CN108354907A - Ternip granule and preparation method thereof for treating pharyngitis - Google Patents
Ternip granule and preparation method thereof for treating pharyngitis Download PDFInfo
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- CN108354907A CN108354907A CN201810207810.2A CN201810207810A CN108354907A CN 108354907 A CN108354907 A CN 108354907A CN 201810207810 A CN201810207810 A CN 201810207810A CN 108354907 A CN108354907 A CN 108354907A
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- ternip
- granule
- auxiliary material
- pharyngitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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Abstract
The present invention provides a kind of for treating ternip granule of pharyngitis and preparation method thereof, and the raw material of the ternip granule of the treatment pharyngitis is ternip.The composition of the granule includes white radish powder and auxiliary material, and the auxiliary material accounts for 1.0~1.5 times of white radish powder quality, and the auxiliary material is by sucrose, soluble starch and dextrin according to mass ratio 3:1:2 form the present invention, and there is Qingre Liqi, eliminating phlegm moistening lung, removing toxic substances to promote the production of body fluid, and strengthen immunity and other effects can be used for treating pharyngitis, and simple for process, applied widely, have no toxic side effect.
Description
Technical field
The invention belongs to tcm fields, specially treat the ternip granule and preparation method thereof of pharyngitis.
Background technology
Pharyngitis (pharyngitis) is pharyngeal nonspecific inflammation, is that various microorganism infections are pharyngeal and generate inflammation
General designation, can individualism, also can with rhinitis, tonsillitis and laryngitis and deposit, or be the premonitory symptom of certain diseases.It can be divided into
Acpuei pharyngitis and chronic pharyngitis.Acpuei pharyngitis is the acute inflammation of pharyngeal mucous membrane and sub-mucosal tissues, and pharynx lymphoid tissue is often tired out
And inflammation early stage can limit to, and entire pharyngeal cavity is often can relate to disease progression, it is with the autumn and winter and at the end of winter and the beginning of spring more typical.Main performance
For pharyngeal drying, scorching hot, pain, it is apparent to swallow pain, congestion of throat swelling etc..Chronic pharyngitis can be divided into chronic simple pharynx again
Scorching, chronic hypertrophic pharyngitis and atrophic pharyngitis, wherein chronic simple pharyngitis is more common, and lesion is mainly in mucous layer, performance
For pharyngeal mucous membrane chronic congestion, connective tissue proliferation under mucous membrane and mucous membrane, mucous gland can be loose, and secreting function is hyperfunction, mucus point
It secretes and increases.Ternip is one kind of radish, is the new fresh quench of crucifer radish.Radish it is wide in variety, have it is white, red, green, but
It is the most universal with ternip.In China, civil radish has the laudatory title of " glabrousleaf asiabell root ", radish to have Qingre Liqi, eliminating phlegm moistening lung, removing toxic substances life
Tianjin and other effects；Radish contributes to the immune function for enhancing body, improves disease-resistant energy containing abundant vitamin C and trace element zinc
Power；Mustard oil in radish can promote gastrointestinal peristalsis, increase appetite, help digest；Amylase in radish can decompose in food
Starch, fat are allowed to adequately be absorbed；Radish contains lignin, can improve the vigor of macrophage, swallows cancer cell.This
Outside, a variety of enzymes contained by radish can decompose carcinogenic inferior ammonium nitrate, have protective effect on cancer risk.Currently, ternip is for treating pharyngitis
Report is seldom, and the research that pharyngitis is treated to ternip is deep not enough.
Invention content
To make up the blank of the prior art, the present invention provides a kind of ternip granule for treating pharyngitis.The ternip
There is granule Qingre Liqi, eliminating phlegm moistening lung, removing toxic substances to promote the production of body fluid, strengthen immunity and other effects, can be used for treating pharyngitis, and work
Skill is simple, applied widely, has no toxic side effect.
To achieve the above object, the present invention provides the following technical solutions：A kind of ternip granule for treating pharyngitis,
Including white radish powder and auxiliary material, the auxiliary material accounts for 1.0~1.5 times of white radish powder quality, and the auxiliary material is by sucrose, soluble starch
With dextrin according to mass ratio 3:1:2 compositions.
Further, also contain magnesium stearate lubricant in the ternip granule, magnesium stearate account for white radish powder and
The 0.5~1.5% of auxiliary material gross mass.
Another object of the present invention is to provide the preparation method of above-mentioned ternip granule, specifically includes following steps：S1.
Ternip is cleaned, is squeezed the juice, ternip juice is obtained；
S2. the ternip juice obtained in step S1 is filtered, obtains filtrate；
S3. the filtrate obtained in step S2 is dried, obtains dried powder；
S4. in the dried powder obtained in step s3 be added auxiliary material be uniformly mixed, with oscillating granulator pelletize to get
Ternip granule.
Further, dry to be spray-dried in the step S3, the inlet temperature of spray drying is 135~185 DEG C, is gone out
Mouth temperature is 80~105 DEG C.
Further, in the step S4, magnesium stearate is added in using oscillating granulator pelletization.
Compared with prior art, the present invention has the advantages that：
1. the present invention is with Qingre Liqi, eliminating phlegm moistening lung, removing toxic substances is promoted the production of body fluid, and strengthen immunity and other effects can be used for
Pharyngitis is treated, and simple for process, it is applied widely, it has no toxic side effect.
2. the present invention is prepared as granular form, easy to carry and use.
Specific implementation mode
The present invention is described in detail below by specific embodiment, but is not limited the scope of the invention.Unless otherwise specified, originally
Experimental method is conventional method used by invention, and experiment equipment used, material, reagent etc. can be obtained from commercial channel.
Embodiment 1
The preparation method for treating the ternip granule of pharyngitis, includes the following steps：
(1) it takes ternip to clean, squeeze the juice, obtains ternip juice；
(2) juice obtained in step (1) is filtered, obtains filtrate；
(3) filtrate is spray-dried, and inlet temperature is 135 DEG C, and outlet temperature is 80 DEG C, obtains dried powder；
(4) 36 parts of sucrose, 12 parts of soluble starch, 24 parts of dextrin are added in the powder, is uniformly mixed；Take 1 part of stearic acid
Magnesium lubricates, and auxiliary material accounts for 1.0 times of white radish powder quality, is pelletized later to get the ternip for the treatment of pharyngitis with oscillating granulator
Granula.
Embodiment 2
The preparation method for treating the ternip granule of pharyngitis, includes the following steps：
(1) it takes ternip to clean, squeeze the juice, obtains ternip juice；
(2) juice obtained in step (1) is filtered, obtains filtrate；
(3) filtrate is spray-dried, and inlet temperature is 140 DEG C, and outlet temperature is 85 DEG C, obtains dried powder；
(4) 30 parts of sucrose, 10 parts of soluble starch, 20 parts of dextrin are added in the powder, is uniformly mixed；Take 1 part of stearic acid
Magnesium lubricates, and auxiliary material accounts for 1.5 times of white radish powder quality, is pelletized later to get the ternip for the treatment of pharyngitis with oscillating granulator
Granula.
Embodiment 3
The preparation method for treating the ternip granule of pharyngitis, includes the following steps：
(1) it takes ternip to clean, squeeze the juice, obtains ternip juice；
(2) juice obtained in step (1) is filtered, obtains filtrate；
(3) filtrate is spray-dried, and inlet temperature is 150 DEG C, and outlet temperature is 80 DEG C, obtains dried powder；
(4) 60 parts of sucrose, 20 parts of soluble starch, dextrin 40 part are added in the powder, is uniformly mixed；Take 2 parts of stearic acid
Magnesium lubricates, and auxiliary material accounts for 1.0 times of white radish powder quality, is pelletized later to get the ternip for the treatment of pharyngitis with oscillating granulator
Granula.
Embodiment 4
The preparation method for treating the ternip granule of pharyngitis, includes the following steps：
(1) it takes ternip to clean, squeeze the juice, obtains ternip juice；
(2) juice obtained in step (1) is filtered, obtains filtrate；
(3) filtrate is spray-dried, and inlet temperature is 150 DEG C, and outlet temperature is 90 DEG C, obtains dried powder；
(4) 48 parts of sucrose, 16 parts of soluble starch, 32 parts of dextrin are added in the powder, is uniformly mixed；Take 2 parts of stearic acid
Magnesium lubricates, and auxiliary material accounts for 1.2 times of white radish powder quality, is pelletized later to get the ternip for the treatment of pharyngitis with oscillating granulator
Granula.
Here is ternip granule prepared by the present invention improves clinical observation statistics for the conditioning of pharyngitis state：
1, case is chosen：Clinically choose the anaphylactia patient 80 made a definite diagnosis, 25~70 years old age, male 32,
Women 48, is divided into four groups of experimental groups 1~4, every group 20.
2, experimental method：The granule for using the embodiment of the present invention 1~4 to prepare respectively to experimental group 1~4, three times a day,
Continuous medication one month, observes and records the recovery situation of patient.
3, curative effect determinate standard：
It is effective：Pharyngitis clinical symptoms disappear, and every sign restores normal, no relapse in half a year；
Effectively：Pharyngitis clinical symptoms improve, before patient compares medication the performance of each sign be clearly better；
In vain：The state of an illness is without any improvement or aggravates.
4, experimental data counts：
| Classification | Case load | It is effective | Effectively | In vain | Adverse reaction | It is efficient |
| Embodiment 1 | 20 | 10 | 8 | 2 | 0 | 90.0 |
| Embodiment 2 | 20 | 11 | 8 | 1 | 0 | 95.0 |
| Embodiment 3 | 20 | 10 | 9 | 1 | 0 | 95.0 |
| Embodiment 4 | 20 | 12 | 7 | 1 | 0 | 95.0 |
5, experimental result：As can be seen from the above experimental data, the ternip granule pair for the treatment pharyngitis that prepared by the present invention
It is 93.75% in the total effective rate of the treatment of pharyngitis, and 80 patients have no any adverse reaction, therefore illustrate, of the invention
The ternip granule for the treatment of pharyngitis is the safe and effective drug for treating pharyngitis, has good clinical expansion meaning.
The preferable specific implementation mode of the above, only the invention, but the protection domain of the invention is not
It is confined to this, any one skilled in the art is in the technical scope that the invention discloses, according to the present invention
The technical solution of creation and its inventive concept are subject to equivalent substitution or change, should all cover the invention protection domain it
It is interior.
Claims (5)
1. the ternip granule for treating pharyngitis, which is characterized in that including white radish powder and auxiliary material, the auxiliary material accounts for ternip
1.0~1.5 times of silty amount, the auxiliary material is by sucrose, soluble starch and dextrin according to mass ratio 3:1:2 compositions.
2. ternip granule according to claim 1, which is characterized in that also contain lubrication in the ternip granule
Agent magnesium stearate, magnesium stearate account for the 0.5~1.5% of white radish powder and auxiliary material gross mass.
3. a kind of preparation method of ternip granule as described in claim 1, which is characterized in that specifically include following steps：
S1. ternip cleaned, squeezed the juice, obtain ternip juice；
S2. the ternip juice obtained in step S1 is filtered, obtains filtrate；
S3. the filtrate obtained in step S2 is dried, obtains dried powder；
S4. auxiliary material is added in the dried powder obtained in step s3 to be uniformly mixed, is pelletized to get white trailing plants with oscillating granulator
Foretell granule.
4. according to the method described in claim 3, it is characterized in that, dry for spray drying, spray drying in the step S3
Inlet temperature be 135~185 DEG C, outlet temperature be 80~105 DEG C.
5. according to the method described in claim 3, it is characterized in that, in the step S4, pelletize using oscillating granulator
Magnesium stearate is added in the process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810207810.2A CN108354907A (en) | 2018-03-14 | 2018-03-14 | Ternip granule and preparation method thereof for treating pharyngitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810207810.2A CN108354907A (en) | 2018-03-14 | 2018-03-14 | Ternip granule and preparation method thereof for treating pharyngitis |
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| Publication Number | Publication Date |
|---|---|
| CN108354907A true CN108354907A (en) | 2018-08-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810207810.2A Pending CN108354907A (en) | 2018-03-14 | 2018-03-14 | Ternip granule and preparation method thereof for treating pharyngitis |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1235032A (en) * | 1998-05-09 | 1999-11-17 | 张玉国 | Chinese medicine for tonsillitis and laryngopharyngitis |
| CN103652935A (en) * | 2013-11-11 | 2014-03-26 | 青岛文创科技有限公司 | Radish juice for relieving cough and reducing sputum and preparation method thereof |
-
2018
- 2018-03-14 CN CN201810207810.2A patent/CN108354907A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1235032A (en) * | 1998-05-09 | 1999-11-17 | 张玉国 | Chinese medicine for tonsillitis and laryngopharyngitis |
| CN103652935A (en) * | 2013-11-11 | 2014-03-26 | 青岛文创科技有限公司 | Radish juice for relieving cough and reducing sputum and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 孛宝珍: "《健康必知的养生细节》", 31 August 2015, 浙江科学技术出版社 * |
| 张伟，等: "《百姓生活健康书系 家庭保健速查手册-小食疗秒治百病》", 30 September 2012, 河北科学技术出版社 * |
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Application publication date: 20180803 |