CN108391432B - 杂环化合物的生物偶联分子 - Google Patents

杂环化合物的生物偶联分子 Download PDF

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Publication number
CN108391432B
CN108391432B CN201680021226.7A CN201680021226A CN108391432B CN 108391432 B CN108391432 B CN 108391432B CN 201680021226 A CN201680021226 A CN 201680021226A CN 108391432 B CN108391432 B CN 108391432B
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adenosylmethionine
sam
acceptor
adenosylhomocysteine
biotin
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Chinese (zh)
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CN108391432A (zh
Inventor
郝秀娟
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Taizhou Huifeng Hetai Biotechnology Co ltd
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Taizhou Huifeng Hetai Biotechnology Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201680021226.7A 2015-04-06 2016-04-06 杂环化合物的生物偶联分子 Active CN108391432B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562143790P 2015-04-06 2015-04-06
US62/143790 2015-04-06
US15/091544 2016-04-05
US15/091,544 US10138267B2 (en) 2015-04-06 2016-04-05 Bioconjugates of heterocyclic compounds
PCT/US2016/026279 WO2016164504A1 (en) 2015-04-06 2016-04-06 Bioconjugates of heterocyclic compounds

Publications (2)

Publication Number Publication Date
CN108391432A CN108391432A (zh) 2018-08-10
CN108391432B true CN108391432B (zh) 2022-03-22

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Country Status (7)

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US (1) US10138267B2 (https=)
EP (2) EP3337804A4 (https=)
JP (2) JP7327898B2 (https=)
CN (1) CN108391432B (https=)
AU (1) AU2016246603B2 (https=)
CA (1) CA2981768C (https=)
WO (1) WO2016164504A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10138267B2 (en) * 2015-04-06 2018-11-27 Hunan Skyworld Biotechnologies Co. Ltd. Bioconjugates of heterocyclic compounds
CA3138608A1 (en) 2019-05-01 2020-11-05 Commonwealth Scientific And Industrial Research Organisation Immunosensor
CN111499724A (zh) * 2020-04-15 2020-08-07 上海领潮生物新材料有限公司 一种s-腺苷同型半胱氨酸-鸡卵白蛋白偶联物的制备方法
CN116367832B (zh) * 2020-10-12 2026-02-17 苏州华明道康生物医药有限公司 取代的杂芳基化合物及其用途
CN112924427B (zh) * 2021-02-02 2022-07-08 中国农业科学院特产研究所 一种消除植物组织自体荧光的方法
CN114315980B (zh) * 2021-12-30 2023-04-28 湖南中晟全肽生化有限公司 抑制il-17a与il-17受体结合的多肽及其应用
WO2024059841A2 (en) * 2022-09-16 2024-03-21 Early Is Good, Inc. Analyte detection and quantification

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009131643A1 (en) * 2008-04-21 2009-10-29 Monabio, Inc. Immunoassay for specific determination of s-adenosymethionine and analogs thereof in biological samples
CN104046682A (zh) * 2013-03-13 2014-09-17 苏州博泰安生物科技有限公司 同型半胱氨酸的检测方法及其诊断试剂盒

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
EP0035317A1 (en) 1980-03-04 1981-09-09 Yoshiaki Nagaura Method for the manufacture of lens-like articles
DE3822750A1 (de) 1988-07-05 1990-01-11 Boehringer Mannheim Gmbh Verfahren zur bestimmung einer spezifisch bindefaehigen substanz
US5202423A (en) 1988-07-08 1993-04-13 Wallac Oy Terpyridine derivatives
FR2664699B1 (fr) 1990-07-13 1995-08-18 Cis Bio Int Procede d'amplification du signal d'emission d'un compose luminescent.
FI88654C (fi) 1991-03-15 1993-06-10 Datacity Center Oy Fluorescenshoejningsmetod
FI91449C (fi) 1992-10-29 1994-06-27 Wallac Oy Menetelmä biologisen aineen määrittämiseksi in situ
WO2009078876A1 (en) 2007-12-18 2009-06-25 Bellbrook Labs, Llc Assay method for group transfer reactions
US8268264B2 (en) 2009-02-09 2012-09-18 Caprotec Bioanalytics Gmbh Devices, systems and methods for separating magnetic particles
US9958447B2 (en) * 2013-03-15 2018-05-01 Hunan Skyworld Biotechnologies Co Immunoassay of S-adenosylmethionine in personalized medicine and health or cancer evaluation
US10138267B2 (en) 2015-04-06 2018-11-27 Hunan Skyworld Biotechnologies Co. Ltd. Bioconjugates of heterocyclic compounds
US10067126B2 (en) * 2015-05-25 2018-09-04 Hunan SkyWorld Biotechnologies Co. LTD Use of fluorescence for the quick and easy determination of s-adenosylmethionine, s-adenosylhomocysteine and homocysteine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009131643A1 (en) * 2008-04-21 2009-10-29 Monabio, Inc. Immunoassay for specific determination of s-adenosymethionine and analogs thereof in biological samples
CN104046682A (zh) * 2013-03-13 2014-09-17 苏州博泰安生物科技有限公司 同型半胱氨酸的检测方法及其诊断试剂盒

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Using S-adenosyl-L-homocysteine capture compounds to characterize S-adenosyl-L-methionine and S-adenosyl-L-homocysteine binding proteins;Lindsey J. Brown et al;《Anal Biochem》;20141215;第467卷;第14-21页 *

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Publication number Publication date
US20160291014A1 (en) 2016-10-06
JP7327898B2 (ja) 2023-08-16
JP7344928B2 (ja) 2023-09-14
JP2021152027A (ja) 2021-09-30
WO2016164504A1 (en) 2016-10-13
EP4219518A2 (en) 2023-08-02
CN108391432A (zh) 2018-08-10
EP3337804A1 (en) 2018-06-27
EP3337804A4 (en) 2019-02-20
JP2018516858A (ja) 2018-06-28
CA2981768C (en) 2022-03-08
AU2016246603B2 (en) 2019-08-15
US10138267B2 (en) 2018-11-27
AU2016246603A1 (en) 2017-11-23
CA2981768A1 (en) 2016-10-13

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