CN108403825A - A kind of middle drug and preparation method thereof for treating sore mouth virus - Google Patents

A kind of middle drug and preparation method thereof for treating sore mouth virus Download PDF

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Publication number
CN108403825A
CN108403825A CN201810586513.3A CN201810586513A CN108403825A CN 108403825 A CN108403825 A CN 108403825A CN 201810586513 A CN201810586513 A CN 201810586513A CN 108403825 A CN108403825 A CN 108403825A
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parts
liquid
campanulaceae
coptis
acetic acid
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CN108403825B (en
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徐泽立
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HENAN SUNWOOD LYUYUAN LIVESTOCK BREEDING Co Ltd
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HENAN SUNWOOD LYUYUAN LIVESTOCK BREEDING Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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Abstract

The invention discloses a kind of middle drug for treating sore mouth virus, the acetic acid that the liquid and mass fraction that drug is boiled by Chinese medicine composition in this are 20% forms, and the volume ratio of the liquid and acetic acid is 1:1, the Chinese medicine composition is made of the raw material of following parts by weight：35 parts of 13 parts of campanulaceae, 13 parts of semen momordicae, 35 parts of the coptis, 0.5 1.5 parts of Cortex Phellodendri and climbing groundsel；The present invention has the function of detumescence, toxic removing and anti-inflammatory.Acetic acid has disinfection and corrosion-resistant effect, and the oxygen in air is avoided various active ingredients to be aoxidized and lost the effect of detumescence, toxic removing and anti-inflammatory.

Description

A kind of middle drug and preparation method thereof for treating sore mouth virus
Technical field
The invention belongs to Veterinary Medicine technical fields, and in particular to a kind of middle drug that treating sore mouth virus and its preparation side Method.
Background technology
Sheep foot and mouth disease common are mouthful hoof bubble rash, a mouth hoof bubble, be by artiodactylous one caused by foot and mouth disease virus Acute, the hot, highly contagious disease of kind.It is characterized by aphtha, hoof sore and skin sore.It is common one of the epidemic disease of sheep, Middle aphtha is most commonly seen one of sheep foot and mouth disease.
Aphtha has the epidemics such as prevalence is fast, propagate wide, morbidity suddenly, harm is big, and epidemic-stricken area incidence is up to 50%- 100%, the sheep death rate being just born is higher, other are then relatively low.Ill domestic animal and incubation period animal are the most dangerous infections sources.Ill domestic animal Contain virus in blister liquid, milk, urine, mouth saliva, tear and excrement.The disease intrusion feature is mainly alimentary canal, also can be through Respiratory tract infection.Though this disease is propagated without apparent seasonality, spring and autumn is more, especially spring.Wind and birds are also long distance One of factor from propagation.
Existing therapeutic reagent is substantially treated by the way of Western medicine, and which is quick, but is treated not thorough Bottom is easy multiple.
Invention content
It is an object of the invention to carry out treating aphtha by the way of Western medicine reagent with quick and easy for above-mentioned The problem of recurrence, the present invention provide a kind of middle drug for treating sore mouth virus.
The technical solution adopted by the present invention is as follows：
A kind of middle drug for treating sore mouth virus, the liquid and mass fraction that drug is boiled by Chinese medicine composition in this are 20% Acetic acid composition, the volume ratio of the liquid and acetic acid is 1:1, the Chinese medicine composition is made of the raw material of following parts by weight：
1-3 parts of campanulaceae
1-3 parts of semen momordicae
3-5 parts of the coptis
0.5-1.5 parts of Cortex Phellodendri
3-5 parts of climbing groundsel.
The operation principle of this programme has the beneficial effect that：Deionized water be used for by campanulaceae, semen momordicae, the coptis, Cortex Phellodendri and Various active ingredients in climbing groundsel boil out so that various active ingredient interactions generate with detumescence, toxic removing and disappear Scorching effect.Acetic acid has disinfection and corrosion-resistant effect, avoid oxygen in air by various active ingredients and it is each effectively at The substance that/interaction generates aoxidizes and loses the effect of detumescence, toxic removing and anti-inflammatory.
Campanulaceae has the function of apocenosis so that the purulence in aphtha can be smoothly discharged out, and accelerate anti-inflammatory；Semen momordicae, which has, to disappear The effect of swollen dissipating bind, can inhibit in aphtha, convenient for discharge；The coptis has heat-clearing and damp-drying drug, purging intense heat and detonicating, antiulcer, antibacterial, resists Scorching and anti-diarrhea effect, can reduce the temperature in oral cavity, aphtha is avoided to deteriorate；Cortex Phellodendri has detoxification sore treatment, sore swollen toxin The effect of eczema wet sore is treated, climbing groundsel has the function for the treatment of eczema boil.
Preferably, the Chinese medicine composition is made of the raw material of following parts by weight：
2 parts of campanulaceae
2 parts of semen momordicae
4 parts of the coptis
1 part of Cortex Phellodendri
4 parts of climbing groundsel.
The present invention also provides a kind of preparation methods of middle drug that treating sore mouth virus, include the following steps：
(1) campanulaceae, semen momordicae, the coptis, Cortex Phellodendri and climbing groundsel are soaked in deionized water, impregnate 5-8 hour, obtains To mixture A；
(2) mixture A is subjected to ebuillition of heated, constantly boiling 1.5-2.3 hours obtains mixture B；
(3) campanulaceae, semen momordicae, the coptis, Cortex Phellodendri and the climbing groundsel in mixture B are pulled out, continues heating until liquid Sticky, cooling obtains liquid；
(4) it is mixed and stirred for the acetic acid that the liquid obtained by step (3) is 20% with mass fraction uniformly, to obtain Chinese medicine Object.
The operation principle of the present invention/have the beneficial effect that：Impregnate 5-8 hours can by campanulaceae, semen momordicae, the coptis, Cortex Phellodendri with And climbing groundsel spread apart come, convenient for the active ingredient in campanulaceae, semen momordicae, the coptis, Cortex Phellodendri and climbing groundsel can enter go from In sub- water, shorten heating time, constantly boiling is used for the active ingredient of campanulaceae, semen momordicae, the coptis, Cortex Phellodendri and climbing groundsel It is discharged and accelerates reacting to each other between each active ingredient.
In conclusion by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
In campanulaceae, semen momordicae, the coptis, Cortex Phellodendri and climbing groundsel various active ingredients interaction generate with detumescence, The effect of toxic removing and anti-inflammatory.Acetic acid has disinfection and corrosion-resistant effect, avoid oxygen in air by various active ingredients with And the substance of each active ingredient interaction generation aoxidizes and loses the effect of detumescence, toxic removing and anti-inflammatory.
Specific implementation mode
All features disclosed in this specification or disclosed all methods or in the process the step of, in addition to mutually exclusive Feature and/or step other than, can combine in any way.It should be appreciated that specific embodiment described herein is only used To explain the present invention, be not intended to limit the present invention, i.e., described embodiments are only a part of the embodiments of the present invention, without It is whole embodiment.
Embodiment one
The middle drug for the treatment of sore mouth virus is made as follows：
(1) by the ingredient of following quality：100 grams of campanulaceae, 100 grams of semen momordicae, 200 grams of the coptis, 50 grams of Cortex Phellodendri and a thousand li 200 grams of light is soaked in 3000 ml deionized waters, is impregnated 6 hours, is obtained mixture C；
(2) it by mixture C ebuillition of heated, boils 2 hours, obtains mixture D；
(3) campanulaceae, semen momordicae, the coptis, Cortex Phellodendri and the climbing groundsel in mixture D are pulled out, continues heating until liquid Volume be 1500 milliliters when stop heating, cooling obtain liquid；
(4) it is mixed and stirred for the acetic acid that liquid and mass fraction are 20% uniformly, to obtain middle drug；
(5) middle drug is directly applied to affected part, smeared 2 times daily.
Embodiment two
The middle drug for the treatment of sore mouth virus is made as follows：
(1) by the ingredient of following quality：5 kilograms of campanulaceae, 5 kilograms of semen momordicae, 10 kilograms of the coptis, 2.5 kilograms of parts of Cortex Phellodendri with And 10 kilograms of climbing groundsel is soaked in 50 liters of deionizations, is impregnated 6 hours, is obtained mixture E；
(2) it by mixture E ebuillition of heated, boils 1.8 hours, obtains mixture F；
(3) campanulaceae, semen momordicae, the coptis, Cortex Phellodendri and the climbing groundsel in mixture F are pulled out, and continuous heating is until liquid The volume of body is 25 liters；Obtain liquid；
(4) it is mixed and stirred for the acetic acid that liquid and mass fraction are 20% uniformly, to obtain middle drug；
(5) middle drug is directly applied to affected part, smeared 2 times daily.
In the present embodiment, by the active ingredient in campanulaceae, semen momordicae, the coptis, Cortex Phellodendri and climbing groundsel boil out and with The acetic acid that mass fraction is 20% mixes, and is directly applied to affected part, and active ingredient is directly combined with the diseased cells in affected part, destroys and suffers from The breeding of sick cell, to achieve the purpose that treatment.
Clinic Case
25 sick sheeps for suffering from aphtha are selected, sick sheep is divided into totally 5 groups of A, B, C, D and E, every group 5, is carried out respectively such as Lower processing；
A groups：Embodiment two is boiled into obtained liquid and is applied directly to sick sheep affected part, 2 times a day；
B groups：The acetic acid that mass fraction is 20% is applied to the affected part of sick sheep, 2 times a day；
C groups：The liquid boiled in embodiment one is applied directly to the affected part of sick sheep, 2 times a day；
D groups：The middle drug in embodiment one is smeared in the way of described in embodiment one；
E groups：The middle drug in embodiment two is smeared in the way of described in embodiment two.
It is as a result as follows after smearing two weeks：
A groups：The aphtha of 5 sick sheeps improves but does not fully recover, and effect is better than B groups；
B groups：The aphtha of 5 sick sheeps improves but does not fully recover；
C groups：The aphtha of 5 sick sheeps improves but does not fully recover, and effect is better than B groups；
D groups：The aphtha recovery from illness of 5 sick sheeps；
E groups：The aphtha recovery from illness of 5 sick sheeps.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention All any modification, equivalent and improvement etc., should all be included in the protection scope of the present invention made by within refreshing and principle.

Claims (3)

1. a kind of middle drug for treating sore mouth virus, which is characterized in that the liquid and quality that drug is boiled by Chinese medicine composition in this The acetic acid that score is 20% forms, and the volume ratio of the liquid and acetic acid is 1:1, the Chinese medicine composition is by following parts by weight Raw material forms：
1-3 parts of campanulaceae
1-3 parts of semen momordicae
3-5 parts of the coptis
0.5-1.5 parts of Cortex Phellodendri
3-5 parts of climbing groundsel.
2. the middle drug for the treatment of sore mouth virus according to claim 1, which is characterized in that the Chinese medicine composition is by following heavy Measure the raw material composition of part：
2 parts of campanulaceae
2 parts of semen momordicae
4 parts of the coptis
1 part of Cortex Phellodendri
4 parts of climbing groundsel.
3. a kind of preparation method of middle drug that treating sore mouth virus, which is characterized in that include the following steps：
(1) campanulaceae, semen momordicae, the coptis, Cortex Phellodendri and climbing groundsel are soaked in deionized water, impregnate 5-8 hour, is mixed Close object A；
(2) mixture A is subjected to ebuillition of heated, constantly boiling 1.5-2.3 hours obtains mixture B；
(3) campanulaceae, semen momordicae, the coptis, Cortex Phellodendri and the climbing groundsel in mixture B are pulled out, continue heating until liquid it is sticky, Cooling obtains liquid；
(4) it is mixed and stirred for the acetic acid that the liquid obtained by step (3) is 20% with mass fraction uniformly, to obtain middle drug.
CN201810586513.3A 2018-06-06 2018-06-06 Traditional Chinese medicine for treating aphtha and preparation method thereof Expired - Fee Related CN108403825B (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105343157A (en) * 2015-11-14 2016-02-24 黄平县野洞河镇丰岩生态种养殖专业合作社 Externally applied drug for treating aphtha in Capra aegagrus hircus
CN105412358A (en) * 2015-12-16 2016-03-23 山东省动物疫病预防与控制中心 Chinese herbal preparation for preventing and controlling cattle and sheep skin mucosa blistering necrotic disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105343157A (en) * 2015-11-14 2016-02-24 黄平县野洞河镇丰岩生态种养殖专业合作社 Externally applied drug for treating aphtha in Capra aegagrus hircus
CN105412358A (en) * 2015-12-16 2016-03-23 山东省动物疫病预防与控制中心 Chinese herbal preparation for preventing and controlling cattle and sheep skin mucosa blistering necrotic disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
李志杰等: "中西医结合治疗羔羊口疮", 《中兽医医药杂志》 *
高改林: "羊口疮病的诊断与防治对策分析", 《甘肃畜牧兽医》 *

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