CN108324822A - A kind of flavorants and preparation method thereof for canker sore - Google Patents
A kind of flavorants and preparation method thereof for canker sore Download PDFInfo
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- CN108324822A CN108324822A CN201810357492.8A CN201810357492A CN108324822A CN 108324822 A CN108324822 A CN 108324822A CN 201810357492 A CN201810357492 A CN 201810357492A CN 108324822 A CN108324822 A CN 108324822A
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K47/02—Inorganic compounds
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
Abstract
The flavorants and preparation method thereof that the invention discloses a kind of for canker sore, the flavorants for canker sore include Chinese medicine extract and physiological saline, and Chinese medicine extract is 2 in the volume proportion of physiological saline：10~20；Chinese medicine extract is made of the bulk pharmaceutical chemicals of following parts by weight：3~5 parts of 15~25 parts of the fruit of glossy privet, 5~12 parts of eclipta, 5~12 parts of mulberry fruit, 4~6 parts of the membrane of a chicken's gizzard, 4~6 parts of dried persimmon, 3~7 parts of Chinese yam, 4~6 parts of matrimony vine, 5~9 parts of Radix Angelicae Sinensis, 5~9 parts of Radix Codonopsis, 3~5 parts of cicada slough, 8~12 parts of honeysuckle, 6~10 parts of Fructus Forsythiae, 3~5 parts of aloe, 2~3 parts of peppermint and Radix Glycyrrhizae.Compared with prior art, the therapeutic effect of the flavorants for canker sore of the invention is notable and uneasy to recur, and preparation method is simple, easy to operate.
Description
Technical field
The invention belongs to oral health technical field, more particularly to a kind of flavorants and its system for canker sore
Preparation Method.
Background technology
After the thing that usually we eat, especially ate after the larger food of the smells such as green onion, garlic or there is peculiar smell in oral cavity
When, it usually needs oral cavity smell is improved by chew gum or mouth sprays, but chewing gum is easy that oral bacteria is made to grow
It gives birth to and enlivens, cause the mouth diseases such as decayed tooth, long-term chewing will cause oral peculiar smell to aggravate, and the jelly of chewing gum is spat
On the ground, environmental sanitation is influenced.Existing mouth sprays only have the function of improving oral cavity smell, without preventing or treating
The effect of canker sore.
Canker sore is a kind of common chronic oral membrane disease, to there is cyclical recurrent on oral mucosa,
Have compared with the characteristics of severe pain and self limiting ulcer.It is apt to occur in lip, tongue, gum and side mucous membrane, recurrent exerbation.Chinese medicine thinks oral cavity
The main cause of curing the disease of ulcer is interior viscerotrauma excess heat, and leads simultaneously dirty and be the heart, spleen and stomach.
The drug for the treatment of canker sore is roughly divided into three categories currently on the market：I.e. medicine for oral administration, containing medication and externally applied drug.Its
Middle medicine for oral administration commonly anti-inflammatory agent, antiviral and Chinese patent drug class.This drug can actually play therapeutic effect in early stage,
But the phase but without effect, or has little effect after the treatment.Containing medication only cool taste when buccal, but its treatment effect
Fruit is bad.
Invention content
It is an object of the present invention to which the above problem existing in terms of for existing flavorants and canker sore, carries
For a kind of flavorants and preparation method thereof for canker sore.
To achieve the goals above, the technical solution that the application uses for：A kind of flavorants for canker sore,
Including Chinese medicine extract and physiological saline, the volume ratio of the Chinese medicine extract and physiological saline is 2：10~20；
The Chinese medicine extract is made of the bulk pharmaceutical chemicals of following parts by weight：15 parts~25 parts of the fruit of glossy privet, 5 parts of eclipta~
12 parts, 5 parts~12 parts of mulberry fruit, 4 parts~6 parts of the membrane of a chicken's gizzard, 4 parts~6 parts of dried persimmon, 3 parts~7 parts of Chinese yam, 4 parts~6 parts of matrimony vine, Radix Angelicae Sinensis
5 parts~9 parts, 5 parts~9 parts of Radix Codonopsis, 3 parts~5 parts of cicada slough, 8 parts~12 parts of honeysuckle, 6 parts~10 parts of Fructus Forsythiae, aloe 3 parts~5
3 parts~5 parts of part, 2 parts~3 parts of peppermint and Radix Glycyrrhizae.
Further, including Chinese medicine extract and physiological saline, the Chinese medicine extract is in the volume proportion of physiological saline
It is 2：15；
The Chinese medicine extract is made of the bulk pharmaceutical chemicals of following parts by weight：18 parts~22 parts of the fruit of glossy privet, 8 parts of eclipta~
10 parts, 8 parts~10 parts of mulberry fruit, 4 parts~6 parts of the membrane of a chicken's gizzard, 4 parts~6 parts of dried persimmon, 4 parts~6 parts of Chinese yam, 4 parts~6 parts of matrimony vine, Radix Angelicae Sinensis
6 parts~8 parts, 6 parts~8 parts of Radix Codonopsis, 3 parts~5 parts of cicada slough, 9 parts~11 parts of honeysuckle, 7 parts~9 parts of Fructus Forsythiae, 3 parts~5 parts of aloe,
3 parts~5 parts of 2 parts~3 parts of peppermint and Radix Glycyrrhizae.
Further, including Chinese medicine extract and physiological saline, the Chinese medicine extract is in the volume proportion of physiological saline
It is 2：15；
The Chinese medicine extract is made of the bulk pharmaceutical chemicals of following parts by weight：20 parts of the fruit of glossy privet, 9 parts of eclipta, mulberry fruit 9
Part, 5 parts of the membrane of a chicken's gizzard, 5 parts of dried persimmon, 5 parts of Chinese yam, 5 parts of matrimony vine, 7 parts of Radix Angelicae Sinensis, 7 parts of Radix Codonopsis, 4 parts of cicada slough, 10 parts of honeysuckle, Fructus Forsythiae 8
4 parts of part, 4 parts of aloe, 3 parts of peppermint and Radix Glycyrrhizae.
A kind of preparation method of flavorants for canker sore, preparation process are as follows：
S1, medicine is taken first, in accordance with proportioning, cleaned, 1000mL~2000mL clear water is used in combination to impregnate 1h~2h；Then it directly decocts
It boils, after boiling, continues small fire and boil 30min~40min；Chinese medicine extract is finally obtained by filtration；
S2, by the Chinese medicine extract obtained in S1 and physiological saline according to volume ratio it is 2：10~20 be uniformly mixed to get
To a kind of flavorants conducive to canker sore.
Compared with prior art, the beneficial effects of the invention are as follows：
(1) fruit of glossy privet has the effect of anti-inflammation detumescence, eliminating stasis and resolving masses, myogenic pain relieving, convergence anti-corrosion, is easy to oral ulcer surface
Adhesion and absorption.The surface of a wound can be protected, relieve the pain anti-inflammatory, promotes ulcer healing.It is used cooperatively with eclipta and mulberry fruit, there is treatment
The function of fever due to yin deficiency, and the deficiency of Yin is a reason of canker sore morbidity.
(2) the membrane of a chicken's gizzard removes food retention, strengthening the spleen and stomach；And Chinese yam and the fleece-flower root have the function of kidney tonifying, are fundamentally counterparts
Chamber ulcer has the function for the treatment of.
(3) dried persimmon also has a large amount of trace element and vitamin, has the effect of curing to canker sore.
(4) cicada slough can alleviate the canker sore caused by being attacked in wind-heat fiery poison with honeysuckle, Fructus Forsythiae adapted.
(5) aloe：There are stronger antibacterial antitoxic action, Aloetin contained therein and A Lao miaows piperazine that can prevent from repeating to feel
Dye, contained another ingredient Ah Laue crow Rosin can promote the formation of fresh granulation tissue, accelerate the ulcer surface healing of defect,
Therefore Aloe recurrent oral ulceration is quick, curative effect is high, has no toxic side effect.
(6) peppermint：Pungent in flavor and cool in property, oral cavity use has the effect of refrigerant, antipruritic, anti-inflammatory, analgesic, and cutaneous nerve can be stimulated last
The tip, first generates cool feeling, then there is slight burning heat sensation, slowly penetrate it is intradermal, have the function that control oral cavity ulcer symptoms；
It also has cough-relieving of refreshing oneself, and has certain mitigation to sore throat sound dumb, alleviates throat's comfort level, removes removing abnormal flavor in oral cavity, eliminates
Halitosis keeps implication more pure and fresh.
Specific implementation mode
In order to make the present invention technological means, creation characteristic, achieving the goal is easy to understand with effect, below in conjunction with
Technical solution is clearly and completely described in specific embodiments of the present invention.
Embodiment 1
A kind of flavorants for canker sore, including Chinese medicine extract and physiological saline, the Chinese medicine extract
In physiological saline volume proportion be 2：10；
Chinese medicine extract is made of the bulk pharmaceutical chemicals of following parts by weight：15 parts of the fruit of glossy privet, 5 parts of eclipta, 5 parts of mulberry fruit, chicken
Interior golden 4 parts, 4 parts of dried persimmon, 3 parts of Chinese yam, 4 parts of matrimony vine, 5 parts of Radix Angelicae Sinensis, 5 parts of Radix Codonopsis, 3 parts of cicada slough, 8 parts of honeysuckle, 6 parts of Fructus Forsythiae, reed
3 parts of 3 parts of luxuriant growth, 2 parts of peppermint and Radix Glycyrrhizae.
The preparation process of the above-mentioned flavorants for canker sore is specific as follows：
S1, medicine is taken first, in accordance with proportioning, cleaned, 1000mL~2000mL clear water is used in combination to impregnate 1h~2h；Then it directly decocts
It boils, after boiling, continues small fire and boil 30min~40min；Chinese medicine extract is finally obtained by filtration；
S2, the Chinese medicine extract obtained in S1 is uniformly mixed with physiological saline to get to a kind of conducive to canker sore
Flavorants.
Embodiment 2
A kind of flavorants for canker sore, including Chinese medicine extract and physiological saline, Chinese medicine extract is in life
The volume proportion for managing brine is 2：20；
Chinese medicine extract is made of the bulk pharmaceutical chemicals of following parts by weight：25 parts of the fruit of glossy privet, 12 parts of eclipta, 12 parts of mulberry fruit,
6 parts of the membrane of a chicken's gizzard, 6 parts of dried persimmon, 7 parts of Chinese yam, 6 parts of matrimony vine, 9 parts of Radix Angelicae Sinensis, 9 parts of Radix Codonopsis, 5 parts of cicada slough, 12 parts of honeysuckle, Fructus Forsythiae 10
5 parts of part, 5 parts of aloe, 3 parts of peppermint and Radix Glycyrrhizae.
The preparation process and embodiment 1 of the above-mentioned flavorants for canker sore are identical.
Embodiment 3
A kind of flavorants for canker sore, including Chinese medicine extract and physiological saline, Chinese medicine extract is in life
The volume proportion for managing brine is 2:15；
Chinese medicine extract is made of the bulk pharmaceutical chemicals of following parts by weight：18 parts of the fruit of glossy privet, 8 parts of eclipta, 8 parts of mulberry fruit, chicken
Interior golden 4 parts, 4 parts of dried persimmon, 4 parts of Chinese yam, 4 parts of matrimony vine, 6 parts of Radix Angelicae Sinensis, 6 parts of Radix Codonopsis, 3 parts of cicada slough, 9 parts of honeysuckle, 7 parts of Fructus Forsythiae, reed
3 parts of 3 parts of luxuriant growth, 2 parts of peppermint and Radix Glycyrrhizae.
The preparation process and embodiment 1 of the above-mentioned flavorants for canker sore are identical.
Embodiment 4
A kind of flavorants for canker sore, including Chinese medicine extract and physiological saline, Chinese medicine extract is in life
The volume proportion for managing brine is 2:15；
Chinese medicine extract is made of the bulk pharmaceutical chemicals of following parts by weight：22 parts of the fruit of glossy privet, 10 parts of eclipta, 10 parts of mulberry fruit,
6 parts of the membrane of a chicken's gizzard, 6 parts of dried persimmon, 6 parts of Chinese yam, 6 parts of matrimony vine, 8 parts of Radix Angelicae Sinensis, 8 parts of Radix Codonopsis, 5 parts of cicada slough, 11 parts of honeysuckle, 9 parts of Fructus Forsythiae,
5 parts of 5 parts of aloe, 3 parts of peppermint and Radix Glycyrrhizae.
The preparation process and embodiment 1 of the above-mentioned flavorants for canker sore are identical.
Embodiment 5
A kind of flavorants for canker sore, including Chinese medicine extract and physiological saline, Chinese medicine extract is in life
The volume proportion for managing brine is 2：15；
Chinese medicine extract is made of the bulk pharmaceutical chemicals of following parts by weight：20 parts of the fruit of glossy privet, 9 parts of eclipta, 9 parts of mulberry fruit, chicken
Interior golden 5 parts, 5 parts of dried persimmon, 5 parts of Chinese yam, 5 parts of matrimony vine, 7 parts of Radix Angelicae Sinensis, 7 parts of Radix Codonopsis, 4 parts of cicada slough, 10 parts of honeysuckle, 8 parts of Fructus Forsythiae, reed
4 parts of 4 parts of luxuriant growth, 3 parts of peppermint and Radix Glycyrrhizae.
The preparation process and embodiment 1 of the above-mentioned flavorants for canker sore are identical.
The treatment for the flavorants for canker sore that the embodiment of the present invention 1~5 provides：
100 patients for suffering from different degrees of canker sore are chosen, are divided into two groups, one group is treatment group, another
It is control group to organize, and there was no significant difference between every group 50, two groups.
Treatment group：By taking the flavorants for canker sore of the embodiment of the present invention 5 as an example, each spray in the morning, afternoon and evening daily
Once, 3 days as a treatment course.
Control group：Oral vitamin B2 pieces, a two panels, three times per day；And buccal Dobell, 2 tablets once, one day three
It is secondary, 3 days as a treatment course.
Diagnostic criteria：1, light-duty canker sore：It is most common, account for about 80%, general diameter 2-4mm, circle or ellipse, surrounding
Clearly, it isolates and is dispersed in, number is few, and 1~5 is differed every time, is apt to occur in the poor region of angling degree, such as lip cheek mucous membrane, angle
The high gum palatine of change degree is less, and ulcer has " recessed, red, yellow, pain " feature, i.e. ulcer concavity when breaking-out, and substrate is not hard, week
Skirt has the congested blush band of about 1mm, surface to be covered with light yellow pseudomembrane, and cusalgia sense is apparent, with submandibular lymph nodes when infecting serious
Swelling and pain, fever, general to continue 1-2 weeks, the intermittent phase is different in size, language, feed, mood is influenced because stimulating pain, to life
Bioplasm amount has an adverse effect；2, heavy canker sore：Ulcer is big and deep when breaking-out, and " like crater " diameter 10-30mm is deep and viscous
Film lower layer is until muscle layer, and periphery redness protuberance, the substrate laid one's hand on is harder, but neat in edge is clear, and often single to occur, stage of attack is reachable
Month remaining even several months, pain is heavier, more after can stay scar, it is rare；3, bleb sample canker sore：Ulcer is small and more, diameter 2mm,
As many as up to dozens of, can the symptoms such as companioned with headache, low-heat, general malaise, regional nodes' enlargement, it is rare.
Criterion of therapeutical effect：Pain disappears, oral ulcer surface healing.Wherein pain disappears, and oral ulcer surface healing completely is to fully recover from an illness
More；Pain disappears, and the healing of oral ulcer surface part has remarkable result for treatment；Pain disappears has effect for treatment, that is, has
Effect；Pain did not both disappear, and oral ulcer surface is also without healing to treat no effect, i.e., in vain.
After the patient for the treatment of group and control group receives treatment simultaneously, the comparison such as table 1 of clinical total treatment.
1 treatment group of table is compared with the clinical total treatment of control group
Two groups of patients, the oral cavity of patient are paid a return visit in order to compare the recurrence for the treatment of group and control group patient, after half a year
The time interval of ulcer recurrence such as table 2 and recurrence number comparison such as table 3.
2 treatment group of table and control group recurrence time interval
3 treatment group of table and control group recur number
In conclusion the therapeutic effect of the flavorants for canker sore of the present invention is notable and uneasy to recur.
Disclosed above is only presently preferred embodiments of the present invention, and still, the embodiment of the present invention is not limited to this, Ren Heben
What the technical staff in field can think variation should all fall into protection scope of the present invention.
Claims (4)
1. a kind of flavorants for canker sore, which is characterized in that including Chinese medicine extract and physiological saline, in described
The volume ratio of medicament extracting solution and physiological saline is 2：10~20；
The Chinese medicine extract is made of the bulk pharmaceutical chemicals of following parts by weight：15 parts~25 parts of the fruit of glossy privet, eclipta 5 parts~12
Part, 5 parts~12 parts of mulberry fruit, 4 parts~6 parts of the membrane of a chicken's gizzard, 4 parts~6 parts of dried persimmon, 3 parts~7 parts of Chinese yam, 4 parts~6 parts of matrimony vine, Radix Angelicae Sinensis 5
Part~9 parts, 5 parts~9 parts of Radix Codonopsis, 3 parts~5 parts of cicada slough, 8 parts~12 parts of honeysuckle, 6 parts~10 parts of Fructus Forsythiae, 3 parts~5 parts of aloe,
3 parts~5 parts of 2 parts~3 parts of peppermint and Radix Glycyrrhizae.
2. a kind of flavorants for canker sore as described in claim 1, which is characterized in that including Chinese medicine extract
And physiological saline, the Chinese medicine extract are 2 in the volume proportion of physiological saline：15；
The Chinese medicine extract is made of the bulk pharmaceutical chemicals of following parts by weight：18 parts~22 parts of the fruit of glossy privet, eclipta 8 parts~10
Part, 8 parts~10 parts of mulberry fruit, 4 parts~6 parts of the membrane of a chicken's gizzard, 4 parts~6 parts of dried persimmon, 4 parts~6 parts of Chinese yam, 4 parts~6 parts of matrimony vine, Radix Angelicae Sinensis 6
Part~8 parts, 6 parts~8 parts of Radix Codonopsis, 3 parts~5 parts of cicada slough, 9 parts~11 parts of honeysuckle, 7 parts~9 parts of Fructus Forsythiae, 3 parts~5 parts of aloe,
3 parts~5 parts of 2 parts~3 parts of peppermint and Radix Glycyrrhizae.
3. a kind of flavorants for canker sore as claimed in claim 2, which is characterized in that including Chinese medicine extract
And physiological saline, the Chinese medicine extract are 2 in the volume proportion of physiological saline：15；
The Chinese medicine extract is made of the bulk pharmaceutical chemicals of following parts by weight：20 parts of the fruit of glossy privet, 9 parts of eclipta, 9 parts of mulberry fruit, chicken
Interior golden 5 parts, 5 parts of dried persimmon, 5 parts of Chinese yam, 5 parts of matrimony vine, 7 parts of Radix Angelicae Sinensis, 7 parts of Radix Codonopsis, 4 parts of cicada slough, 10 parts of honeysuckle, 8 parts of Fructus Forsythiae, reed
4 parts of 4 parts of luxuriant growth, 3 parts of peppermint and Radix Glycyrrhizae.
4. a kind of preparation method of flavorants for canker sore as described in any one of claim 1-3,
It is characterized in that, preparation process is as follows：
S1, medicine is taken first, in accordance with proportioning, cleaned, 1000mL~2000mL clear water is used in combination to impregnate 1h~2h；Then it directly decocts, waits for
After boiling, continues small fire and boil 30min~40min；Chinese medicine extract is finally obtained by filtration；
S2, the Chinese medicine extract obtained in S1 is uniformly mixed with physiological saline to get to a kind of implication conducive to canker sore
Freshener.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814208A (en) * | 2005-12-02 | 2006-08-09 | 钟祖光 | Oral Chinese medicine for treating and preventing recurrence of uecerative stomatitis |
| CN104352387A (en) * | 2014-10-18 | 2015-02-18 | 安徽翔远安防科技有限公司 | Breath spray favorable for oral ulcer |
-
2018
- 2018-04-20 CN CN201810357492.8A patent/CN108324822A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814208A (en) * | 2005-12-02 | 2006-08-09 | 钟祖光 | Oral Chinese medicine for treating and preventing recurrence of uecerative stomatitis |
| CN104352387A (en) * | 2014-10-18 | 2015-02-18 | 安徽翔远安防科技有限公司 | Breath spray favorable for oral ulcer |
Non-Patent Citations (1)
| Title |
|---|
| 萧毅: "《吃对食物健康来》", 31 January 2007, 航空工业出版社 * |
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Application publication date: 20180727 |