CN108403616A - A kind of radioresistance skin care compositions - Google Patents
A kind of radioresistance skin care compositions Download PDFInfo
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- CN108403616A CN108403616A CN201810407904.4A CN201810407904A CN108403616A CN 108403616 A CN108403616 A CN 108403616A CN 201810407904 A CN201810407904 A CN 201810407904A CN 108403616 A CN108403616 A CN 108403616A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The present invention provides a kind of skin care compositions, including skin progenitor cell culture supernatant, the skin progenitor cell is irradiated using low dosage ultraviolet light.The present invention improves the defense function of skin Antiradiation injury；It is used in the sensitive flesh of external boundary's stimulation extreme sensitivity, can also there is good radioresistance effect.The various active ingredients of the present invention are synergistic each other, enhance skin barrier function, improve the immunity of damaged skin, improve a variety of symptoms such as cutaneous sensibility.
Description
Technical field
The invention belongs to beauty and make-up fields, relate generally to skin care compositions.
Background technology
Skin is the significant defense barrier of human body, and skin barrier is the natural bodyguard of human skin, everyone skin table
Layer has one layer of natural skin barrier, and effect is to protect each organ in human body not by the shadow of the variations such as temperature, humidity
It rings, and resists stimulation of the external environment to human body, such as ultraviolet light, pollutant etc., and homeostasis is being maintained to play
Important function.However, ultraviolet light, from the excessive physical chemistry stimulation of external environment and pressure, nutritional deficiency etc. making skin
Normal function degenerate, keep skin barrier impaired, keratinization occur, form wrinkle etc..Wherein, such as purple from external radiation
Outside line etc. is the stimulus that skin is difficult to avoid, and is the important factor in order that various problems occurs in skin.
And sensitive is a kind of state that skin is highly sensitive, skin esthesis is strong, vulnerable, easily stimulated
And cause uncomfortable to a certain degree, the fragile state of skin presentation.Sensitive is when in face of outside stimulus such as ultraviolet lights, even more
Without the power resisted, easily there is shouting pain, tingle, the burn feeling of hair flaking, blanching sense, sense of discomfort, tightens the symptoms such as sense,
Even there is erythema and decortication etc..
However do not make skin, especially sensitive skin to anti-ultraviolet method well at present, it is common sun-proof
The skin care item such as frost, the ingredients such as sun-screening agent contained therein, alcohol increase the insecurity such as irritation, light sensitivity, improve production
The probability of raw condition susceptible.Moreover, found in factual survey, it is long-term to apply even if there is not apparent stimulation and allergic reaction
Smearing high irritation and has the cosmetics of anaphylactogen, can also make skin damage, occur it is coarse, the symptoms such as play pimple, itch.
Invention content
It is non-stimulated to skin the purpose of the present invention is to provide a kind of composition for resisting the radiation such as ultraviolet light, and
It can effectively improve the defective modes such as skin sensitivity.
The purpose of the present invention is what is realized by following measures：
A kind of skin care compositions, including skin progenitor cell culture supernatant, the skin progenitor cell are ultraviolet using low dosage
Line irradiates.The composition is named as anti-spoke flesh liquid.
Preferably, skin progenitor cell culture supernatant is the supernatant collected to skin progenitor cell culture 3 days or more.
Above-mentioned ultraviolet light is radiated at Continuous irradiation 2-24 hours after skin progenitor cell culture 6-24 hours.Preferably, the ultraviolet light shines
It is 3-7mJ/cm to penetrate dosage2.Dosage is adjusted according to irradiation time.
In order to be suitable for sensitive skin, neural stem cell lysate is added in the skin progenitor cell culture medium.The god
The mixing obtained after the release of cell and intracellular matter after stem cell lysate refers to neural stem cell destruction or dissolving
Object.Including cytosolic fractions, cell wall fraction and metabolite etc..Preferably, the cell cracking uses freeze-thaw method；Specifically,
Neural stem cell is placed in cooling in liquid nitrogen, 35-40 DEG C melts, and is repeated 3 times above；Membrane filtration collected film object to get.It is described
Film uses the apertures 250-500nm filter membrane.
Preferably, after skin progenitor cell ultraviolet light is irradiated and cultivated, above-mentioned neural stem cell is added in the medium
Lysate.It finds in an experiment, 2-12 hours addition neural stem cell lysates after ultraviolet light irradiates, and continues to cultivate
12-48 hours, be conducive to the collaboration of various composition.
The culture medium that above-mentioned skin progenitor cell culture uses is：Basal medium DMEM/F12,25-30 μ g/L VEGF,
30-40 μ g/L EGF, the NGF of 5-10 μ g/L, the human albumin of 5~50mg/L, 20-30 μ g/L vitamin Es, ironic citrate 1-
3mmol/L, glutamine 1-2mmol/L, gentamicin 10-100g/L, putrescine 0.8-2.0mg/L.Neural stem cell lysate
Dosage is the 0.5-2wt% of culture medium.
In order to be further applicable to sensitive skin, above-mentioned skin care compositions includes：Skin progenitor cell culture supernatant
800-1500 parts, 3-8 parts of aloe extract, 0.5-5 parts of alkannin, 0.05-0.5 parts of glutamine, adenosine phosphate 0.005-
0.05 part, 0.5-2 parts of allantoin, 0.5-5 parts of Hydrolyzed Collagen, in terms of mass fraction.
The present invention also provides a kind of skin care item, containing above-mentioned composition and conventional cosmetic grade auxiliary agent, wherein being free of
Alcohol, essence or preservative.
The present invention also provides application of the above-mentioned composition in preparing radioresistance skin care item.
Combination of the present invention can be used for various products preparation together with other skin actives, for example, toner,
Mildy wash, emulsion such as lotion, face cream, facial mask, gel etc..
Composition of the present invention is used as conservative or rinse-off compositions.For example, leave-on composition can be with
It is to retain by locally application to skin and on the skin a period of time (such as 5-30min or 1-24h)；Rinse-off compositions can
Be application to skin then in such as less than 5min for a period of time from skin removed or the product washed away.Rinse-off compositions can
To be skin cleaner, shampoo, hair conditioner or soap.Example of leave-on composition can be skin moisturizer, sun-screening agent,
Facial mask, late frost or day cream.
Advantageous effect
1. the present invention improves the defense function of skin Antiradiation injury；It is used in the quick of external boundary's stimulation extreme sensitivity
Feel flesh, can also there is good radioresistance effect.The various active ingredients of the present invention are synergistic each other, enhance skin barrier function,
The immunity of damaged skin is improved, a variety of symptoms such as cutaneous sensibility are improved.
2. the present invention is safe, non-stimulated, has no toxic side effect, long-time service will not cause the accumulative injury of skin.
3. it is toxic that the present invention does not add preservative, emulsifier, alcohol ethers, antioxidant, stabilizer, pigment, essence etc.
Substance can have the effect of excellent radioresistance, repair sensitive skin.
Description of the drawings
Fig. 1 cell experiment results
Specific implementation mode
The present invention is specifically described below by embodiment, it is necessary to which indicated herein to be the present embodiment can only use
In invention is further explained, it should not be understood as limiting the scope of the invention, the people that is skilled in technique in the field
Member can make some nonessential modifications and adaptations according to the content of aforementioned present invention.Anti- spoke flesh liquid of the present invention meets
《Cosmetics safety technical specification》.
Embodiment 1
A kind of composition for skin care, including following preparation process：
1. the preparation of neural stem cell lysate
Human nerve stem cell is placed in liquid nitrogen cooling 30min, melts in 37 DEG C of cell incubators, is repeated 3 times；250nm
Aperture membrane filtration collected film object to get.It is spare to be put into 37 DEG C of heat preservations.
2. the preparation of skin progenitor cell culture supernatant：
(1) culture medium is configured：Basal medium be DMEM/F12,25 μ g/L VEGF, 35 μ g/L EGF, 8 μ g/L NGF,
The human albumin of 20mg/L, 25 μ g/L vitamin Es, ironic citrate 2mmol/L, glutamine 2mmol/L, gentamicin 50g/
L, putrescine 1.6mg/L.
(2) it will be cultivated in application on human skin stem cell step (1) culture medium, 37 DEG C are cultivated 12 hours, and 5mJ/cm is then used2It is ultraviolet
Line Continuous irradiation cell 18 hours continues to cultivate 6h after irradiation.
(3) neural stem cell lysate made from 1wt% steps 1 is added in the medium, is further cultured for for 24 hours, then collecting
Cell liquid, centrifugation, takes supernatant, the apertures 500nm membrane filtration to get.
3. the preparation of flesh liquid
(1) after the gel after removing the peel Caulis Aloe washes with water, broken juice is carried out, aloe extract is obtained after removing slag.
(2) by 5 parts of aloe extract, 2 parts of alkannin, 0.1 part of glutamine, 0.02 part of adenosine phosphate, 1 part of allantoin,
2 parts of Hydrolyzed Collagen is added in step 2 gained skin progenitor cell culture supernatant (1200 parts) and is sufficiently mixed；It is protected at 50 DEG C
Temperature 2 hours is placed in 4 DEG C of household freezers and preserves.
Unless otherwise instructed, number of the present invention is in terms of mass fraction.
Embodiment 2
A kind of composition for skin care, including following preparation process：
1. the preparation of neural stem cell lysate
Human nerve stem cell is placed in liquid nitrogen cooling 30min, melts in 37 DEG C of cell incubators, is repeated 4 times；300nm
Aperture membrane filtration collected film object to get.It is spare to be put into 37 DEG C of heat preservations.
2. the preparation of skin progenitor cell culture supernatant：
(1) culture medium is configured：Basal medium be DMEM/F12,28 μ g/L VEGF, 28 μ g/L EGF, 8 μ g/L NGF,
The human albumin of 20mg/L, 25 μ g/L vitamin Es, ironic citrate 2.5mmol/L, glutamine 1.6mmol/L, gentamicin
50g/L, putrescine 1.5mg/L.
(2) by application on human skin stem cell in step (1) inoculation of medium, 37 DEG C are cultivated 24 hours, and 7mJ/cm is then used2It is purple
Outside line Continuous irradiation cell 5 hours continues to cultivate 12h after irradiation.
(3) neural stem cell lysate made from 2wt% steps 1 is added in the medium, is further cultured for 36h, then collects
Cell liquid, centrifugation, takes supernatant, the apertures 500nm membrane filtration to get.
3. the preparation of flesh liquid
(1) after the gel after removing the peel Caulis Aloe washes with water, broken juice is carried out, aloe extract is obtained after removing slag.
(2) by 5 parts of aloe extract, 0.8 part of alkannin, 0.2 part of glutamine, 0.045 part of adenosine phosphate, allantoin
1.5 parts, 3 parts of Hydrolyzed Collagen are added in step 2 gained skin progenitor cell culture supernatant (1500 parts) and are sufficiently mixed；
50 DEG C keep the temperature 2 hours, are placed in 4 DEG C of household freezers and preserve.
Embodiment 3
A kind of composition for skin care, including following preparation process：
1. the preparation of neural stem cell lysate
Human nerve stem cell is placed in liquid nitrogen cooling 30min, melts in 37 DEG C of cell incubators, is repeated 3 times；450nm
Aperture membrane filtration collected film object to get.It is spare to be put into 37 DEG C of heat preservations.
2. the preparation of skin progenitor cell culture supernatant：
(1) culture medium is configured：Basal medium be DMEM/F12,25 μ g/LVEGF, 40 μ g/L EGF, 5 μ g/L NGF,
The human albumin of 35mg/L, 20 μ g/L vitamin Es, ironic citrate 1mmol/L, glutamine 1.2mmol/L, gentamicin
80g/L, putrescine 1.0mg/L.
(2) it will be cultivated in application on human skin stem cell step (1) culture medium, 37 DEG C are cultivated 6 hours, and 3mJ/cm is then used2It is ultraviolet
Line Continuous irradiation cell 22 hours continues to cultivate 3h after irradiation.
(3) neural stem cell lysate made from 0.8wt% steps 1 is added in the medium, is further cultured for 45h, then receives
Collect cell liquid, centrifugation takes supernatant, the apertures 500nm membrane filtration to get.
3. the preparation of flesh liquid
(1) after the gel after removing the peel Caulis Aloe washes with water, broken juice is carried out, aloe extract is obtained after removing slag.
(2) by 4 parts of aloe extract, 5 parts of alkannin, 0.35 part of glutamine, 0.01 part of adenosine phosphate, allantoin 0.5
Part, 3 parts of Hydrolyzed Collagen are added in step 2 gained skin progenitor cell culture supernatant (800 parts) and are sufficiently mixed；At 50 DEG C
Heat preservation 2 hours is placed in 4 DEG C of household freezers and preserves.
Embodiment 4
Influence of the anti-spoke flesh liquid of one, to human skin cell
1. selecting Human keratinocytes HaCAT, it is placed in 37 DEG C, 5%CO2Incubator in cultivate, logarithmic growth phase
Cell is for testing；
2. HaCAT cell controls group (routine culture liquid) is arranged, (routine culture liquid simultaneously contains 20% anti-spoke to anti-1 group of spoke flesh liquid
Flesh liquid), anti-2 groups of spoke flesh liquid (routine culture liquid simultaneously contain 10% anti-spoke flesh liquid), (routine culture liquid is simultaneously anti-containing 5% for anti-3 groups of spoke flesh liquid
Spoke flesh liquid), inoculating cell.
3. gamma ray (exposure dose 20Gy) is used to irradiate each group HaCAT cells, irradiation time is irradiation side for 24 hours
Formula is arranged two groups, and one group is that anti-spoke flesh liquid is added to carry out radiation exposure at once, and one group is being added anti-spoke flesh liquid progress cell culture
Radiation exposure is carried out after 12h.
4.MTT detects cell proliferative conditions：48h MTT are detected after cell inoculation.Cell survival rate (proliferation rate) result is such as
Shown in Fig. 1.
Experimental result shows that the anti-spoke flesh liquid of the present invention has and Human keratinocytes proliferation, raising cell is promoted to resist spoke
The ability of damage is penetrated, and shows dose dependent.
Two, skins improve test
1. tested crowd：
Sensitive skin crowd test：After smearing 10% lactic acid solution to volunteer's nose side, volunteer's self-appraisal thorn
Pain feels that standards of grading are 0~4 point：0 point to be painless, 1 point is slight shouting pain, and 2 points are slight shouting pain, and 3 points are moderate shouting pain, 4
It is strong to be divided into shouting pain.The individual of moderate or strong tingling sensation thinks it with sensitive skin.By sensitive skin volunteer and certainly
It is willing to participate in erythema experimenter as tested crowd.Screen 25 sensitive skin.
2. experimental method：
The minimum erythema value for measuring each volunteer before tested using sun protection factor detecting and analysing system, i.e., in fixed light source
With the time required to causing skin to generate just visible erythema under conditions of irradiation distance.
Thereafter, importing this anti-spoke flesh liquid with introducing apparatus after every volunteer's daily cleaning face once in the morning and once at night continuously makes
Other functional skin care item are not used with 12 weeks, during experiment.
Terminate within tested 12 weeks, carry out minimum erythema value test again, compares the difference of tested front and back minimum erythema value.And by
It pays a return visit within 3 months after examination, tests minimum erythema value again.
3. experimental result：(1) average time of tested crowd's minimum erythema value is after 8.5h rises to treatment before treatment
16.5h。
(2) pay a return visit within 3 months after tested, minimum erythema value maintain it is tested at the end of state, do not decline.
It is sensitive skin before tested crowd is tested, sensitive to environmental stimuli, after treatment in 12 weeks, skin generates erythema
Time is substantially increased, and subject's sensitive skin is substantially increased light radiation tolerance, and not only skin light loss symptom is able to significantly
Alleviate, and this product not only without any sensitization situation or aggravates skin sensitivity situation, skin sensitivity situation obtains after treating instead
To improvement；Therapeutic effect long-acting can be kept simultaneously, will not be repeatedly.
Claims (10)
1. a kind of skin care compositions, including skin progenitor cell culture supernatant, the skin progenitor cell uses low dosage ultraviolet light
Irradiation culture.
2. skin care compositions as described in claim 1, the ultraviolet light is radiated at skin progenitor cell inoculated and cultured 6-24 hours
Continuous irradiation 2-24 hours afterwards.
3. skin care compositions as claimed in claim 1 or 2, the ultraviolet irradiating dose is 3-7 mJ/cm2。
4. skin care compositions as claimed in claim 1,2 or 3, addition neural stem cell is split in the skin progenitor cell culture medium
Solve object.
5. skin care compositions as claimed in claim 4, the cell cracking uses freeze-thaw method；The freeze-thaw method is by nerve cord
Cell is placed in cooling in liquid nitrogen, and 35-40 DEG C melts, and is repeated 3 times above；Film was collected using the apertures 250-500nm membrane filtration
Object to get.
6. skin care compositions as described in claim 4 or 5, after skin progenitor cell ultraviolet light is irradiated and cultivated described in addition
Neural stem cell lysate.
7. skin care compositions as claimed in claim 6,2-12 hours addition neural stem cell are split after ultraviolet light irradiates
Object is solved, and continues culture 12-48 hours.
8. the skin care compositions as described in claim 1-7 is any, the culture medium prescription that the skin progenitor cell culture uses
For：Basal medium DMEM/F12,25-30 μ g/L VEGF, 30-40 μ g/L EGF, the NGF of 5-10 μ g/L, 5~50mg/L
Human albumin, 20-30 μ g/L vitamin Es, ironic citrate 1-3mmol/L, glutamine 1-2mmol/L, gentamicin 10-
100g/L, putrescine 0.8-2.0mg/L；Neural stem cell lysate dosage is the 0.5-2wt% of culture medium.
9. the skin care compositions as described in claim 1-8 is any, the skin care compositions include：Skin progenitor cell culture
800-1500 parts of supernatant, 3-8 parts of aloe extract, 0.5-5 parts of alkannin, 0.05-0.5 parts of glutamine, adenosine phosphate
0.005-0.05 parts, 0.5-2 parts of allantoin, 0.5-5 parts of Hydrolyzed Collagen, in terms of mass fraction.
10. any skin care item of claim 1-9, are made one of following form：Toner, mildy wash, emulsion such as breast
Liquid, face cream, facial mask, gel, skin cleaner, shampoo, hair conditioner, soap, skin moisturizer, sun-screening agent, facial mask, late frost or day
Frost.
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| CN201810407904.4A CN108403616A (en) | 2018-04-28 | 2018-04-28 | A kind of radioresistance skin care compositions |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810407904.4A CN108403616A (en) | 2018-04-28 | 2018-04-28 | A kind of radioresistance skin care compositions |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1618981A (en) * | 2003-11-20 | 2005-05-25 | 中国人民解放军军事医学科学院野战输血研究所 | Dry cell secretion factor and its preparation method and application |
| CN101400787A (en) * | 2006-01-27 | 2009-04-01 | 株式会社Prostemics | Mass producing method of growth factor using adipose derived adult stem cells |
| CN106244652A (en) * | 2016-08-17 | 2016-12-21 | 广州宏柯源生物科技有限公司 | The preparation method of a kind of human mesenchymal stem cell culture supernatant lyophilized powder and prepared lyophilized powder |
-
2018
- 2018-04-28 CN CN201810407904.4A patent/CN108403616A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1618981A (en) * | 2003-11-20 | 2005-05-25 | 中国人民解放军军事医学科学院野战输血研究所 | Dry cell secretion factor and its preparation method and application |
| CN101400787A (en) * | 2006-01-27 | 2009-04-01 | 株式会社Prostemics | Mass producing method of growth factor using adipose derived adult stem cells |
| CN106244652A (en) * | 2016-08-17 | 2016-12-21 | 广州宏柯源生物科技有限公司 | The preparation method of a kind of human mesenchymal stem cell culture supernatant lyophilized powder and prepared lyophilized powder |
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Application publication date: 20180817 |