CN1083707A - A kind of production technology of NAOXUESHUAN PIAN - Google Patents

Abstract

The invention discloses a kind of production technology of NAOXUESHUAN PIAN; concrete system adds water and ethanol lixiviate respectively for 225 parts with Flos Carthami, Hirudo, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, each 900 weight portion of Semen Persicae and ground beetle; make extractum or clear paste; other gets the artificial Calculus Bovis and Cornu procaprae gutturosae half concentrates each 112.5 parts in powder; 900 parts in Radix Paeoniae Rubra powder; make binding agent with Flos Carthami extract and Hirudo extract and granulate, make tablet.By the product taking convenience that technology of the present invention makes, therapeutic effect excellence, the effect that have blood circulation promoting and blood stasis dispelling, brain-refreshing and channel obstruction-removing, the moon of diving relieves dizziness, high fever, infantile convulsions, epilepsy, etc.

Description

A kind of production technology of NAOXUESHUAN PIAN

The present invention relates to a kind of production technology of NAOXUESHUAN PIAN.

Cerebral embolism is commonly encountered diseases, the frequently-occurring disease in the mid-aged population, in recent years, raising along with living standards of the people, the eating patterns of consumer progressively change, higher fatty acid, high cholesterol count in the diet and other composite factor have facilitated thrombotic disease to make the group development to low year, the patient is part LOM then gently, and is heavy then death by accident takes place.

The production technology that the purpose of this invention is to provide a kind of NAOXUESHUAN PIAN, it is good that the product of being made by technology of the present invention has therapeutic effect concurrently, the characteristic of taking convenience.

The objective of the invention is to adopt following technical scheme to be achieved: (if no special instructions following, umber by weight)

A, get 900 parts on Flos Carthami, add 8-10 decocting doubly and boil secondary, each one hour, merge and boil liquid, it is the clear paste of 1.25-1.27 that concentrating under reduced pressure becomes relative density, makes Flos Carthami extract A;

900 parts of b, water intaking trematodiasiss, decoct with water three times, add for the first time 5-8 times of water gaging, soak after 4 hours, decocted 2 hours, and respectively added 5-8 times of water gaging for the second time, for the third time, decocted 1.5-2 hour, collecting decoction, filter, to be condensed into relative density be 1.24 clear paste to filtrate, adds 95% ethanol, to concentration of alcohol be 75%, it is static more than 24 hours fully to stir the back, get supernatant, filter decompression recycling ethanol, it is 1.10-1.20 that liquid is evaporated to relative density, and weight is the extractum B of 150-200 weight portion (making binding agent during granulation);

C, get each 900 parts of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Semen Persicae, 225 parts of Eupolyphaga Seu Steleophagas, doubly extract secondary with 70% ethanol according to the heavy 5-8 of medicine respectively, merge extractive liquid, is evaporated to the extractum that relative density is 1.25-1.30, vacuum drying, make dry extract 350-400 weight portion, moisture percentage 3-6% pulverizes the back and crosses sieve 6 or No. 7, it is standby to make mixed extract S, reclaims ethanol in the decompression process and recycles;

D, get 112.5 parts of artificial Calculus Boviss, Cornu procaprae gutturosae half concentrates 112.5 parts in powder, pulverizes sieve 6 or No. 7, will pulverize afterwards powder D and mixed extract S mixing for standby use;

E, get 900 parts of Radix Paeoniae Rubra, be ground into fine powder, the control fineness is the 100-120 order, and it is standby to make Radix Paeoniae Rubra powder E;

F, be that binding agent is granulated with Flos Carthami extract A, Hirudo extractum B with above-mentioned gained raw material D, S, E, drying, the flat stamping of the dark circle of control φ 9.5-10mm, the control substrate heavily is 0.3 gram, coating, packing get final product.

Because the present invention adopts Hirudo extract to be aided with the Flos Carthami extract binding agent, the component drug effect of having held concurrently simultaneously, strengthened the active ingredient in the medicine, eliminated the impurity of some no pharmacologic actions, the extract dissolubility is better, is convenient to stripping and absorption, and the medication effect of making is good, taking convenience is for vast thrombosis patient has brought Gospel.

Below in conjunction with embodiment in detail the present invention is described in detail:

(if no special instructions following, umber by weight)

Get 900 parts of Radix Paeoniae Rubra, be ground into fine powder standby (control fineness 100-120 order);

Get 900 parts on Flos Carthami, add 8-10 decocting doubly and boil secondary, each one hour, merge and boil liquid, it is the clear paste of 1.25-1.27 that concentrating under reduced pressure becomes relative density, makes Flos Carthami extract A;

900 parts of water intaking trematodiasiss, decoct with water three times, add for the first time 5-8 times of water gaging, soak after 1 hour, decocted 2 hours, and respectively added 5-8 times of water gaging for the second time, for the third time, decocted 1.5-2 hour, collecting decoction, filter, to be condensed into relative density be 1.24 clear paste to filtrate, adds 95% ethanol, to concentration of alcohol be 75%, it is static more than 24 hours fully to stir the back, get supernatant, filter decompression recycling ethanol, it is 1.10-1.20 that liquid is evaporated to relative density, and weight is the extractum B of 150-200 weight portion (making binding agent during granulation);

Get respectively 900 parts in Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Semen Persicae, 225 parts of Eupolyphaga Seu Steleophagas, doubly extract secondary with 70% ethanol according to the heavy 5-8 of medicine respectively, merge extractive liquid, is evaporated to the extractum that relative density is 1.25-1.30, vacuum drying, make dry extract 350-400 weight portion, moisture percentage 3-6% pulverizes the back and crosses sieve 6 or No. 7, it is standby to make mixed extract S, reclaims ethanol in the decompression process and recycles.

Get 112.5 parts of artificial Calculus Boviss, Cornu procaprae gutturosae half concentrates 112.5 parts in powder, pulverizes sieve 6 or No. 7, will pulverize back powder D and mixed extract S mixing for standby use.

With above steps gained raw material and mixed extract S mix homogeneously, be that binding agent is granulated with Flos Carthami extract A, Hirudo extractum B, in dry below 80 ℃, the flat stamping of the dark circle of control φ 9.5-10mm, the control substrate heavily is 0.3 gram, coating, packing get final product.

The medicine substrate that technology of the present invention makes is a sepia, the acrid in the mouth hardship, outer sugar coating, general take four at every turn, effect with blood circulation promoting and blood stasis dispelling, brain-refreshing and channel obstruction-removing, suppressing hyper-yang to eliminate wind, to diseases such as the aphasia due to apoplexy at cerebral thrombosis initial stage, facial hemiparalysis, numb limbs and tense tendons, hemiplegia, significant curative effect is arranged, be fit to vast thrombosis patient and take.

Claims (1)

1, a kind of production technology of NAOXUESHUAN PIAN is characterized in that:

A, get 900 parts on Flos Carthami, add 8-10 decocting doubly and boil secondary, each one hour, merge and boil liquid, it is the clear paste of 1.25-1.27 that concentrating under reduced pressure becomes relative density, makes Flos Carthami extract A;

900 parts of b, water intaking trematodiasiss, decoct with water three times, add for the first time 5-8 times of water gaging, soak after 4 hours, decocted 2 hours, respectively add 5-8 times of water gaging for the second time, for the third time, decocted 1.5-2 hour, collecting decoction filters, and it is 1.24 clear paste that filtrate is condensed into relative density, add 95% ethanol, to concentration of alcohol be 75%, it is static more than 24 hours fully to stir the back, gets supernatant, filter, it is 1.10-1.20 that decompression recycling ethanol, liquid are evaporated to relative density, and weight is the extractum B of 150-200 weight portion (making binding agent during granulation);

C, get each 900 parts of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Semen Persicae, 225 parts of Eupolyphaga Seu Steleophagas, doubly extract secondary with 70% ethanol according to the heavy 5-8 of medicine respectively, merge extractive liquid, is evaporated to the extractum that relative density is 1.25-1.30, vacuum drying, make dry extract 350-400 weight portion, moisture percentage 3-6% pulverizes the back and crosses sieve 6 or No. 7, it is standby to make mixed extract S, reclaims ethanol in the decompression process and recycles;

D, get 112.5 parts of artificial Calculus Boviss, Cornu procaprae gutturosae half concentrates 112.5 parts in powder, pulverizes sieve 6 or No. 7, will pulverize afterwards powder D and mixed extract S mixing for standby use;

E, get 900 parts of Radix Paeoniae Rubra, be ground into fine powder, the control fineness is the 100-120 order, and it is standby to make Radix Paeoniae Rubra powder E;

F, be that binding agent is granulated with Flos Carthami extract A, Hirudo extractum B with above-mentioned gained raw material D, S, E, drying, the flat stamping of the dark circle of control φ 9.5-10mm, the control substrate heavily is 0.3 gram, coating, packing are finished product.