CA2998134A1 - Compounds and formulations for treating ophthalmic diseases - Google Patents
Compounds and formulations for treating ophthalmic diseases Download PDFInfo
- Publication number
- CA2998134A1 CA2998134A1 CA2998134A CA2998134A CA2998134A1 CA 2998134 A1 CA2998134 A1 CA 2998134A1 CA 2998134 A CA2998134 A CA 2998134A CA 2998134 A CA2998134 A CA 2998134A CA 2998134 A1 CA2998134 A1 CA 2998134A1
- Authority
- CA
- Canada
- Prior art keywords
- formulation
- optionally substituted
- pharmaceutical formulation
- compound
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 229960000497 trovafloxacin Drugs 0.000 description 1
- WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical compound C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 description 1
- 229940008349 truvada Drugs 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940040064 ubiquinol Drugs 0.000 description 1
- QNTNKSLOFHEFPK-UPTCCGCDSA-N ubiquinol-10 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(O)=C1OC QNTNKSLOFHEFPK-UPTCCGCDSA-N 0.000 description 1
- 238000004704 ultra performance liquid chromatography Methods 0.000 description 1
- KCFYEAOKVJSACF-UHFFFAOYSA-N umifenovir Chemical compound CN1C2=CC(Br)=C(O)C(CN(C)C)=C2C(C(=O)OCC)=C1CSC1=CC=CC=C1 KCFYEAOKVJSACF-UHFFFAOYSA-N 0.000 description 1
- 229960004626 umifenovir Drugs 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 229940093257 valacyclovir Drugs 0.000 description 1
- 229960002004 valdecoxib Drugs 0.000 description 1
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
- 229960002149 valganciclovir Drugs 0.000 description 1
- 229940108442 valtrex Drugs 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1
- PXXNTAGJWPJAGM-UHFFFAOYSA-N vertaline Natural products C1C2C=3C=C(OC)C(OC)=CC=3OC(C=C3)=CC=C3CCC(=O)OC1CC1N2CCCC1 PXXNTAGJWPJAGM-UHFFFAOYSA-N 0.000 description 1
- 229950009860 vicriviroc Drugs 0.000 description 1
- 229960003636 vidarabine Drugs 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
- 229960000523 zalcitabine Drugs 0.000 description 1
- 229960001028 zanamivir Drugs 0.000 description 1
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 description 1
- 229960002555 zidovudine Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
- 229960003414 zomepirac Drugs 0.000 description 1
- ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562215629P | 2015-09-08 | 2015-09-08 | |
| US62/215,629 | 2015-09-08 | ||
| US201562269019P | 2015-12-17 | 2015-12-17 | |
| US201562269013P | 2015-12-17 | 2015-12-17 | |
| US62/269,019 | 2015-12-17 | ||
| US62/269,013 | 2015-12-17 | ||
| PCT/US2016/050823 WO2017044659A1 (en) | 2015-09-08 | 2016-09-08 | Compounds and formulations for treating ophthalmic diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2998134A1 true CA2998134A1 (en) | 2017-03-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2998134A Abandoned CA2998134A1 (en) | 2015-09-08 | 2016-09-08 | Compounds and formulations for treating ophthalmic diseases |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20180250313A1 (enExample) |
| EP (1) | EP3347368A4 (enExample) |
| JP (1) | JP2018526423A (enExample) |
| CN (1) | CN108350021A (enExample) |
| AU (1) | AU2016321254A1 (enExample) |
| CA (1) | CA2998134A1 (enExample) |
| HK (1) | HK1258588A1 (enExample) |
| WO (1) | WO2017044659A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113234114A (zh) | 2011-10-14 | 2021-08-10 | 萨奇治疗股份有限公司 | 3,3-二取代的19-去甲孕甾烷化合物、组合物、及其用途 |
| WO2014169836A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids and methods of use thereof |
| WO2014169831A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof |
| WO2014169832A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids and methods of use thereof |
| MX362543B (es) | 2013-04-17 | 2019-01-24 | Sage Therapeutics Inc | Esteroides c21-n-pirazolilo 19-nor c3,3- disustituidos y metodos de uso de los mismos. |
| HRP20210610T1 (hr) | 2013-07-19 | 2021-05-28 | Sage Therapeutics, Inc. | Neuroaktivni steroidi, pripravci i njihove uporabe |
| PT3035940T (pt) | 2013-08-23 | 2019-01-28 | Sage Therapeutics Inc | Esteroides neuroativos, composições e seus usos |
| WO2015195962A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| EP3885352B1 (en) | 2014-10-16 | 2024-11-27 | Sage Therapeutics, Inc. | A compound, compositions thereof and this compound for use in methods of treating cns disorders |
| EP4275748A3 (en) | 2014-10-16 | 2024-01-03 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| RS60343B1 (sr) | 2014-11-27 | 2020-07-31 | Sage Therapeutics Inc | Kompozicije i postupci za lečenje poremećaja cns-a |
| SMT202100113T1 (it) | 2015-01-26 | 2021-05-07 | Sage Therapeutics Inc | Composizioni e metodi per trattare disturbi del snc |
| EP3258939B1 (en) | 2015-02-20 | 2022-09-07 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| JP6949838B2 (ja) | 2015-10-29 | 2021-10-13 | フィルメニッヒ インコーポレイテッドＦｉｒｍｅｎｉｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ | 高甘味度甘味料 |
| AU2017296295B2 (en) | 2016-07-11 | 2022-02-24 | Sage Therapeutics, Inc. | C7, C12, and C16 substituted neuroactive steroids and their methods of use |
| MA45599A (fr) | 2016-07-11 | 2019-05-15 | Sage Therapeutics Inc | Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation |
| JOP20190022B1 (ar) | 2016-08-23 | 2023-03-28 | Sage Therapeutics Inc | ستيرويد 19- نور c3، 3- به استبدال ثنائي لـ c21-n بيرازوليل بلوري |
| JP7285786B2 (ja) | 2017-05-03 | 2023-06-02 | フィルメニッヒ インコーポレイテッド | 高強度の甘味料の製造方法 |
| CN108794556B (zh) * | 2017-05-05 | 2021-01-29 | 清华大学 | 化合物及其在治疗白内障中的应用 |
| MY205909A (en) * | 2017-06-08 | 2024-11-20 | Eye Therapies Llc | Low-dose brimonidine combinations and uses thereof |
| WO2019097434A1 (en) * | 2017-11-17 | 2019-05-23 | Mahmood Piraee | Combinations of lanosterol or 25-hydroxycholesterol including derivatives thereof useful in the treatment of lens disorders |
| AU2018372826B2 (en) * | 2017-11-22 | 2023-12-07 | Bausch & Lomb Incorporated | Ophthalmic viscoelastic compositions |
| US20200276211A1 (en) * | 2017-11-28 | 2020-09-03 | Viewpoint Therapeutics, Inc. | Compounds for treating near vision disorders |
| WO2019191200A1 (en) | 2018-03-27 | 2019-10-03 | American Genomics, Llc | Method and formulation for producing anesthesia of internal aspect of eye wall by topical application |
| SG11202012473UA (en) * | 2018-06-27 | 2021-01-28 | Cellix Bio Private Ltd | Ophthalmic compositions and methods for the treatment of eye disorders |
| US12286661B2 (en) | 2018-11-07 | 2025-04-29 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| JP2022512931A (ja) | 2018-11-07 | 2022-02-07 | フィルメニッヒ インコーポレイテッド | 高甘味度甘味料の製造方法 |
| AU2020245203A1 (en) * | 2019-03-26 | 2021-11-11 | Martin Uram | Anesthetic composition and method of anesthetizing the eye |
| AR119047A1 (es) | 2019-05-31 | 2021-11-17 | Sage Therapeutics Inc | Esteroides neuroactivos como moduladores de gabaa y su uso en el tratamiento de trastornos del snc |
| WO2021113411A1 (en) * | 2019-12-02 | 2021-06-10 | Ampersand Biopharmaceuticals, Inc. | Transdermal penetrant formulations for vitamins, minerals and supplements |
| WO2021113410A1 (en) * | 2019-12-02 | 2021-06-10 | Ampersand Biopharmaceuticals, Inc. | Transdermal penetrant formulations for vitamins, minerals and supplements |
| WO2022023822A1 (en) * | 2020-07-30 | 2022-02-03 | Indoco Remedies Limited | A stable ophthalmic composition of posaconazole |
| US20230302032A1 (en) * | 2020-08-04 | 2023-09-28 | Harrow Ip Llc | Antibacterial compositions and methods for fabricating thereof |
| US20220112208A1 (en) * | 2020-10-08 | 2022-04-14 | King Abdullah University Of Science And Technology | Compounds with antiinflammatory activity and methods of use thereof |
| CN113583950A (zh) * | 2021-08-06 | 2021-11-02 | 合肥滴碧云生物科技有限公司 | 一种制备干细胞活性因子的方法及其应用 |
| CN115737654B (zh) * | 2021-09-03 | 2025-11-21 | 成都瑞沐生物医药科技有限公司 | 一种滴眼给药预防和/或治疗白内障的眼用制剂 |
| CN119136683A (zh) * | 2022-05-02 | 2024-12-13 | 祖姆森斯有限公司 | 耐降解含醛组合物 |
Family Cites Families (11)
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| US4743597A (en) * | 1986-01-27 | 1988-05-10 | Javitt Norman B | Composition comprising an oxygenated cholesterol and use thereof for topical treatment of diseases |
| FR2663850B1 (fr) * | 1990-07-02 | 1994-01-14 | Gird Galderma | Composition pharmaceutique ou cosmetique contenant en association un retinouide et un sterol. |
| US6821774B1 (en) * | 1999-06-18 | 2004-11-23 | Cv Therapeutics, Inc. | Compositions and methods for increasing cholesterol efflux and raising HDL using ATP binding cassette transporter ABC1 |
| US6281774B1 (en) * | 1999-09-10 | 2001-08-28 | Sumitomo Special Metals Co., Ltd. | Corrosion-resistant permanent magnet and method for producing the same |
| US20030162758A1 (en) * | 2001-12-07 | 2003-08-28 | Schwartz Daniel M. | Treatment for age-related macular degeneration (AMD) |
| US7906147B2 (en) * | 2006-10-12 | 2011-03-15 | Nanoprobes, Inc. | Functional associative coatings for nanoparticles |
| US8758802B2 (en) * | 2009-12-14 | 2014-06-24 | University Of Massachusetts | Methods of inhibiting cataracts and presbyopia |
| SG11201500288QA (en) * | 2012-07-17 | 2015-02-27 | Univ Michigan | Inhibitors of alpha-crystallin aggregation for the treatment for cataract |
| EP2968239B1 (en) * | 2013-03-14 | 2019-04-24 | The University of Massachusetts | Methods of inhibiting cataracts and presbyopia |
| US10314917B2 (en) * | 2013-03-15 | 2019-06-11 | The Brigham And Women's Hospital, Inc. | Targeted polymeric inflammation-resolving nanoparticles |
| EP3328389A1 (en) * | 2015-07-27 | 2018-06-06 | Catacore, Inc. | Compositions for the treatment of cataracts |
-
2016
- 2016-09-08 WO PCT/US2016/050823 patent/WO2017044659A1/en not_active Ceased
- 2016-09-08 EP EP16845069.0A patent/EP3347368A4/en not_active Withdrawn
- 2016-09-08 AU AU2016321254A patent/AU2016321254A1/en not_active Abandoned
- 2016-09-08 US US15/758,705 patent/US20180250313A1/en not_active Abandoned
- 2016-09-08 JP JP2018513359A patent/JP2018526423A/ja active Pending
- 2016-09-08 CA CA2998134A patent/CA2998134A1/en not_active Abandoned
- 2016-09-08 CN CN201680065262.3A patent/CN108350021A/zh active Pending
- 2016-09-08 HK HK19100945.5A patent/HK1258588A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016321254A1 (en) | 2018-04-05 |
| WO2017044659A1 (en) | 2017-03-16 |
| JP2018526423A (ja) | 2018-09-13 |
| CN108350021A (zh) | 2018-07-31 |
| US20180250313A1 (en) | 2018-09-06 |
| EP3347368A1 (en) | 2018-07-18 |
| EP3347368A4 (en) | 2019-01-23 |
| HK1258588A1 (zh) | 2019-11-15 |
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