CN108350405A - 支持生物活性的一次性生物处理系统 - Google Patents

支持生物活性的一次性生物处理系统 Download PDF

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Publication number
CN108350405A
CN108350405A CN201680057198.4A CN201680057198A CN108350405A CN 108350405 A CN108350405 A CN 108350405A CN 201680057198 A CN201680057198 A CN 201680057198A CN 108350405 A CN108350405 A CN 108350405A
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China
Prior art keywords
liquid
container
medium
valve
disposable
Prior art date
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Pending
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CN201680057198.4A
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English (en)
Chinese (zh)
Inventor
P·施托贝
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Stobe Co ltd
Original Assignee
Shi Tobey Pharmaceutical Technology Ltd By Share Ltd
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Publication of CN108350405A publication Critical patent/CN108350405A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/38—Caps; Covers; Plugs; Pouring means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/04—Seals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201680057198.4A 2015-08-08 2016-05-17 支持生物活性的一次性生物处理系统 Pending CN108350405A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201500453 2015-08-08
DKPA201500453 2015-08-08
PCT/EP2016/061000 WO2017025210A1 (en) 2015-08-08 2016-05-17 Disposable bioprocess system supporting biological activity

Publications (1)

Publication Number Publication Date
CN108350405A true CN108350405A (zh) 2018-07-31

Family

ID=56068872

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680057198.4A Pending CN108350405A (zh) 2015-08-08 2016-05-17 支持生物活性的一次性生物处理系统

Country Status (7)

Country Link
US (5) US11414642B2 (https=)
EP (1) EP3331983A1 (https=)
JP (4) JP2018534940A (https=)
KR (2) KR20230156168A (https=)
CN (1) CN108350405A (https=)
CA (1) CA2993709A1 (https=)
WO (1) WO2017025210A1 (https=)

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EP3665261A1 (en) * 2017-12-20 2020-06-17 Sartorius Stedim Biotech GmbH Insertable components for single-use containers
TWI718621B (zh) * 2018-10-11 2021-02-11 南韓商Ｌｇ化學股份有限公司 整合盒
CN114945659A (zh) * 2020-01-02 2022-08-26 豪夫迈·罗氏有限公司 具有一个或多个原位在线传感器的一次性细胞培养容器
CN116371080A (zh) * 2021-12-31 2023-07-04 帕尔公司 具有一次性使用过滤器的流体过滤系统及其用于自动过滤器调节的方法
TWI874409B (zh) * 2019-06-13 2025-03-01 美商安進公司 生物製品製造中基於生物量之自動灌注控制

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FI4221057T3 (fi) 2017-06-16 2025-11-28 Wilus Inst Standards & Tech Inc Menetelmä, laitteisto ja järjestelmä ohjauskanavan ja datakanavan lähettämiseksi tai vastaanottamiseksi langattomassa viestintäjärjestelmässä
US20190136173A1 (en) * 2017-09-29 2019-05-09 Lonza Ltd. Perfusion apparatus for use in bioreactor systems
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DE102017127017A1 (de) * 2017-11-16 2019-05-16 Sartorius Stedim Biotech Gmbh Automatisierte Einweg-Filtrationsvorrichtung und Verfahren zur Steuerung einer automatisierten Einweg-Filtrationsvorrichtung
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CN110241012B (zh) * 2018-03-09 2022-11-01 嘉和生物药业有限公司 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用
JP7144958B2 (ja) * 2018-03-30 2022-09-30 株式会社エビデント 観察装置および観察システム
DE102018006286B3 (de) * 2018-08-08 2019-10-10 Sartorius Stedim Biotech Gmbh Bioreaktor mit Filtereinheit und Verfahren zur Behandlung einer Zellbrühe
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US11103827B2 (en) * 2019-02-05 2021-08-31 Generon Igs, Inc. Two-stage gas separation unit contained within a single housing
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EP3854867A1 (de) * 2020-01-23 2021-07-28 FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V. Vorkehrung zur kultivierung von prokryotischen und eukaryotischen zellen in einer strukturierten matrix unter physikalischer kräfteeinwirkung
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TW202204603A (zh) * 2020-07-06 2022-02-01 德商馬克專利公司 用於製備細胞培養基及進行細胞培養之裝置及方法
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KR20230156168A (ko) * 2015-08-08 2023-11-13 스토베 게엠베하 생물학적 활동을 지원하는 일회용 생물 공정 시스템

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3665261A1 (en) * 2017-12-20 2020-06-17 Sartorius Stedim Biotech GmbH Insertable components for single-use containers
TWI718621B (zh) * 2018-10-11 2021-02-11 南韓商Ｌｇ化學股份有限公司 整合盒
TWI874409B (zh) * 2019-06-13 2025-03-01 美商安進公司 生物製品製造中基於生物量之自動灌注控制
CN114945659A (zh) * 2020-01-02 2022-08-26 豪夫迈·罗氏有限公司 具有一个或多个原位在线传感器的一次性细胞培养容器
CN116371080A (zh) * 2021-12-31 2023-07-04 帕尔公司 具有一次性使用过滤器的流体过滤系统及其用于自动过滤器调节的方法

Also Published As

Publication number Publication date
US20220333059A1 (en) 2022-10-20
US20230203426A1 (en) 2023-06-29
KR102621101B1 (ko) 2024-01-05
WO2017025210A1 (en) 2017-02-16
US12110484B2 (en) 2024-10-08
US20260028580A1 (en) 2026-01-29
EP3331983A1 (en) 2018-06-13
KR20180040134A (ko) 2018-04-19
JP2018534940A (ja) 2018-11-29
US20180237737A1 (en) 2018-08-23
US12157878B2 (en) 2024-12-03
JP7298054B2 (ja) 2023-06-27
KR20230156168A (ko) 2023-11-13
US20180155667A1 (en) 2018-06-07
US11414642B2 (en) 2022-08-16
JP2025148484A (ja) 2025-10-07
JP2021061853A (ja) 2021-04-22
CA2993709A1 (en) 2017-02-16
JP2023100943A (ja) 2023-07-19

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