CN108420743A - A kind of purposes of the active skin care item preparation method of active cell and this method product - Google Patents
A kind of purposes of the active skin care item preparation method of active cell and this method product Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
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- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention relates to function protecting product to receive,More particularly relate to a kind of skin care item preparation method and usage thereof,Being dissolved in isostearic acid isopropyl especially by Isorhamnetin is extremely used as oil phase that reaction vessel is added,The mode pumped under liquid level is controlled with peristaltic pump, and mannosan is added,It is slowly pumped into sodium pyrosulfite after part mannosan is added,Argon gas is poured to react under the conditions of pressurized, heated,Mannosan is set to react with Isorhamnetin under pressure,It is depressured reduction of heat after half is added in sodium pyrosulfite,After being emulsified after also former base protection is added at 5 20 DEG C after VC to be dissolved in water and being pumped into sodium pyrosulfite reaction,Remaining mannosan is added to pour the slow pressurization of argon gas and be stirred to react,The shielding manufactured in the method for the present invention is set to pass through the contact for blocking skin with air,Inhibit sebum secretion and sweat evaporation that skin temperature is made to increase,To promote skin of face blood circulation,Play the role of cleaning and skin care,There is extensive use in cosmetics and healthcare field.
Description
Technical field
The present invention relates to function protecting product to receive, and more particularly relates to a kind of active skin care item preparation side of active cell
Method and usage thereof.
Background technology
Abundant etc. recently as environmental pollution, rhythm of life quickening, night life, more and more people are chronically at Asia
Health status, so as to cause the dim heavy, color spot of skin increases, aging is accelerated phenomena such as, increasingly aggravate.Everybody has a love of beauty,
The skin of smooth whitening is the target that everybody pursues, especially female friend, with the raising of living standard, people by
Step pursues quality of the life, pursues crude.Currently, skin care item in the market are mainly made with various natural plant extracts
For active ingredient.Wherein, though Whitening, spot skin care item type is various, and effect is irregular, mostly to the removal of melanin
Effect is not notable, and the effect is unsatisfactory for Whitening, spot, and existing whitening one is by inhibiting dermal melanin cell Proliferation, subtracting
The quantity that few melanocyte generates；Second is that by inhibiting the catalysis of key enzyme-tyrosinase of dermal melanin generation to live
Property, to reduce the generating rate of melanin to reach whitening purpose；Third, by sun-proof, prevent sunlight middle-ultraviolet lamp to skin
The injury of skin reduces the risk that skin is tanned or tans severely, slows down skin aging；Fourth, being removed in skin by using antioxidant
Oxygen radical, slow down melanin production and delay skin aging, therefore, while whitening, reinforce Green Tea Extract nor
It is often important.There are many product of whitening class in the prior art, and free radical activity is low, and reproducibility is not high, cannot effectively activate thin
Born of the same parents swash can be with activity, and whitening effect is not apparent enough, while purposes is unable to health care less, and there is also asking for cost of material limitation
Topic.
Invention content
To solve the above-mentioned problems, the present invention provides a kind of technological parameter scheme, specially a kind of active cell activity
Skin care item preparation method, which includes the following steps：The first step, at least using including containing mannosan, different sandlwood
Element is the raw material of manufacture, further includes cruel, sodium pyrosulfite, VC, fragrance, containing alcohol group compound using isostearic acid isopropyl
As raw material；
Second step, choose the first step in raw material in reaction vessel, by ratio of weight and the number of copies for 4-20 parts Isorhamnetin,
1-4 parts of mannosans, 0-35 parts of VC carry out reaction manufacture in 0.00001-0.55 parts of ambergris as fragrance；
Third walks, and the reaction vessel argon gas in the second step excludes oxygen and pours part argon gas, uses isostearic acid
Isopropyl is extremely oil phase, and reaction temperature is controlled at 40-78 DEG C, and reaction sequence and parameter in the second step are：1. will be described
0.5-35 parts of VC are used as spare water phase after ambergris is added at 5-20 DEG C after being dissolved in 0.5-2 parts of water, then by the 4-
Reaction vessel is added as oil phase in 20 parts of Isorhamnetin, is added with the mode pumped under peristaltic pump control liquid level 1-4 parts described
Mannosan is added after part mannosan is added and is slowly pumped into sodium pyrosulfite, pours argon gas in pressurized, heated condition
Lower reaction, when by the sodium pyrosulfite be added half and react after be depressured reduction of heat, then be added described in 1. in spare water phase
After continuing to be pumped into sodium pyrosulfite after emulsification and reacting a period of time, remainder mannosan is added pours argon gas and slowly add
It presses and reacts 3 hours under stirring until the reaction is complete；
4th step is cooled to room temperature to obtain skin care item.
Preferably, in the second step further include 1, the 2- pentanediol compounds being added with taking catalytic hydrogenation method method to generate
As the third step 1. described in oil phase substance,
The catalytic hydrogenation method method is in the medium by hydrogen that volume parts are 1-2 part furfuryl alcohols and 5-20 parts in fragrance
Compressive reaction generates under the conditions of the lower warm vacuum tightness of control of tin zinc compound catalysis.
Preferably, the medium is the methanol and aqueous mixtures for counting 30-50 parts in an amount, counts the oxygen in parts by weight
It is 1-7 to change tin, described zinc oxide 5-15 parts, and the vacuum tightness reaction can simultaneously pressurize for that can vacuumize with suction under vacuum
Reactor, the reaction time be 1.5-9h, the hydrogen feed postition be 0.5-1.5 hours in be slowly pressed into, it is described
Ranging from 34-78 DEG C of temperature control, lower reaction of pressurizeing.
Preferably, further include using polyalcohol in the first step, the fragrance in the second step is plant essence.
Preferably, further include in the second step be added in parts by weight count 0.1-5 part lauryl sodium sulfate with
0.1-3 parts of citric acid or lemon with react.
It is another object of the present invention to the skin care item for treating dermopathic usage, be incited somebody to action it includes there is the first step
The shin moisturizer takes 0.1-5 parts to be added in the evaporating chamber that ointment is prepared in container by volume, and the ointment prepares container energy
Stirring and temperature control；32-85 DEG C of second step temperature control, stirring then pass to 94-99 parts of steams by volume, third step control evaporation
Ointment is made after so that moisture content is reached critical solid-state in pressure in storehouse.
Preferably, the component of the bletilla striata or iodine Wine additive as ointment is additionally added after the first step
Scheme is acted on and is had the beneficial effect that in the used above scheme present invention：
1, the present invention is chosen first containing mannosan, the VC of Isorhamnetin, containing alcohol group raw material, can make multifunctional protection
Product have its each distinctive performance of group, the present invention in have Isorhamnetin have have protection angiocarpy, enhance be immunized
Power, inhibit tumour, treatment stomach tract disease, anti-aging, radioresistance, it is anti-inflammatory, anti-oxidant the effects that, be a kind of rare
Health material, there is stronger oxidation resistance, anti-aging can be played the role of and also had rich in various trace elements
Significant anti-oxidant, whitening effect
Based on the above reason, the specific adjustment structure of alcohol groups, increase molecular skeleton, the effect of reconciliation shielding performance, this
Raw material components in inventive method generate the shielding of each group's performance set by the method reaction, especially can
Shielding in health care, method Isorhamnetin of the invention, mannosan, VC etc. react the more work(of composite realization
Energy dissolubility and activity of the shielding in argon medium and the protective in the case where exposing to the weather, specifically, argon gas of the present invention removes
Oxygen provides reaction medium, control pressure temperature, selects control selections reaction process, quickening or inhibits reaction process, passes through breast
Liquid polymerization is conducive to the existing reaction of first gaining the upper hand in oil phase such as Isorhamnetin, mannosan in the present invention then in conjunction with VC
Etc. water phases advantageous characteristic reaction after realize product stickiness it is suitable, ductility is preferable, uniform and smooth, has to skin and preferably oozes
Permeability, when use, do not play informal voucher, using rear skin without greasy feeling, moisten performance optimization and selection, product is facilitated to use, save
The energy, it is environment friendly and pollution-free small, oil phase is used as by Isorhamnetin, reaction vessel is added, with methanol and lauryl sodium sulfate energy
It realizes the maximum solvent of Isorhamnetin and mannosan and prevents technical process substance and electron energy from exchanging and interrupt, be to provide
The oil-phase medium of high Isorhamnetin and mannosan reaction transformation efficiency controls the mode pumped under liquid level with peristaltic pump and is added
The mannosan can realize that mannosan liquid internal is agitated and be collided with mass transfer, prevent liquid level from overflowing, it is poly- that part sweet dew is added
It is added after sugar and is slowly pumped into sodium pyrosulfite, poured argon gas and reacted under the conditions of pressurized, heated, can be enabled under pressure
Make mannosan that effective react occur with Isorhamnetin and realizes that fluorine atom and silicon atom are close to the greatest extent in molecular structure
Apart from intensive assembly, make Isorhamnetin and VC in the shielding molecule manufactured in the method for the present invention that respective characteristic property occur
And the synergistic effect that the two be combined with each other and promotes can be generated, its is embodied in by blocking contact of the skin with air, inhibits skin
Fat is secreted and sweat evaporation makes skin temperature rise, to promote skin of face blood circulation；And it can cutin-softening, expansion hair
Cleaning and skin care are played the role of in hole.Meanwhile contain in the active skin care item of active cell nutriment, effect at
Skin can be penetrated by dividing, and can more be enhanced skin function, be effectively improved skin quality.When half is added simultaneously in the appropriate sodium pyrosulfite
Decompression, which subtracts heat catalysis, after decompression reduction of heat can enable molecules hydroxyl groups molecule assemble after reaction makes decrease hydroxyl assemble and is next
Step molecule chain growth and the other molecular radicals of access create conditions, and are then dissolved in appropriate part water when suitable VC is added in addition
It is used as continuing to be pumped into sodium pyrosulfite after spare water phase emulsifies after ambergris is added at a suitable temperature afterwards and reacts one section
Time can make VC molecules form activist's structural chains of more structure alcoholic extract hydroxyl groups, and the method synthesis shielding point of the present invention
In son polyhydroxylated molecule assemble active force between moieties VC section long chains can be enable to swing so that entire strand is had flexible, separately
Ring in outer VC molecules and thereon hydroxyl mutually wind and are formed together with other groups in overall molecule branched and in softness
Swinging makes overall molecule generation enliven free radical performance under long-chain, slowly pressurizeed simultaneously with argon gas when in addition part mannosan
It is being stirred to react certain time completion reaction, can gradually reinforced in strand again when boosting again and mannosan being added
Polyhydroxylated molecule assemble and the more structure alcoholic extract hydroxyl group strands of VC can be made to gradually increase simultaneously, and make also to access part on VC strands
Isorhamnetin increases the new energy of liberation of hydrogen of intensity and guarantee in argon gas liquid to carry out protection to it.It is controllable by above structure
The functional molecular shielding that generates of synthetic method be not only easily reduced in protecting use while overall molecule is activated, it is whole
The molecular structure performance of body makes skin care item have good protection active cell performance.It is former as a result of cheap VC groups
Reason can be such that shielding cost significantly declines, and can realize that preferable economic benefit protrudes.Polyfunctional molecule shielding also has ring
It protects without free of contamination feature.The technology profile is controllable, and synthesis is suitable for most organic groups such as hydroxy kind and alkene, alcohol aldol ring
Group participates in reaction, and synthesis application range is unrestricted, high conversion rate, and product pentanediol amount is high and distribution and molecular structure can be real
Now target is reached in control, and building-up process process parameter objectives are with strong points, the W-response when variationization pressure and other parameters
Super target direction runs smooth, control fining, with the function protecting product of the synthesis such as Isorhamnetin, mannosan, VC in skin
There is breakthrough application in caring.
2, when 1,2- pentanediol compounds participation reaction complex functionality shielding is made with the method in the present invention, by
In this method be catalyzed by tin zinc compound and method in produce under whole technique and parameter alcoholic extract hydroxyl group and more carbon potentials away from
From closer to higher 1, the 2- pentanediols polymerized monomer of dense degree and joining and under the method for the present invention shin moisturizer being obtained by the reaction, can make
There is function protecting product liberation of hydrogen outstanding newly function protecting product molecule can be made whole with the ability of active reduction more outstanding
The barrier propterty of body is more preferable, more beneficial in low temperature and high temperature environment when being used in protecting use.
3, when in the present invention use polyalcohol can to functional molecular in protecting use other synthesis such as free radical activity
Level provide it is high, when fragrance is that be the function protecting moral character that the method for the present invention obtains can advanced optimize plant essence, applicability
It is stronger.
4, when in the method for the present invention with lauryl sodium sulfate and citric acid or lemon with can make function anti-when reacting
Shield product Molecule Set body forms traffic hydroxyl reactive group and carbon potential structure, to increase molecule free radical activity and reduction
Property and reduction group quantity performance.It is easier to dissolve when this kind of function protecting product use in skin care item, it is active free
The quantity of base reduction group easily activates, and protection active cell performance is good and easily absorbs.
Specific implementation mode
Carry out detailed description of the preferred embodiments of the present invention below in conjunction with table and embodiment, thereby such as to the present invention
What applied technology method solves technical problem and reaches the realization process of technical effect to fully understand and implement.
Embodiment 1
A kind of active skin care item preparation method of active cell of the present invention, method include the following steps：The first step uses
Including containing mannosan, Isorhamnetin, isostearic acid isopropyl is cruel, the compound of containing alcohol group is preferably different as raw material, this example
Rhamnetin, containing alcohol group compound make it is also preferred that mannosan, VC as reaction raw materials.
Second step chooses tri- kinds of Isorhamnetin, mannosan, VC raw materials in the first step, is by ratio of weight and the number of copies 4 parts
Isorhamnetin, 1 part of mannosan, 0.5 part of VC reaction manufacture is carried out under 0.000001 fragrance, the present embodiment preferably restores
Under conditions of base protection and fragrance；
Third walks, and the reaction kettle argon gas in second step is excluded oxygen and pours part argon gas, with preferred isostearic acid
Isopropyl is extremely used as oil phase, oil water phase mass ratio 1：1, reaction temperature reaction sequence of the control in 5 DEG C, the second step and
Parameter is：1. being used as spare water at 5 DEG C plus after 0.003 ammonium peroxide fragrance after 0.5 part of VC is dissolved in 1 part of water
Then the molten 1 part of isostearic acid isopropyl of 4 parts of the Isorhamnetin is extremely used as oil phase that reaction vessel reaction kettle is added by phase, use is compacted
1 part of mannosan is added in the mode pumped under dynamic pump control liquid level, is added after 0.6 mannosan is added and is slowly pumped into
Sodium pyrosulfite 0.007 pours argon gas and is reacted under the conditions of pressurized, heated, when half and anti-is added in the sodium pyrosulfite
Should after be depressured reduction of heat, be then added it is described 1. in spare water phase emulsify after continue to be pumped into sodium pyrosulfite and when reacting 1.5h
Between after, remainder mannosan be added pour argon gas and slowly pressurize and react 3 hours under stirring up to having reacted
At；
4th step, is cooled to room temperature to obtain shin moisturizer A, or shin moisturizer dehydrated with evaporation to obtain cold cream A.
Further, also choosing includes 1, the 2- pentanediols being added with taking catalytic hydrogenation method method to generate in the second step
Close object as the third walk 1. described in oil phase substance
The method of manufacturing technology of following detailed description 1,2- pentanediol raw materials of compound substances：
The catalytic hydrogenation method method be in the medium 1 part of furfuryl alcohol and 2 parts of hydrogen in fragrance tin zinc impregnation conjunction by volume parts
It reacts and generates under the conditions of the lower warm vacuum tightness of control of object catalysis.
Further, raw material will be added in reaction kettle by volume parts is 1 part of furfuryl alcohol and 2 parts of hydrogen, is added by weight
To be calculated as tin oxide be 1 to number, closed after 5 parts of zinc oxide to vacuumize and the medium is added as in an amount in suction under vacuum
The methanol and aqueous mixtures of 30 parts of meter, under the conditions of minute-pressure, raw hydrogen feed postition is to be reacted after being slowly pressed into 0.5 hour
1.5, and 35 DEG C of temperature control is controlled, reaction completes postcooling and is dried to obtain 1,2- pentanediol raw materials of compound.
Further, further include that polyalcohol such as prenol is added as synthesis material in the first step.
In addition the present invention also aims to illustrate the shin moisturizer of process manufacture through the invention in treatment skin disease
Usage, specifically,
The shin moisturizer is taken 0.1 part to be added in the evaporating chamber that ointment is prepared in container by the first step by volume, described
Ointment prepares container and can stir and temperature control；32 DEG C of second step temperature control, stirring then pass to 94 parts of steams by volume, third step
Ointment is made after so that moisture content is reached critical solid-state in pressure in control evaporating chamber.
Embodiment 2
A kind of active skin care item preparation method of active cell of the present invention, method include the following steps：The first step uses
Including containing mannosan, Isorhamnetin, isostearic acid isopropyl is cruel, containing alcohol group compound is as raw material, such as metering system
Acid, methyl acrylate, tert-butyl acrylate etc., the preferred Isorhamnetin of this example, mannosan, VC are as reaction raw materials.
Second step chooses tri- kinds of Isorhamnetin, mannosan, VC raw materials in the first step, is by ratio of weight and the number of copies 12 parts
Isorhamnetin, 2 parts of mannosans, 17 parts of VC carry out reaction manufacture, the present embodiment under 0.0001 fragrance preferentially also former base are protected
Shield and fragrance；
Third walks, and the reaction kettle argon gas in second step is excluded oxygen and pours part argon gas, with preferred isostearic acid
Isopropyl is extremely used as oil phase, oil water phase mass ratio 1：1, reaction temperature reaction sequence of the control in 47 DEG C, the second step and
Parameter is：1. being used as spare water phase at 13 DEG C plus after 0.15 fragrance after 17 parts of VC are dissolved in 1.5 parts of water, then
12 parts of the Isorhamnetin, which is dissolved in 1.5 parts of isostearic acid isopropyls, is extremely used as oil phase that reaction vessel reaction kettle is added, with wriggling
2 parts of mannosans are added in the mode pumped under pump control liquid level, are added after 0.6 mannosan is added and are slowly pumped into coke
Sodium sulfite 0.15 pours argon gas and is reacted under the conditions of pressurized, heated, after half is added in the sodium pyrosulfite and is reacted
Be depressured reduction of heat, be then added it is described 1. in spare water phase emulsify after continue to be pumped into sodium pyrosulfite and react the 1.5h times after,
Remainder mannosan is added to pour the slow pressurization of argon gas and react 5 hours under stirring until the reaction is complete；
4th step, is cooled to room temperature to obtain shin moisturizer B, or shin moisturizer dehydrated with evaporation drying etc. protected
Skin cream B.
Further, also choosing includes 1, the 2- pentanediols being added with taking catalytic hydrogenation method method to generate in the second step
Close object as the third walk 1. described in oil phase substance
The method of manufacturing technology of following detailed description 1,2- pentanediol raw materials of compound substances：
The catalytic hydrogenation method method is in the medium by hydrogen that volume parts are 1-2 part furfuryl alcohols and 5-20 parts in fragrance
It reacts and generates under the conditions of the lower warm vacuum tightness of control of tin zinc compound catalysis.
Further, raw material will be added in reaction kettle by volume parts is 1.5 parts of furfuryl alcohols and 3 parts of hydrogen, is added by weight
It is 4 that number, which is calculated as tin oxide, closed after 7 parts of zinc oxide to vacuumize and the medium is added in suction under vacuum is by total
The methanol and aqueous mixtures of 38 parts of gauge, under pressurized conditions, raw hydrogen feed postition is anti-after being slowly pressed into 0.8 hour
5h is answered, and 60 DEG C of temperature control is controlled, reaction completes postcooling and is dried to obtain 1,2- pentanediol raw materials of compound.
In addition the present invention also aims to illustrate the shin moisturizer of process manufacture through the invention in treatment skin disease
Usage, prepared in evaporating chamber in container specifically, the shin moisturizer is taken 2 parts ointment are added by the first step by volume, institute
The ointment stated prepares container and can stir and temperature control；50 DEG C of second step temperature control, stirring, then passes to 90 parts of steams by volume, the
Ointment is made after so that moisture content is reached critical solid-state in pressure in three steps control evaporating chamber.
Further, the component that tincture of iodine additive is used as protection is additionally added after the first step.
Embodiment 3
A kind of active skin care item preparation method of active cell of the present invention, method include the following steps：The first step uses
Including containing mannosan, Isorhamnetin, isostearic acid isopropyl is cruel, containing alcohol group compound is as raw material, such as vinyl acetate
Ester, tetrafluoropropanol, hexafluoro butanol methyl methacrylate etc., the preferred Isorhamnetin of this example, mannosan, VC are as reaction
Raw material.
Second step chooses tri- kinds of Isorhamnetin, mannosan, VC raw materials in the first step, is by ratio of weight and the number of copies 20 parts
Isorhamnetin, 4 parts of mannosans, 35 parts of VC carry out reaction manufacture, the present embodiment under 0.01-0.55 fragrance and preferentially restore
Base is protected and fragrance；
Third walks, and the reaction kettle argon gas in second step is excluded oxygen and pours part argon gas, with preferred isostearic acid
Isopropyl is extremely used as oil phase, oil water phase mass ratio 1：1, reaction temperature reaction sequence of the control in 85 DEG C, the second step and
Parameter is：1. being used as spare water phase at 20 DEG C plus after 0.15 fragrance after 35 parts of VC are dissolved in 2 parts of water, then will
20 parts of the Isorhamnetin is dissolved in 3 parts of isostearic acid isopropyls and is extremely used as oil phase that reaction vessel reaction kettle is added, with peristaltic pump control
4 parts of mannosans are added in the mode pumped under liquid level processed, are added after 0.6 mannosan is added and are slowly pumped into burnt sulfurous
Sour sodium 0.15 pours argon gas and is reacted under the conditions of pressurized, heated, is depressured after half and reaction is added in the sodium pyrosulfite
Reduction of heat, be then added it is described 1. in the emulsification of spare water phase after continue to be pumped into sodium pyrosulfite and react the 1.5h times after, addition
Remainder mannosan pours argon gas and slowly pressurizes and react 10 hours under stirring until the reaction is complete；
4th step, is cooled to room temperature to obtain shin moisturizer C, or shin moisturizer dehydrated with evaporation drying etc. protected
Skin cream C.
Further, also choosing includes 1, the 2- pentanediols being added with taking catalytic hydrogenation method method to generate in the second step
Close object as the third walk 1. described in oil phase substance
The method of manufacturing technology of following detailed description 1,2- pentanediol raw materials of compound substances：
The catalytic hydrogenation method method is in the medium by hydrogen that volume parts are 1-2 part furfuryl alcohols and 5-20 parts in fragrance
It reacts and generates under the conditions of the lower warm vacuum tightness of control of tin zinc compound catalysis.
It is 3 parts of furfuryl alcohols and 5 parts of hydrogen that raw material will further be added in reaction kettle by volume parts, is added by weight
To be calculated as tin oxide be 7 to number, closed after 5 parts of zinc oxide to vacuumize and the medium is added as in an amount in suction under vacuum
50 parts of methanol and aqueous mixtures of meter, under pressurized conditions, raw hydrogen feed postition is to be reacted after being slowly pressed into 1.5 hours
9h, and 85 DEG C of temperature control is controlled, reaction completes postcooling and is dried to obtain 1,2- pentanediol raw materials of compound.
In addition the present invention also aims to illustrate the shin moisturizer of process manufacture through the invention in treatment skin disease
Usage, prepared in evaporating chamber in container specifically, the shin moisturizer is taken 5 parts ointment are added by the first step by volume, institute
The ointment stated prepares container and can stir and temperature control；85 DEG C of second step temperature control, stirring, then passes to 99 parts of steams by volume, the
Ointment is made after so that moisture content is reached critical solid-state in pressure in three steps control evaporating chamber.
Further, the component that the bletilla striata and tincture of iodine additive are used as protection is additionally added after the first step,
Embodiment 4
A kind of active skin care item preparation method of active cell of the present invention, method include the following steps：The first step uses
Including containing mannosan, Isorhamnetin, isostearic acid isopropyl is cruel, containing alcohol group compound is as raw material, such as vinyl benzoate
Ester, ternary alkenols, fluorinated alkanes alcohol etc., the preferred Isorhamnetin of this example, mannosan, VC are as reaction raw materials.
Second step chooses tri- kinds of Isorhamnetin, mannosan, VC raw materials in the first step, is by ratio of weight and the number of copies 15 parts
Isorhamnetin, 3 parts of mannosans, 33 parts of VC carry out reaction manufacture, the present embodiment under 0.01-0.55 fragrance and preferentially restore
Base is protected and fragrance；
Third walks, and the reaction kettle argon gas in second step is excluded oxygen and pours part argon gas, with preferred isostearic acid
Isopropyl is extremely used as oil phase, oil water phase mass ratio 1：1, reaction temperature reaction sequence of the control in 70 DEG C, the second step and
Parameter is：1. being used as spare water phase at 18 DEG C plus after 0.15 fragrance after 33 parts of VC are dissolved in 1.8 parts of water, then
15 parts of the Isorhamnetin, which is dissolved in 2.6 parts of isostearic acid isopropyls, is extremely used as oil phase that reaction vessel reaction kettle is added, with wriggling
3 parts of mannosans are added in the mode pumped under pump control liquid level, are added after 1.8 mannosan is added and are slowly pumped into coke
Sodium sulfite 0.15 pours argon gas and is reacted under the conditions of pressurized, heated, after half is added in the sodium pyrosulfite and is reacted
Be depressured reduction of heat, be then added it is described 1. in spare water phase emulsify after continue to be pumped into sodium pyrosulfite and react the 1.5h times after,
Remainder mannosan is added to pour the slow pressurization of argon gas and react 7 hours under stirring until the reaction is complete；
4th step, is cooled to room temperature to obtain shin moisturizer D, or shin moisturizer dehydrated with evaporation drying etc. protected
Skin cream D.
Further, also choosing includes that the lauryl sodium sulfate of 0.1-5 parts of meter in parts by weight is added in the second step
With 0.1-3 parts of citric acid or lemon with react.Such as the lauryl sodium sulfate of preferably 0.1 part of this example and 0.1 part
Citric acid or lemon are reacted with experiment.
The present invention also aims to illustrate another through the invention process manufacture shin moisturizer treatment skin
The shin moisturizer is taken 4 parts of addition ointment to prepare the evaporating chamber in container by the usage of skin disease, the specially first step by volume
In, the ointment prepares container and can stir and temperature control；75 DEG C of second step temperature control, stirring then pass to 89 parts of steamings by volume
Gas, third step control after the pressure in evaporating chamber makes moisture content reach critical solid-state and ointment are made.
Further, the component that the bletilla striata or tincture of iodine additive are used as protection is additionally added after the first step,
The functional product of present invention process method manufacture is as follows in free radical activity the performance test results：
Product A, B, C, D in Example 1-4 are configured to 0.5% concentration of mass number respectively, and pure VC is taken to be configured to homogeneity
Amount number is 0.5% concentration, is denoted as E and compares, its reducing power is measured using potassium ferricyanide reduction method, and principle is sample by iron
Potassium cyanide is reduced into potassium ferrocyanide, and potassium ferrocyanide is Prussian blue with ferric chloride reaction generation again, and extinction is surveyed in 700nm
Angle value judges that the strong and weak of tested material reducing power takes the prepare liquid of different quality concentration, 1g/dL respectively by measuring absorbance
Potassium ferricyanide aqueous solution and each 1.0mL of 0.2mol/L phosphate buffers (pH=6.6) are added in test tube, 50 DEG C of water-bath 25min,
It is cooled down rapidly after taking-up and 10g/dL solution of trichloroacetic acid 1.0mL are added, shakes up, then extract reaction solution 1mL, sequentially adds
200 μ L of distilled water 1mL and 0.1g/dL ferric chloride aqueous solutions are mixed well after 10min with distilled water as blank control enzyme
Mark instrument measures its absorbance at 700nm wavelength, and absorbance is bigger, illustrates that reducing power is stronger, it is as follows that measured value is shown in Table 1.
Table 1
According to the above test result, according to table 1 can test result show the free radical activities of skin care item greatly with pure VC from
It is strong by base activity, and product reducing power of the present invention, it is protruded to embody the method for the present invention properties of product advantage, in conclusion
Due to the design of molecular structure, the shielding is easier to dissolve when being used in skin care item, and enlivens radical reduction group
Quantity easily activates, and protection active cell performance is good and easily absorbs.
The product of process manufacture simultaneously has the good performance that skin care item are nursed and protected with active cell.
It should also be noted that, the terms "include", "comprise" or its any other variant are intended to nonexcludability
Including so that process, method, commodity or equipment including a series of elements include not only those elements, but also wrap
Include other elements that are not explicitly listed, or further include for this process, method, commodity or equipment intrinsic want
Element.In the absence of more restrictions, the element limited by sentence "including a ...", it is not excluded that including described
There is also other identical elements in the process of element, method, commodity or equipment.
Claims (7)
1. a kind of active skin care item preparation method of active cell, the process include the following steps：The first step at least uses
Include containing the raw material that mannosan, Isorhamnetin are manufacture, it is characterised in that：Further include cruel, Jiao Ya using isostearic acid isopropyl
Sodium sulphate, VC, fragrance, containing alcohol group compound as raw material；
Second step, choose the first step in raw material in reaction vessel, by ratio of weight and the number of copies for 4-20 parts Isorhamnetin, 1-4 parts
Mannosan, 0-35 part VC carry out reaction manufacture in 0.00001-0.55 parts of ambergris as fragrance；
Third walks, and the reaction vessel argon gas in the second step excludes oxygen and pours part argon gas, with isostearic acid isopropyl
It is extremely oil phase, reaction temperature is controlled at 40-78 DEG C, and reaction sequence and parameter in the second step are：1. by the 0.5-35
Part VC is used as spare water phase after ambergris is added at 5-20 DEG C after being dissolved in 0.5-2 parts of water, then by described 4-20 parts
Reaction vessel is added as oil phase in Isorhamnetin, and it is poly- that the 1-4 parts of sweet dew is added with the mode pumped under peristaltic pump control liquid level
Sugar is added after part mannosan is added and is slowly pumped into sodium pyrosulfite, pours argon gas and reacted under the conditions of pressurized, heated, when
The sodium pyrosulfite is added half and is depressured reduction of heat after reacting, be then added it is described 1. in spare water phase emulsify after continue
After being pumped into sodium pyrosulfite and reacting a period of time, remainder mannosan is added and pours the slow pressurization of argon gas and in stirring shape
3 hours are reacted under state until the reaction is complete；
4th step is cooled to room temperature to obtain skin care item.
2. the active skin care item preparation method of active cell as described in claim 1, it is characterised in that：In the second step also
Including be added with take catalytic hydrogenation method method generate 1,2- pentanediols compound as the third step 1. described in oil phase object
Matter,
The catalytic hydrogenation method method is in the medium by hydrogen that volume parts are 1-2 part furfuryl alcohols and 5-20 parts in fragrance tin zinc impregnation
Compressive reaction generates under the conditions of closing the lower warm vacuum tightness of control of object catalysis.
3. the active skin care item preparation method of active cell as claimed in claim 2, it is characterised in that：The medium is by total
The methanol and aqueous mixtures of 30-50 parts of gauge, it is 1-7 to count the tin oxide in parts by weight, described zinc oxide 5-15 parts, institute
Vacuum tightness reaction is stated as the reactor that can simultaneously pressurize with suction under vacuum can be vacuumized, the reaction time is 1.5-9h,
The hydrogen feed postition is slowly to be pressed into 0.5-1.5 hours, ranging from 34-78 DEG C of the temperature control, lower reaction of pressurizeing.
4. the active skin care item preparation method of active cell as described in claim 1, it is characterised in that：In the first step also
Including using polyalcohol, the fragrance in the second step is plant essence.
5. the active skin care item preparation method of active cell as described in claim 1, it is characterised in that：In the second step also
It counts 0.1-5 parts of lauryl sodium sulfate and 0.1-3 parts of citric acid or lemon in parts by weight including being added and reacts.
6. a kind of skin care item of the method manufacture in 1-5 such as claim as described in any type are treating dermopathic usage,
It is characterized in that：The shin moisturizer is taken 0.1-5 parts to be added in the evaporating chamber that ointment is prepared in container by the first step by volume, described
Ointment prepare container and can stir and temperature control；32-85 DEG C of second step temperature control, stirring then pass to 94-99 parts of steamings by volume
Gas, third step control after the pressure in evaporating chamber makes moisture content reach critical solid-state and ointment are made.
7. shin moisturizer as claimed in claim 6 is treating dermopathic usage, it is characterised in that：It is additionally added after the first step white
The component of splendid achnatherum or iodine Wine additive as ointment.
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