4 hours, leaching filtrate；Filter residue adds 5.5 times of water boiling and extractions 0.6 hour, leaching filtrate；Filter residue adds 5.5 times of water boiling and extractions 0.9 hour, leaching filtrate；Merging filtrate, it is concentrated into three/ One volume adds ethyl alcohol to alcohol content up to 70%, is mixed, and stands 24 hours；The filtrate of supernatant and deposit is taken, ethyl alcohol is recycled, Be concentrated to density up to 1.25~1.30 (40 DEG C) clear cream, it is spare；(2) prepared rehmannia root, Herba Epimedii, Herba Cistanches, cervus elaphus linnaeus is made to add 6 times Water impregnate 12 hours, then decoct extraction 1 hour, leaching filtrate；Filter residue adds 4 times of water boiling and extractions 0.8 hour, leaching filter Liquid；Filter residue adds 5.5 times of water boiling and extractions 0.5 hour, leaching filtrate；Merging filtrate is concentrated into one third volume, adds ethyl alcohol extremely Alcohol content is mixed up to 70%, stands 24 hours；The filtrate of supernatant and deposit is taken, ethyl alcohol is recycled, is concentrated to density up to 1.25 The clear cream of~1.30 (40 DEG C), it is spare；(3) Cordyceps militaris is uniformly mixed with 2.2 times of weight xylitols and 3 times of weight waters, is homogenized It can extremely be set at 50 DEG C and be placed 11 hours by 120 mesh stainless (steel) wires, slurries, then make itself and clear cream obtained by step (1) and step (2) Mixing, with 30% water dissolution of recipe quantity, stirs evenly；(4) the 20% water dissolution xylitol for using recipe quantity, is added step (3) Gained mixed liquor, stirring and dissolving add water to recipe quantity, filter, packing, and 120 DEG C of pressure sterilizings 20 minutes are to get in oral solution shape The composition of formula.Per bottled 100ml.

It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power Profit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims Variation is included within the present invention.

Claims

1. for the composition for inhibiting growth of tumour cell to improve cardiovascular and cerebrovascular microcirculation that slows down aging, by selected from following object Matter is made：Ginseng, Cordyceps militaris, prepared rehmannia root, Herba Epimedii, Herba Cistanches, cervus elaphus linnaeus and the acceptable carrier of optional physiology.

2. composition according to claim 1, by being made selected from following substance：8 parts by weight of ginseng, 4~8 weight of Cordyceps militaris Part, 4~8 parts by weight of prepared rehmannia root, 4~8 parts by weight of Herba Epimedii, 1~3 parts by weight of Herba Cistanches, 1~3 parts by weight of cervus elaphus linnaeus, Yi Jiren The acceptable carrier of physiology of choosing.

3. composition according to claim 1, by being made selected from following substance：8 parts by weight of ginseng, 5~7 weight of Cordyceps militaris Part, 5~7 parts by weight of prepared rehmannia root, 5~7 parts by weight of Herba Epimedii, 1.5~2.5 parts by weight of Herba Cistanches, 1.5~2.5 weight of cervus elaphus linnaeus Part and the acceptable carrier of optional physiology.

4. composition according to claim 1, by being made selected from following substance：8 parts by weight of ginseng, 6 parts by weight of Cordyceps militaris, 6 parts by weight of prepared rehmannia root, 6 parts by weight of Herba Epimedii, 2 parts by weight of Herba Cistanches, 2 parts by weight of cervus elaphus linnaeus and optional physiology can connect The carrier received.

5. composition according to claim 1, in the form of tablet or granule or oral solution.

6. composition according to claim 1, in the form of oral solution, wherein：

The acceptable carrier of physiology includes xylitol；

In terms of every 8 parts by weight ginseng, the amount of xylitol is 6~10 parts by weight, such as 7~9 parts by weight, such as 8 parts by weight；With/ Or

The inventory of ginseng is 6~10g, such as 7~9g, such as 8g in every 100ml oral solutions.

7. composition according to claim 1 in the form of oral solution, and is prepared into according to the method included the following steps It arrives：

(1) people is participated in 5~8 times of water boiling and extraction 1~1.5 hour, leaching filtrate；Filter residue adds 4~6 times of water boiling and extractions 0.5~1 hour, leaching filtrate；Filter residue adds 4~6 times of water boiling and extractions 0.5~1 hour, leaching filtrate；Merging filtrate is concentrated into One third volume adds ethyl alcohol to alcohol content up to 70~75%, is mixed, and stands 24 hours；The filtrate of supernatant and deposit is taken, Recycle ethyl alcohol, be concentrated to density up to 1.25~1.30 (40 DEG C) clear cream, it is spare；

(2) make prepared rehmannia root, Herba Epimedii, Herba Cistanches, cervus elaphus linnaeus that 5~8 times of water be added to impregnate 12 hours, then decoct extraction 1~1.5 Hour, leaching filtrate；Filter residue adds 4~6 times of water boiling and extractions 0.5~1 hour, leaching filtrate；Filter residue adds 4~6 times of water decoctions to carry It takes 0.5~1 hour, leaching filtrate；Merging filtrate is concentrated into one third volume, adds ethyl alcohol to alcohol content up to 70~75%, mixes , 24 hours are stood；The filtrate of supernatant and deposit is taken, ethyl alcohol is recycled, is concentrated to density up to 1.25~1.30 (40 DEG C) Clear cream, it is spare；

(3) Cordyceps militaris is uniformly mixed with 2~3 times of weight xylitols and 3 times of weight waters, homogenate can extremely pass through 120 mesh stainless steels Net, slurries are set and are placed 8~12 hours at 50 DEG C, then it is made to be mixed with clear cream obtained by step (1) and step (2), with recipe quantity 30% water dissolution, stirs evenly；

(4) the 20% water dissolution xylitol for using recipe quantity, is added mixed liquor obtained by step (3), and stirring and dissolving adds water to prescription Amount filters, packing, and 120 DEG C of pressure sterilizings 20 minutes are to get in the composition of drink form.

8. composition according to claim 7, wherein the water of the recipe quantity refers to making ginseng in every 100ml oral solutions Inventory is 6~10g, such as 7~9g, such as the water of the amount of 8g.

9. the method for preparing any one of claim 1~8 composition, the composition is in the form of oral solution, this method Include the following steps：

10. any one of claim 1~7 composition inhibits growth of tumour cell to improve heart and brain in preparation for slowing down aging Purposes in the product of blood vessel microcirculation.