CN108403825B - Traditional Chinese medicine for treating aphtha and preparation method thereof - Google Patents

Traditional Chinese medicine for treating aphtha and preparation method thereof Download PDF

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Publication number
CN108403825B
CN108403825B CN201810586513.3A CN201810586513A CN108403825B CN 108403825 B CN108403825 B CN 108403825B CN 201810586513 A CN201810586513 A CN 201810586513A CN 108403825 B CN108403825 B CN 108403825B
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traditional chinese
chinese medicine
parts
acetic acid
aphtha
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CN108403825A (en
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徐泽立
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Henan Sunwood Lyuyuan Livestock Breeding Co ltd
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Henan Sunwood Lyuyuan Livestock Breeding Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

The invention discloses a traditional Chinese medicine for treating aphtha, which consists of a liquid medicine decocted by a traditional Chinese medicine composition and acetic acid with the mass fraction of 20%, wherein the volume ratio of the liquid medicine to the acetic acid is 1:1, and the traditional Chinese medicine composition consists of the following raw materials in parts by weight: 1-3 parts of platycodon grandiflorum, 1-3 parts of semen momordicae, 3-5 parts of coptis chinensis, 0.5-1.5 parts of phellodendron amurense and 3-5 parts of groundsel; the invention has the functions of detumescence, detoxification and anti-inflammation. The acetic acid has effects of sterilizing and antisepticising, and can prevent oxygen in air from oxidizing various effective components to lose effects of detumescence, removing toxic substance and diminishing inflammation.

Description

Traditional Chinese medicine for treating aphtha and preparation method thereof
Technical Field
The invention belongs to the technical field of veterinary medicines, and particularly relates to a traditional Chinese medicine for treating aphtha and a preparation method thereof.
Background
Common foot and mouth disease of sheep has foot and mouth bubble rash and foot and mouth blister, and is an acute, hot and highly contact infectious disease of artiodactyl caused by foot and mouth disease virus. It is characterized by aphtha, hoof sores and skin sores. Is one of the common epidemic diseases of sheep, wherein aphtha is one of the most common sheep foot and mouth diseases.
Aphtha has epidemiological characteristics of fast prevalence, wide spread, acute morbidity, great harm and the like, the morbidity of an epidemic area can reach 50-100%, the mortality of sheep born right now is high, and the mortality of other sheep is low. Sick animals and latent animals are the most dangerous sources of infection. The vesicular fluid, milk, urine, saliva, tears and feces of the sick livestock contain viruses. The invasion route of the disease is mainly the digestive tract, and the disease can also be transmitted through the respiratory tract. Although the disease has no obvious seasonal nature, it is more common in spring and autumn, especially in spring. Wind and birds are also one of the factors that spread over long distances.
The existing treatment reagent basically adopts a western medicine mode to treat, and the mode has quick response, but the treatment is not thorough and is easy to recover.
Disclosure of Invention
The invention aims to solve the problems of quick response and easy relapse of aphtha treated by adopting a western medicine reagent mode, and provides a traditional Chinese medicine for treating the aphtha.
The technical scheme adopted by the invention is as follows:
the traditional Chinese medicine for treating the aphtha consists of a liquid medicine decocted by a traditional Chinese medicine composition and 20% by mass of acetic acid, wherein the volume ratio of the liquid medicine to the acetic acid is 1:1, and the traditional Chinese medicine composition consists of the following raw materials in parts by weight:
1-3 parts of platycodon grandiflorum
1-3 parts of semen momordicae
Coptis root 3-5 parts
0.5 to 1.5 portions of phellodendron
3-5 parts of groundsel.
The working principle or the beneficial effects of the scheme are as follows: the deionized water is used for decocting various effective components in the platycodon grandiflorum, the semen momordicae, the coptis chinensis, the golden cypress and the climbing groundsel so that the effective components interact with each other to generate the functions of detumescence, detoxification and inflammation diminishing. The acetic acid has effects of sterilizing and antisepticising, and can prevent oxygen in air from oxidizing various effective components and substances generated by interaction between the effective components to lose effects of detumescence, removing toxic substance and diminishing inflammation.
The platycodon grandiflorum has the function of discharging pus, so that the pus in the aphtha can be smoothly discharged, and the inflammation is quickly reduced; semen Momordicae has effects of relieving swelling and resolving hard mass, and can inhibit aphtha and facilitate discharge; the rhizoma Coptidis has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substance, resisting ulcer, resisting bacteria, resisting inflammation and diarrhea, and can reduce oral cavity temperature and avoid aphtha deterioration; cortex Phellodendri has effects of removing toxic substance, treating sore, pyocutaneous disease, toxic swelling, and eczema, and herba Senecionis Scandentis has effects of treating eczema, sore, and furuncle.
Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight:
platycodon grandiflorum 2 parts
Semen Momordicae 2 parts
Coptis root 4 parts
1 part of phellodendron bark
4 parts of groundsel.
The invention also provides a preparation method of the traditional Chinese medicine for treating the aphtha, which comprises the following steps:
(1) soaking radix Platycodi, semen Momordicae, Coptidis rhizoma, cortex Phellodendri and Concha Haliotidis in deionized water for 5-8 hr to obtain mixture A;
(2) heating the mixture A to boil, and continuously boiling for 1.5-2.3 hours to obtain a mixture B;
(3) taking out the platycodon grandiflorum, the semen momordicae, the coptis chinensis, the golden cypress and the climbing groundsel herb in the mixture B, continuously heating until the liquid is sticky, and cooling to obtain a liquid medicine;
(4) and (4) mixing the liquid medicine prepared in the step (3) with acetic acid with the mass fraction of 20%, and uniformly stirring to obtain the traditional Chinese medicine.
The working principle/beneficial effects of the invention are as follows: the platycodon grandiflorum, the momordica cochinchinensis seed, the coptis chinensis, the golden cypress and the groundsel can be unfolded after being soaked for 5-8 hours, so that active ingredients in the platycodon grandiflorum, the momordica cochinchinensis seed, the coptis chinensis, the golden cypress and the groundsel can enter deionized water conveniently, the heating time is shortened, the boiling is continued, the active ingredients in the platycodon grandiflorum, the momordica cochinchinensis seed, the golden cypress and the groundsel are discharged, and the mutual reaction among the active ingredients is accelerated.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
the effective components of the platycodon root, the cochinchina momordica seed, the coptis root, the phellodendron and the groundsel act mutually to generate the functions of detumescence, detoxication and antiphlogosis. The acetic acid has effects of sterilizing and antisepticising, and can prevent oxygen in air from oxidizing various effective components and substances generated by interaction of the effective components to lose effects of detumescence, removing toxic substance and diminishing inflammation.
Detailed Description
All of the features disclosed in this specification, or all of the steps in any method or process so disclosed, may be combined in any combination, except combinations of features and/or steps that are mutually exclusive. It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.
Example one
The traditional Chinese medicine for treating the aphtha is prepared by the following steps:
(1) the following components by mass: soaking 100 g of platycodon grandiflorum, 100 g of momordica cochinchinensis, 200 g of coptis chinensis, 50 g of phellodendron amurense and 200 g of groundsel in 3000 ml of deionized water for 6 hours to obtain a mixture C;
(2) heating the mixture C to boil for 2 hours to obtain a mixture D;
(3) taking out the platycodon grandiflorum, the semen momordicae, the coptis chinensis, the golden cypress and the climbing groundsel in the mixture D, continuing heating until the volume of the liquid is 1500 ml, stopping heating, and cooling to obtain a liquid medicine;
(4) mixing the liquid medicine with 20% acetic acid by mass and stirring uniformly to obtain the traditional Chinese medicine;
(5) the Chinese medicinal composition is directly applied to affected part for 2 times per day.
Example two
The traditional Chinese medicine for treating the aphtha is prepared by the following steps:
(1) the following components by mass: soaking 5 kg of platycodon grandiflorum, 5 kg of semen momordicae, 10 kg of coptis chinensis, 2.5 kg of phellodendron and 10 kg of groundsel in 50L of deionized water for 6 hours to obtain a mixture E;
(2) heating the mixture E to boil for 1.8 hours to obtain a mixture F;
(3) taking out the platycodon grandiflorum, the semen momordicae, the coptis chinensis, the golden cypress and the climbing groundsel herb in the mixture F, and continuously heating until the volume of the liquid is 25 liters; obtaining a liquid medicine;
(4) mixing the liquid medicine with 20% acetic acid by mass and stirring uniformly to obtain the traditional Chinese medicine;
(5) the Chinese medicinal composition is directly applied to affected part for 2 times per day.
In the embodiment, the effective components in the platycodon grandiflorum, the momordica cochinchinensis, the coptis chinensis, the phellodendron amurense and the groundsel are decocted and mixed with acetic acid with the mass fraction of 20%, the mixture is directly applied to an affected part, and the effective components are directly combined with diseased cells on the affected part to destroy the propagation of the diseased cells, so that the purpose of treatment is achieved.
Clinical examples
Selecting 25 diseased sheep with aphtha, dividing the diseased sheep into 5 groups of A, B, C, D and E, and respectively carrying out the following treatment on 5 diseased sheep in each group;
group A: directly smearing the liquid medicine obtained by decocting in the second embodiment on affected parts of the diseased sheep for 2 times a day;
group B: applying 20% acetic acid to affected part of affected sheep for 2 times per day;
group C: directly applying the liquid medicine obtained by decoction in the first embodiment to the affected part of the diseased sheep for 2 times a day;
group D: applying the traditional Chinese medicine in the first embodiment in the manner described in the first embodiment;
group E: the drugs of example two were applied in the manner described in example two.
After half a month of application, the results were as follows:
group A: the aphtha of 5 diseased sheep is improved but not cured, and the effect is better than that of the group B;
group B: canker sores of 5 affected sheep were improved but not healed;
group C: the aphtha of 5 diseased sheep is improved but not cured, and the effect is better than that of the group B;
group D: aphtha of 5 affected sheep healed;
group E: canker sore of 5 affected sheep was healed.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims (1)

1. The traditional Chinese medicine for treating the aphtha is characterized by consisting of a liquid medicine decocted by a traditional Chinese medicine composition and 20% by mass of acetic acid, wherein the volume ratio of the liquid medicine to the acetic acid is 1:1, and the traditional Chinese medicine composition consists of the following raw materials by mass:
root of balloonflower 100 g
Semen Momordicae 100 g
Coptis root, rhizoma Coptidis 200 g
Phellodendron bark, cortex Phellodendri 50 g
200 g of groundsel;
the preparation method of the traditional Chinese medicine for treating the aphtha comprises the following steps:
(1) soaking platycodon grandiflorum, semen momordicae, coptis chinensis, golden cypress and groundsel in 3000 ml of deionized water for 6 hours to obtain a mixture C;
(2) heating and boiling the mixture C for 2 hours to obtain a mixture D;
(3) taking out the platycodon grandiflorum, the semen momordicae, the coptis chinensis, the golden cypress and the climbing groundsel in the mixture D, continuing heating until the volume of the liquid is 1500 ml, stopping heating, and cooling to obtain a liquid medicine;
(4) and (4) mixing the liquid medicine prepared in the step (3) with acetic acid with the mass fraction of 20%, and uniformly stirring to obtain the traditional Chinese medicine.
CN201810586513.3A 2018-06-06 2018-06-06 Traditional Chinese medicine for treating aphtha and preparation method thereof Expired - Fee Related CN108403825B (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105343157A (en) * 2015-11-14 2016-02-24 黄平县野洞河镇丰岩生态种养殖专业合作社 Externally applied drug for treating aphtha in Capra aegagrus hircus
CN105412358A (en) * 2015-12-16 2016-03-23 山东省动物疫病预防与控制中心 Chinese herbal preparation for preventing and controlling cattle and sheep skin mucosa blistering necrotic disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105343157A (en) * 2015-11-14 2016-02-24 黄平县野洞河镇丰岩生态种养殖专业合作社 Externally applied drug for treating aphtha in Capra aegagrus hircus
CN105412358A (en) * 2015-12-16 2016-03-23 山东省动物疫病预防与控制中心 Chinese herbal preparation for preventing and controlling cattle and sheep skin mucosa blistering necrotic disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
中西医结合治疗羔羊口疮;李志杰等;《中兽医医药杂志》;19991231(第06期);第29-30页 *
羊口疮病的诊断与防治对策分析;高改林;《甘肃畜牧兽医》;20161231;第46卷(第07期);第75-76页 *

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