TW201722464A - 用於傷口癒合之纖維蛋白溶酶原給藥方案 - Google Patents

用於傷口癒合之纖維蛋白溶酶原給藥方案 Download PDF

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Publication number
TW201722464A
TW201722464A TW105136489A TW105136489A TW201722464A TW 201722464 A TW201722464 A TW 201722464A TW 105136489 A TW105136489 A TW 105136489A TW 105136489 A TW105136489 A TW 105136489A TW 201722464 A TW201722464 A TW 201722464A
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TW
Taiwan
Prior art keywords
wound
plasminogen
biologically active
active variant
dose
Prior art date
Application number
TW105136489A
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English (en)
Chinese (zh)
Inventor
烏夫 貝特海姆
托爾 尼
皮爾瑞 拉瑞琳
馬丁 羅比泰利
Original Assignee
波麥堤克生化科學有限公司
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Application filed by 波麥堤克生化科學有限公司 filed Critical 波麥堤克生化科學有限公司
Publication of TW201722464A publication Critical patent/TW201722464A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/484Plasmin (3.4.21.7)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21007Plasmin (3.4.21.7), i.e. fibrinolysin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
TW105136489A 2015-11-10 2016-11-09 用於傷口癒合之纖維蛋白溶酶原給藥方案 TW201722464A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562253352P 2015-11-10 2015-11-10

Publications (1)

Publication Number Publication Date
TW201722464A true TW201722464A (zh) 2017-07-01

Family

ID=57485826

Family Applications (1)

Application Number Title Priority Date Filing Date
TW105136489A TW201722464A (zh) 2015-11-10 2016-11-09 用於傷口癒合之纖維蛋白溶酶原給藥方案

Country Status (14)

Country Link
US (1) US20180326023A1 (https=)
EP (1) EP3373957A1 (https=)
JP (1) JP2018534306A (https=)
KR (1) KR20180070708A (https=)
CN (1) CN108289934A (https=)
AU (1) AU2016352183A1 (https=)
BR (1) BR112018009476A8 (https=)
CA (1) CA3004509A1 (https=)
IL (1) IL259172A (https=)
MX (1) MX2018005876A (https=)
RU (1) RU2018121234A (https=)
TW (1) TW201722464A (https=)
WO (1) WO2017081529A1 (https=)
ZA (1) ZA201803010B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI868051B (zh) * 2017-06-23 2025-01-01 美商波麥堤克生物治療股份有限公司 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
CN111050763B (zh) * 2017-12-26 2024-10-11 福冈大太朗 用于増毛、头皮或皮肤的改质、创伤治愈、骨形成促进或毛发的改质的药物组合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067492B2 (en) * 2001-09-06 2006-06-27 Omnio Ab Method of promoting healing of a tympanic membrane perforation
GB0509438D0 (en) 2005-05-09 2005-06-15 Prometic Biosciences Ltd Affinity adsorbets for fibrinogen
WO2009093970A1 (en) * 2008-01-22 2009-07-30 Omnio Healer Ab Method of improving wound healing
JP6085568B2 (ja) 2011-01-05 2017-02-22 スロンボジェニックス・ナムローゼ・フェンノートシャップThromboGenics NV プラスミノーゲンおよびプラスミンの変異体
US9644196B2 (en) 2011-08-12 2017-05-09 Thrombogenics Nv Plasminogen and plasmin variants
PY1577621A (es) * 2014-12-19 2017-10-02 Prometic Biotherapeutics Inc Composicion farmaceutica que comprende plasminogeno y uso para el mismo
TWI801331B (zh) * 2015-11-03 2023-05-11 美商波麥堤克生物治療股份有限公司 纖維蛋白溶酶原缺乏症之纖維蛋白溶酶原替代療法

Also Published As

Publication number Publication date
WO2017081529A1 (en) 2017-05-18
ZA201803010B (en) 2019-07-31
JP2018534306A (ja) 2018-11-22
BR112018009476A2 (pt) 2018-11-13
US20180326023A1 (en) 2018-11-15
CA3004509A1 (en) 2017-05-18
AU2016352183A1 (en) 2018-06-28
IL259172A (en) 2018-06-28
KR20180070708A (ko) 2018-06-26
MX2018005876A (es) 2018-11-09
EP3373957A1 (en) 2018-09-19
RU2018121234A3 (https=) 2020-03-12
RU2018121234A (ru) 2019-12-13
BR112018009476A8 (pt) 2019-02-26
CN108289934A (zh) 2018-07-17

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