CN108289934A - 用于伤口愈合的纤溶酶原给药方案 - Google Patents

用于伤口愈合的纤溶酶原给药方案 Download PDF

Info

Publication number
CN108289934A
CN108289934A CN201680065255.3A CN201680065255A CN108289934A CN 108289934 A CN108289934 A CN 108289934A CN 201680065255 A CN201680065255 A CN 201680065255A CN 108289934 A CN108289934 A CN 108289934A
Authority
CN
China
Prior art keywords
wound
plasminogen
medicament
dosage
purposes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680065255.3A
Other languages
English (en)
Chinese (zh)
Inventor
U·伯塞姆
T·奈
P·劳伦
马丁·罗比塔耶
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Plo Mitic Biological Therapeutics Ltd
Original Assignee
Plo Mitic Biological Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plo Mitic Biological Therapeutics Ltd filed Critical Plo Mitic Biological Therapeutics Ltd
Publication of CN108289934A publication Critical patent/CN108289934A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201680065255.3A 2015-11-10 2016-11-10 用于伤口愈合的纤溶酶原给药方案 Pending CN108289934A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562253352P 2015-11-10 2015-11-10
US62/253352 2015-11-10
PCT/IB2016/001606 WO2017081529A1 (en) 2015-11-10 2016-11-10 Plasminogen dosage regimen for wound healing

Publications (1)

Publication Number Publication Date
CN108289934A true CN108289934A (zh) 2018-07-17

Family

ID=57485826

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680065255.3A Pending CN108289934A (zh) 2015-11-10 2016-11-10 用于伤口愈合的纤溶酶原给药方案

Country Status (14)

Country Link
US (1) US20180326023A1 (https=)
EP (1) EP3373957A1 (https=)
JP (1) JP2018534306A (https=)
KR (1) KR20180070708A (https=)
CN (1) CN108289934A (https=)
AU (1) AU2016352183A1 (https=)
BR (1) BR112018009476A8 (https=)
CA (1) CA3004509A1 (https=)
IL (1) IL259172A (https=)
MX (1) MX2018005876A (https=)
RU (1) RU2018121234A (https=)
TW (1) TW201722464A (https=)
WO (1) WO2017081529A1 (https=)
ZA (1) ZA201803010B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116490200A (zh) * 2020-11-17 2023-07-25 泰伦基国际有限公司 一种提高ngf水平的方法和药物

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI868051B (zh) * 2017-06-23 2025-01-01 美商波麥堤克生物治療股份有限公司 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
JP6628946B2 (ja) * 2017-12-26 2020-01-15 大太朗 福岡 増毛、頭皮若しくは皮膚の改質、創傷治癒、骨形成促進、または毛髪の改質に用いるための医薬組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1585649A (zh) * 2001-09-06 2005-02-23 奥姆尼奥公司 改善伤口愈合的方法
US20110142819A1 (en) * 2008-01-22 2011-06-16 Omnio Healer Ab Method of improving would healing

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0509438D0 (en) 2005-05-09 2005-06-15 Prometic Biosciences Ltd Affinity adsorbets for fibrinogen
EP2661493B1 (en) 2011-01-05 2016-03-30 ThromboGenics N.V. Plasminogen and plasmin variants
JP6000353B2 (ja) 2011-08-12 2016-09-28 スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ プラスミノーゲンおよびプラスミンの変異体
PY1577621A (es) * 2014-12-19 2017-10-02 Prometic Biotherapeutics Inc Composicion farmaceutica que comprende plasminogeno y uso para el mismo
TWI801331B (zh) * 2015-11-03 2023-05-11 美商波麥堤克生物治療股份有限公司 纖維蛋白溶酶原缺乏症之纖維蛋白溶酶原替代療法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1585649A (zh) * 2001-09-06 2005-02-23 奥姆尼奥公司 改善伤口愈合的方法
US20110142819A1 (en) * 2008-01-22 2011-06-16 Omnio Healer Ab Method of improving would healing

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YUE SHEN等: "Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds", 《BLOOD》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116490200A (zh) * 2020-11-17 2023-07-25 泰伦基国际有限公司 一种提高ngf水平的方法和药物

Also Published As

Publication number Publication date
MX2018005876A (es) 2018-11-09
TW201722464A (zh) 2017-07-01
CA3004509A1 (en) 2017-05-18
AU2016352183A1 (en) 2018-06-28
JP2018534306A (ja) 2018-11-22
RU2018121234A3 (https=) 2020-03-12
EP3373957A1 (en) 2018-09-19
BR112018009476A8 (pt) 2019-02-26
BR112018009476A2 (pt) 2018-11-13
IL259172A (en) 2018-06-28
US20180326023A1 (en) 2018-11-15
KR20180070708A (ko) 2018-06-26
WO2017081529A1 (en) 2017-05-18
RU2018121234A (ru) 2019-12-13
ZA201803010B (en) 2019-07-31

Similar Documents

Publication Publication Date Title
Cui et al. Clinical safety and preliminary efficacy of plasmid pUDK-HGF expressing human hepatocyte growth factor (HGF) in patients with critical limb ischemia
TW201904990A (zh) 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
CN108289934A (zh) 用于伤口愈合的纤溶酶原给药方案
Liu et al. Experimental study on the effect of chrysin on skin injury induced by amiodarone extravasation in rats
Lai et al. The establishment and evaluation of a swine model of deinagkistrodon acutus snakebite envenomation
WO2019008014A1 (en) MIXTURES OF GASES CONTAINING LOW XENON AND ARGON CONCENTRATIONS PROVIDE NEUROPROTECTION WITHOUT INHIBITING THE CATALYTIC ACTIVITY OF THROMBOLYTIC AGENTS
US20040146496A1 (en) Method of treatment of connective tissue disorders by administration of streptolysin O
JP6873387B2 (ja) 創傷治癒に対するａｐｃ類似体の使用
US20200297649A1 (en) Devices and methods for delivery of oxygen to a wound
Ling Successful management of nose arterial occlusion and impending skin necrosis after filler injection
US20210023140A1 (en) Platelet formulations and medical uses thereof
Jethwa et al. Diabetes associated delay in wound healing and strategies for its management
Yoon et al. Treatment of scleroderma skin ulcers using becaplermin gel and hydrocolloid membrane
Hon et al. Snakebite in a child: could we avoid the anaphylaxis or the fasciotomies?
RU2133610C1 (ru) Способ лечения псориатической эритродермии
Humphries Embolia cutis medicamentosa after polidocanol injection of neovessels in Achilles tendinosis
Rather et al. Autologous Subcutaneous Platelet-Rich Plasma in the Management of Non-Healing Trophic Ulcer in Leprosy
Zambre et al. AYURVEDIC TREATMENT MODALITIES OF DEEP VEIN THROMBOSIS: A CASE STUDY
Wynn et al. Case Report: Wound Care of a Diabetic Foot Ulcer
Pavlovich et al. Injecting material for skin regeneration Lacerta application in treatment of trophic ulcers in patients with diabetic foot syndrome
Katkar et al. Healingwith integrative management of Diabetic foot ulcer-A case report
Siddiqui et al. Enhancing Quality of Life in Venous Ulcer Patient with Irsal-e-Alaq (Hirudotherapy): A Case Report.
Yadav et al. Leech Therapy-aided recovery: A case study on accelerated healing of Decubitus ulcers in paraplegic patients
Prashanth et al. AYURVEDIC MANAGEMENT OF CHRONIC INFECTIVE DIABETIC FOOT ULCER–A CASE REPORT
RU2614666C1 (ru) Способ поликомпонентной терапии при трофических язвах нижних конечностей венозной этиологии

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20180717

WD01 Invention patent application deemed withdrawn after publication