CN107970381A - A kind of Xuancheng's pawpaw tea of resolving sputum and its preparation method and application - Google Patents
A kind of Xuancheng's pawpaw tea of resolving sputum and its preparation method and application Download PDFInfo
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- CN107970381A CN107970381A CN201711154128.3A CN201711154128A CN107970381A CN 107970381 A CN107970381 A CN 107970381A CN 201711154128 A CN201711154128 A CN 201711154128A CN 107970381 A CN107970381 A CN 107970381A
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Abstract
The present invention provides a kind of Xuancheng's pawpaw tea of resolving sputum, it is prepared by the bulk pharmaceutical chemicals of following parts by weight：8 12 parts of Xuancheng's pawpaw, 10 15 parts of lophatherum gracile, 10 18 parts of lotus leaf, 8 12 parts of dandelion, 6 10 parts of purple perilla, 8 12 parts of reed root, extracting method includes water extract-alcohol precipitation, spray drying, the present invention has good resolve phlegm effect, and can treat cough variant asthma in childhood: prednison comparing.
Description
Technical field
The present invention relates to health tea technical field, and in particular to Xuancheng's pawpaw tea of a kind of resolving sputum and preparation method thereof and should
With.
Background technology
Resolving sputum the common drug such as tuber of pinellia, dried orange peel, Poria cocos, fritillaria etc..Phlegm card stays resistance part position clinical manifestations and the interpretation of the cause, onset and process of an illness because of disease and evil
Difference, often the method such as pleasant with facilitaing lung heat-clearing eliminating dampness invigorating the spleen temperature sun or the checking exuberance of yang that relieves dizziness, high fever, infantile convulsions, epilepsy, etc. is respectively cooperating with applying Circulation Resolving Phlegm.Phlegm is
Body fluid.Body fluid is human normal physiological body fluid, and phlegm is a kind of tangible pathological product.It is more because catch cold it is damp and hot it
Contain, internal damage by the excessive seven emotions diet it is strongly fragrant so that circulation of vital energy in the wrong direction liquid is turbid into the dilute viscous juice of volume.Phlegm usually mutually claims with drink, clinically has again
Differentiate：Viscous and thick person is phlegm, and clear and dilute person is drink.Phlegm color Huang person belongs to heat symptom-complex, and the white person of color belongs to cold card.Greasy fur on tongue person belongs to wet more
Phlegm, the red dry person of tongue is mostly sticky sputum.Therefore research and development resolving sputum health protection tea seems very significant.
Xuancheng's pawpaw contains 19 kinds of amino acid, 18 kinds of mine trace elements, and vitamin C, while also contains
Saponin, flavones, malic acid, oleanolic acid, citric acid, citric acid, tartaric acid, ascorbic acid, fumaric acid, tannin etc., contain
There are catalase, phenol oxidase, oxidizing ferment, especially rich in hepatocuprein (SOD) and oleanolic acid.Its SOD's contains
Amount is impayable in all fruit in the world, and the content of one gram of Xuancheng's pawpaw fresh fruit SOD is up to 3227 international units.SOD is
The core substance of modern beauty beauty treatment product, can effectively eliminate superfluous free radical in vivo, promote body cell renewal.Olive
Acid has broad-spectrum antibacterial action, has the effects such as protect liver drop enzyme, promoting immunity, anti-inflammatory, reducing blood lipid blood glucose.
The content of the invention
Goal of the invention：To solve the above-mentioned problems, the present inventor has found in long-term clinical test, and the present invention can change
Phlegm, plays the role of cough variant asthma in childhood: prednison comparing good.
Technical solution：The purpose of the present invention is what is realized by following scheme：
A kind of Xuancheng's pawpaw tea of resolving sputum, it is prepared by the bulk pharmaceutical chemicals of following parts by weight：8-12 parts of Xuancheng's pawpaw, henon bamboo
10-15 parts of leaf, 10-18 parts of lotus leaf, 8-12 parts of dandelion, 6-10 parts of purple perilla, 8-12 parts of reed root.
The Xuancheng's pawpaw tea of the resolving sputum, it is prepared by the bulk pharmaceutical chemicals of following parts by weight：10 parts of Xuancheng's pawpaw, lophatherum gracile
12 parts, 14 parts of lotus leaf, 10 parts of dandelion, 8 parts of purple perilla, 10 parts of reed root.
The Xuancheng's pawpaw tea of the resolving sputum, preparation method include the following steps：Above bulk pharmaceutical chemicals are taken to add water to cook 2 times, every time
Amount of water is 10 times of amounts of medicinal material weight, and when decoction 2 is small every time, collecting decoction, relative density is 1.10 when being concentrated into 65 DEG C, is added
Ethanol makes the percent by volume of alcohol content stir, stand, filtering, relative density is when filtrate decompression is concentrated into 65 DEG C up to 65%
1.20 and ethanol is recycled, obtain concentrate, be spray-dried, spray drying condition is：Inlet air temperature is 100, and leaving air temp is 80 DEG C,
Temperature of charge is 70 DEG C, and atomizing pressure is 0.2 megapascal, and spray velocity 10ml/s, is ground into dry extract, is pelletized, packing, i.e.,
Obtain Xuancheng's pawpaw tea.
Application of the Xuancheng's pawpaw tea of the resolving sputum in resolving sputum health products are prepared.
The Xuancheng's pawpaw tea of the resolving sputum is preparing the application in treating cough variant asthma in childhood: prednison comparing health products.
Beneficial effect：Xuancheng's pawpaw of the present invention has the effects such as protect liver drop enzyme, promoting immunity, anti-inflammatory, reducing blood lipid blood glucose, lophatherum gracile
There are refrigerant, antipyretic, diuresis and the effect hastened parturition；Cure mainly：In the heart disease heat, cough with dyspnea, haematemesis, heat toxin wind, only quench one's thirst, press borax
Poison, dissolving phlegm, control fanatical unhappy, apoplectic aphasia in silence, pain intermittent headache, stop palpitate with fear, pestilence fan are vexed, kill small worm, except the slow spleen of heat.Lotus leaf is clear
Perfume rise dissipate have effects that to clear away heart-fire relieving summer-heat, dissipate stasis of blood hemostasis, disappear wind clearing damp.Cure mainly hot summer weather polydipsia, pediatric epilepsy scared, married woman's blood inverse dusk
Fan, gets injured by a fall spitting blood, irregular menstruation, uterine bleeding, wet sore mange.Dandelion is clearing heat and detoxicating, diuresis dissipating bind.Control acute mastitis, lymph
Adenositis, scrofula, boil poisonous soreness, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, courage
Capsulitis, urinary tract infections.Perilla leaf can dissipate exterior cold, and sweating power is stronger, for chill table disease, see the disease such as aversion to cold, fever, lossless, often
With ginger with use；As table disease has the stagnation of the circulation of vital energy concurrently, have with rhizoma cyperi, dried orange peel to be equal and use.The wide middle perilla leaf of promoting the circulation of qi is used for the taste stagnation of the circulation of vital energy, chest
Vexed, evil of vomitting.Reed root, nickname reed lalang grass rhizome, reed root, reed head, reed stems root, are born in rivers lakes and marshes, pond irrigation canals and ditches bank and swale.
It is Chinese medicine name, for pyreticosis polydipsia, gastropyretic vomiting, cough with lung heat, lung carbuncle pyemesis, puckery pain of heat gonorrhea.Complete square compatibility 5, Xuancheng's pawpaw are monarch
Medicine, lophatherum gracile, lotus leaf, dandelion, purple perilla are ministerial drug, and reed root is adjuvant, have good resolve phlegm effect.
Embodiment
Form by the following examples, is described in further detail the above of the present invention again, but should not be by this
The scope for being interpreted as the above-mentioned theme of the present invention is only limitted to following example, and all technologies for being realized based on the above of the present invention are equal
Belong to the scope of the present invention.
Embodiment 1：8 parts of Xuancheng's pawpaw, 15 parts of lophatherum gracile, 10 parts of lotus leaf, 12 parts of dandelion, 6 parts of purple perilla, 12 parts of reed root are taken,
Preparation method includes the following steps：Above bulk pharmaceutical chemicals are taken to add water to cook 2 times, each amount of water is 10 times of amounts of medicinal material weight, often
It is secondary decoct 2 it is small when, collecting decoction, when being concentrated into 65 DEG C relative density be 1.10, the percent by volume that adding ethanol makes alcohol content reaches
65%, stir, stand, filtering, relative density is 1.20 and recycles ethanol when filtrate decompression is concentrated into 65 DEG C, obtains concentrate, sprays
Mist is dried, and spray drying condition is：Inlet air temperature is 100, and leaving air temp is 80 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is
0.2 megapascal, spray velocity 10ml/s, is ground into dry extract, pelletizes, packing, up to Xuancheng's pawpaw tea.
Embodiment 2：12 parts of Xuancheng's pawpaw, 10 parts of lophatherum gracile, 18 parts of lotus leaf, 8 parts of dandelion, 10 parts of purple perilla, 8 parts of reed root are taken,
Preparation method includes the following steps：Above bulk pharmaceutical chemicals are taken to add water to cook 2 times, each amount of water is 10 times of amounts of medicinal material weight, often
It is secondary decoct 2 it is small when, collecting decoction, when being concentrated into 65 DEG C relative density be 1.10, the percent by volume that adding ethanol makes alcohol content reaches
65%, stir, stand, filtering, relative density is 1.20 and recycles ethanol when filtrate decompression is concentrated into 65 DEG C, obtains concentrate, sprays
Mist is dried, and spray drying condition is：Inlet air temperature is 100, and leaving air temp is 80 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is
0.2 megapascal, spray velocity 10ml/s, is ground into dry extract, pelletizes, packing, up to Xuancheng's pawpaw tea.
Embodiment 3：10 parts of Xuancheng's pawpaw, 12 parts of lophatherum gracile, 14 parts of lotus leaf, 10 parts of dandelion, 8 parts of purple perilla, 10 parts of reed root are taken,
Preparation method includes the following steps：Above bulk pharmaceutical chemicals are taken to add water to cook 2 times, each amount of water is 10 times of amounts of medicinal material weight, often
It is secondary decoct 2 it is small when, collecting decoction, when being concentrated into 65 DEG C relative density be 1.10, the percent by volume that adding ethanol makes alcohol content reaches
65%, stir, stand, filtering, relative density is 1.20 and recycles ethanol when filtrate decompression is concentrated into 65 DEG C, obtains concentrate, sprays
Mist is dried, and spray drying condition is：Inlet air temperature is 100, and leaving air temp is 80 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is
0.2 megapascal, spray velocity 10ml/s, is ground into dry extract, pelletizes, packing, up to Xuancheng's pawpaw tea.
Embodiment 4：Xuancheng's pawpaw tea of the present invention is to resolving sputum drug effect testing data
Animal：ICR mouse, cleaning grade, half male and half female, weight 16-18g, is carried by Medical University Of Anhui's Experimental Animal Center
For.
Health products：Xuancheng's pawpaw tea, specification are prepared into by above-described embodiment 3：5g crude drugs/g, ammonium chloride (Nanjing chemical reagent
Factory, lot number：20150608).
Influence to the phenol red expectoration amount of mouse tracheae：
Packet：Mouse is randomly divided into 5 groups：Blank control group (isometric(al) physiological saline), ammonium chloride group (1.0g/kg), sheet
(10g/kg), Xuancheng's pawpaw tea low (5g/kg) three dosage groups in invention Xuancheng's pawpaw tea height (20g/kg), Xuancheng's pawpaw tea.
Experimental method：The random packet of mouse 50 is taken, gastric infusion, the 1h after administration in the 5th day, it is phenol red to be injected intraperitoneally 5%
(0.1ml/10g weight), puts to death mouse after 30min.One section tracheae of the mouse from thyroid cartilage to tracheae bifurcation is cut, is put into
In the test tube for filling 2ml physiological saline, shaking, adds 0.1ml1mol/LNaOH, with 754 spectrophotometers (Shanghai) in ripple
OD values are surveyed under the conditions of long 550nm.The phenol red discharge rate of tracheae of every mouse is found according to phenol red standard curve.
Experimental result：Xuancheng's pawpaw tea of the present invention is high, middle dose group can substantially increase the phenol red discharge rate of mouse tracheae, and right
There is conspicuousness (P according to group comparing difference<0.05 or P<0.01) (it is shown in Table 1).
Influence of the Xuancheng's pawpaw tea of the present invention of table 1. to the phenol red expectoration amount of mouse tracheae
Note：The * P compared with blank control group<0.05；**P<0.01
Conclusion test result indicates that Xuancheng's pawpaw tea of the present invention can be effectively increased mouse tracheal mucus secretion, make phenol red discharge rate
Obvious increase.Therefore prompting Xuancheng's pawpaw tea of the present invention has resolve phlegm effect, has certain help to improving symptom.
Embodiment 5：Xuancheng's pawpaw tea of the present invention treats cough variant asthma in childhood: prednison comparing clinical research
General data：Xuancheng's pawpaw tea of the present invention is applied to clinical observation cough variant asthma in childhood: prednison comparing case 100, year
1~9 years old age.The course of disease most short person 1 month, most elder was up to 1 year.
Diagnostic criteria：Continue with reference to CVA diagnostic criteria [1] (1) that national During Prevention of Asthma in Children cooperative groups in 1998 are formulated
Cough or cough recurrent exerbation ＞ January, often in night or early morning ictal cough, few phlegm, after movement, to the cold air, smell spy
Cough and aggravate after different odor.(2) it is invalid without infection sign, through a long time antibiosis extract for treating.(3) trachea expanding agent diagnostic treatment
Cough can be alleviated.(4) there are a personal allergies and family's allergies, Allergic skin test is positive, and air flue is in high response feature, branch gas
The pipe provocative test positive can be used as auxiliary diagnosis.
Test method：Xuancheng's pawpaw tea is prepared by 3 preparation method of above-described embodiment, specification is 10 grams every bag, is treated for one within five days
Journey, one day three bags, it is point early, middle and late that half an hour takes before meals three times.Raw and cold, pungent, stimulation is avoided eating during medication and rots it
Thing.Blank group oral placebo granule, five days as a treatment course, one day three bags, it is point early, middle and late that half an hour takes before meals three times.
Criterion of therapeutical effect：Reference《Chinese medical disease Standardization of diagnosis and curative effect》：Recovery from illness：1~2 course for the treatment of is treated, cough, coughs up phlegm, flows
The symptoms such as tears disappear, and symptom has no repeatedly in 1 year；Effectively：Through treating 2~3 courses for the treatment of, cough, cough up phlegm, runny nose is clearly better, 1
There is repeatedly symptom, plus-minus treatment, symptom are wholly absent again in year, observes 1 year without repeatedly.It is invalid：It is clinical after 3~4 courses for the treatment of
Symptom is still without improvement, or even aggravates.
Therapeutic effect：It is shown in Table 2.
2 two groups of curative effects of table compare
| Group | n | Recovery from illness | Effectively | It is invalid | Total effective rate (%) |
| Treatment group | 50 | 20 | 26 | 4 | 92 |
| Blank group | 50 | 2 | 1 | 27 | 6 |
As it can be seen that Xuancheng's pawpaw tea produced by the present invention can safely and effectively treat cough variant asthma in childhood: prednison comparing, and nontoxic pair
Effect.
Claims (5)
1. the Xuancheng's pawpaw tea of a kind of resolving sputum, it is characterised in that it is prepared by the bulk pharmaceutical chemicals of following parts by weight：Xuancheng's pawpaw 8-
12 parts, 10-15 parts of lophatherum gracile, 10-18 parts of lotus leaf, 8-12 parts of dandelion, 6-10 parts of purple perilla, 8-12 parts of reed root.
2. the Xuancheng's pawpaw tea of resolving sputum as claimed in claim 1, it is characterised in that it is prepared into by the bulk pharmaceutical chemicals of following parts by weight
Arrive：10 parts of Xuancheng's pawpaw, 12 parts of lophatherum gracile, 14 parts of lotus leaf, 10 parts of dandelion, 8 parts of purple perilla, 10 parts of reed root.
3. the Xuancheng's pawpaw tea of resolving sputum according to claim 1, it is characterised in that preparation method includes the following steps：Take the above
Bulk pharmaceutical chemicals add water to cook 2 times, and each amount of water is 10 times of amounts of medicinal material weight, and when decoction 2 is small every time, collecting decoction, is concentrated into
Relative density is 1.10 at 65 DEG C, adds ethanol the percent by volume of alcohol content is stirred, is stood, filter, filtrate decompression up to 65%
Relative density is 1.20 and recycles ethanol when being concentrated into 65 DEG C, obtains concentrate, is spray-dried, spray drying condition is：Into wind-warm syndrome
Spend for 100, leaving air temp is 80 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure be 0.2 megapascal, spray velocity 10ml/s, crushing
Into dry extract, pelletize, packing, up to Xuancheng's pawpaw tea.
4. application of the Xuancheng's pawpaw tea of resolving sputum in resolving sputum health products are prepared according to claim 1.
5. the Xuancheng's pawpaw tea of resolving sputum answering in treatment cough variant asthma in childhood: prednison comparing health products are prepared according to claim 1
With.
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| CN108888996A (en) * | 2018-06-28 | 2018-11-27 | 吴承章 | A kind of dingchuan decoction extract alcohol sink device changed based on draught head |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846792A (en) * | 2012-09-13 | 2013-01-02 | 山东东阿阿胶股份有限公司 | Phlegm-dampness constitution composition, preparation method and applications of composition |
| CN103623103A (en) * | 2013-12-13 | 2014-03-12 | 于凤洋 | Traditional Chinese medicine preparation for treating coughing and phlegmy throat |
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2017
- 2017-11-20 CN CN201711154128.3A patent/CN107970381A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846792A (en) * | 2012-09-13 | 2013-01-02 | 山东东阿阿胶股份有限公司 | Phlegm-dampness constitution composition, preparation method and applications of composition |
| CN103623103A (en) * | 2013-12-13 | 2014-03-12 | 于凤洋 | Traditional Chinese medicine preparation for treating coughing and phlegmy throat |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108888996A (en) * | 2018-06-28 | 2018-11-27 | 吴承章 | A kind of dingchuan decoction extract alcohol sink device changed based on draught head |
| CN108888996B (en) * | 2018-06-28 | 2021-02-02 | 王晓娟 | Asthma-relieving decoction liquid alcohol precipitation device based on air pressure difference change |
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Effective date of registration: 20181205 Address after: 242000 Pioneering Road 23-3-2, Xuancheng Economic and Technological Development Zone, Xuancheng City, Anhui Province Applicant after: XUANCHENG HUAKE XUANMUGUA BIOTECHNOLOGY CO., LTD. Address before: 242000 Dangui Apartment, Renmin Road, Ningguo City, Xuancheng City, Anhui Province, 2 West 112 Storage, West 112, West 212 Applicant before: Ningguo balanced Health Management Company Limited |
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