CN108310199A - 一种治疗冠心病心绞痛的中药组合物及其制剂 - Google Patents
一种治疗冠心病心绞痛的中药组合物及其制剂 Download PDFInfo
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Abstract
本发明公开一种治疗冠心病心绞痛的中药组合物,由扶芳藤、夜交藤、鸡血藤、党参、黄芪、麦冬、五味子、白芍、丹参、檀香、木香、桂枝、炙甘草制备而成;本发明的中药组合物由多种中药材制备而成,安全温和,对人体副作用极小,具有补血养心、益气活血、补脾和胃,益气复脉、通络止痛、补气固表等作用,有效治疗冠心病心绞痛;本发明的中药组合物还可制成胶囊剂、颗粒剂、口服液等多种制剂,服用、携带方便,满足不同病况的病患服用和携带,适用人群广;此外,本发明的中药组合物配方科学合理,副作用小,制备方法简单,制备成本低,可大大减轻患者的身体和经济负担,具有很大的推广价值。
Description
技术领域
本发明涉及医药领域,具体涉及一种治疗冠心病心绞痛的中药组合物及其制剂。
背景技术
冠心病是一种最常见的心脏病,是指因冠状动脉狭窄、供血不足而引起的心肌机能障碍和/或器质性病变,故又称缺血性心肌病。世界卫生组织对冠心病分类如下:(1)原发性心脏骤停;(2)心绞痛;(3)心肌梗塞;(4)缺血性心脏病中的心力衰竭;(5)心律失常。冠心病是一个危害人类健康的主要的、非传感性疾病。根据WHO的统计,冠心病是世界上最常见的死亡原因,被称为“第一杀手”,2014年全世界死于心血管病约为2500万人,占总死亡人数的1/4,其中冠心病死亡占1/2以上。我区也是胸痹心痛(冠心病心绞痛)高发区域,由于广西人民钟爱食用内脏下水等高脂食材,导致近年来我区的冠心病发病率呈不断上升趋势,严重地危害人民的身体健康。
冠心病心绞痛属于祖国医学"胸痹心痛"范畴,是心血管疾病中的常见病,也是心内科的疑难病症。胸痹心痛以膻中或左胸部发作性憋闷、疼痛为主证,轻者偶发短暂轻微的胸部沉闷或隐痛,或为发作性膻中或左胸含糊不清的不适感;重者疼痛剧烈,或呈压榨样绞痛。常伴有心悸,气短,呼吸不畅,甚至喘促,惊恐不安,面色苍白,冷汗自出等。
目前,中医认为胸痹心痛的发病病因多由正气亏虚、饮食、情志、寒邪等引起的痰浊、瘀血、气滞、寒凝痹阻心脉,因劳累、饱餐、寒冷及情绪激动而诱发,亦可无明显诱因或安静时发病。而壮医理论认为,冠心病心绞痛是因为气虚血弱,导致龙路不畅,三气不同步,瘀血阻滞而发病。治疗原则是“益气养心、疏通龙路、通调三气”。
西医治疗冠心病心绞痛的有效药物如硝酸酯类、他汀类降血脂药、抗血小板制剂等,但这些药物多以速效救急为主,而中草药及其制剂无论在病因病机、辩证论治及预防保健方面均有独到之处。中医疗效确切,副作用小,有利于长期服用,因而中草药防治胸痹心痛具有一定的优势。中草药作为一种有效的治疗胸痹心痛的方法,逐渐成为医药工作者研究的热点。因此寻求有效的、实用的中医中药治疗胸痹心痛的方法和药物,已成为一项重要的任务和课题。申请人在全国名老中医李锡光教授治疗冠心病心绞痛的经验方“养心通脉方”的基础上加入壮族民间治疗冠心病心绞痛有很好疗效的扶芳藤、夜交藤、鸡血藤,使原方更适合广西冠心病心绞痛的特点,疗效更显著,目前在国内同类报道中,无与本方组方相同的报道。
发明内容
本发明的目的在于克服现有技术存在的缺陷,提供一种治疗冠心病心绞痛的中药组合物及其制剂。
为了实现上述目的,本发明采用的技术方案如下:
本发明的治疗冠心病心绞痛的中药组合物,由如下重量份的原料制备而成的:扶芳藤50-150份、夜交藤50-150份、鸡血藤50-150份、党参150-280份、黄芪150-250份、麦冬50-120份、五味子60-125份、白芍60-120份、丹参70-140份、檀香40-90份、木香50-90份、桂枝75-135份、炙甘草45-90份。
优选地,是由如下重量份的原料制备而成的:扶芳藤80-120份、夜交藤80-120份、鸡血藤80-120份、党参190-230份、黄芪180-220份、麦冬70-100份、五味子80-100份、白芍80-100份、丹参95-115份、檀香60-75份、木香65-75份、桂枝100-115份、炙甘草60-80份。
以下是本发明中药组合物的药材来源:
扶芳藤,为卫矛科卫矛属植物扶芳藤Euonymus fortunei(Turcz.)Hand.-Mazz.,以茎、叶入药。苦、甘,温。可散瘀止血,舒筋活络。用于咯血,月经不调,功能性子宫出血,风湿性关节痛;外用治跌打损伤,骨折,创伤出血。
夜交藤,为蓼科植物何首乌的藤茎或带叶藤茎。甘微苦,平。可养心,安神,通络,祛风。治失眠,劳伤,多汗,血虚身痛,痈疽,瘰疬,风疮疥癣。
鸡血藤,为豆科植物密花豆的干燥藤茎。味苦,微甘;性温。归心经、脾经。具有活血舒筋,养血调经的功效。主治手足麻木,肢体瘫痪,风湿痹痛,妇女月经不调,痛经,闭经。
党参,为桔梗科植物党参Codonopsis pilosula(Franch.)Nannf.、素花党参(西党参)Codonopsis pilosulaNannf.var.modesta(Nannf.)L.T.Shen或川党参Codonopsistangshen Oliv.的干燥根。甘,平。可补中益气,健脾益肺。用于脾肺虚弱,气短心悸,食少便溏,虚喘咳嗽,内热消渴。
黄芪,拉丁名为Leguminosae,别名北芪、北蓍,黄芪属,为豆科草本植物蒙古黄芪、膜荚黄芪的干燥根。性温、味甘、微甜。具有具有补气固表,利尿托毒,排脓,敛疮生肌的作用。
麦冬,为百合科植物麦冬(沿阶草)Ophiopogonjaponicus(Thunb.)Ker-Gawl.的干燥块根。甘,微苦,微寒。可养阴生津,润肺清心。用于肺燥干咳。虚痨咳嗽,津伤口渴,心烦失眠,内热消渴,肠燥便秘,咽白喉。
五味子,为木兰科植物五味子Schisandra chinensis(Turcz.)Baill.或华中五味子Schisandra sphenanthera Rehd.etWils.的干燥成熟果实。酸、甘,温。可收敛固涩,益气生津,补肾宁心。用于久嗽虚喘,梦遗滑精,遗尿尿频,久泻不止,自汗,盗汗,津伤口渴,短气脉虚,内热消渴,心悸失眠。
白芍,为毛茛科芍药属Paeonia sternianaFletcherin Journ.草本植物,以根茎入药。苦、酸,微寒。归肝、脾经。具有补血柔肝、平肝止痛,敛阴收汗等功效,用于阴虚发热、月经不调、胸腹胁肋疼痛、四肢挛急,泻痢腹痛、自汗盗汗、崩漏。
丹参,为唇形科植物丹参SalviamiltiorrhizaBge.的干燥根和根茎。苦,微寒。归心、肝经。具有活血祛瘀,通经止痛,清心除烦,凉血消痈的作用。用于胸痹心痛,脘腹胁痛,瘕瘕积聚,热痹疼痛,心烦不眠,月经不调,痛经经闭,疮疡肿痛。
檀香,为檀香科檀香属植物檀香Santalum album L.树干的心材。辛,温。可行气温中,开胃止痛。用于寒凝气滞,胸痛,腹痛,胃痛食少,冠心病,心绞痛。
木香,为菊科植物木香AucklandialappaDecne.的干燥根。辛、苦,温。可行气止痛,健脾消食。用于胸脘胀痛,泻痢后重,食积不消,不思饮食。煨木香实肠止泻。用于泄泻腹痛。
桂枝,为樟科植物肉桂Cinnamomum cassiaPresl的干燥嫩枝。辛、甘,温。发汗解肌,温通经脉,助阳化气,平冲降气。用于风寒感冒,脘腹冷痛,血寒经闭,关节痹痛,痰饮,水肿,心悸,奔豚。
炙甘草,为甘草的炮制加工品。甘,平。可补脾和胃,益气复脉。用于脾胃虚弱,倦怠乏力,心动悸,脉结代。
本发明的另一目的是提供本发明中药组合物的活性成分的制备方法,该方法是采用水提或40-70%体积百分浓度的乙醇提取制备而成。具体制备方法如下:
方案一:取全部药材,混合后加水提取2-3次,每次加水量相当于药材总重量的6-12倍,每次提取时间为1-3小时,合并提取液,过滤,滤液浓缩70-80℃时相对密度为1.10-1.20的清膏,即得活性成分。
方案二:取全部药材,混合后用40-70%乙醇回流提取2-3次,每次乙醇用量为药材总量的4-10倍,提取时间为1-4小时,合并提取液,过滤,滤液浓缩至70-80℃时相对密度为1.05-1.20的清膏,即得活性成分。
方案三:取全部药材,混合后加水提取2-3次,每次加水量相当于药材总重量的6-12倍,每次提取时间为1-3小时,合并提取液,过滤,滤液浓缩至70-80℃时相对密度为1.10-1.20的清膏,加入乙醇,使含醇量为40-70%,静置12-24小时,过滤,滤液浓缩至70-80℃时相对密度为1.05-1.20的浸膏,即得活性成分。
本发明所述的治疗冠心病心绞痛的中药组合物,还可以与医药学上可接受的载体配合,制成各种制剂,如片剂、胶囊剂、口服液、糖浆剂、合剂、颗粒剂等。
本发明的药学上可接受的载体包括但不限于以下:
稀释剂:淀粉、糖粉、乳糖、糊精、微晶纤维素、无机盐、糖醇类等。
润湿剂与粘合剂:纯化水、乙醇、明胶、聚乙二醇、纤维素衍生物等。
崩解剂:淀粉、羧甲基淀粉钠、纤维素衍生物、交联聚维酮等。
润滑剂:硬脂酸镁、微粉硅胶、滑石粉、聚乙二醇等。
助溶剂:水、乙醇、甘油、丙二醇、液状石蜡、植物油等。
矫味剂:蔗糖、单糖、芳香剂等。
防腐剂:苯甲酸、山梨酸、甲酯、乙酯、丙酯等。
方法1:片剂
取方案一至方案三所得活性成分之一,加入片剂常用辅料,按常规生产方法制备得本发明片剂。
上述片剂常用辅料包括稀释剂、润湿剂、粘合剂、崩解剂、润滑剂之一或全部。
方法2:胶囊剂
取方案一至方案三所得活性成分之一,加入胶囊剂常用辅料,按常规生产方法制备得本发明胶囊剂。
上述胶囊剂常用辅料包括稀释剂、润湿剂、粘合剂、崩解剂、润滑剂之一或全部。
方法3:糖浆剂
取方案一至方案三所得活性成分之一,加入糖浆剂常用辅料,按常规生产方法制备得本发明糖浆剂。
上述糖浆剂常用辅料包括矫味剂、防腐剂、助溶剂之一或全部。
方法4:合剂
取方案一至方案三所得活性成分之一,加入合剂常用辅料,按常规生产方法制备得本发明合剂。
上述合剂常用辅料包括矫味剂、防腐剂之一或全部。
方法5:口服液
取方案一至方案三所得活性成分之一,溶解后净化、浓缩,加入口服液常用辅料,按常规生产方法制备得本发明口服液。
上述口服液常用辅料包括矫味剂、防腐剂、助溶剂之一或全部。
方法6:颗粒剂
取方案一至方案三所得活性成分之一,加入颗粒剂常用辅料,按常规生产方法制备得本发明颗粒剂。
上述颗粒剂常用辅料包括稀释剂、润湿剂、粘合剂、崩解剂、润滑剂之一或全部。
本申请人结合传统中医辨证治疗和现代药理研究成果,经过多年研究试验,比较多种配方,得出具有补血养心、益气活血、补脾和胃,益气复脉、通络止痛、补气固表等作用的中药组合物。本发明的中药组合物以扶芳藤、夜交藤、鸡血藤、丹参和木香为君药,可活血、行气、止痛;以白芍、檀香为臣药,可散瘀定痛,以助君药活血止痛之功;以党参、黄芪、麦香、五味子、桂枝为佐药,可补中益气,健脾益肺,养阴生津,补肾宁心,温通经脉,助阳化气,佐药使气血推行有力,既能佐助君药和臣药活血散瘀行气,又能佐制其活血行气太过以损耗气血;炙甘草为使药,调和诸药,全方共奏活血养血、祛瘀通络、行气止痛之功,有效治疗冠心病心绞痛。壮医理论则从冠心病心绞痛的发病机理“气血亏虚,瘀血阻络”入手,认为扶芳藤、夜交藤、鸡血藤、白芍、麦冬、五味子可补血养心,是谓疏通“龙路”;党参、黄芪、炙甘草、檀香、木香、丹参益气活血,可通调“气道”、“谷道”;桂枝温经利水,通调“水道”。诸药合用,有“益气养心、疏通龙路、通调三气”之功。
本发明由于采用了上述技术方案,具有以下有益效果:
(1)本发明的中药组合物及其制剂由多种中药材制备而成,安全温和,对人体副作用极小,具有补血养心、益气活血、补脾和胃,益气复脉、通络止痛、补气固表等作用,夜交藤养心安神,通经活络,既活血又养血,祛瘀而不伤正;白芍中芍药甙显著对抗急性心肌缺血,扩张冠状动脉,增加冠脉流量;丹参能活血化瘀,通络止痛,养血宁心,可增加冠心病血流量,改善心肌收缩力,而不增加心肌缺氧量,促进侧支循环及血流再分配;黄芪能增强心肌收缩力,扩张冠脉,改善心肌血供和心肌代谢,五味子可扩张血管;全方共奏活血养血、祛瘀通络、行气止痛之功,且通过大量临床及药理研究已证明行气活血中药有抑制血小板聚集、降低血粘度、改善微循环作用,目前广泛应用于心脑血管疾病的治疗。
(2)本发明的中药组合物及其制剂经临床试验证明,对稳定型心绞痛的治愈率达30.56%,总有效率为93.89%;对不稳定型心绞痛的治愈率为27.83%,总有效率为94.78%,可见本发明中药组合物及其制剂可以有效治疗冠心病心绞痛,经临床观察表明,本发明中药组合物及其制剂对冠心病心绞痛有显著疗效,且疗效迅速,对心绞痛、胸闷、心悸、乏力等症状,患者普遍在服药一周后就可感到明显减轻或消失,其心电图、血压、血脂、血糖等也明显得到改善,对患者的肝、肾功能以及造血系统未见异常变化和不良反应,停药后病情不出现“反弹”,临床服用安全可靠。
(3)本发明的中药组合物制成多种制剂,服用、携带方便,满足不同病况的病患服用和携带,适用人群广。
(4)本发明的中药组合物及其制剂配方科学合理,副作用小,制备方法简单,制备成本低,可大大减轻患者的身体和经济负担,具有很大的推广价值。
具体实施方式
为使本发明的目的、技术方案及优点更加清楚明白,以下举出优选实施例,对本发明进一步详细说明。然而,需要说明的是,说明书中列出的许多细节仅仅是为了使读者对本发明的一个或多个方面有一个透彻的理解,即便没有这些特定的细节也可以实现本发明的这些方面。除非另有说明,本发明中的乙醇量的百分数是体积百分数,v/v表示溶液的体积比。
实施例1片剂
称取扶芳藤50kg、夜交藤50kg、鸡血藤50kg、党参150kg、黄芪150kg、麦冬50kg、五味子60kg、白芍60kg、丹参70kg、檀香40kg、木香50kg、桂枝75kg、炙甘草45kg;取全部药材,混合后加水提取2次,每次加水量相当于药材总重量的12倍、10倍,两次提取时间分别为3小时、2小时,合并提取液,过滤,滤液浓缩70℃时相对密度为1.10的清膏,加入片剂辅料糊精、滑石粉、羧甲基淀粉钠、纤维素衍生物,按常规方案制得片剂。
实施例2片剂
称取扶芳藤60kg、夜交藤60kg、鸡血藤60kg、党参160kg、黄芪160kg、麦冬57kg、五味子68kg、白芍65kg、丹参75kg、檀香46kg、木香55kg、桂枝82kg、炙甘草50kg;取全部药材,混合后用40%乙醇回流提取3次,每次乙醇用量为药材总量的10倍、8倍、6倍,三次提取时间分别为4小时、2小时、1小时,合并提取液,过滤,滤液浓缩至70℃时相对密度为1.05的清膏,加入片剂辅料糖粉、淀粉、聚乙二醇、滑石粉、纤维素衍生物,按常规方案制得片剂。
实施例3胶囊剂
称取扶芳藤70kg、夜交藤70kg、鸡血藤70kg、党参170kg、黄芪168kg、麦冬62kg、五味子72kg、白芍72kg、丹参83kg、檀香52kg、木香60kg、桂枝90kg、炙甘草55kg;取全部药材,混合后加水提取2次,每次加水量相当于药材总重量的12倍、8倍,每次提取时间分别为3小时、2小时,合并提取液,过滤,滤液浓缩至70℃时相对密度为1.10的清膏,加入乙醇,使含醇量为40%,静置12小时,过滤,滤液浓缩至70℃时相对密度为1.05的浸膏,加入胶囊剂辅料淀粉、乙醇、硬脂酸镁,按常规方案制得胶囊剂。
实施例4胶囊剂
称取扶芳藤100kg、夜交藤100kg、鸡血藤100kg、党参200kg、黄芪200kg、麦冬100kg、五味子100kg、白芍100kg、丹参100kg、檀香67kg、木香67kg、桂枝100kg、炙甘草67kg;取全部药材,混合后加水提取3次,每次加水量相当于药材总重量的10倍、8倍、6倍,每次提取时间分别为3小时、2小时、1小时,合并提取液,过滤,滤液浓缩74℃时相对密度为1.15的清膏,在清膏中加入胶囊剂辅料羧甲基淀粉钠、微晶纤维素、微粉硅胶、聚乙二醇,按常规方案制得胶囊剂。
实施例5糖浆剂
称取扶芳藤80kg、夜交藤80kg、鸡血藤80kg、党参190kg、黄芪180kg、麦冬70kg、五味子80kg、白芍80kg、丹参95kg、檀香60kg、木香65kg、桂枝100kg、炙甘草60kg;取全部药材,混合后用50%乙醇回流提取3次,每次乙醇用量为药材总量的8倍、6倍、4倍,每次提取时间分别为3小时、2小时、1小时,合并提取液,过滤,滤液浓缩至77℃时相对密度为1.10的清膏,在清膏中加入糖浆剂辅料单糖、山梨酸及水搅拌均匀,制得糖浆剂。
实施例6合剂
称取扶芳藤110kg、夜交藤108kg、鸡血藤112kg、党参215kg、黄芪211kg、麦冬86kg、五味子88kg、白芍93kg、丹参105kg、檀香70kg、木香72kg、桂枝107kg、炙甘草74kg;取全部药材,混合后加水提取3次,每次加水量相当于药材总重量的10倍、8倍、6倍,每次提取时间分别为3小时、2小时、1小时,合并提取液,过滤,滤液浓缩至75℃时相对密度为1.15的清膏,加入乙醇,使含醇量为55%,静置18小时,过滤,滤液浓缩至74℃时相对密度为1.10的浸膏,在浸膏中加入合剂辅料蔗糖、苯甲酸,搅拌均匀,制得合剂。
实施例7口服液
称取扶芳藤120kg、夜交藤120kg、鸡血藤120kg、党参230kg、黄芪220kg、麦冬100kg、五味子100kg、白芍100kg、丹参115kg、檀香75kg、木香75kg、桂枝115kg、炙甘草80kg;取全部药材,混合后加水提取3次,每次加水量相当于药材总重量的10倍、7倍、6倍,每次提取时间分别为3小时、1小时、1小时,合并提取液,过滤,滤液浓缩80℃时相对密度为1.20的清膏,在清膏中加入口服液辅料山梨酸、甲酯、水搅拌均匀,分装,制得口服液。
实施例8颗粒剂
称取扶芳藤135kg、夜交藤128kg、鸡血藤138kg、党参255kg、黄芪235kg、麦冬110kg、五味子115kg、白芍108kg、丹参126kg、檀香82kg、木香84kg、桂枝125kg、炙甘草84kg;取全部药材,混合后用70%乙醇回流提取2次,每次乙醇用量为药材总量的6倍、4倍,提取时间分别为2小时、1小时,合并提取液,过滤,滤液浓缩至80℃时相对密度为1.20的清膏,在清膏中加入辅料乳糖、明胶、淀粉、微晶纤维素,制粒、干燥、整粒,制得颗粒剂。
实施例9颗粒剂
称取扶芳藤150kg、夜交藤150kg、鸡血藤150kg、党参280kg、黄芪250kg、麦冬120kg、五味子125kg、白芍120kg、丹参140kg、檀香90kg、木香90kg、桂枝135kg、炙甘草90kg;取全部药材,混合后加水提取2次,每次加水量相当于药材总重量的12倍、6倍,每次提取时间为3小时、2小时,合并提取液,过滤,滤液浓缩至80℃时相对密度为1.20的清膏,加入乙醇,使含醇量为70%,静置24小时,过滤,滤液浓缩至80℃时相对密度为1.20的浸膏,在浸膏中加入辅料糊精、水、聚乙二醇、交联聚维酮,制粒、干燥、整粒,制得颗粒剂。
临床试验总结一
1基本资料
1.1选择确诊为冠心病心绞痛的患者295例,所有病例均未经过治疗。其中年龄最大者72岁,最小者23岁,平均年龄40.52岁;病程1-15年;稳定型心绞痛180例,不稳定型心绞痛115例。排除妊娠及哺乳期妇女,对本药过敏者、严重心肺功能障碍、非冠心病性心脏病、肾脏疾病、高血压、胃病者。
2诊断标准
参照1993年中华人民共和国卫生部颁布的《中药新药治疗胸痹(冠心病心绞痛)的临床研究指导原则》的诊断标准。
3治疗方法
使用本发明实施例4的胶囊剂给予治疗,每天3次,每次5g,30天为一疗程。
4疗效判断标准
治愈:症状消失,停药半年后检查无复发。
显效:症状基本消失。
有效:症状部分缓解,疼痛发作次数,程度及持续时间有明显减轻。
无效:症状无任何改善,基本与治疗前相同,或者疼痛发作次数,程度及持续时间有所加重。
5结果
经过三个疗程的治疗,临床疗效见表1。
表1治疗效果
病症 | 治愈/例 | 显著/例 | 有效/例 | 无效/例 | 治愈率/% | 总有效率/% |
稳定型心绞痛 | 55 | 69 | 45 | 11 | 30.56 | 93.89 |
不稳定型心绞痛 | 32 | 45 | 32 | 6 | 27.83 | 94.78 |
从表1可以看出,经过两个个疗程的治疗,对稳定型心绞痛的治愈率达30.56%,总有效率为93.89%;对不稳定型心绞痛的治愈率为27.83%,总有效率为94.78%,可见本发明中药组合物及其制剂可以有效治疗冠心病及心绞痛,经临床观察表明,本发明中药组合物及其制剂对冠心病心绞痛有显著疗效,且疗效迅速,对心绞痛、胸闷、心悸、乏力等症状,患者普遍在服药一周后就可感到明显减轻或消失,其心电图、血压、血脂、血糖等也明显得到改善,对患者的肝、肾功能以及造血系统未见异常变化和不良反应,停药后病情不出现“反弹”,临床服用安全可靠。
典型病例
病例1:张XX,女,37岁。
胸闷伴胸中阵发性疼痛多年,长期服用西药症状不能缓解;近日加重,伴心悸气少,倦怠乏力,动则喘息;心电图提示:冠状动脉供血不足,服用本发明实施例1的片剂2个月余,复查心电图完全正常,停药1年后未复发。
病例2:何X,男,50岁。
患者于15年之前开始感觉心前压迫性疼痛,并伴有头晕,咳嗽,出冷汗等症状。经医院心电图报告窦性心律急性冠状动脉供血不足。经常以杜冷丁、氨茶碱等药物来缓解病情。患者有饮酒、吸烟、支气管炎史,服用本发明实施例5糖浆剂药物3个月,诸症减轻;再连服2个月巩固疗效,心绞痛等症状已消失,心电图检查,恢复正常,停药半年后未复发。
病例3:陈XX,男,65岁。
患者反复发作性心前区疼痛7年,平时服用消心痛及硝酸甘油治疗,并口服速效救心丸,心前区疼痛发作频繁且疼痛加重,尤以运动后为甚,持续时间6-10分钟,每天发作3-5次,需含化硝酸甘油缓解,乏力,心悸,时有汗出。经检查确诊为冠心病劳累性心绞痛,服用本发明实施例7的口服液2个月,诸症减轻;再连服3个月巩固疗效,心绞痛症状已消失,停药18个月后未复发。
病例4:钱X,女,39岁。
患者因阵发性心前区疼痛伴胸闷,憋气3年,近一周来心前区疼痛加重,每遇劳累及情志不畅发作,持续10-15分钟,每日发作3-5次,含化硝酸甘油后3-5分钟疼痛可缓解。经检查确诊为冠心病劳累性心绞痛,服用本发明实施例6的合剂3个月,心绞痛症状已消失,停药1年后未复发。
Claims (7)
1.一种治疗冠心病心绞痛的中药组合物,其特征在于,由如下重量份的原料制备而成的:扶芳藤50-150份、夜交藤50-150份、鸡血藤50-150份、党参150-280份、黄芪150-250份、麦冬50-120份、五味子60-125份、白芍60-120份、丹参70-140份、檀香40-90份、木香50-90份、桂枝75-135份、炙甘草45-90份。
2.根据权利要求1所述的治疗冠心病心绞痛的中药组合物,其特征在于,由如下重量份的原料制备而成的:扶芳藤80-120份、夜交藤80-120份、鸡血藤80-120份、党参190-230份、黄芪180-220份、麦冬70-100份、五味子80-100份、白芍80-100份、丹参95-115份、檀香60-75份、木香65-75份、桂枝100-115份、炙甘草60-80份。
3.根据权利要求1或2所述的治疗冠心病心绞痛的中药组合物,其特征在于:它的活性成分是采用水提或40-70%体积百分浓度的乙醇提取制备而成。
4.根据权利要求3所述的治疗冠心病心绞痛的中药组合物,其特征在于,它的活性成分是通过以下方法制备而成的:取全部药材,混合后加水提取2-3次,每次加水量相当于药材总重量的6-12倍,每次提取时间为1-3小时,合并提取液,过滤,滤液浓缩至70-80℃时相对密度为1.10-1.20的清膏,即得活性成分。
5.根据权利要求3所述的治疗冠心病心绞痛的中药组合物,其特征在于,它的活性成分是通过以下方法制备而成的:取全部药材,混合后用40-70%乙醇回流提取2-3次,每次乙醇用量为药材总量的4-10倍,提取时间为1-4小时,合并提取液,过滤,滤液浓缩至70-80℃时相对密度为1.05-1.20的清膏,即得活性成分。
6.根据权利要求3所述的治疗冠心病心绞痛的中药组合物,其特征在于,它的活性成分是通过以下方法制备而成的:取全部药材,混合后加水提取2-3次,每次加水量相当于药材总重量的6-12倍,每次提取时间为1-3小时,合并提取液,过滤,滤液浓缩至70-80℃时相对密度为1.10-1.20的清膏,加入乙醇,使含醇量为40-70%,静置12-24小时,过滤,滤液浓缩至70-80℃时相对密度为1.05-1.20的浸膏,即得活性成分。
7.一种治疗冠心病心绞痛的中药制剂,由权利要求1-6任一项所述的治疗冠心病心绞痛的中药组合物与医药学上可接受的载体配合制备而成。
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