CN108290896B - 2-苯基-3,4-二氢吡咯并[2,1-f][1,2,4]三嗪酮衍生物及其用途 - Google Patents

2-苯基-3,4-二氢吡咯并[2,1-f][1,2,4]三嗪酮衍生物及其用途 Download PDF

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CN108290896B
CN108290896B CN201680066773.7A CN201680066773A CN108290896B CN 108290896 B CN108290896 B CN 108290896B CN 201680066773 A CN201680066773 A CN 201680066773A CN 108290896 B CN108290896 B CN 108290896B
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propyl
dihydropyrrolo
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CN108290896A (zh
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R·纳夫
H·特诺
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Topadur Pharma AG
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CN201680066773.7A 2015-11-16 2016-11-15 2-苯基-3,4-二氢吡咯并[2,1-f][1,2,4]三嗪酮衍生物及其用途 Active CN108290896B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15194727 2015-11-16
EP15194727.2 2015-11-16
PCT/EP2016/077720 WO2017085056A1 (en) 2015-11-16 2016-11-15 2-phenyl-3,4-dihydropyrrolo[2,1 -f] [1,2,4]triazinone derivatives as phosphodiesterase inhibitors and uses thereof

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CN108290896A CN108290896A (zh) 2018-07-17
CN108290896B true CN108290896B (zh) 2021-09-28

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JP (1) JP6868635B2 (da)
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AU (1) AU2016355854B2 (da)
CA (1) CA3001728A1 (da)
DK (1) DK3377495T3 (da)
ES (1) ES2912648T3 (da)
HK (1) HK1257071A1 (da)
HR (1) HRP20220475T1 (da)
IL (1) IL259163B (da)
LT (1) LT3377495T (da)
MX (1) MX2018005239A (da)
NZ (1) NZ741733A (da)
PH (1) PH12018501041A1 (da)
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SI (1) SI3377495T1 (da)
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CA3001744A1 (en) 2015-10-09 2017-04-13 ACEA Therapeutics, Inc. Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same
KR20210041596A (ko) 2018-08-06 2021-04-15 니콕스 에스아 산화질소 방출 포스포디에스테라제 타입 5 억제제
MX2021005892A (es) * 2018-11-28 2021-06-23 Topadur Pharma Ag Novedosos activadores de guanilato ciclasa soluble e inhibidores de fosfodiesterasa con modo de accion dual y usos de estos.
WO2021094209A1 (en) 2019-11-12 2021-05-20 Bayer Aktiengesellschaft Substituted pyrrolo triazine carboxamide derivatives as prostaglandin ep3 receptor antagonists
WO2021156275A1 (en) 2020-02-05 2021-08-12 Nicox S.A. Compositions for the treatment of glaucoma and ocular hypertension
CN113493459B (zh) * 2020-04-07 2022-12-13 广州白云山医药集团股份有限公司白云山制药总厂 Pde5抑制剂化合物及其制备方法和应用
WO2021245192A1 (en) 2020-06-04 2021-12-09 Topadur Pharma Ag Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
WO2022022669A1 (en) * 2020-07-30 2022-02-03 Biofront Therapeutics (Beijing) Co., Ltd. Dual-functional compounds and methods of use
CN113767104B (zh) * 2020-07-30 2023-08-22 百放英库医药科技(北京)有限公司 双功能化合物及其使用方法
CN116456963A (zh) 2020-11-02 2023-07-18 尼科斯股份有限公司 用于治疗干性年龄相关性黄斑变性、地图状萎缩和青光眼相关性神经变性的no-pde5抑制剂
WO2023005180A1 (en) * 2021-07-30 2023-02-02 Biofront Therapeutics (Beijing) Co., Ltd. Dual-functional compounds and methods of use
JP2024536047A (ja) 2021-09-29 2024-10-04 トパデュール ファルマ アーゲー 2-フェニル-3,4-ジヒドロピロロ[2,l-f][1,2,4]トリアジノン誘導体の局所組成物及びその使用
CN113754612B (zh) * 2021-10-26 2023-09-26 山东安舜制药有限公司 一种西地那非中间体的制备方法
KR20230129639A (ko) * 2022-03-02 2023-09-11 연세대학교 산학협력단 이중작용 pde5 억제제/질산유기에스터의 국소 혈류 증진을 위한 경피 투약 형태

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CN1057464A (zh) * 1990-06-20 1992-01-01 美国辉瑞有限公司 吡唑并嘧啶酮类抗心绞痛剂
CN1278822A (zh) * 1997-11-12 2001-01-03 拜尔公司 用作磷酸二酯酶抑制剂的2-苯基取代的咪唑并三嗪酮
CN1422271A (zh) * 2000-02-17 2003-06-04 Sk化学株式会社 吡咯并嘧啶酮衍生物,其制备方法及用途

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US5250534A (en) 1990-06-20 1993-10-05 Pfizer Inc. Pyrazolopyrimidinone antianginal agents
GB9823103D0 (en) 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
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CN1278822A (zh) * 1997-11-12 2001-01-03 拜尔公司 用作磷酸二酯酶抑制剂的2-苯基取代的咪唑并三嗪酮
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CN108290896A (zh) 2018-07-17
IL259163A (en) 2018-07-31
HRP20220475T1 (hr) 2022-05-27
KR20180081535A (ko) 2018-07-16
HK1257071A1 (zh) 2019-10-11
US20220169655A1 (en) 2022-06-02
ES2912648T3 (es) 2022-05-26
US20200239478A1 (en) 2020-07-30
JP6868635B2 (ja) 2021-05-12
CA3001728A1 (en) 2017-05-26
EP3377495A1 (en) 2018-09-26
EP3377495B1 (en) 2022-03-16
US20240343730A1 (en) 2024-10-17
WO2017085056A1 (en) 2017-05-26
BR112018009805A8 (pt) 2019-02-26
US11242347B2 (en) 2022-02-08
LT3377495T (lt) 2022-05-25
RS63158B1 (sr) 2022-05-31
US20180312513A1 (en) 2018-11-01
PT3377495T (pt) 2022-05-06
PH12018501041B1 (en) 2019-01-28
DK3377495T3 (da) 2022-05-09
JP2018535259A (ja) 2018-11-29
AU2016355854B2 (en) 2021-05-06
SG11201802710YA (en) 2018-06-28
ZA201802181B (en) 2019-01-30
MX2018005239A (es) 2019-09-04
SI3377495T1 (sl) 2022-06-30
RU2018111752A3 (da) 2020-02-18
AU2016355854A1 (en) 2018-05-10
NZ741733A (en) 2024-08-30
US10570137B2 (en) 2020-02-25
US11897890B2 (en) 2024-02-13
IL259163B (en) 2021-12-01
RU2018111752A (ru) 2019-12-18
PL3377495T3 (pl) 2022-05-16
PH12018501041A1 (en) 2019-01-28
BR112018009805A2 (pt) 2018-11-06

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