CN108350434B - 表达细胞因子和羧酸酯酶的修饰的溶瘤痘苗病毒及其使用方法 - Google Patents

表达细胞因子和羧酸酯酶的修饰的溶瘤痘苗病毒及其使用方法 Download PDF

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CN108350434B
CN108350434B CN201680064990.2A CN201680064990A CN108350434B CN 108350434 B CN108350434 B CN 108350434B CN 201680064990 A CN201680064990 A CN 201680064990A CN 108350434 B CN108350434 B CN 108350434B
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cancer
promoter
virus
vaccinia virus
vaccinia
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CN108350434A (zh
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黄泰晧
李南喜
赵恩娥
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Sillajen Inc
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CN201680064990.2A 2015-09-08 2016-09-02 表达细胞因子和羧酸酯酶的修饰的溶瘤痘苗病毒及其使用方法 Active CN108350434B (zh)

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US201562215651P 2015-09-08 2015-09-08
US62/215,651 2015-09-08
PCT/KR2016/009866 WO2017043815A1 (en) 2015-09-08 2016-09-02 Modified oncolytic vaccinia viruses expressing a cytokine and a car- boxylesterase and methods of use thereof

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US12226440B2 (en) 2017-10-31 2025-02-18 Kalivir Immunotherapeutics, Inc. Platform oncolytic vector for systemic delivery
US12403165B2 (en) 2020-11-19 2025-09-02 KaliVir Immunotherapeutcs, Inc. Oncolytic immunotherapy by tumor micro-environment remodeling

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EP4122492A1 (en) 2015-02-25 2023-01-25 Memorial Sloan Kettering Cancer Center Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors
KR20180006916A (ko) 2015-04-17 2018-01-19 메모리얼 슬로안-케터링 캔서 센터 고형 종양에 대한 면역치료제로서 mva 또는 mva델타e3l의 용도
CN108025056B (zh) * 2015-06-19 2022-01-14 新罗杰股份有限公司 用于病毒栓塞的组合物和方法
JP7025339B2 (ja) 2016-02-25 2022-02-24 メモリアル スローン ケタリング キャンサー センター 癌免疫療法のための、チミジンキナーゼの欠失を伴い、ヒトｆｌｔ３ｌまたはｇｍ－ｃｓｆの発現を伴うかまたは伴わない、複製可能な弱毒化ワクシニアウイルス
CN109152827B (zh) 2016-02-25 2023-07-21 纪念斯隆凯特琳癌症中心 重组mva或表达人flt3l的mvaδe3l及其作为抗固体肿瘤的免疫治疗剂的用途
EP3610870A4 (en) * 2017-03-31 2020-12-09 Ogata, Hisanobu METHOD OF EXPANSION OF AN ONCOLYTIC VIRUS AND ANTI-TUMOR AGENT
EP3621646A4 (en) 2017-05-12 2021-06-02 Memorial Sloan Kettering Cancer Center VACCINIA VIRUS MUTANTS FOR CANCER IMMUNOTHERAPY
CN109554353B (zh) * 2017-09-26 2021-08-06 杭州康万达医药科技有限公司 分离的重组溶瘤痘病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途
US11786569B2 (en) * 2018-01-26 2023-10-17 University of Pittsburgh—of the Commonwealth System of Higher Education Expression of metabolic modulators in tumor microenvironment to improve tumor therapy
WO2020014543A2 (en) 2018-07-11 2020-01-16 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
BR112021004692A2 (pt) * 2018-09-15 2021-06-08 Memorial Sloan Kettering Cancer Center poxvírus recombinantes para imunoterapia de câncer
CN109735558B (zh) * 2018-12-12 2022-04-15 中南大学 一种重组car19-il24基因、慢病毒载体、car19-il24-t细胞及应用
US12024709B2 (en) 2019-02-27 2024-07-02 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
CN113748124A (zh) 2019-02-27 2021-12-03 阿克蒂姆治疗有限公司 工程化以定植肿瘤、肿瘤驻留免疫细胞和肿瘤微环境的免疫刺激性细菌
JP7625589B2 (ja) * 2019-10-16 2025-02-03 カリヴィル イムノセラピューティクス， インコーポレイテッド 改変細胞外エンベロープウイルス
CA3161450A1 (en) 2019-11-12 2021-05-20 Actym Therapeutics, Inc. Immunostimulatory bacteria delivery platforms and their use for delivery of therapeutic products
CA3163805A1 (en) * 2019-12-12 2021-06-17 Ignite Immunotherapy, Inc. Variant oncolytic vaccinia virus and methods of use thereof
WO2022036159A2 (en) 2020-08-12 2022-02-17 Actym Therapeutics, Inc. Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms
US20240102912A1 (en) * 2020-11-09 2024-03-28 Thrive Bioscience, Inc. Plaque counting assay method
EP4329786A4 (en) 2021-04-30 2024-12-11 KaliVir Immunotherapeutics, Inc. Oncolytic viruses for modified mhc expression
CA3235418A1 (en) 2021-11-09 2023-05-19 Actym Therapeutics, Inc. Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment

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