CN107929415A - A kind of Chinese medicine composition for treating the infection of the upper respiratory tract and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating the infection of the upper respiratory tract and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a kind of Chinese medicine composition for treating the infection of the upper respiratory tract, it includes：Marigold root, firecracker floral leaf, Herba Hyperici Patuli, cordate houttuynia, Acacia, white willow, fortune paulownia flower, Ageratum conyzoides, Angelica sinensis, fleshy-root gentian root, seguin argyreia herb, the invention also discloses the preparation method of above-mentioned Chinese medicine composition.Have the advantages that good effect, cost are low, cure rate is high in terms of using such a Chinese medicine composition in the treatment respiratory tract infection, have no adverse reaction.The Chinese medicine of the present invention has dispelling wind and heat from the body, moistening lung for removing phlegm, the effect of ventilating the lung and relieving cough, and have the advantages that preparation method simply, short treating period, convenient to take, cost is low.
Description
Technical field
The present invention relates to a kind of medicinal preparation, more particularly to a kind of Chinese medicine composition for being used to treat the infection of the upper respiratory tract
And preparation method thereof.
Background technology
Feel on infection of the upper respiratory tract abbreviation, also known as common cold.It is the general name for including nasal cavity, pharynx or acute throat inflammation.
The upper sense of narrow sense is also known as common cold, is most common acute infections of respiratory tract disease, more in self limiting, but incidence compared with
It is high.The infection of the upper respiratory tract has 70%~80% to be caused by virus.Including rhinovirus, coronavirus, adenovirus, influenza and parainfluenza
Virus, Respiratory Syncytial Virus(RSV), echovirus, Coxsackie virus etc..The another upper sense for having 20%~30% is caused by bacterium.Bacterium
Infection can direct infection or secondary to virus infect after, using hemolytic streptococcus as most common, secondly be haemophilus influenzae,
Pneumococcus, staphylococcus etc., are occasionally gram-negative bacteria.It is various to cause what whole body or respiratory tract local defense function reduced
Reason, such as suffers from cold, drenches with rain, abrupt change of climate, fatigue can make original be present in disease that the is upper respiratory tract or being invaded from the external world
Poison or bacterium breed rapidly, so as to induce this disease.
The traditional Chinese medical science thinks, this disease cause of disease more by accumulation of heart and spleen, fire excess from yin deficiency cause.Factor is physically weak weak, the heresy of the diseases caused by external factors six external factors which cause diseases, causes
Make breakdown of the normal physiological coordination between the heart and the kidney, flaring up of deficient fire is fumigated and fallen ill.Treating the infection of the upper respiratory tract should be in clearing heat and detoxicating, tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung
To want.
The content of the invention
To solve the above-mentioned problems, the present invention provides a kind of energy dispelling wind and heat from the body, moistening lung for removing phlegm, ventilating the lung and relieving cough, preparation method
Simply, short treating period, the Chinese medicine composition for the treatment infection of the upper respiratory tract that convenient to take, cost is low.
The technical solution adopted by the present invention is：A kind of Chinese medicine composition for treating the infection of the upper respiratory tract, the Chinese traditional medicine composition
The each component of thing is marigold root, firecracker floral leaf, Herba Hyperici Patuli, cordate houttuynia, Acacia, white willow, fortune paulownia flower, Ageratum conyzoides, Angelica sinensis, chrysanthemum
Hua Can, seguin argyreia herb.
Preferably, the ratio of weight and number of various components is 25-35 parts of marigold root, 15-25 parts of firecracker floral leaf, Herba Hyperici Patuli
15-25 parts, 10-20 parts of cordate houttuynia, 10-20 parts of Acacia, 5-15 parts of white willow, 5-15 parts of fortune paulownia flower, 5-15 parts of Ageratum conyzoides, Angelica sinensis
5-15 parts, 5-15 parts of fleshy-root gentian root, 5-15 parts of seguin argyreia herb.
It is furthermore preferred that the ratio of weight and number of various components is 30-35 parts of marigold root, 20-25 parts of firecracker floral leaf, Herba Hyperici Patuli
20-25 parts, 10-15 parts of cordate houttuynia, 10-15 parts of Acacia, 5-10 parts of white willow, 5-10 parts of fortune paulownia flower, 5-10 parts of Ageratum conyzoides, Angelica sinensis
5-10 parts, 5-10 parts of fleshy-root gentian root, 5-10 parts of seguin argyreia herb.
Wherein, the formulation of the Chinese medicine composition is：Film coated tablet, sublimed preparation, emplastrum, syrup, oral liquid, mouth containing
Agent, granule, powder, injection, sugar coated tablet, capsule.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the formulation of the Chinese medicine is capsule, bag
Include：
The first step, firecracker floral leaf, Herba Hyperici Patuli mix in proportion, and the determining alcohol with 2-3 times equivalent to mixture quality is 70-
80% normal propyl alcohol refluxing extraction 2-4 times, merging filtrate, is concentrated under reduced pressure, dries and be ground into powder, then use ethyl alcohol purification 1-
2 times, merge extracting solution, ethanol is recovered under reduced pressure and is concentrated into the lotion that relative density at 60 DEG C is 1.21-1.24, drying simultaneously crushes
Into powder；
Second step, cordate houttuynia, Acacia, white willow, fortune paulownia flower are extracted 2-3 times with the normal propyl alcohol that determining alcohol is 80-90%,
Merge extracting solution, be concentrated under reduced pressure and be dried, be ground into powder, it is 2-4 that the powder after crushing, which is added relative to its quality,
The water dissolving of times amount, when static 1-3 is small, filtering, filtrate decompression concentration be relative density is 1.21-1.24 at 60 DEG C lotion simultaneously
It dry, pulverize into powder；
3rd step, remaining component is smashed and is mixed in proportion, is added water to cook 2 times, when each 2-3 is small, is filtered respectively,
Merging filtrate, filtrate are condensed into lotion and dry, pulverize into powder, and the quality of the water added is the mixture quality of the 3rd step
2-4 times；
4th step, above-mentioned powder and starch are mixed, and are then carried out pelletization treatment and drying, are obtained compound particles, then
Magnesium stearate is added into compound particles, the magnesium stearate and the compound particles mass ratio are 0.25-100:
0.5-100, obtains capsule 's content, and the capsule 's content is fitted into capsule housing up to capsule.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the formulation of the Chinese medicine is injection, bag
Include：
The first step, firecracker floral leaf, Herba Hyperici Patuli mix in proportion, and the determining alcohol with 2-3 times equivalent to mixture quality is 70-
80% normal propyl alcohol refluxing extraction 2-4 times, merging filtrate, is concentrated under reduced pressure, dries and be ground into powder, then use ethyl alcohol purification 1-
2 times, merge extracting solution, ethanol is recovered under reduced pressure and is concentrated into the lotion that relative density at 60 DEG C is 1.21-1.24, drying simultaneously crushes
Into powder；
Second step, cordate houttuynia, Acacia, white willow, fortune paulownia flower are extracted 2-3 times with the normal propyl alcohol that determining alcohol is 80-90%,
Merge extracting solution, be concentrated under reduced pressure and be dried, be ground into powder, it is 2-4 that the powder after crushing, which is added relative to its quality,
The water dissolving of times amount, when static 1-3 is small, filtering, filtrate decompression concentration be relative density is 1.21-1.24 at 60 DEG C lotion simultaneously
It dry, pulverize into powder；
3rd step, remaining component is smashed and is mixed in proportion, is added water to cook 2 times, when each 2-3 is small, is filtered respectively,
Merging filtrate, filtrate are condensed into lotion and dry, pulverize into powder, and the quality of the water added is the mixture quality of the 3rd step
2-4 times；
4th step, above-mentioned powder is mixed, and is then dissolved in the water that quality is 2-4 times of mixture, stirs lower addition phase
For the sodium hydroxide hydrotropy of powder quality 5%-15%, filtering, adds the salt acid for adjusting pH value that concentration is 1mol/L to be 5-6, mistake
Filter, precipitation is spare, and by polyamide column decontamination is first washed with water, the normal propyl alcohol for being then 80-90% with determining alcohol is washed in filtrate
It is de-, normal propyl alcohol eluent is collected, precipitation is extracted 2 times with the normal propyl alcohol that determining alcohol is 80-90%, filtering, filtrate and above-mentioned elution
Liquid merges, and recycles normal propyl alcohol, is concentrated under reduced pressure into lotion and is spray dried to powder, the powder of acquisition is added relative to its quality 1-
2 times of sodium chloride and appropriate water for injection, further injects water to the volume of needs after dissolving, filtering, embedding, goes out
Bacterium, obtains the parenteral solution of needs.
Marigold root, bitter, cool in nature, removing toxicity for detumescence.For the infection of the upper respiratory tract, pertussis, bronchitis, cornea
Inflammation, pharyngitis, stomatitis, toothache；Parotitis, mastitis, ulcerative carbuncle pyogenic infections are controlled in external application.
Firecracker floral leaf, bitter, micro-puckery are mild-natured, heat-clearing, throat, for the infection of the upper respiratory tract, cough, abscess of throat, liver
Scorching, bronchitis.
Herba Hyperici Patuli, mildly bitter flavor, taste are trembled with fear, clearing heat and detoxicating, cooling blood and hemostasis, and desinsection is antipruritic.Herb：The infection of the upper respiratory tract, liver
Inflammation, dysentery, ephritis.
Cordate houttuynia, acrid flavour, cold nature are distributed in lung channel, clearing heat and detoxicating, the carbuncle that disappears apocenosis, inducing diuresis for treating strangurtia.For lung carbuncle pyemesis, phlegm
Heat panting cough, hot dysentery, heat gonorrhea, carbuncle sore tumefacting virus.
White willow, bitter is cold in nature, clearing away damp-heat, wind-damp dispelling.Cure mainly acute tonsillitis, the infection of the upper respiratory tract, sphagitis, basin
Chamber is scorching, ephritis, boil.
Acacia, taste is slightly sour, puckery, mild-natured, the carbuncle that disappears apocenosis, astringing to arrest bleeding.Cure mainly the infection of the upper respiratory tract, cold abscess, wind
Wet arthritis.
Fortune paulownia flower, controls the infection of the upper respiratory tract, Bronchopneumonia, acute tonsillitis, bacillary dysentery, chordapsus, acute conjunctiva
Inflammation, parotitis, furuncle.
Ageratum conyzoides, acrid flavour, slight bitter, cool in nature, expelling wind and clearing away heat, relieves pain, and hemostasis, arranges stone.For the infection of the upper respiratory tract, tonsillotome
Inflammation, sphagitis, acute gastroenteritis, stomachache, abdominal pain, uterine bleeding, kidney stone, vesical calculus；Eczema, thrush are controlled in external application, and ulcerative carbuncle swells
Poison, cellulitis, the ulcer of lower limb, tympanitis, traumatic hemorrhage.
Angelica sinensis, it is sweet in flavor, pungent, warm, enter the heart, liver, lung three and pass through, there is benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation, anticancer, resist
The effect of old anti-old, immune.
Fleshy-root gentian root, acrid flavour, sweet, warm-natured, tonifying the lung to relieve cough, resolving sputum.Cough due to deficiency of the lung is cured mainly, chronic cough is more than, bronchitis.
Seguin argyreia herb, taste micro-puckery is warm-natured, refutes bone, and hemostasis, myogenic, convergence, clears away heart-fire, moistening lung, cough-relieving.Control internal injury.
Beneficial effects of the present invention：
Relative to the medicine with treatment infection of the upper respiratory tract effect of the prior art, existed using such a Chinese medicine composition
Have the advantages that good effect, cost are low, cure rate is high in terms of the treatment infection of the upper respiratory tract, have no adverse reaction.The Chinese medicine of the present invention
With dispelling wind and heat from the body, moistening lung for removing phlegm, ventilating the lung and relieving cough effect, and with preparation method is simple, short treating period, convenient to take, cost
The advantages of low.
Embodiment
Embodiment 1：
(1) a kind of Chinese medicine for treating the infection of the upper respiratory tract, is formed by following raw material medicaments in part by weight proportioning：
30 parts of marigold root, 25 parts of firecracker floral leaf, 20 parts of Herba Hyperici Patuli, 15 parts of cordate houttuynia, 15 parts of Acacia, 10 parts of white willow,
10 parts of fortune paulownia flower, 10 parts of Ageratum conyzoides, 10 parts of Angelica sinensis, 5 parts of fleshy-root gentian root, 5 parts of seguin argyreia herb.
(2) preparation method：
The first step, firecracker floral leaf, Herba Hyperici Patuli mix in proportion, are 70% with determining alcohols of 2 times equivalent to mixture quality
Normal propyl alcohol refluxing extraction 2 times, merging filtrate, is concentrated under reduced pressure, is dry and be ground into powder, then with ethyl alcohol purification 1-2 time, conjunction
And extracting solution, ethanol is recovered under reduced pressure and is concentrated into the lotion that relative density at 60 DEG C is 1.21-1.24, drying is simultaneously crushed into powder
End；
Second step, cordate houttuynia, Acacia, white willow, fortune paulownia flower are extracted 2-3 times with the normal propyl alcohol that determining alcohol is 80-90%,
Merge extracting solution, be concentrated under reduced pressure and be dried, be ground into powder, it is 2 times that the powder after crushing, which is added relative to its quality,
Amount water dissolving, it is static 1 it is small when, filtering, filtrate decompression concentration be 60 DEG C at relative density be 1.21-1.24 lotion and do
It is dry, it is ground into powder；
3rd step, remaining component is smashed and is mixed in proportion, adds water to cook 2 times, every time 2 it is small when, filter, close respectively
And filtrate, filtrate are condensed into lotion and dry, pulverize into powder, the quality of the water added is the mixture quality of the 3rd step
2 times；
4th step, above-mentioned powder and starch are mixed, and are then carried out pelletization treatment and drying, are obtained compound particles, then
Magnesium stearate is added into compound particles, the magnesium stearate and the compound particles mass ratio are 0.25:0.5, obtain
Capsule 's content is obtained, the capsule 's content is fitted into capsule housing up to capsule.
Embodiment 2：
(1) a kind of Chinese medicine for treating the infection of the upper respiratory tract, is formed by following raw material medicaments in part by weight proportioning：Same embodiment
1。
(2) preparation method：
The first step, firecracker floral leaf, Herba Hyperici Patuli mix in proportion, are 70% with determining alcohols of 2 times equivalent to mixture quality
Normal propyl alcohol refluxing extraction 2 times, merging filtrate, is concentrated under reduced pressure, is dry and be ground into powder, then with ethyl alcohol purification 1 time, merges
Extracting solution, is recovered under reduced pressure ethanol and is concentrated into the lotion that relative density at 60 DEG C is 1.21-1.24, drying is simultaneously ground into powder；
Second step, cordate houttuynia, Acacia, white willow, the normal propyl alcohol that fortune paulownia flower determining alcohol is 80% are extracted 2 times, merged
Extracting solution, is concentrated under reduced pressure and is dried, is ground into powder, and the powder after crushing is added what is measured relative to its quality for 2 times
Water dissolve, it is static 1 it is small when, filtering, filtrate decompression concentration be 60 DEG C at relative density be 1.21-1.24 lotion and drying, powder
It is broken into powder；
3rd step, remaining component is smashed and is mixed in proportion, adds water to cook 2 times, every time 2 it is small when, filter, close respectively
And filtrate, filtrate are condensed into lotion and dry, pulverize into powder, the quality of the water added is the mixture quality of the 3rd step
2 times；
4th step, above-mentioned powder is mixed, and is then dissolved in the water that quality is 2 times of mixture, stirs lower add relatively
In the sodium hydroxide hydrotropy of powder quality 5%, filtering, it is 5-6 to add the salt acid for adjusting pH value that concentration is 1mol/L, is filtered, precipitation
Spare, filtrate is first washed with water decontamination, is then eluted with the normal propyl alcohol that determining alcohol is 80, collect normal propyl alcohol by polyamide column
Eluent, the normal propyl alcohol that precipitation determining alcohol is 80 extract 2 times, and filtering, filtrate merges with above-mentioned eluent, recycles normal propyl alcohol,
It is concentrated under reduced pressure into lotion and is spray dried to powder, the powder of acquisition is added into the sodium chloride and injection relative to 2 times of its quality
Appropriate amount of water, further injects water to the volume of needs after dissolving, filtering, embedding, sterilizing, obtains the parenteral solution of needs.
Embodiment 3：
1st, long term toxicity test process：
Experimental drug is set as using Wistar rats (Beijing Vital River Experimental Animals Technology Co., Ltd.'s offer)
High, medium and low three dosage, is respectively capsule 8g/kg, 4g/kg, 2g/kg that embodiment 1 is formulated.By people with dosage 0.1g/
Kg/ sky-backings calculate, and are 80 times, 40 times and 20 times of people's effective dose respectively；It is another to set a control group, continuous gavage administration 90
My god, after 180 days and Some Animals are discontinued 10 days, observe the influence to rat items physiology, biochemical indicator.Test result indicates that：
With various dose to rat continuous oral 180 days, the food-intake and body weight increase on rat are without influence.To hepatic and renal function not
It was found that overt toxicity acts on.Blood routine, blood biochemistry, urine biochemistry and marrow piece etc. are showed no and significantly affected, between each group with it is right
Compare no significant difference according to group.
2nd, acute toxicity test process：
Using ICR mouse (Beijing Vital River Experimental Animals Technology Co., Ltd.'s offer) 40, weight at 25-30 grams,
Carry out acute toxicity testing.Mouse is randomly divided into two groups, i.e. control group, administration group, when fasting 12 is small before experiment, then give as
Capsule (is dissolved in water and obtains suspension) gavage by the Chinese medicine capsules suspension of the invention that embodiment 1 is prepared,
To the median lethal dose (LD of administration50) experiment measure has been carried out, but LD is not measured50, therefore carried out mtd test.
As a result：With Cmax (60%), maximum dosage-feeding (120ml/kg, part gives for four times in one day) 100g/kg gavages, equivalent to
Crude drug amount 60g/kg, equivalent to clinical 300 times (the pressing 75kg) for intending daily dosage of adult, none dead, execution of mouse in seven days
Each internal organs of mouse anatomic observation do not find toxic reaction, and administration group is with control group mice without any difference.
Embodiment 4：
The clinical treatment observation of the present invention is as follows：
(1) patient 180,90 are male, and 90 are women.
(2) diagnostic criteria：
Diagnostic criteria：Reference《Chinese medical disease Standardization of diagnosis and curative effect》In diagnosis basis carry out clinical diagnosis：
Primary symptom：(1) body heat, (2) foul wind；
Minor symptom：(1) pharyngalgia, (2) are thirsty, (3) cough, (4) sweating, (5) nasal obstruction runny nose.Thin white fur of tongue is micro- yellow or thin Huang,
Superficial and rapid pulse or sliding number.Possess primary symptom 2 and minor symptom 2 or more than 2, be provided simultaneously with above-mentioned tongue vein as person.
(3) treatment method：1 group：Using the capsule 100g as made from 1 preparation method of embodiment, it is divided into 10 parts, daily
Be administered at empty stomach portion in the morning, and 7 days as a course for the treatment of, takes a course for the treatment of；2 groups：Using the note as made from 2 preparation method of embodiment
Agent 100g is penetrated, is divided into 10 parts, every morning injects portion on an empty stomach, and 7 days as a course for the treatment of, injects a course for the treatment of；Separately set a control
Group.
(4) efficacy assessment standard：
Criterion of therapeutical effect：
Overall efficacy evaluation reference《New Chinese medicine guideline of clinical investigations》Relevant criterion：
Cure：Cardinal symptom, sign are wholly or substantially alleviated, and objective indicator recovers normal；
Effectively：Cardinal symptom, sign are relieved or improve, and objective indicator is close normal or makes moderate progress；
It is invalid：Cardinal symptom, sign are unchanged, objective indicator change unobvious or exacerbation.
(5) treatment results are shown in Table 1：
1 treatment results of table
| Group | Recovery from illness | Effectively | It is invalid |
| Control group | 6 | 8 | 46 |
| 1 group | 57 | 3 | 0 |
| 2 groups | 59 | 1 | 0 |
Above-described embodiment is in the art the purpose is to be to allow simply to illustrate that the technical concepts and features of the present invention
Those of ordinary skill can understand present disclosure and implement according to this, and it is not intended to limit the scope of the present invention.It is all
It is the equivalent change or modification according to the present invention made by the essence of content, should all covers in protection scope of the present invention.
Claims (6)
- A kind of 1. Chinese medicine composition for treating the infection of the upper respiratory tract, it is characterised in that：The each component of the Chinese medicine composition is ten thousand Shou Jugen, firecracker floral leaf, Herba Hyperici Patuli, cordate houttuynia, Acacia, white willow, fortune paulownia flower, Ageratum conyzoides, Angelica sinensis, fleshy-root gentian root, seguin argyreia herb.
- 2. Chinese medicine composition as claimed in claim 1, it is characterised in that：The ratio of weight and number of various components is marigold root 25-35 parts, 15-25 parts of firecracker floral leaf, 15-25 parts of Herba Hyperici Patuli, 10-20 parts of cordate houttuynia, 10-20 parts of Acacia, 5-15 parts of white willow, 5-15 parts of fortune paulownia flower, 5-15 parts of Ageratum conyzoides, 5-15 parts of Angelica sinensis, 5-15 parts of fleshy-root gentian root, 5-15 parts of seguin argyreia herb.
- 3. Chinese medicine composition as claimed in claim 1, it is characterised in that：The ratio of weight and number of various components is marigold root 30-35 parts, 20-25 parts of firecracker floral leaf, 20-25 parts of Herba Hyperici Patuli, 10-15 parts of cordate houttuynia, 10-15 parts of Acacia, 5-10 parts of white willow, 5-10 parts of fortune paulownia flower, 5-10 parts of Ageratum conyzoides, 5-10 parts of Angelica sinensis, 5-10 parts of fleshy-root gentian root, 5-10 parts of seguin argyreia herb.
- 4. the Chinese medicine composition of the infection of the upper respiratory tract is treated as any one of claim 1-3, it is characterised in that in described The formulation of drug composition is：Film coated tablet, sublimed preparation, emplastrum, syrup, oral liquid, mouth containing agent, granule, powder, injection Agent, sugar coated tablet, capsule.
- 5. a kind of preparation method for the Chinese medicine composition that the infection of the upper respiratory tract is treated as any one of claim 1-3, its It is characterized in that：When the formulation of the Chinese medicine is capsule, including：The first step, firecracker floral leaf, Herba Hyperici Patuli mix in proportion, and the determining alcohol with 2-3 times equivalent to mixture quality is 70-80% Normal propyl alcohol refluxing extraction 2-4 times, merging filtrate, is concentrated under reduced pressure, is dry and be ground into powder, then with ethyl alcohol purification 1-2 times, Merge extracting solution, ethanol is recovered under reduced pressure and is concentrated into the lotion that relative density at 60 DEG C is 1.21-1.24, drying is simultaneously crushed into powder End；Second step, cordate houttuynia, Acacia, white willow, fortune paulownia flower are extracted 2-3 times with the normal propyl alcohol that determining alcohol is 80-90%, merged Extracting solution, is concentrated under reduced pressure and is dried, is ground into powder, and the powder after crushing is added and is measured relative to its quality for 2-4 times Water dissolving, when static 1-3 is small, filtering, filtrate decompression concentration is the lotion that relative density is 1.21-1.24 at 60 DEG C and does It is dry, it is ground into powder；3rd step, remaining component is smashed and is mixed in proportion, is added water to cook 2 times, when each 2-3 is small, is filtered respectively, is merged Filtrate, filtrate are condensed into lotion and dry, pulverize into powder, and the quality of the water added is the 2- of the mixture quality of the 3rd step 4 times；4th step, above-mentioned powder and starch are mixed, and then carry out pelletization treatment and drying, obtain compound particles, then to mixed Magnesium stearate is added in polymer beads, the magnesium stearate and the compound particles mass ratio are 0.25-100:0.5- 100, capsule 's content is obtained, the capsule 's content is fitted into capsule housing up to capsule.
- 6. a kind of preparation method for the Chinese medicine composition that the infection of the upper respiratory tract is treated as any one of claim 1-3, its It is characterized in that：When the formulation of the Chinese medicine is injection, including：The first step, firecracker floral leaf, Herba Hyperici Patuli mix in proportion, and the determining alcohol with 2-3 times equivalent to mixture quality is 70-80% Normal propyl alcohol refluxing extraction 2-4 times, merging filtrate, is concentrated under reduced pressure, is dry and be ground into powder, then with ethyl alcohol purification 1-2 times, Merge extracting solution, ethanol is recovered under reduced pressure and is concentrated into the lotion that relative density at 60 DEG C is 1.21-1.24, drying is simultaneously crushed into powder End；Second step, cordate houttuynia, Acacia, white willow, fortune paulownia flower are extracted 2-3 times with the normal propyl alcohol that determining alcohol is 80-90%, merged Extracting solution, is concentrated under reduced pressure and is dried, is ground into powder, and the powder after crushing is added and is measured relative to its quality for 2-4 times Water dissolving, when static 1-3 is small, filtering, filtrate decompression concentration is the lotion that relative density is 1.21-1.24 at 60 DEG C and does It is dry, it is ground into powder；3rd step, remaining component is smashed and is mixed in proportion, is added water to cook 2 times, when each 2-3 is small, is filtered respectively, is merged Filtrate, filtrate are condensed into lotion and dry, pulverize into powder, and the quality of the water added is the 2- of the mixture quality of the 3rd step 4 times；4th step, above-mentioned powder is mixed, and is then dissolved in the water that quality is 2-4 times of mixture, the lower addition of stirring relative to The sodium hydroxide hydrotropy of powder quality 5%-15%, filtering, it is 5-6 to add the salt acid for adjusting pH value that concentration is 1mol/L, is filtered, and is sunk Form sediment spare, by polyamide column decontamination is first washed with water, the normal propyl alcohol for being then 80-90% with determining alcohol elutes, and collects in filtrate Normal propyl alcohol eluent, precipitation are extracted 2 times with the normal propyl alcohol that determining alcohol is 80-90%, and filtering, filtrate merges with above-mentioned eluent, Normal propyl alcohol is recycled, lotion is concentrated under reduced pressure into and is spray dried to powder, the powder of acquisition is added into the chlorine relative to 1-2 times of its quality Change sodium and appropriate water for injection, the volume of needs is further injected water to after dissolving, filtering, embedding, sterilizing, is needed The parenteral solution wanted.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109200219A (en) * | 2018-11-14 | 2019-01-15 | 张建美 | A kind of Chinese medicine composition and preparation method thereof that urinary tract infections is stifling |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585360A (en) * | 2013-11-12 | 2014-02-19 | 刘洪强 | Traditional Chinese medicinal preparation for treating upper respiratory tract infection |
| CN104225412A (en) * | 2014-09-18 | 2014-12-24 | 时新杰 | Traditional Chinese medicine for treating upper respiratory infection |
| CN106880673A (en) * | 2017-03-14 | 2017-06-23 | 青岛友诚高新技术有限公司 | It is a kind of to treat Chinese medicine composition of coronary heart disease and preparation method thereof |
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2017
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585360A (en) * | 2013-11-12 | 2014-02-19 | 刘洪强 | Traditional Chinese medicinal preparation for treating upper respiratory tract infection |
| CN104225412A (en) * | 2014-09-18 | 2014-12-24 | 时新杰 | Traditional Chinese medicine for treating upper respiratory infection |
| CN106880673A (en) * | 2017-03-14 | 2017-06-23 | 青岛友诚高新技术有限公司 | It is a kind of to treat Chinese medicine composition of coronary heart disease and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109200219A (en) * | 2018-11-14 | 2019-01-15 | 张建美 | A kind of Chinese medicine composition and preparation method thereof that urinary tract infections is stifling |
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