CN108368102A - 2-氨基-1,3,4-噻二嗪和基于2-氨基-1,3,4-恶二嗪的抗真菌剂 - Google Patents

2-氨基-1,3,4-噻二嗪和基于2-氨基-1,3,4-恶二嗪的抗真菌剂 Download PDF

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Publication number
CN108368102A
CN108368102A CN201680053383.6A CN201680053383A CN108368102A CN 108368102 A CN108368102 A CN 108368102A CN 201680053383 A CN201680053383 A CN 201680053383A CN 108368102 A CN108368102 A CN 108368102A
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CN
China
Prior art keywords
thiadiazin
amine
alkyl
butyl
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201680053383.6A
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English (en)
Chinese (zh)
Inventor
格雷厄姆·爱德华·莫里斯·西布利
拉尔斯·乔纳斯·马尔姆斯特伦
约翰娜·玛丽亚·拉森
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F2G Ltd
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F2G Ltd
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Filing date
Publication date
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Publication of CN108368102A publication Critical patent/CN108368102A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201680053383.6A 2015-07-14 2016-07-14 2-氨基-1,3,4-噻二嗪和基于2-氨基-1,3,4-恶二嗪的抗真菌剂 Pending CN108368102A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1512286.4A GB201512286D0 (en) 2015-07-14 2015-07-14 Chemical compounds
GB1512286.4 2015-07-14
PCT/GB2016/052132 WO2017009651A1 (en) 2015-07-14 2016-07-14 2-amino-1,3,4-thiadiazine and 2-amino-1,3,4-oxadiazine based antifungal agents

Publications (1)

Publication Number Publication Date
CN108368102A true CN108368102A (zh) 2018-08-03

Family

ID=54013916

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680053383.6A Pending CN108368102A (zh) 2015-07-14 2016-07-14 2-氨基-1,3,4-噻二嗪和基于2-氨基-1,3,4-恶二嗪的抗真菌剂

Country Status (9)

Country Link
US (1) US20180201592A1 (enExample)
EP (1) EP3322705A1 (enExample)
JP (1) JP2018527316A (enExample)
KR (1) KR20180030166A (enExample)
CN (1) CN108368102A (enExample)
AU (1) AU2016293316A1 (enExample)
CA (1) CA2991684A1 (enExample)
GB (1) GB201512286D0 (enExample)
WO (1) WO2017009651A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120329218A (zh) * 2025-06-23 2025-07-18 富祥(山东)新材料有限公司 一种抗hiv病毒类药物中间体的制备方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2903161T3 (es) * 2017-04-12 2022-03-31 Momentum Bioscience Ltd Detección y definición de microorganismos mediante el uso del gen ILV3
CN108586273B (zh) * 2018-03-07 2019-12-10 江南大学 一种盐酸普萘洛尔的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS428033Y1 (enExample) * 1966-11-05 1967-04-24
US4254259A (en) * 1978-11-02 1981-03-03 Indiana University Foundation 2-Amino-5-ethylovalyl-6H-1,3,4-thiadiazine oxime
WO2014182950A1 (en) * 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3779736A (en) * 1971-01-04 1973-12-18 Gulf Research Development Co 1,3,4-thiadiazine herbicides
JPS49110696A (enExample) * 1973-03-10 1974-10-22
JPS58177482A (ja) * 1982-04-10 1983-10-18 Mitsui Petrochem Ind Ltd ２，６−ジ−ｔｅｒｔ−ブチル−４−アシロキシメチルフエノ−ルの製法
AU2011276539A1 (en) * 2010-06-28 2013-02-07 President And Fellows Of Harvard College Compounds for the inhibition of cellular proliferation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS428033Y1 (enExample) * 1966-11-05 1967-04-24
US4254259A (en) * 1978-11-02 1981-03-03 Indiana University Foundation 2-Amino-5-ethylovalyl-6H-1,3,4-thiadiazine oxime
WO2014182950A1 (en) * 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BY REGINALD E. BUSBY ET AL.: "The Rearrangement of 2-Amino-1,3,4-thiadiazines to 3-Amino-2-thiazol-imines. Part1. The Rates of Rearrangement of a Series of 5-Alkyl- and 5-Aryl-2-amnio-1,3,4-thiadiazines at 30and 50 ℃", 《J.C.S.PERKIN II》 *
D.B.ARUNA KUMAR ET AL.: "Microwave Assisted Synthesis and Pharmacological Evaluation of some Potent Naphho and Benzofuro Thiazolyl, Oxazolyl, Thio and Oxadiazalyl Derivatives", 《INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES》 *
MILAN CACIC ET AL.: "Design and Synthesis of Some New 1,3,4-Thiadiazines with Coumarin Moieties and Their Antioxidative and Antifungal Activity", 《MOLECULES》 *
PRIYA GOTHWAL ET AL.: "Microwave Induced Synthesis of some substituted 2-amino thiadiazines as a prospective antimicrobial agents.", 《DER CHEMICA SINICA》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120329218A (zh) * 2025-06-23 2025-07-18 富祥(山东)新材料有限公司 一种抗hiv病毒类药物中间体的制备方法

Also Published As

Publication number Publication date
AU2016293316A1 (en) 2018-01-25
US20180201592A1 (en) 2018-07-19
KR20180030166A (ko) 2018-03-21
WO2017009651A1 (en) 2017-01-19
GB201512286D0 (en) 2015-08-19
CA2991684A1 (en) 2017-01-19
JP2018527316A (ja) 2018-09-20
EP3322705A1 (en) 2018-05-23

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