CN108567835A - A kind of Chinese medicine preparation for treating chicken respiratory tract disease - Google Patents
A kind of Chinese medicine preparation for treating chicken respiratory tract disease Download PDFInfo
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- CN108567835A CN108567835A CN201810663163.6A CN201810663163A CN108567835A CN 108567835 A CN108567835 A CN 108567835A CN 201810663163 A CN201810663163 A CN 201810663163A CN 108567835 A CN108567835 A CN 108567835A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of Chinese medicine preparations for treating chicken respiratory tract disease, are related to poultry technical field of traditional Chinese medicines, are made of the raw material of following parts by weight：40 60 parts of desmodium, 20 30 parts of floral leaf bitter dish, 20 30 parts of leaves of Hawthorn, 5 10 parts of ginkgo leaf, 5 10 parts of wormwood, 15 parts of Cassia grass, 15 parts of Prunella vulgaris, 5 10 parts of brown sugar.The present invention is constituted the Chinese medicine preparation for the treatment of chicken respiratory tract disease with 8 taste Chinese medicines through specific proportioning, the formula follows strictly the monarch compatibility relationship of Chinese medicine, it is different from the Chinese medicine preparation of existing treatment chicken respiratory tract disease, Chinese medicine type used in the Chinese medicine preparation is few and cheap and easy to get, and it is significant in efficacy, take rear quick, recurrence rate is low, has no toxic side effect.
Description
Technical field：
The present invention relates to poultry technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine preparation for treating chicken respiratory tract disease.
Background technology：
The respiratory syndrome of birds is mainly a variety of by virus, bacterium, mycoplasma, immunosuppressive disease and adverse environment etc.
Factor is primary, secondary or mixed infection causes, and is the breathing problem syndrome that a kind of course of disease is very long, the cause of disease is complicated.Clinical table
It now sheds tears, have a running nose, cough or sneezes, breathe, rale and expiratory dyspnea etc..The dissection discovery overwhelming majority dies of illness there are two types of fowl
Or two or more lesions, wherein more with larynx and airway inflammation, common air bag thickens, air bag inflammation, Bronchopneumonia, suppuration
Property pneumonia, polyserositis etc..
For chicken, once occur breathing problem, mutual cross infection, spread speed quickly, caused by damage
It loses inestimable.The drug for the treatment of chicken respiratory tract disease mainly has Western medicine, Chinese medicine and Integrated TCM three categories, Western medicine to see now
Effect is fast, but since the side effect of Western medicine is larger, the possible do harm to huamn body of hazard residue, so using being restricted；Chinese medicine
Although treatment side effect is small, it is long to cure the period.
Invention content：
Technical problem to be solved by the present invention lies in providing, a kind of preparation method is easy and therapeutic effect is significantly treated
The Chinese medicine preparation of chicken respiratory tract disease.
The technical problems to be solved by the invention are realized using technical solution below：
A kind of Chinese medicine preparation for treating chicken respiratory tract disease, is made of the raw material of following parts by weight：
40-60 parts of desmodium, 20-30 parts of floral leaf bitter dish, 20-30 parts of leaves of Hawthorn, 5-10 parts of ginkgo leaf, 5-10 parts of wormwood,
1-5 parts of Cassia grass, 1-5 parts of Prunella vulgaris, 5-10 parts of brown sugar.
The Chinese medicine preparation of above-mentioned treatment chicken respiratory tract disease, preparation method include the following steps：
(1) liquid medicine carries in：All Chinese medicines in addition to brown sugar are mixed, and the 5-10 times of water measured is added to impregnate, are added after immersion
Heat keeps the temperature to reflux state and extracts, and filtering takes filtrate；Then add the 3-8 times of water measured into gained filter residue, be again heated to reflux
State heat preservation extraction, filtering take filtrate；Merging filtrate, filtrate is through being concentrated under reduced pressure into the 1/4-1/3 of original volume to get concentrate；
(2) Chinese medicine extract is refined：Absolute ethyl alcohol and refining aid is added under stirring into above-mentioned made concentrate, makes second
Alcohol volume content reaches 60-70%, stands, filtering, and filtrate is through being concentrated under reduced pressure recycling ethyl alcohol to get refined liquid；
(3) prepared by Chinese medicine preparation：Brown sugar is added into above-mentioned made refined liquid, reflux shape is heated to after stirring and dissolving is complete
State insulated and stirred, filtering take filtrate, concentrating filter liquor that dry extract is made, and powder is made to get Chinese medicine system through crushing in dry extract
Agent.
The dosage of the refining aid is the 1-5% of all Chinese medicine gross dry weights in addition to brown sugar.
The refining aid selection decyl glucoside-proline ester compound, specific preparation method are：By decyl grape
Glucosides and L-PROLINE are dissolved in absolute ethyl alcohol, and dilute sulfuric acid is added dropwise and adjusts solution ph to 4-5, are again heated to reflux state
Insulated and stirred react, esterification terminate after through be concentrated under reduced pressure recycle ethyl alcohol, condensate residue is vacuum dried to constant weight, finally
Micro mist is made to get refining aid through micronizer.
The decyl glucoside and the molar ratio of L-PROLINE are 1:3-8.
The Chinese medicine preparation of above-mentioned treatment chicken respiratory tract disease, preparation method include the following steps：
(1) liquid medicine carries in：Add the 5-10 times of water measured to impregnate in all Chinese medicines in addition to brown sugar, boiled after immersion, is filtered,
Take filtrate；Add the 3-8 times of water measured into filter residue again, boil, filters, take filtrate；Merging filtrate, concentrating filter liquor to original volume
To get concentrate；
(2) Chinese medicine extract is refined：Absolute ethyl alcohol and refining aid is added under stirring into above-mentioned made concentrate, makes second
Alcohol volume content reaches 60-70%, stands, filtering, and concentrating filter liquor recycles ethyl alcohol to get level-one refined liquid；It is refined to level-one
Adsorption aid is added in liquid, and is heated to 40-50 DEG C of insulated and stirred, stands, filters to get two level refined liquid；
(3) prepared by Chinese medicine preparation：Brown sugar is added into above-mentioned made two level refined liquid, is heated to back after stirring and dissolving is complete
Stream mode insulated and stirred, filtering take filtrate, concentrating filter liquor that dry extract is made, and powder is made to get Chinese medicine through crushing in dry extract
Preparation.
The dosage of the adsorption aid is the 3-8% of all Chinese medicine gross dry weights in addition to brown sugar.
The adsorption aid selection modified molecular screen, specific preparation method are：By 4A molecular screen primary powders in 100-110 DEG C
It dries to constant weight in baking oven, and is roasted at 450-500 DEG C, be added in absolute ethyl alcohol, add after cooled to room temperature
It is anti-to be then heated to reflux state insulated and stirred for allyl polyethenoxy ether, N hydroxymethyl acrylamide and azodiisobutyronitrile
It answers, recycles ethyl alcohol through being concentrated under reduced pressure after reaction, be sent into freeze drier after condensate residue washing, dry obtained solid
Powder is made through pulverizer, the global molecular that diameter 3-5mm is most made through granulator afterwards sieves.
The matter of the 4A molecular screen primary powders, allyl polyethenoxy ether, N hydroxymethyl acrylamide and azodiisobutyronitrile
Amount is than being 15-30:5-10:1-5:0.1-0.5.
The pharmacological action of Chinese medicine of the present invention：
Desmodium：Reducing fever and causing diuresis, wind-expelling pain-stopping, hemostasia and promoting granulation, eliminating inflammation and expelling toxin, desinsection；Monarch drug in a prescription.
Floral leaf bitter dish：Clearing heat and cooling blood, diuresis；Ministerial drug.
Leaves of Hawthorn：Promoting blood circulation and removing blood stasis, qi-regulating is promoted blood circulation, and changes turbid lipid-loweringing；Ministerial drug.
Ginkgo leaf：It is promoting blood circulation and removing blood stasis, it removes obstruction in channels to relieve pain, astringes the lung and relieving asthma, change turbid lipid-loweringing；Adjutant.
Wormwood：Eliminating cold to remove dampness, qi-regulating and blood, regulating menstruation, hemostasis；Adjutant.
Cassia grass：It clears liver and improve vision, sharp water defaecation；Adjutant.
Prunella vulgaris：Clearing heat-fire, improving eyesight, mass dissipating and swelling eliminating；Make medicine.
Brown sugar：Embellish lung, and in help spleen, delay irritability, make medicine.
The beneficial effects of the invention are as follows：
(1) present invention is constituted the Chinese medicine preparation for the treatment of chicken respiratory tract disease with 8 taste Chinese medicines through specific proportioning, and the formula is stringent
The monarch compatibility relationship for following Chinese medicine is different from the Chinese medicine preparation of existing treatment chicken respiratory tract disease, the Chinese medicine preparation institute
It is few and cheap and easy to get and significant in efficacy with Chinese medicine type, take rear quick, recurrence rate is low, has no toxic side effect；
(2) Chinese medicine preparation is made by water extraction and alcohol precipitation method in the present invention, and operation is simple, and improves effective component
Content, to shorten onset time and healing time under same medicine dosage；
(3) use of refining aid is efficiently to remove the insoluble small suspension in precipitation solution when the present invention passes through alcohol precipitation
Grain, further increases the content of effective component；And the refining aid is nontoxic, can be formed and be wadded a quilt with cotton with insoluble suspended particulate
Condensate, and can be separated off from refined liquid through filtering；
(4) present invention is further removed by the use of adsorption aid without the insoluble small of refining aid flocculation removing
Suspended particulate, and the absorption property of adsorption aid used is better than conventional molecular sieve, allyl polyethenoxy ether and N- methylols
The aggregated reaction of acrylamide generates copolymer, and copolymer and molecular sieve are through three-dimensional cross-linked formation new space structures, to carry
The absorption property of macromolecule sieve.
Specific implementation mode：
In order to make the technical means, the creative features, the aims and the efficiencies achieved by the present invention be easy to understand, tie below
Specific embodiment is closed, the present invention is further explained.
Embodiment 1
(1) liquid medicine carries in：By 45g desmodiums, 25g floral leaves bitter dish, 20g leaves of Hawthorn, 5g ginkgo leaves, 5g wormwoods, 3g Cassia
Grass, the mixing of 2g Prunella vulgaris, and 800g water is added to impregnate, it is heated to reflux state heat preservation extraction 3h after impregnating 1h, filtering takes filtrate；
Then the water for adding 5 times of amounts into gained filter residue, are again heated to reflux state heat preservation extraction 2h, and filtering takes filtrate；Merge filter
Liquid, filtrate is through being concentrated under reduced pressure into the 1/4 of original volume to get concentrate；
(2) Chinese medicine extract is refined：Absolute ethyl alcohol and refining aid is added under stirring into above-mentioned made concentrate, makes second
Alcohol volume content reaches 70%, stands 30min, filtering, filtrate is through being concentrated under reduced pressure recycling ethyl alcohol to get refined liquid；
(3) prepared by Chinese medicine preparation：5g brown sugar is added into above-mentioned made refined liquid, is heated to flowing back after stirring and dissolving is complete
State insulated and stirred 10min, filtering, takes filtrate, and concentrating filter liquor is made dry extract, dry extract through crush be made powder to get
Chinese medicine preparation.
The dosage of refining aid is 3.5% of all Chinese medicine gross dry weights in addition to brown sugar.
The preparation of refining aid：1mol decyl glucosides and 5mol L-PROLINEs are dissolved in absolute ethyl alcohol, and dripped
Add dilute sulfuric acid to adjust solution ph to 4-5, is again heated to the reaction of reflux state insulated and stirred, esterification is dense through depressurizing after terminating
It retracts and receives ethyl alcohol, condensate residue is vacuum dried to constant weight, and micro mist most is made to get refining aid through micronizer afterwards.
Embodiment 2
(1) liquid medicine carries in：By 45g desmodiums, 25g floral leaves bitter dish, 20g leaves of Hawthorn, 5g ginkgo leaves, 5g wormwoods, 3g Cassia
Grass, the mixing of 2g Prunella vulgaris, and 800g water is added to impregnate, it is heated to reflux state heat preservation extraction 3h after impregnating 1h, filtering takes filtrate；
Then the water for adding 5 times of amounts into gained filter residue, are again heated to reflux state heat preservation extraction 2h, and filtering takes filtrate；Merge filter
Liquid, filtrate is through being concentrated under reduced pressure into the 1/4 of original volume to get concentrate；
(2) Chinese medicine extract is refined：Absolute ethyl alcohol and refining aid is added under stirring into above-mentioned made concentrate, makes second
Alcohol volume content reaches 70%, stands 30min, filtering, filtrate is through being concentrated under reduced pressure recycling ethyl alcohol to get refined liquid；
(3) prepared by Chinese medicine preparation：5g brown sugar is added into above-mentioned made refined liquid, is heated to flowing back after stirring and dissolving is complete
State insulated and stirred 10min, filtering, takes filtrate, and concentrating filter liquor is made dry extract, dry extract through crush be made powder to get
Chinese medicine preparation.
The dosage of refining aid is 5% of all Chinese medicine gross dry weights in addition to brown sugar.
The preparation of refining aid：1mol decyl glucosides and 5mol L-PROLINEs are dissolved in absolute ethyl alcohol, and dripped
Add dilute sulfuric acid to adjust solution ph to 4-5, is again heated to the reaction of reflux state insulated and stirred, esterification is dense through depressurizing after terminating
It retracts and receives ethyl alcohol, condensate residue is vacuum dried to constant weight, and micro mist most is made to get refining aid through micronizer afterwards.
Embodiment 3
(1) liquid medicine carries in：By 45g desmodiums, 25g floral leaves bitter dish, 20g leaves of Hawthorn, 5g ginkgo leaves, 5g wormwoods, 3g Cassia
Grass, the mixing of 2g Prunella vulgaris, and 800g water is added to impregnate, it is heated to reflux state heat preservation extraction 3h after impregnating 1h, filtering takes filtrate；
Then the water for adding 5 times of amounts into gained filter residue, are again heated to reflux state heat preservation extraction 2h, and filtering takes filtrate；Merge filter
Liquid, filtrate is through being concentrated under reduced pressure into the 1/4 of original volume to get concentrate；
(2) Chinese medicine extract is refined：Absolute ethyl alcohol and refining aid is added under stirring into above-mentioned made concentrate, makes second
Alcohol volume content reaches 70%, stands 30min, filtering, and concentrating filter liquor recycles ethyl alcohol to get level-one refined liquid；To level-one essence
Adsorption aid is added in liquid processed, and is heated to 40-50 DEG C of insulated and stirred 30min, stands 30min, filtering is refined to get two level
Liquid；
(3) prepared by Chinese medicine preparation：5g brown sugar is added into above-mentioned made two level refined liquid, is heated to after stirring and dissolving is complete
Reflux state insulated and stirred 10min, filtering take filtrate, concentrating filter liquor that dry extract is made, and powder is made through crushing in dry extract,
Up to Chinese medicine preparation.
The dosage of refining aid is 5% of all Chinese medicine gross dry weights in addition to brown sugar.
The preparation of refining aid：1mol decyl glucosides and 5mol L-PROLINEs are dissolved in absolute ethyl alcohol, and dripped
Add dilute sulfuric acid to adjust solution ph to 4-5, is again heated to the reaction of reflux state insulated and stirred, esterification is dense through depressurizing after terminating
It retracts and receives ethyl alcohol, condensate residue is vacuum dried to constant weight, and micro mist most is made to get refining aid through micronizer afterwards.
The dosage of adsorption aid is 5% of all Chinese medicine gross dry weights in addition to brown sugar.
The preparation of adsorption aid：30g 4A molecular screen primary powders are dried in 110 DEG C of baking ovens to constant weight, and at 500 DEG C
Roasting is added in absolute ethyl alcohol after cooled to room temperature, adds 5g allyl polyethenoxy ethers, 3g N- methylols third
Acrylamide and 0.3g azodiisobutyronitriles are then heated to reflux state insulated and stirred and react 3h, dense through depressurizing after reaction
It retracts and receives ethyl alcohol, be sent into freeze drier after condensate residue washing, powder is made through pulverizer in dry obtained solid, finally
The global molecular sieve of diameter 3-5mm is made through granulator.
Embodiment 4
(1) liquid medicine carries in：By 45g desmodiums, 25g floral leaves bitter dish, 20g leaves of Hawthorn, 5g ginkgo leaves, 5g wormwoods, 3g Cassia
Grass, the mixing of 2g Prunella vulgaris, and 800g water is added to impregnate, it is heated to reflux state heat preservation extraction 3h after impregnating 1h, filtering takes filtrate；
Then the water for adding 5 times of amounts into gained filter residue, are again heated to reflux state heat preservation extraction 2h, and filtering takes filtrate；Merge filter
Liquid, filtrate is through being concentrated under reduced pressure into the 1/4 of original volume to get concentrate；
(2) Chinese medicine extract is refined：Absolute ethyl alcohol and refining aid is added under stirring into above-mentioned made concentrate, makes second
Alcohol volume content reaches 70%, stands 30min, filtering, and concentrating filter liquor recycles ethyl alcohol to get level-one refined liquid；To level-one essence
Adsorption aid is added in liquid processed, and is heated to 40-50 DEG C of insulated and stirred 30min, stands 30min, filtering is refined to get two level
Liquid；
(3) prepared by Chinese medicine preparation：5g brown sugar is added into above-mentioned made two level refined liquid, is heated to after stirring and dissolving is complete
Reflux state insulated and stirred 10min, filtering take filtrate, concentrating filter liquor that dry extract is made, and powder is made through crushing in dry extract,
Up to Chinese medicine preparation.
The dosage of refining aid is 5% of all Chinese medicine gross dry weights in addition to brown sugar.
The preparation of refining aid：1mol decyl glucosides and 5mol L-PROLINEs are dissolved in absolute ethyl alcohol, and dripped
Add dilute sulfuric acid to adjust solution ph to 4-5, is again heated to the reaction of reflux state insulated and stirred, esterification is dense through depressurizing after terminating
It retracts and receives ethyl alcohol, condensate residue is vacuum dried to constant weight, and micro mist most is made to get refining aid through micronizer afterwards.
The dosage of adsorption aid is 5% of all Chinese medicine gross dry weights in addition to brown sugar.
The preparation of adsorption aid：25g 4A molecular screen primary powders are dried in 110 DEG C of baking ovens to constant weight, and at 500 DEG C
Roasting is added in absolute ethyl alcohol after cooled to room temperature, adds 5g allyl polyethenoxy ethers, 3g N- methylols third
Acrylamide and 0.3g azodiisobutyronitriles are then heated to reflux state insulated and stirred and react 3h, dense through depressurizing after reaction
It retracts and receives ethyl alcohol, be sent into freeze drier after condensate residue washing, powder is made through pulverizer in dry obtained solid, finally
The global molecular sieve of diameter 3-5mm is made through granulator.
Reference examples 1
(1) liquid medicine carries in：By 45g desmodiums, 25g floral leaves bitter dish, 20g leaves of Hawthorn, 5g ginkgo leaves, 5g wormwoods, 3g Cassia
Grass, the mixing of 2g Prunella vulgaris, and 800g water is added to impregnate, it is heated to reflux state heat preservation extraction 3h after impregnating 1h, filtering takes filtrate；
Then the water for adding 5 times of amounts into gained filter residue, are again heated to reflux state heat preservation extraction 2h, and filtering takes filtrate；Merge filter
Liquid, filtrate is through being concentrated under reduced pressure into the 1/4 of original volume to get concentrate；
(2) Chinese medicine extract is refined：Absolute ethyl alcohol and refining aid is added under stirring into above-mentioned made concentrate, makes second
Alcohol volume content reaches 70%, stands 30min, filtering, and concentrating filter liquor recycles ethyl alcohol to get level-one refined liquid；To level-one essence
Adsorption aid is added in liquid processed, and is heated to 40-50 DEG C of insulated and stirred 30min, stands 30min, filtering is refined to get two level
Liquid；
(3) prepared by Chinese medicine preparation：5g brown sugar is added into above-mentioned made two level refined liquid, is heated to after stirring and dissolving is complete
Reflux state insulated and stirred 10min, filtering take filtrate, concentrating filter liquor that dry extract is made, and powder is made through crushing in dry extract,
Up to Chinese medicine preparation.
The dosage of refining aid is 5% of all Chinese medicine gross dry weights in addition to brown sugar.
The preparation of refining aid：1mol decyl glucosides and 5mol L-PROLINEs are dissolved in absolute ethyl alcohol, and dripped
Add dilute sulfuric acid to adjust solution ph to 4-5, is again heated to the reaction of reflux state insulated and stirred, esterification is dense through depressurizing after terminating
It retracts and receives ethyl alcohol, condensate residue is vacuum dried to constant weight, and micro mist most is made to get refining aid through micronizer afterwards.
The dosage of adsorption aid is 5% of all Chinese medicine gross dry weights in addition to brown sugar, select diameter 3-5mm spherical 4A points
Son sieve.
Reference examples 2
(1) liquid medicine carries in：By 45g desmodiums, 25g floral leaves bitter dish, 20g leaves of Hawthorn, 5g ginkgo leaves, 5g wormwoods, 3g Cassia
Grass, the mixing of 2g Prunella vulgaris, and 800g water is added to impregnate, it is heated to reflux state heat preservation extraction 3h after impregnating 1h, filtering takes filtrate；
Then the water for adding 5 times of amounts into gained filter residue, are again heated to reflux state heat preservation extraction 2h, and filtering takes filtrate；Merge filter
Liquid, filtrate is through being concentrated under reduced pressure into the 1/4 of original volume to get concentrate；
(2) Chinese medicine extract is refined：Absolute ethyl alcohol and refining aid is added under stirring into above-mentioned made concentrate, makes second
Alcohol volume content reaches 70%, stands 30min, filtering, and concentrating filter liquor recycles ethyl alcohol to get level-one refined liquid；To level-one essence
Adsorption aid is added in liquid processed, and is heated to 40-50 DEG C of insulated and stirred 30min, stands 30min, filtering is refined to get two level
Liquid；
(3) prepared by Chinese medicine preparation：5g brown sugar is added into above-mentioned made two level refined liquid, is heated to after stirring and dissolving is complete
Reflux state insulated and stirred 10min, filtering take filtrate, concentrating filter liquor that dry extract is made, and powder is made through crushing in dry extract,
Up to Chinese medicine preparation.
The dosage of refining aid is 5% of all Chinese medicine gross dry weights in addition to brown sugar, selects polyacrylamide.
The dosage of adsorption aid is 5% of all Chinese medicine gross dry weights in addition to brown sugar.
The preparation of adsorption aid：25g 4A molecular screen primary powders are dried in 110 DEG C of baking ovens to constant weight, and at 500 DEG C
Roasting is added in absolute ethyl alcohol after cooled to room temperature, adds 5g allyl polyethenoxy ethers, 3g N- methylols third
Acrylamide and 0.3g azodiisobutyronitriles are then heated to reflux state insulated and stirred and react 3h, dense through depressurizing after reaction
It retracts and receives ethyl alcohol, be sent into freeze drier after condensate residue washing, powder is made through pulverizer in dry obtained solid, finally
The global molecular sieve of diameter 3-5mm is made through granulator.
Reference examples 3
(1) liquid medicine carries in：By 45g desmodiums, 25g floral leaves bitter dish, 20g leaves of Hawthorn, 5g ginkgo leaves, 5g wormwoods, 3g Cassia
Grass, the mixing of 2g Prunella vulgaris, and 800g water is added to impregnate, it is heated to reflux state heat preservation extraction 3h after impregnating 1h, filtering takes filtrate；
Then the water for adding 5 times of amounts into gained filter residue, are again heated to reflux state heat preservation extraction 2h, and filtering takes filtrate；Merge filter
Liquid, filtrate is through being concentrated under reduced pressure into the 1/4 of original volume to get concentrate；
(2) Chinese medicine extract is refined：Absolute ethyl alcohol and refining aid is added under stirring into above-mentioned made concentrate, makes second
Alcohol volume content reaches 70%, stands 30min, filtering, and concentrating filter liquor recycles ethyl alcohol to get level-one refined liquid；To level-one essence
Adsorption aid is added in liquid processed, and is heated to 40-50 DEG C of insulated and stirred 30min, stands 30min, filtering is refined to get two level
Liquid；
(3) prepared by Chinese medicine preparation：5g brown sugar is added into above-mentioned made two level refined liquid, is heated to after stirring and dissolving is complete
Reflux state insulated and stirred 10min, filtering take filtrate, concentrating filter liquor that dry extract is made, and powder is made through crushing in dry extract,
Up to Chinese medicine preparation.
The dosage of refining aid is 5% of all Chinese medicine gross dry weights in addition to brown sugar, selects molar ratio 1:5 decyl grape
The mixture of glucosides and L-PROLINE.
The dosage of adsorption aid is 5% of all Chinese medicine gross dry weights in addition to brown sugar.
The preparation of adsorption aid：25g 4A molecular screen primary powders are dried in 110 DEG C of baking ovens to constant weight, and at 500 DEG C
Roasting is added in absolute ethyl alcohol after cooled to room temperature, adds 5g allyl polyethenoxy ethers, 3g N- methylols third
Acrylamide and 0.3g azodiisobutyronitriles are then heated to reflux state insulated and stirred and react 3h, dense through depressurizing after reaction
It retracts and receives ethyl alcohol, be sent into freeze drier after condensate residue washing, powder is made through pulverizer in dry obtained solid, finally
The global molecular sieve of diameter 3-5mm is made through granulator.
Reference examples 4
(1) liquid medicine carries in：By 45g desmodiums, 25g floral leaves bitter dish, 20g leaves of Hawthorn, 5g ginkgo leaves, 5g wormwoods, 3g Cassia
Grass, the mixing of 2g Prunella vulgaris, and 800g water is added to impregnate, it is heated to reflux state heat preservation extraction 3h after impregnating 1h, filtering takes filtrate；
Then the water for adding 5 times of amounts into gained filter residue, are again heated to reflux state heat preservation extraction 2h, and filtering takes filtrate；Merge filter
Liquid, filtrate is through being concentrated under reduced pressure into the 1/4 of original volume to get concentrate；
(2) Chinese medicine extract is refined：Absolute ethyl alcohol is added into above-mentioned made concentrate under stirring, makes alcohol volume content
Reach 70%, stands 30min, filtering, filtrate is through being concentrated under reduced pressure recycling ethyl alcohol to get refined liquid；
(3) prepared by Chinese medicine preparation：5g brown sugar is added into above-mentioned made refined liquid, is heated to flowing back after stirring and dissolving is complete
State insulated and stirred 10min, filtering, takes filtrate, and concentrating filter liquor is made dry extract, dry extract through crush be made powder to get
Chinese medicine preparation.
Embodiment 5
Based on embodiment 4, reference examples 1 using equivalent 4A molecular sieves as adsorption aid are set, with equivalent polypropylene
Amide as the reference examples 2 of refining aid, using the mixture of equivalent decyl glucoside and L-PROLINE as refining aid
Reference examples 3.Wherein, 4A molecular sieves select the 4A global moleculars of the diameter 3-5mm of Teng Long material for water treatment Co., Ltd of Gongyi City
Sieve, polyacrylamide select 8,000,000 anionic polyacrylamide of Henan Sai Ke Environmental Protection Technology Co., Ltd.
Be utilized respectively embodiment 1-4, reference examples 1-3 prepares Chinese medicine preparation, while being arranged without using adsorption aid and refined
The reference examples 4 of auxiliary agent, and the content of drug effect components of made Chinese medicine preparation is measured.With 4 made Chinese medicine preparation of reference examples
On the basis of content of drug effect components, embodiment 1-4, raisings of the reference examples 1-3 relative to reference examples 4 to content of drug effect components are calculated
Rate, as shown in table 1.
The content of drug effect components of the made Chinese medicine preparation of 1 embodiment of the present invention of table
As shown in Table 1, the addition of refining aid and adsorption aid can improve the content of drug effect components of made Chinese medicine preparation, and
And the flocculation refining effect of made refining aid is better than anionic polyacrylamide, the adsorption refining effect of adsorption aid is better than normal
Advise molecular sieve.
Embodiment 6
900 chickens for suffering from breathing problem, half male and half female are chosen, stochastic averagina is divided into the first and second the third three groups, and wherein first group takes
With 1 made Chinese medicine preparation of embodiment, second group takes the made Chinese medicine compositions of patent CN201110071886.5, and third group is taken promise fluorine
Sha Xing, three groups of drug administration amounts are pressed per the kg daily 20mg of chicken, record treatment, as shown in table 2.
The treatment of the made Chinese medicine preparation of 2 embodiment of the present invention of table
| Project | 3 days cure rate/% | 4 days cure rate/% | 5 days cure rate/% | 7 days cure rate/% |
| First group | 41.5 | 72.3 | 98.9 | 99.7 |
| Second group | 35.7 | 68.6 | 98.1 | 98.5 |
| Third group | 38.2 | 70.5 | 92.4 | 94.3 |
As shown in Table 2,1 made Chinese medicine preparation of the embodiment of the present invention is better than patent to the therapeutic effect of chicken respiratory tract disease
The made Chinese medicine compositions of CN201110071886.5 and Western medicine Norfloxacin.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (9)
1. a kind of Chinese medicine preparation for treating chicken respiratory tract disease, which is characterized in that be made of the raw material of following parts by weight：
40-60 parts of desmodium, 20-30 parts of floral leaf bitter dish, 20-30 parts of leaves of Hawthorn, 5-10 parts of ginkgo leaf, 5-10 parts of wormwood, Cassia
1-5 parts careless, 1-5 parts of Prunella vulgaris, 5-10 parts of brown sugar.
2. the Chinese medicine preparation for the treatment of chicken respiratory tract disease according to claim 1, which is characterized in that preparation method includes
Following steps：
(1) liquid medicine carries in：All Chinese medicines in addition to brown sugar are mixed, and the 5-10 times of water measured is added to impregnate, are heated to after immersion
Reflux state heat preservation extraction, filtering take filtrate；Then add the 3-8 times of water measured into gained filter residue, be again heated to reflux state
Heat preservation extraction, filtering take filtrate；Merging filtrate, filtrate is through being concentrated under reduced pressure into the 1/4-1/3 of original volume to get concentrate；
(2) Chinese medicine extract is refined：Absolute ethyl alcohol and refining aid is added under stirring into above-mentioned made concentrate, makes ethyl alcohol body
Product content reaches 60-70%, stands, filtering, and filtrate is through being concentrated under reduced pressure recycling ethyl alcohol to get refined liquid；
(3) prepared by Chinese medicine preparation：Brown sugar is added into above-mentioned made refined liquid, reflux state guarantor is heated to after stirring and dissolving is complete
Temperature stirring, filtering take filtrate, concentrating filter liquor that dry extract is made, and powder is made to get Chinese medicine preparation through crushing in dry extract.
3. the Chinese medicine preparation for the treatment of chicken respiratory tract disease according to claim 1, which is characterized in that preparation method includes
Following steps：
(1) liquid medicine carries in：Add the 5-10 times of water measured to impregnate in all Chinese medicines in addition to brown sugar, boiled after immersion, filters, take filter
Liquid；Add the 3-8 times of water measured into filter residue again, boil, filters, take filtrate；Merging filtrate, the 1/4- of concentrating filter liquor to original volume
1/3 to get concentrate；
(2) Chinese medicine extract is refined：Absolute ethyl alcohol and refining aid is added under stirring into above-mentioned made concentrate, makes ethyl alcohol body
Product content reaches 60-70%, stands, filtering, and concentrating filter liquor recycles ethyl alcohol to get level-one refined liquid；Into level-one refined liquid
Adsorption aid is added, and is heated to 40-50 DEG C of insulated and stirred, stands, filters to get two level refined liquid；
(3) prepared by Chinese medicine preparation：Brown sugar is added into above-mentioned made two level refined liquid, reflux shape is heated to after stirring and dissolving is complete
State insulated and stirred, filtering take filtrate, concentrating filter liquor that dry extract is made, and powder is made to get Chinese medicine system through crushing in dry extract
Agent.
4. the Chinese medicine preparation for the treatment of chicken respiratory tract disease according to claim 2 or 3, it is characterised in that：Described refine is helped
The dosage of agent is the 1-5% of all Chinese medicine gross dry weights in addition to brown sugar.
5. the Chinese medicine preparation for the treatment of chicken respiratory tract disease according to claim 2 or 3, it is characterised in that：Described refine is helped
Agent selection decyl glucoside-proline ester compound, specific preparation method are：Decyl glucoside and L-PROLINE are dissolved
In absolute ethyl alcohol, and dilute sulfuric acid is added dropwise and adjusts solution ph to 4-5, is again heated to the reaction of reflux state insulated and stirred, esterification
Ethyl alcohol is recycled through being concentrated under reduced pressure after reaction, condensate residue is vacuum dried to constant weight, is most made afterwards through micronizer
Micro mist is to get refining aid.
6. the Chinese medicine preparation for the treatment of chicken respiratory tract disease according to claim 5, it is characterised in that：The decyl glucose
The molar ratio of glycosides and L-PROLINE is 1:3-8.
7. the Chinese medicine preparation for the treatment of chicken respiratory tract disease according to claim 3, it is characterised in that：The adsorption aid
Dosage is the 3-8% of all Chinese medicine gross dry weights in addition to brown sugar.
8. the Chinese medicine preparation for the treatment of chicken respiratory tract disease according to claim 3, it is characterised in that：The adsorption aid choosing
With modified molecular screen, specific preparation method is：4A molecular screen primary powders are dried in 100-110 DEG C of baking oven to constant weight, and in
It is roasted at 450-500 DEG C, is added in absolute ethyl alcohol after cooled to room temperature, adds allyl polyethenoxy ether, N- hydroxyls
Methacrylamide and azodiisobutyronitrile are then heated to the reaction of reflux state insulated and stirred, dense through depressurizing after reaction
It retracts and receives ethyl alcohol, be sent into freeze drier after condensate residue washing, powder is made through pulverizer in dry obtained solid, finally
The global molecular sieve of diameter 3-5mm is made through granulator.
9. the Chinese medicine preparation for the treatment of chicken respiratory tract disease according to claim 8, it is characterised in that：The 4A molecular screen primaries
Powder, allyl polyethenoxy ether, N hydroxymethyl acrylamide and azodiisobutyronitrile mass ratio be 15-30:5-10:1-5:
0.1-0.5。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810663163.6A CN108567835A (en) | 2018-06-25 | 2018-06-25 | A kind of Chinese medicine preparation for treating chicken respiratory tract disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810663163.6A CN108567835A (en) | 2018-06-25 | 2018-06-25 | A kind of Chinese medicine preparation for treating chicken respiratory tract disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108567835A true CN108567835A (en) | 2018-09-25 |
Family
ID=63573668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810663163.6A Withdrawn CN108567835A (en) | 2018-06-25 | 2018-06-25 | A kind of Chinese medicine preparation for treating chicken respiratory tract disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108567835A (en) |
-
2018
- 2018-06-25 CN CN201810663163.6A patent/CN108567835A/en not_active Withdrawn
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Application publication date: 20180925 |
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