CN108350021A - 用于治疗眼科疾病的化合物和制剂 - Google Patents
用于治疗眼科疾病的化合物和制剂 Download PDFInfo
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- CN108350021A CN108350021A CN201680065262.3A CN201680065262A CN108350021A CN 108350021 A CN108350021 A CN 108350021A CN 201680065262 A CN201680065262 A CN 201680065262A CN 108350021 A CN108350021 A CN 108350021A
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- YEZNLOUZAIOMLT-UHFFFAOYSA-N tolfenamic acid Chemical compound CC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=O YEZNLOUZAIOMLT-UHFFFAOYSA-N 0.000 description 1
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- VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 description 1
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- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
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- WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical compound C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 description 1
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- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
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- 229960002149 valganciclovir Drugs 0.000 description 1
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- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
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- 238000009423 ventilation Methods 0.000 description 1
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- 229920002554 vinyl polymer Polymers 0.000 description 1
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- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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- 229960000523 zalcitabine Drugs 0.000 description 1
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562215629P | 2015-09-08 | 2015-09-08 | |
| US62/215,629 | 2015-09-08 | ||
| US201562269019P | 2015-12-17 | 2015-12-17 | |
| US201562269013P | 2015-12-17 | 2015-12-17 | |
| US62/269,013 | 2015-12-17 | ||
| US62/269,019 | 2015-12-17 | ||
| PCT/US2016/050823 WO2017044659A1 (en) | 2015-09-08 | 2016-09-08 | Compounds and formulations for treating ophthalmic diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108350021A true CN108350021A (zh) | 2018-07-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201680065262.3A Pending CN108350021A (zh) | 2015-09-08 | 2016-09-08 | 用于治疗眼科疾病的化合物和制剂 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20180250313A1 (enExample) |
| EP (1) | EP3347368A4 (enExample) |
| JP (1) | JP2018526423A (enExample) |
| CN (1) | CN108350021A (enExample) |
| AU (1) | AU2016321254A1 (enExample) |
| CA (1) | CA2998134A1 (enExample) |
| HK (1) | HK1258588A1 (enExample) |
| WO (1) | WO2017044659A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113583950A (zh) * | 2021-08-06 | 2021-11-02 | 合肥滴碧云生物科技有限公司 | 一种制备干细胞活性因子的方法及其应用 |
| WO2023030430A1 (zh) * | 2021-09-03 | 2023-03-09 | 成都瑞沐生物医药科技有限公司 | 一种滴眼给药预防和/或治疗白内障的眼用制剂 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113234114A (zh) | 2011-10-14 | 2021-08-10 | 萨奇治疗股份有限公司 | 3,3-二取代的19-去甲孕甾烷化合物、组合物、及其用途 |
| SI2986624T1 (sl) | 2013-04-17 | 2020-10-30 | Sage Therapeutics, Inc. | 19-nor nevroaktivni steroidi za metode zdravljenja |
| TR201901745T4 (tr) | 2013-04-17 | 2019-03-21 | Sage Therapeutics Inc | 19-nor C3,3-disübstitüe edilmiş C21- n-pirazolil steroidleri ve bunların kullanım yöntemleri. |
| US20160068563A1 (en) | 2013-04-17 | 2016-03-10 | Boyd L. Harrison | 19-nor neuroactive steroids and methods of use thereof |
| US9725481B2 (en) | 2013-04-17 | 2017-08-08 | Sage Therapeutics, Inc. | 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof |
| PL3021852T3 (pl) | 2013-07-19 | 2021-07-05 | Sage Therapeutics, Inc. | Neuroaktywne steroidy, kompozycje i ich zastosowania |
| PT3035940T (pt) | 2013-08-23 | 2019-01-28 | Sage Therapeutics Inc | Esteroides neuroativos, composições e seus usos |
| US10246482B2 (en) | 2014-06-18 | 2019-04-02 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| PT3206493T (pt) | 2014-10-16 | 2020-08-03 | Sage Therapeutics Inc | Composições e métodos para tratamento de transtornos do snc |
| KR20230170816A (ko) | 2014-10-16 | 2023-12-19 | 세이지 테라퓨틱스, 인크. | Cns 장애의 치료를 위한 조성물 및 방법 |
| JP6893173B2 (ja) | 2014-11-27 | 2021-06-23 | セージ セラピューティクス， インコーポレイテッド | Ｃｎｓ障害を処置するための組成物および方法 |
| HUE054092T2 (hu) | 2015-01-26 | 2021-08-30 | Sage Therapeutics Inc | Központi idegrendszeri zavarok kezelésére szolgáló kompozíciók és eljárások |
| US10329320B2 (en) | 2015-02-20 | 2019-06-25 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| JP6949838B2 (ja) | 2015-10-29 | 2021-10-13 | フィルメニッヒ インコーポレイテッドＦｉｒｍｅｎｉｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ | 高甘味度甘味料 |
| CA3030420C (en) | 2016-07-11 | 2025-11-18 | Sage Therapeutics, Inc. | C7, C12 AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND ASSOCIATED METHODS OF USE |
| NZ790226A (en) | 2016-07-11 | 2025-08-29 | Sage Therapeutics Inc | C17, C20, and C21 substituted neuroactive steroids and their methods of use |
| NZ791594A (en) | 2016-08-23 | 2025-08-29 | Sage Therapeutics Inc | A crystalline 19-nor C3, 3-disubstituted C21-N-pyrazolyl steroid |
| MY199685A (en) | 2017-05-03 | 2023-11-17 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| CN108794556B (zh) * | 2017-05-05 | 2021-01-29 | 清华大学 | 化合物及其在治疗白内障中的应用 |
| KR20200018580A (ko) * | 2017-06-08 | 2020-02-19 | 아이 쎄러피스 엘엘씨 | 저용량 브리모니딘 조합 및 그의 용도 |
| GB2581656A (en) * | 2017-11-17 | 2020-08-26 | Piraee Mahmood | Combinations of lanosterol or 25-hydroxycholesterol including derivatives thereof useful in the treatment of lens disorders |
| US12419990B2 (en) | 2017-11-22 | 2025-09-23 | Bausch & Lomb Incorporated | Ophthalmic viscoelastic compositions |
| US20200276211A1 (en) * | 2017-11-28 | 2020-09-03 | Viewpoint Therapeutics, Inc. | Compounds for treating near vision disorders |
| WO2019191200A1 (en) | 2018-03-27 | 2019-10-03 | American Genomics, Llc | Method and formulation for producing anesthesia of internal aspect of eye wall by topical application |
| CA3104234A1 (en) * | 2018-06-27 | 2020-01-02 | Cellix Bio Private Limited | Ophthalmic compositions and methods for the treatment of eye disorders |
| CA3118675A1 (en) | 2018-11-07 | 2020-05-14 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| US12286661B2 (en) | 2018-11-07 | 2025-04-29 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| AU2020245203A1 (en) * | 2019-03-26 | 2021-11-11 | Martin Uram | Anesthetic composition and method of anesthetizing the eye |
| CN114206900A (zh) | 2019-05-31 | 2022-03-18 | 萨奇治疗股份有限公司 | 神经活性类固醇及其组合物 |
| WO2021113410A1 (en) * | 2019-12-02 | 2021-06-10 | Ampersand Biopharmaceuticals, Inc. | Transdermal penetrant formulations for vitamins, minerals and supplements |
| WO2021113411A1 (en) * | 2019-12-02 | 2021-06-10 | Ampersand Biopharmaceuticals, Inc. | Transdermal penetrant formulations for vitamins, minerals and supplements |
| WO2022023822A1 (en) * | 2020-07-30 | 2022-02-03 | Indoco Remedies Limited | A stable ophthalmic composition of posaconazole |
| US20230302032A1 (en) * | 2020-08-04 | 2023-09-28 | Harrow Ip Llc | Antibacterial compositions and methods for fabricating thereof |
| US20220112208A1 (en) * | 2020-10-08 | 2022-04-14 | King Abdullah University Of Science And Technology | Compounds with antiinflammatory activity and methods of use thereof |
| WO2023215706A1 (en) * | 2022-05-02 | 2023-11-09 | ZoomEssence, Inc. | Degradation-resistant aldehyde-containing compositions |
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| CN104768615A (zh) * | 2012-07-17 | 2015-07-08 | 密执安大学评议会 | 治疗白内障的非手术方法 |
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| FR2663850B1 (fr) * | 1990-07-02 | 1994-01-14 | Gird Galderma | Composition pharmaceutique ou cosmetique contenant en association un retinouide et un sterol. |
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| CA2468989A1 (en) * | 2001-12-07 | 2003-06-19 | Daniel M. Schwartz | Treatment for age-related macular degeneration |
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| EP2512492A1 (en) * | 2009-12-14 | 2012-10-24 | University of Massachusetts | Methods of inhibiting cataracts and presbyopia |
| BR112015023348B1 (pt) * | 2013-03-14 | 2023-04-25 | The University Of Massachusetts | Composição oftálmica |
| WO2014145749A1 (en) * | 2013-03-15 | 2014-09-18 | The Brigham And Women's Hospital, Inc. | Targeted polymeric inflammation-resolving nanoparticles |
| EP3328389A1 (en) * | 2015-07-27 | 2018-06-06 | Catacore, Inc. | Compositions for the treatment of cataracts |
-
2016
- 2016-09-08 EP EP16845069.0A patent/EP3347368A4/en not_active Withdrawn
- 2016-09-08 WO PCT/US2016/050823 patent/WO2017044659A1/en not_active Ceased
- 2016-09-08 AU AU2016321254A patent/AU2016321254A1/en not_active Abandoned
- 2016-09-08 US US15/758,705 patent/US20180250313A1/en not_active Abandoned
- 2016-09-08 CN CN201680065262.3A patent/CN108350021A/zh active Pending
- 2016-09-08 HK HK19100945.5A patent/HK1258588A1/zh unknown
- 2016-09-08 JP JP2018513359A patent/JP2018526423A/ja active Pending
- 2016-09-08 CA CA2998134A patent/CA2998134A1/en not_active Abandoned
Patent Citations (2)
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|---|---|---|---|---|
| US4743597A (en) * | 1986-01-27 | 1988-05-10 | Javitt Norman B | Composition comprising an oxygenated cholesterol and use thereof for topical treatment of diseases |
| CN104768615A (zh) * | 2012-07-17 | 2015-07-08 | 密执安大学评议会 | 治疗白内障的非手术方法 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113583950A (zh) * | 2021-08-06 | 2021-11-02 | 合肥滴碧云生物科技有限公司 | 一种制备干细胞活性因子的方法及其应用 |
| WO2023030430A1 (zh) * | 2021-09-03 | 2023-03-09 | 成都瑞沐生物医药科技有限公司 | 一种滴眼给药预防和/或治疗白内障的眼用制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3347368A1 (en) | 2018-07-18 |
| WO2017044659A1 (en) | 2017-03-16 |
| EP3347368A4 (en) | 2019-01-23 |
| AU2016321254A1 (en) | 2018-04-05 |
| JP2018526423A (ja) | 2018-09-13 |
| HK1258588A1 (zh) | 2019-11-15 |
| US20180250313A1 (en) | 2018-09-06 |
| CA2998134A1 (en) | 2017-03-16 |
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