CN108432955A - A kind of prevention weanling pig stress Chinese herbal and crude drugs preparations and preparation method thereof - Google Patents

A kind of prevention weanling pig stress Chinese herbal and crude drugs preparations and preparation method thereof Download PDF

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Publication number
CN108432955A
CN108432955A CN201810312381.5A CN201810312381A CN108432955A CN 108432955 A CN108432955 A CN 108432955A CN 201810312381 A CN201810312381 A CN 201810312381A CN 108432955 A CN108432955 A CN 108432955A
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parts
chinese herbal
crude drugs
drugs preparations
weanling pig
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赵凌平
谭世图
王占彬
王轶敏
孙平
赵芙蓉
樊文娜
武晓红
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Henan University of Science and Technology
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Henan University of Science and Technology
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/30Feeding-stuffs specially adapted for particular animals for swines
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K10/00Animal feeding-stuffs
    • A23K10/10Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/14Pretreatment of feeding-stuffs with enzymes
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K10/00Animal feeding-stuffs
    • A23K10/30Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/105Aliphatic or alicyclic compounds
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/158Fatty acids; Fats; Products containing oils or fats
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/20Inorganic substances, e.g. oligoelements
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/20Inorganic substances, e.g. oligoelements
    • A23K20/28Silicates, e.g. perlites, zeolites or bentonites
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/60Feeding-stuffs specially adapted for particular animals for weanlings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87Re-use of by-products of food processing for fodder production

Abstract

It is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations, by following parts by weight bulk pharmaceutical chemicals extraction be made:9 11 parts of the seed of Oriental arborvitae, 8 15 parts of wrinkled giant hyssop, 37 parts of folium isatidis, 38 parts of Radix Glycyrrhizae, 5 12 parts of hawthorn, 8 12 parts of Divine Comedy, 5 10 parts of dried orange peel, 10 18 parts of rhizoma atractylodis, 47 parts of fennel seeds, 48 parts of Chloranthus glaber, 5 11 parts of frutus cnidii, 8 12 parts of Radix Astragali.The present invention prevention weanling pig stress Chinese herbal and crude drugs preparations, it can adequately by tannin, albumen, organic acid, fat, ketone, alkaloid, phenol, polysaccharide and the glycoside material collection in traditional Chinese medicine ingredients and preserve, and it is come into full contact with substances such as digestive ferments in the digestive system of piglet, it is fully absorbed conducive to by animal, has both nutrition and medicinal function.It is remarkably improved the immune function and growth performance of weanling pig, improves physiological and biochemical index, adverse reaction caused by alleviating and avoiding weaning stress improves the growth rate of weanling pig.

Description

A kind of prevention weanling pig stress Chinese herbal and crude drugs preparations and preparation method thereof
Technical field
The invention belongs to field of feed additive technology, and in particular to it is a kind of prevention weanling pig stress Chinese herbal medicine system Agent.
Background technology
The usual early weaning of modern intensiveization pig raising causes the weaning stress of piglet syndrome up to 20 d or so.Wean Stress piglet spirit is depressed, loss of appetite, serious, body of having loose bowels become thin, lose flesh, survival rate reduces, efficiency of feed utilization is low, growth Slowly, arrest of development even forms cad pig.Simultaneously as diarrhea causes constitution to decline, immunity reduces, and easy secondary infection is a variety of Disease seriously threatens the sound development of pig breeding industry, causes a large amount of consumption of feed, veterinary drug, vaccine and manpower and materials.Breeding enterprise Generally use vaccine inoculation, addition feed addictive, reinforce environment temperature, humidity control and disinfection, addition antibiotic and The modes such as prebiotic mushroom drug inhibit weaned piglet to meet an urgent need syndrome, to establish good inside and outside environment, improve immune function And digestive function, promote feed digestion to absorb, improves the swinery speed of growth.
Extensively and profoundly with herbal medicine research, numerous studies are confirmed with stomach strengthening and digestion promoting, tranquilizing and allaying excitement, warming kidney and enhancing body, taste Yin and promoting production of body liquid, clearing heat and cooling blood, antibacterial anti-inflammatory function herbal medicine can effectively improve the digestive function and immunity function of animal, alleviate heat Stress and weaning stress.This is because:Tannin, albumen, organic acid, fat, ketone, alkaloid, phenol, polysaccharide in natural Chinese medicinal herb and The ingredients such as glycosides can improve animal body Physiology and biochemistry state and immune function after modern technologies are extracted, and improve meat and life Long performance has broad application prospects and market value to reduce aquaculture cost, increase economic efficiency.
Invention content
The purpose of the present invention is prepare a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations, which can fill Point will tannin, albumen, organic acid, fat, ketone, alkaloid, phenol, polysaccharide and the glycoside material collection in traditional Chinese medicine ingredients and preserve under Come, and come into full contact with substances such as digestive ferments in the digestive system of piglet, is fully absorbed conducive to by animal, have both nutrition and medicine Use function.After the Chinese herbal and crude drugs preparations are eaten as feed addictive by piglet, it is remarkably improved the digestive function of weanling pig, exempts from Epidemic disease function and growth performance improve physiological and biochemical index, alleviate and avoid adverse reaction caused by weaning stress, improve spiritual shape State improves the growth rate of weanling pig.
The technical solution adopted in the present invention is:It is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations, by following weight The bulk pharmaceutical chemicals extraction of number is made:9-11 parts of the seed of Oriental arborvitae, 8-15 parts of wrinkled giant hyssop, 3-7 parts of folium isatidis, 3-8 parts of Radix Glycyrrhizae, hawthorn 5-12 Part, 8-12 parts of Divine Comedy, 5-10 parts of dried orange peel, 10-18 parts of rhizoma atractylodis, 4-7 parts of fennel seeds, 4-8 parts of Chloranthus glaber, 5-11 parts of frutus cnidii, Huang 8-12 parts of stilbene.
Further, the prevention weanling pig stress Chinese herbal and crude drugs preparations, by following parts by weight bulk pharmaceutical chemicals extract system At:It is 10 parts of the seed of Oriental arborvitae, 12 parts of wrinkled giant hyssop, 5 parts of folium isatidis, 5 parts of Radix Glycyrrhizae, 8 parts of hawthorn, 10 parts of Divine Comedy, 7 parts of dried orange peel, 15 parts of rhizoma atractylodis, small 5 parts of fennel, 5 parts of Chloranthus glaber, 8 parts of frutus cnidii, 10 parts of Radix Astragali.
Further, during powder obtained need to be coated on and is made on pretreated zeolite granular after bulk pharmaceutical chemicals extraction Herbal medicinal product.
Further, the grain size of the zeolite granular is 0.5-4 ㎜.
It is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations preparation method, include the following steps:
Step 1: the preparation of zeolite granular
A takes zeolite materials to be ground into the feed particles that grain size is 0.5-2 ㎝ and feed particles is placed in acidic activated liquid later Activation process 1.5-2.5h is carried out, after taking-up is dried, is placed in progress calcination 25-30min under 650-750 DEG C of temperature condition, later, Transposition carries out the cooling 20-30min that impregnates in absolute ethyl alcohol and carries out drying and processing, and be ground into grain size and be after filtering taking-up The particle of 0.5-4 ㎜, it is spare;
Particle after b crushes step a is placed in the CaO powder that can be flooded, and after being thoroughly mixed, is screened out Grain, and transposition carries out oscillation treatment 10-20min in processor for ultrasonic wave, and zeolite granular is made, it is spare;
Step 2: the preparation of Chinese medical extract dry powder
A weighs the seed of Oriental arborvitae, wrinkled giant hyssop, folium isatidis, Radix Glycyrrhizae, hawthorn, Divine Comedy, dried orange peel, rhizoma atractylodis, fennel fruit respectively according to above-mentioned parts by weight Perfume, Chloranthus glaber, frutus cnidii and Radix Astragali, which are put into micronizer, carries out ultramicro grinding, later, crosses 70-90 mesh sieve, is mixed Powder, low temperature drying preserves, spare;
It is molten to be added to the ethyl alcohol that mass concentration is 55-65% according to the solid-liquid ratio of 1g/20mL by b for mixed-powder made from step a In liquid, and cellulase, pectase and zytase are added thereto, after being sufficiently mixed, in 45-55 DEG C of thermostat water bath Enzymolysis processing 0.8-1.2 h are carried out, enzymolysis liquid is made, it is spare;
It is 45-55 DEG C, power 250-280W that enzymolysis liquid made from step b is placed in temperature by c, and frequency is the ultrasound of 20-30kHz Ultrasonic extraction 0.8-1.5 h are carried out in extractor;
D by after step c ultrasonic extractions gained liquid be placed in 45-55 DEG C, pressure be 0.07-0.1 atmospheric pressure environmental condition under Vacuum rotary steam is carried out, extract concentrated solution is made, it is spare;
E is spray-dried extract concentrated solution made from step d, Chinese medical extract dry powder is made, low temperature drying preserves, standby With;
Step 3: the preparation of Chinese herbal and crude drugs preparations
According to 1:The weight proportion of 2.4-3.2 weighs Chinese medicine made from zeolite granular made from step 1 and step 2 and carries respectively Object dry powder is taken, later, the liquid fat of 0.2-0.3 times of its quality is added into the Chinese medical extract dry powder weighed, fully stirs After mixing mixing, which is uniformly adhered on zeolite granular by the bur that thick-pasty is made later, after dry, i.e., Obtain finished product Chinese herbal and crude drugs preparations.
Further, in step 1, the acidic activated liquid is by the acetum and matter that mass concentration is 40-50% The hydrochloric acid solution of a concentration of 30-35% is measured according to 2:1 volume ratio is mixed, and in the mixed liquor also be added with stearic acid and Ammonium chloride, wherein stearic weight addition proportioning is 0.3-0.4%, the weight addition proportioning of ammonium chloride is 0.8-1.1%.
Further, in step 1, the feed particles carry out to be surpassed when activation process in acidic activated liquid Processing 20-30min is swung in acoustic shock.
Further, the ultrasonic power of the ultrasonic vibration processing is 50-60KHz.
Further, in step 1, after the feed particles calcination need in 1-2min transposition in ethanol solution into Row is cooling to be impregnated.
Further, in step 2, the addition between the cellulase, pectase and zytase and mixed-powder Relationship is respectively 20 μ g/g, 100 μ g/g and 10 μ g/g.
The Chinese herbal and crude drugs preparations of the present invention are when for feeding weanling pig, in the agent of first week Chinese herbal and crude drugs preparations addition of weaning Amount is the 1% of feed total weight, and the dosage of second week Chinese herbal and crude drugs preparations addition later is the 2% of feed total weight, third Zhou Yihou The dosage of Chinese herbal and crude drugs preparations addition is the 3% of feed total weight.
Advantageous effect:
1, Chinese herbal and crude drugs preparations prepared by the present invention have effects that Appetizing spleen-tonifying, improve body's immunity, warming kidney and enhancing body, at The ingredients such as tannin, albumen, organic acid, fat, ketone, alkaloid, phenol, polysaccharide, vitamin and the glycosides contained in point can carry for piglet For nutritional supplementation, drug and trophism are had concurrently.Piglet immunity of organisms and digestive function are effectively increased, the abdomen of piglet is reduced Rate and incidence are rushed down, growth performance is improved.Meanwhile Chinese medicine preparation raw material also has green natural, safety non-pollution, without residual Stay, be free of preservative, it is harmless to carcass the advantages that.
2, in traditional Chinese medicine ingredients of the invention, containing the volatile oil and saponin for extracting from the seed of Oriental arborvitae, there is mental-tranquilization and profit The effect of intestines defaecation.Estragole, anisole, anisaldehyde, (R)-4-isopropenyl-1-methyl-1-cyclohexene and the p- methoxyl group cinnaldehydrum contained in wrinkled giant hyssop Deng having and eliminate dampness with aromatics and middle preventing or arresting vomiting, deliver relieving summer-heat and antibacterial, sterilizing function.The alkaloid of folium isatidis, organic acid, glycosides and The Trace Elements such as zinc, iron and calcium have resisiting influenza virus, antibacterial, antiendotoxin and immunological enhancement.Contain in Radix Glycyrrhizae There are glycyrrhizic acid, liquiritin, enoxolone, liquiritin and isoliquiritin etc., there is clearing heat and detoxicating and spleen stomach invigorating, anti-inflammatory and anti-mistake Quick function.Hawthorn contains flavones, organic acid, Vitexin, Quercetin, vitamin C and vitamin B2Deng with reducing blood lipid, blood The effects that pressure, cardiac stimulant, arrhythmia, spleen benefiting and stimulating the appetite, relieving dyspepsia and phlegm reduction of blood circulation promoting.The saccharomycete that contains in Divine Comedy, enzyme, The ingredients such as vitamin B complex, ergosterol, volatile oil and glycoside play the role of promoting digestion and improve appetite.Dried orange peel contains The ingredients such as volatile oil, flavones, alkaloid and polysaccharide have appetizing, eliminating dampness and eliminating phlegm and antibacterial anti-inflammatory work in regulating QI and lowering the adverseness, tune With.Rhizoma atractylodis contain the ingredients such as hinesol, elemol, atractylone and celery dienone, have drying damp and strengthening spleen, expelling wind and clearing away cold, resist and burst The effects that ulcer, tranquilizing and allaying excitement, liver protection, anti-inflammatory and antibacterial.Fennel seeds contain anisole, fenchone, anisaldehyde and stigmasterol etc. at Point, there is eliminating cold to stop pain and regulating qi-flowing for harmonizing stomach effect.Chloranthus glaber contains the ingredient of fumaric acid, succinic acid, glycosides displayed and tannin, tool There is the effects that antibacterial anti-inflammatory, dispelling wind and eliminating dampness and promoting blood circulation and stopping pain.Frutus cnidii contain firpene, amphene, bornival, isoborneol and The ingredients such as osthole have the function of warming kidney and enhancing body, anti-arrhythmia, enhancing immune function and broad-spectrum antiseptic.Radix Astragali Saponin(e, flavones, polysaccharide and amino acid etc., have enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, decompression and Wide antibacterial action.12 taste Chinese medicine scientific compatibilities, complement each other, have complementary advantages, bring out the best in each other, fundamentally improve and The growth performance for improving piglet, adverse reaction caused by alleviating and avoiding weaning stress improve its state of mind, improve The growth rate and physical function of weanling pig.
3, Chinese herbal and crude drugs preparations of the invention crush Chinese medicine material using micronizer, combined-enzyme method decomposes, ultrasound carries Take with Rotary Evaporators be concentrated under reduced pressure, spray drying etc. composition operations extracting mode, retain and be enriched Chinese medicine to greatest extent In effective pharmaceutical component and nutriment, and by its small molecule as far as possible, in favor of the weaker piglet of digestive system into Row effectively absorbs.Meanwhile Chinese medical extract has given up the larger wood fibre ingredient of volume in woody herbal medicine, to reduce medicine With the volume of ingredient, reduces transport and preserve cost, improve the economic benefit of aquaculture.
4, preparation method of the invention, it is unique that inside and outside clad type structure has been made in Chinese medicine preparation, wherein Chinese medicine preparation Outer layer wrap up in it is attached be with stress regulatory function Chinese herbal medicine extract component, and the kernel of Chinese medicine preparation package be have compared with The zeolite of strong adsorption function.The stronger adsorption capacity of zeolite itself and larger specific surface area can be Chinese herbal medicine extract component More bond area is provided, and it is firmly adsorbed on zeolite surface, makes Chinese medicine preparation energy in the digestive system of piglet It is enough gradually to be come into full contact with endogenous substances such as digestive ferments, the utilization rate of traditional Chinese medicine ingredients is improved, and can be preferably by piglet Absorb and realize medicinal effects.Wait for that the traditional Chinese medicine extraction component of zeolite surface is completely absorbed in digestive system, converts and utilizes Afterwards, granular zeolite is arrived substantially in the enteron aisle organ and excretory organs of piglet, at this point, exposed zeolite will utilize Absorption, screening and the cation and anion exchange function of its own inhale the bacterium substance in intestine of young pigs, heavy metal substance Situations such as echoing ion infiltration, eliminating bacterium in intestine of young pigs to play, purify the function of enteron aisle, avoid grice diarrhoea Occur, and ensure that the acid-base balance of piglet digestive system, improves the premunition and physical function of piglet.
5, preparation method of the invention is provided with pair in the preparation process of Chinese herbal and crude drugs preparations inner core materials zeolite granular Zeolite carries out activation process, the step of high temperature sintering and solution cooling.Acidic activated liquid energy by uniqueness allotment is enough to zeolite Etched inside and surface modified active are carried out, makes the inside of zeolite that there is the specific surface area in more apertures and bigger.Subsequently into Capable high temperature sintering can not only remove the crystallization water in rack-like structural zeolite to greatest extent, be conducive to subsequent oxidation calcium in zeolite Internal seals up for safekeeping, additionally it is possible to make expanded foamed on zeolite recurring structure, further increase the bore clearance of zeolite interior, increase Its specific surface area and Adsorption and Sterilization ability.And the processing that ethanol solution cooling immediately is impregnated after high temperature sintering can make in zeolite Crystal solidification, sizing, and the impurity in zeolite granular aperture is promoted to fall off, dispel out of aperture after shrinkage, it further increases The aperture rate of zeolite interior, improves its adsorption capacity.
6, Chinese herbal and crude drugs preparations prepared by the present invention, are attached with CaO powder, CaO powder on pretreated zeolite granular After being mixed with zeolite granular, a degree of filling can be carried out to the aperture inside zeolite granular, make the inside of zeolite granular It is coated with CaO ingredients.The zeolite granular that inside filling is coated with CaO powder wraps up in attached middle school's herbal medicine extract component on surface layer, and young Pig after intake, can smoothly absorb water, and exothermic reaction occurs in the digestive system of piglet.Heat caused by the exothermic reaction The digestive ferment in animal body can not only be activated, accelerates the absorption to medicinal ingredient outside Chinese medicine preparation, additionally it is possible to Chinese medicine system The medicinal ingredient of agent outer layer is heated, its volatilization and small moleculeization is promoted to decompose, it is made to be more easy to the absorption of more animal body.Together When, the calcium hydroxide that is generated after CaO and water exothermic reaction, additionally it is possible to after zeolite granular adsorbs bacterium, structure be carried out to bacterium It destroys and corrodes, to play bactericidal effect.
7, in preparation method of the invention, after CaO powder is mixed with zeolite granular, the operation of supersonic oscillations processing, energy It is enough to be attached to CaO powder inside the aperture of zeolite granular by the way that high-frequency vibration effect is firm, and extra CaO powder is shaken It falls, be detached from zeolite granular, when avoiding CaO powder excessive, the corrosion of animal body is injured.Meanwhile in order to avoid zeolite granular Contact and deliquescence of the internal CaO powder with moisture in air cause its failure, and the application is unique to mix medium-height grass using liquid fat Medicament extract powder carries out the cladding outside zeolite granular, and the internal zeolite granular surface for sealing CaO powder up for safekeeping is made to obtain grease Closing, only after the digestive ferment of internal animal is digested and assimilated, CaO could react with water in body, discharge its heat, and Play function.
Specific implementation mode
To make present disclosure be clearer and more comprehensible, below in conjunction with specific embodiment, the present invention will be described in detail.
It is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations, by following parts by weight bulk pharmaceutical chemicals extraction be made:Cedar seed It is 9-11 parts of benevolence, 8-15 parts of wrinkled giant hyssop, 3-7 parts of folium isatidis, 3-8 parts of Radix Glycyrrhizae, 5-12 parts of hawthorn, 8-12 parts of Divine Comedy, 5-10 parts of dried orange peel, grey 10-18 parts of art, 4-7 parts of fennel seeds, 4-8 parts of Chloranthus glaber, 5-11 parts of frutus cnidii, 8-12 parts of Radix Astragali.
Further, the prevention weanling pig stress Chinese herbal and crude drugs preparations, by following parts by weight bulk pharmaceutical chemicals extract system At:It is 10 parts of the seed of Oriental arborvitae, 12 parts of wrinkled giant hyssop, 5 parts of folium isatidis, 5 parts of Radix Glycyrrhizae, 8 parts of hawthorn, 10 parts of Divine Comedy, 7 parts of dried orange peel, 15 parts of rhizoma atractylodis, small 5 parts of fennel, 5 parts of Chloranthus glaber, 8 parts of frutus cnidii, 10 parts of Radix Astragali.
Further, during powder obtained need to be coated on and is made on pretreated zeolite granular after bulk pharmaceutical chemicals extraction Herbal medicinal product.
Further, the grain size of the zeolite granular is 0.5-4 ㎜.
It is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations preparation method, include the following steps:
Step 1: the preparation of zeolite granular
A takes zeolite materials to be ground into the feed particles that grain size is 0.5-2 ㎝ and feed particles is placed in acidic activated liquid later Activation process 1.5-2.5h is carried out, after taking-up is dried, is placed in progress calcination 25-30min under 650-750 DEG C of temperature condition, later, Transposition carries out the cooling 20-30min that impregnates in absolute ethyl alcohol and carries out drying and processing, and be ground into grain size and be after filtering taking-up The particle of 0.5-4 ㎜, it is spare;
Particle after b crushes step a is placed in the CaO powder that can be flooded, and after being thoroughly mixed, is screened out Grain, and transposition carries out oscillation treatment 10-20min in processor for ultrasonic wave, and zeolite granular is made, it is spare;
Step 2: the preparation of Chinese medical extract dry powder
A weighs the seed of Oriental arborvitae, wrinkled giant hyssop, folium isatidis, Radix Glycyrrhizae, hawthorn, Divine Comedy, dried orange peel, rhizoma atractylodis, fennel fruit respectively according to above-mentioned parts by weight Perfume, Chloranthus glaber, frutus cnidii and Radix Astragali, which are put into micronizer, carries out ultramicro grinding, later, crosses 70-90 mesh sieve, is mixed Powder, low temperature drying preserves, spare;
It is molten to be added to the ethyl alcohol that mass concentration is 55-65% according to the solid-liquid ratio of 1g/20mL by b for mixed-powder made from step a In liquid, and cellulase, pectase and zytase are added thereto, after being sufficiently mixed, in 45-55 DEG C of thermostat water bath Enzymolysis processing 0.8-1.2 h are carried out, enzymolysis liquid is made, it is spare;
It is 45-55 DEG C, power 250-280W that enzymolysis liquid made from step b is placed in temperature by c, and frequency is the ultrasound of 20-30kHz Ultrasonic extraction 0.8-1.5 h are carried out in extractor;
D by after step c ultrasonic extractions gained liquid be placed in 45-55 DEG C, pressure be 0.07-0.1 atmospheric pressure environmental condition under Vacuum rotary steam is carried out, extract concentrated solution is made, it is spare;
E is spray-dried extract concentrated solution made from step d, Chinese medical extract dry powder is made, low temperature drying preserves, standby With;
Step 3: the preparation of Chinese herbal and crude drugs preparations
According to 1:The weight proportion of 2.4-3.2 weighs Chinese medicine made from zeolite granular made from step 1 and step 2 and carries respectively Object dry powder is taken, later, the liquid fat of 0.2-0.3 times of its quality is added into the Chinese medical extract dry powder weighed, fully stirs After mixing mixing, which is uniformly adhered on zeolite granular by the bur that thick-pasty is made later, after dry, i.e., Obtain finished product Chinese herbal and crude drugs preparations.
Further, in step 1, the acidic activated liquid is by the acetum and matter that mass concentration is 40-50% The hydrochloric acid solution of a concentration of 30-35% is measured according to 2:1 volume ratio is mixed, and in the mixed liquor also be added with stearic acid and Ammonium chloride, wherein stearic weight addition proportioning is 0.3-0.4%, the weight addition proportioning of ammonium chloride is 0.8-1.1%.
Further, in step 1, the feed particles carry out to be surpassed when activation process in acidic activated liquid Processing 20-30min is swung in acoustic shock.
Further, the ultrasonic power of the ultrasonic vibration processing is 50-60KHz.
Further, in step 1, after the feed particles calcination need in 1-2min transposition in ethanol solution into Row is cooling to be impregnated.
Further, in step 2, the addition between the cellulase, pectase and zytase and mixed-powder Relationship is respectively 20 μ g/g, 100 μ g/g and 10 μ g/g.
The Chinese herbal and crude drugs preparations of the present invention are when for feeding weanling pig, in the agent of first week Chinese herbal and crude drugs preparations addition of weaning Amount is the 1% of feed total weight, and the dosage of second week Chinese herbal and crude drugs preparations addition later is the 2% of feed total weight, third Zhou Yihou The dosage of Chinese herbal and crude drugs preparations addition is the 3% of feed total weight.
After the Chinese herbal and crude drugs preparations of the present invention are eaten as feed addictive by piglet, it is remarkably improved the digestion of weanling pig Function, immune function and growth performance, improve physiological and biochemical index, and adverse reaction caused by alleviating and avoiding weaning stress changes The kind state of mind, improves the growth rate of weanling pig.
Embodiment 1:
It is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations, by following parts by weight bulk pharmaceutical chemicals extraction be made:The seed of Oriental arborvitae 10 Part, 12 parts of wrinkled giant hyssop, 5 parts of folium isatidis, 5 parts of Radix Glycyrrhizae, 8 parts of hawthorn, 10 parts of Divine Comedy, 7 parts of dried orange peel, 15 parts of rhizoma atractylodis, 5 parts of fennel seeds, grass 5 parts of coral, 8 parts of frutus cnidii, 10 parts of Radix Astragali.
It is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations preparation method, include the following steps:
Step 1: the preparation of zeolite granular
A takes zeolite materials to be ground into the feed particles that grain size is 1 ㎝ and feed particles is placed in acidic activated liquid and are carried out later Activation process 2h after taking-up is dried, is placed in progress calcination 27min under 700 DEG C of temperature conditions, later, transposition is in nothing in 1min The cooling 30min that impregnates is carried out in water-ethanol and carries out drying and processing after filtering taking-up, and is ground into the particle that grain size is 2 ㎜, it is standby With;
Wherein, the hydrochloric acid solution that the acetum and mass concentration that the acidic activated liquid is 45% by mass concentration are 32% by According to 2:1 volume ratio is mixed, and stearic acid and ammonium chloride are also added in the mixed liquor, stearic weight addition proportioning It is 0.35%, the weight addition proportioning of ammonium chloride is 0.9%.The feed particles carry out needing when activation process in acidic activated liquid It carries out ultrasonic vibration and handles 30min.The ultrasonic power of the ultrasonic vibration processing is 60KHz.
Particle after b crushes step a is placed in the CaO powder that can be flooded, and after being thoroughly mixed, is screened out Particle, and transposition carries out oscillation treatment 20min in processor for ultrasonic wave, and zeolite granular is made, it is spare;
Step 2: the preparation of Chinese medical extract dry powder
A weighs the seed of Oriental arborvitae, wrinkled giant hyssop, folium isatidis, Radix Glycyrrhizae, hawthorn, Divine Comedy, dried orange peel, rhizoma atractylodis, fennel fruit respectively according to above-mentioned parts by weight Perfume, Chloranthus glaber, frutus cnidii and Radix Astragali, which are put into micronizer, carries out ultramicro grinding, later, crosses 80 mesh sieve, obtains mixed powder End, low temperature drying preserves, spare;
Mixed-powder made from step a is added to the ethanol solution that mass concentration is 60% by b according to the solid-liquid ratio of 1g/20mL In, and add cellulase, pectase and zytase thereto, wherein cellulase, pectase and zytase with mix Addition relationship between powder is respectively 20 μ g/g, 100 μ g/g and 10 μ g/g, after being sufficiently mixed, in 50 DEG C of thermostat water baths 1 h of enzymolysis processing is carried out, enzymolysis liquid is made, it is spare;
C by enzymolysis liquid made from step b be placed in temperature be 50 DEG C, power 260W, frequency be 26kHz ultrasonic extraction tank in into 1 h of row ultrasonic extraction;
D by after step c ultrasonic extractions gained liquid be placed in 50 DEG C, pressure be 0.08 atmospheric pressure environmental condition under depressurize Extract concentrated solution is made in revolving, spare;
E is spray-dried extract concentrated solution made from step d, Chinese medical extract dry powder is made, low temperature drying preserves, standby With;
Step 3: the preparation of Chinese herbal and crude drugs preparations
According to 1:2.8 weight proportion weighs Chinese medical extract made from zeolite granular made from step 1 and step 2 respectively The liquid fat of 0.25 times of its quality is added into the Chinese medical extract dry powder weighed, is thoroughly mixed later for dry powder Afterwards, which is uniformly adhered on zeolite granular by the bur that thick-pasty is made later, to get finished product after drying Chinese herbal and crude drugs preparations.
The Chinese herbal and crude drugs preparations of the present invention are when for feeding weanling pig, in the agent of first week Chinese herbal and crude drugs preparations addition of weaning Amount is the 1% of feed total weight, and the dosage of second week Chinese herbal and crude drugs preparations addition later is the 2% of feed total weight, third Zhou Yihou The dosage of Chinese herbal and crude drugs preparations addition is the 3% of feed total weight.
Embodiment 2:
It is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations, by following parts by weight bulk pharmaceutical chemicals extraction be made:The seed of Oriental arborvitae 9 Part, 15 parts of wrinkled giant hyssop, 7 parts of folium isatidis, 3 parts of Radix Glycyrrhizae, 5 parts of hawthorn, 12 parts of Divine Comedy, 10 parts of dried orange peel, 10 parts of rhizoma atractylodis, 7 parts of fennel seeds, grass 8 parts of coral, 5 parts of frutus cnidii, 8 parts of Radix Astragali.
It is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations preparation method, include the following steps:
Step 1: the preparation of zeolite granular
A takes zeolite materials to be ground into the feed particles that grain size is 2 ㎝ and feed particles is placed in acidic activated liquid and are carried out later Activation process 1.5h after taking-up is dried, is placed under 750 DEG C of temperature conditions progress calcination 25min, later, in 2min transposition in The cooling 20min that impregnates is carried out in absolute ethyl alcohol and carries out drying and processing after filtering taking-up, and is ground into that grain size is 0.5 ㎜ Grain, it is spare;
Wherein, the hydrochloric acid solution that the acetum and mass concentration that the acidic activated liquid is 50% by mass concentration are 30% by According to 2:1 volume ratio is mixed, and stearic acid and ammonium chloride are also added in the mixed liquor, stearic weight addition proportioning It is 0.4%, the weight addition proportioning of ammonium chloride is 0.8%.The feed particles carry out needing when activation process in acidic activated liquid It carries out ultrasonic vibration and handles 20min.The ultrasonic power of the ultrasonic vibration processing is 50KHz.
Particle after b crushes step a is placed in the CaO powder that can be flooded, and after being thoroughly mixed, is screened out Particle, and transposition carries out oscillation treatment 10min in processor for ultrasonic wave, and zeolite granular is made, it is spare;
Step 2: the preparation of Chinese medical extract dry powder
A weighs the seed of Oriental arborvitae, wrinkled giant hyssop, folium isatidis, Radix Glycyrrhizae, hawthorn, Divine Comedy, dried orange peel, rhizoma atractylodis, fennel fruit respectively according to above-mentioned parts by weight Perfume, Chloranthus glaber, frutus cnidii and Radix Astragali, which are put into micronizer, carries out ultramicro grinding, later, crosses 70 mesh sieve, obtains mixed powder End, low temperature drying preserves, spare;
Mixed-powder made from step a is added to the ethanol solution that mass concentration is 55% by b according to the solid-liquid ratio of 1g/20mL In, and add cellulase, pectase and zytase thereto, wherein cellulase, pectase and zytase with mix Addition relationship between powder is respectively 20 μ g/g, 100 μ g/g and 10 μ g/g, after being sufficiently mixed, in 55 DEG C of thermostat water baths 1.2 h of enzymolysis processing is carried out, enzymolysis liquid is made, it is spare;
C by enzymolysis liquid made from step b be placed in temperature be 45 DEG C, power 280W, frequency be 30kHz ultrasonic extraction tank in into 1.5 h of row ultrasonic extraction;
D by after step c ultrasonic extractions gained liquid be placed in 55 DEG C, pressure be 0.07 atmospheric pressure environmental condition under depressurize Extract concentrated solution is made in revolving, spare;
E is spray-dried extract concentrated solution made from step d, Chinese medical extract dry powder is made, low temperature drying preserves, standby With;
Step 3: the preparation of Chinese herbal and crude drugs preparations
According to 1:2.4 weight proportion weighs Chinese medical extract made from zeolite granular made from step 1 and step 2 respectively The liquid fat of 0.3 times of its quality is added into the Chinese medical extract dry powder weighed later for dry powder, after being thoroughly mixed, The bur is uniformly adhered on zeolite granular by the bur that thick-pasty is made later, to get in finished product after drying Herbal medicinal product.
The Chinese herbal and crude drugs preparations of the present invention are when for feeding weanling pig, in the agent of first week Chinese herbal and crude drugs preparations addition of weaning Amount is the 1% of feed total weight, and the dosage of second week Chinese herbal and crude drugs preparations addition later is the 2% of feed total weight, third Zhou Yihou The dosage of Chinese herbal and crude drugs preparations addition is the 3% of feed total weight.
Embodiment 3:
It is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations, by following parts by weight bulk pharmaceutical chemicals extraction be made:The seed of Oriental arborvitae 11 Part, 8 parts of wrinkled giant hyssop, 3 parts of folium isatidis, 8 parts of Radix Glycyrrhizae, 12 parts of hawthorn, 8 parts of Divine Comedy, 5 parts of dried orange peel, 18 parts of rhizoma atractylodis, 4 parts of fennel seeds, careless coral 4 parts of coral, 11 parts of frutus cnidii, 12 parts of Radix Astragali.
It is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations preparation method, include the following steps:
Step 1: the preparation of zeolite granular
A take zeolite materials be ground into grain size be 0.5 ㎝ feed particles, later, by feed particles be placed in acidic activated liquid into Row activation process 2.5h after taking-up is dried, is placed in progress calcination 30min under 650 DEG C of temperature conditions, later, turns in 1.5min It is placed in absolute ethyl alcohol and carries out cooling immersion 25min, after filtering is taken out, carry out drying and processing, and be ground into that grain size is 4 ㎜ Grain, it is spare;
Wherein, the hydrochloric acid solution that the acetum and mass concentration that the acidic activated liquid is 40% by mass concentration are 35% by According to 2:1 volume ratio is mixed, and stearic acid and ammonium chloride are also added in the mixed liquor, stearic weight addition proportioning It is 0.3%, the weight addition proportioning of ammonium chloride is 1.1%.The feed particles carry out needing when activation process in acidic activated liquid It carries out ultrasonic vibration and handles 25min.The ultrasonic power of the ultrasonic vibration processing is 55KHz.
Particle after b crushes step a is placed in the CaO powder that can be flooded, and after being thoroughly mixed, is screened out Particle, and transposition carries out oscillation treatment 15min in processor for ultrasonic wave, and zeolite granular is made, it is spare;
Step 2: the preparation of Chinese medical extract dry powder
A weighs the seed of Oriental arborvitae, wrinkled giant hyssop, folium isatidis, Radix Glycyrrhizae, hawthorn, Divine Comedy, dried orange peel, rhizoma atractylodis, fennel fruit respectively according to above-mentioned parts by weight Perfume, Chloranthus glaber, frutus cnidii and Radix Astragali, which are put into micronizer, carries out ultramicro grinding, later, crosses 90 mesh sieve, obtains mixed powder End, low temperature drying preserves, spare;
Mixed-powder made from step a is added to the ethanol solution that mass concentration is 65% by b according to the solid-liquid ratio of 1g/20mL In, and add cellulase, pectase and zytase thereto, wherein cellulase, pectase and zytase with mix Addition relationship between powder is respectively 20 μ g/g, 100 μ g/g and 10 μ g/g, after being sufficiently mixed, in 45 DEG C of thermostat water baths 0.8 h of enzymolysis processing is carried out, enzymolysis liquid is made, it is spare;
C by enzymolysis liquid made from step b be placed in temperature be 55 DEG C, power 250W, frequency be 20kHz ultrasonic extraction tank in into 0.8 h of row ultrasonic extraction;
D by after step c ultrasonic extractions gained liquid be placed in 45 DEG C, pressure be 0.1 atmospheric pressure environmental condition under depressurize Extract concentrated solution is made in revolving, spare;
E is spray-dried extract concentrated solution made from step d, Chinese medical extract dry powder is made, low temperature drying preserves, standby With;
Step 3: the preparation of Chinese herbal and crude drugs preparations
According to 1:3.2 weight proportion weighs Chinese medical extract made from zeolite granular made from step 1 and step 2 respectively The liquid fat of 0.2 times of its quality is added into the Chinese medical extract dry powder weighed later for dry powder, after being thoroughly mixed, The bur is uniformly adhered on zeolite granular by the bur that thick-pasty is made later, to get in finished product after drying Herbal medicinal product.
The Chinese herbal and crude drugs preparations of the present invention are when for feeding weanling pig, in the agent of first week Chinese herbal and crude drugs preparations addition of weaning Amount is the 1% of feed total weight, and the dosage of second week Chinese herbal and crude drugs preparations addition later is the 2% of feed total weight, third Zhou Yihou The dosage of Chinese herbal and crude drugs preparations addition is the 3% of feed total weight.
Related experiment and its data statistics:
Using the weanling pig prepared by the embodiment of the present invention 1 stress Chinese herbal and crude drugs preparations, in Luoyang, herding company is to this feeding The effect of feed additives carries out contrast test:
150 weanling pigs are selected, three groups, respectively test group, control group and blank group, the identical feeding of three groups of feedings are divided into Material, test group adds the Chinese herbal and crude drugs preparations prepared of the invention as feed addictive in the feed of feeding, control group fed Normal diet additive is added in feed, and feed addictive is not added in the pig starter feed of blank group feeding.Test group and control It is the 1% of feed total weight in the dosage for first week Chinese herbal and crude drugs preparations addition of weaning, after second week when group feeding weanling pig The dosage of Chinese herbal and crude drugs preparations addition is the 2% of feed total weight, and the dosage of third Zhou Yihou Chinese herbal and crude drugs preparations addition is feed gross weight The 3% of amount.
Then weanling pig is allowed normally to be raised as far as possible in the identical environment of other conditions, statistical test was grown The average daily gain of piglet, average daily gain and average sick rate in journey, wherein averagely sick rate be all sick numbers with The ratio of piglet quantity.Through statistics, the results are shown in Table 1:
Table 1:
Index group Average daily gain(g) Average daily gain(g) Average diarrhea rate(%) Average sick rate(%)
Test group 650.28 445.72 0% 5%
Control group 590.63 395.36 10% 15%
Blank group 490.41 327.53 34% 42%
From the above data, the average daily gain of the piglet of test group and average daily gain are compared with control group and blank group Height, average sick rate is significant lower, and diarrhea rate is even directly reduced to zero.Chinese herbal and crude drugs preparations additive prepared by the present invention contains Ketone, alkaloid, phenol, polysaccharide, glycosides, etc. ingredients, have the double action of nutriment and drug concurrently.The feed addictive can be improved disconnected Digestive function, immune function and the growth performance of milk piglet, improve physiological and biochemical index, and alleviation weaning stress is brought bad anti- It answers, reduces weaning stress harmful effect caused by piglet, enhancing piglet adapts to the ability and the state of mind of environment, improves piglet Growth performance.
This feed addictive can also be applied to other domestic animals.
The above is presently preferred embodiments of the present invention, and not to limit the present invention, all design, preparations in the present invention are former The processing such as any modification, replacement, improvement in then should all be included in the protection scope of the present invention.

Claims (10)

1. it is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations, which is characterized in that by following parts by weight bulk pharmaceutical chemicals extract It is made:9-11 parts of the seed of Oriental arborvitae, 8-15 parts of wrinkled giant hyssop, 3-7 parts of folium isatidis, 3-8 parts of Radix Glycyrrhizae, 5-12 parts of hawthorn, 8-12 parts of Divine Comedy, dried orange peel 5-10 parts, 10-18 parts of rhizoma atractylodis, 4-7 parts of fennel seeds, 4-8 parts of Chloranthus glaber, 5-11 parts of frutus cnidii, 8-12 parts of Radix Astragali.
2. it is according to claim 1 it is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations, which is characterized in that by following heavy The bulk pharmaceutical chemicals extraction of amount number is made:10 parts of the seed of Oriental arborvitae, 12 parts of wrinkled giant hyssop, 5 parts of folium isatidis, 5 parts of Radix Glycyrrhizae, 8 parts of hawthorn, Divine Comedy 10 Part, 7 parts of dried orange peel, 15 parts of rhizoma atractylodis, 5 parts of fennel seeds, 5 parts of Chloranthus glaber, 8 parts of frutus cnidii, 10 parts of Radix Astragali.
3. it is according to claim 1 it is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations, it is characterised in that:The raw material Powder obtained, which need to be coated on pretreated zeolite granular, after medicine extraction is made Chinese herbal and crude drugs preparations.
4. it is according to claim 3 it is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations, it is characterised in that:The zeolite The grain size of particle is 0.5-4 ㎜.
5. it is according to claim 3 or 4 it is a kind of prevention weanling pig stress Chinese herbal and crude drugs preparations preparation method, feature It is, includes the following steps:
Step 1: the preparation of zeolite granular
A takes zeolite materials to be ground into the feed particles that grain size is 0.5-2 ㎝ and feed particles is placed in acidic activated liquid later Activation process 1.5-2.5h is carried out, after taking-up is dried, is placed in progress calcination 25-30min under 650-750 DEG C of temperature condition, later, Transposition carries out the cooling 20-30min that impregnates in absolute ethyl alcohol and carries out drying and processing, and be ground into grain size and be after filtering taking-up The particle of 0.5-4 ㎜, it is spare;
Particle after b crushes step a is placed in the CaO powder that can be flooded, and after being thoroughly mixed, is screened out Grain, and transposition carries out oscillation treatment 10-20min in processor for ultrasonic wave, and zeolite granular is made, it is spare;
Step 2: the preparation of Chinese medical extract dry powder
A weighs the seed of Oriental arborvitae, wrinkled giant hyssop, folium isatidis, Radix Glycyrrhizae, hawthorn, Divine Comedy, dried orange peel, rhizoma atractylodis, fennel fruit respectively according to above-mentioned parts by weight Perfume, Chloranthus glaber, frutus cnidii and Radix Astragali, which are put into micronizer, carries out ultramicro grinding, later, crosses 70-90 mesh sieve, is mixed Powder, low temperature drying preserves, spare;
It is molten to be added to the ethyl alcohol that mass concentration is 55-65% according to the solid-liquid ratio of 1g/20mL by b for mixed-powder made from step a In liquid, and cellulase, pectase and zytase are added thereto, after being sufficiently mixed, in 45-55 DEG C of thermostat water bath Enzymolysis processing 0.8-1.2 h are carried out, enzymolysis liquid is made, it is spare;
It is 45-55 DEG C, power 250-280W that enzymolysis liquid made from step b is placed in temperature by c, and frequency is the ultrasound of 20-30kHz Ultrasonic extraction 0.8-1.5 h are carried out in extractor;
D by after step c ultrasonic extractions gained liquid be placed in 45-55 DEG C, pressure be 0.07-0.1 atmospheric pressure environmental condition under Vacuum rotary steam is carried out, extract concentrated solution is made, it is spare;
E is spray-dried extract concentrated solution made from step d, Chinese medical extract dry powder is made, low temperature drying preserves, standby With;
Step 3: the preparation of Chinese herbal and crude drugs preparations
According to 1:The weight proportion of 2.4-3.2 weighs Chinese medicine made from zeolite granular made from step 1 and step 2 and carries respectively Object dry powder is taken, later, the liquid fat of 0.2-0.3 times of its quality is added into the Chinese medical extract dry powder weighed, fully stirs After mixing mixing, which is uniformly adhered on zeolite granular by the bur that thick-pasty is made later, after dry, i.e., Obtain finished product Chinese herbal and crude drugs preparations.
6. a kind of prevention weanling pig according to claim 5 stress Chinese herbal and crude drugs preparations preparation method, feature exists In:In step 1, acetum and mass concentration that the acidic activated liquid is 40-50% by mass concentration are 30-35% Hydrochloric acid solution according to 2:1 volume ratio is mixed, and stearic acid and ammonium chloride are also added in the mixed liquor, wherein stearic The weight addition proportioning of acid is 0.3-0.4%, and the weight addition proportioning of ammonium chloride is 0.8-1.1%.
7. a kind of prevention weanling pig according to claim 5 stress Chinese herbal and crude drugs preparations preparation method, feature exists In:In step 1, the feed particles carry out that ultrasonic vibration processing 20- need to be carried out when activation process in acidic activated liquid 30min。
8. a kind of prevention weanling pig according to claim 7 stress Chinese herbal and crude drugs preparations preparation method, feature exists In:The ultrasonic power of the ultrasonic vibration processing is 50-60KHz.
9. a kind of prevention weanling pig according to claim 5 stress Chinese herbal and crude drugs preparations preparation method, feature exists In:In step 1, cooling immersion need to be carried out in ethanol solution by transposition in 1-2min after the feed particles calcination.
10. a kind of prevention weanling pig according to claim 5 stress Chinese herbal and crude drugs preparations preparation method, feature exists In:In step 2, the addition relationship between the cellulase, pectase and zytase and mixed-powder is respectively 20 μ G/g, 100 μ g/g and 10 μ g/g.
CN201810312381.5A 2018-04-09 2018-04-09 A kind of prevention weanling pig stress Chinese herbal and crude drugs preparations and preparation method thereof Pending CN108432955A (en)

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Application publication date: 20180824