CN108264535A - 一种抗抑郁化合物及其制备方法和应用 - Google Patents
一种抗抑郁化合物及其制备方法和应用 Download PDFInfo
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- CN108264535A CN108264535A CN201611260514.6A CN201611260514A CN108264535A CN 108264535 A CN108264535 A CN 108264535A CN 201611260514 A CN201611260514 A CN 201611260514A CN 108264535 A CN108264535 A CN 108264535A
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Classifications
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- C07J71/0005—Oxygen-containing hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
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| JP2019536014A JP6901569B2 (ja) | 2016-12-30 | 2017-12-29 | 抗うつ化合物およびその製造方法と使用 |
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| PCT/CN2017/120134 WO2018121770A1 (zh) | 2016-12-30 | 2017-12-29 | 一种抗抑郁化合物及其制备方法和应用 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109053854A (zh) * | 2018-09-29 | 2018-12-21 | 莱芜清博汇能医药科技有限公司 | 基于知母菝契皂苷元结构的衍生物、药物组合物及其应用 |
| CN109206472A (zh) * | 2018-09-27 | 2019-01-15 | 华东理工大学 | 薯蓣皂苷元衍生物、其药物组合物及其应用 |
| CN109988218A (zh) * | 2017-12-29 | 2019-07-09 | 中国科学院上海药物研究所 | 一种菝葜皂苷元衍生物及其制备方法和应用 |
| CN113831382A (zh) * | 2020-06-24 | 2021-12-24 | 中国科学院上海药物研究所 | 一种甾体化合物 |
| CN116621912A (zh) * | 2022-02-18 | 2023-08-22 | 北京清博汇能医药科技有限公司 | 基于菝契皂苷元结构的衍生物及其药物组合物的用途 |
| WO2023155757A1 (zh) * | 2022-02-18 | 2023-08-24 | 北京清博汇能医药科技有限公司 | 基于菝契皂苷元结构的衍生物及其药物组合物的用途 |
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|---|---|---|---|---|
| WO2019129176A1 (zh) * | 2017-12-29 | 2019-07-04 | 中国科学院上海药物研究所 | 一种菝葜皂苷元衍生物及其制备方法和应用 |
| WO2020259612A1 (zh) * | 2019-06-26 | 2020-12-30 | 中国科学院上海药物研究所 | 一种抗抑郁甾体化合物 |
| CN113831381A (zh) * | 2020-06-24 | 2021-12-24 | 中国科学院上海药物研究所 | 一种用于治疗抑郁症的甾体化合物 |
| CN113292629B (zh) * | 2021-06-21 | 2022-04-26 | 西南民族大学 | 薯蓣皂苷元羟肟酸类衍生物及其制备方法和应用 |
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| GB9923077D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| GB0000228D0 (en) * | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
| NZ547344A (en) * | 2002-03-27 | 2007-11-30 | Phytopharm Plc | Therapeutic methods and uses of sapogenins and their derivatives |
| WO2005051381A1 (en) | 2003-11-26 | 2005-06-09 | Biovitrum Ab | Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R) |
| WO2005051380A1 (en) * | 2003-11-26 | 2005-06-09 | Biovitrum Ab | Substituted urea-octahydroindols as antagonists of melanin concentrating hormone receptor 1 (mch1r) |
| US20050245495A1 (en) * | 2004-04-07 | 2005-11-03 | Chen Zhao | Azacyclosteroid histamine-3 receptor ligands |
| NZ553202A (en) | 2004-08-19 | 2010-12-24 | Vertex Pharma | Modulators of muscarinic receptors |
| CN101214253B (zh) | 2008-01-07 | 2011-09-21 | 中国人民解放军第二军医大学 | 知母皂苷b-ⅱ用于制备抗抑郁产品的用途 |
| JP2011513350A (ja) | 2008-03-05 | 2011-04-28 | エフ．ホフマン−ラ ロシュ アーゲー | ２−アミノキノリン類 |
| CN101768202B (zh) * | 2009-02-18 | 2013-10-30 | 沈阳药科大学 | 知母中菝葜皂苷元及其衍生物的制备方法及其医药新用途 |
| CN102924559B (zh) * | 2012-11-16 | 2015-10-28 | 沈阳药科大学 | 菝葜皂苷元衍生物及其制备和应用 |
| WO2015163318A1 (ja) * | 2014-04-25 | 2015-10-29 | レジリオ株式会社 | アルツハイマー病の治療剤を含む、神経細胞の軸索の機能不全が関与する疾患の治療剤 |
| WO2019129176A1 (zh) | 2017-12-29 | 2019-07-04 | 中国科学院上海药物研究所 | 一种菝葜皂苷元衍生物及其制备方法和应用 |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109988218A (zh) * | 2017-12-29 | 2019-07-09 | 中国科学院上海药物研究所 | 一种菝葜皂苷元衍生物及其制备方法和应用 |
| CN109988218B (zh) * | 2017-12-29 | 2022-11-25 | 中国科学院上海药物研究所 | 一种菝葜皂苷元衍生物及其制备方法和应用 |
| CN109206472A (zh) * | 2018-09-27 | 2019-01-15 | 华东理工大学 | 薯蓣皂苷元衍生物、其药物组合物及其应用 |
| KR102655595B1 (ko) * | 2018-09-29 | 2024-04-08 | 피토벤트 바이오파마 | 지모의 사르사사포게닌 구조를 기반으로 하는 유도체, 약물 조성물 및 그의 용도 |
| WO2020062883A1 (zh) * | 2018-09-29 | 2020-04-02 | 深圳清博汇能医药科技有限公司 | 基于知母菝契皂苷元结构的衍生物、药物组合物及其应用 |
| CN109053854B (zh) * | 2018-09-29 | 2021-05-14 | 深圳清博汇能医药科技有限公司 | 基于知母菝契皂苷元结构的衍生物、药物组合物及其应用 |
| KR20210096074A (ko) * | 2018-09-29 | 2021-08-04 | 피토벤트 바이오파마 | 지모의 사르사사포게닌 구조를 기반으로 하는 유도체, 약물 조성물 및 그의 용도 |
| CN109053854A (zh) * | 2018-09-29 | 2018-12-21 | 莱芜清博汇能医药科技有限公司 | 基于知母菝契皂苷元结构的衍生物、药物组合物及其应用 |
| AU2019345516B2 (en) * | 2018-09-29 | 2022-10-20 | Phytovent Biopharma | Derivative of sarsasapogenin, pharmaceutical composition and use thereof |
| US12448410B2 (en) | 2018-09-29 | 2025-10-21 | Phytovent Biopharma | Derivative of sarsasapogenin, pharmaceutical composition and use thereof |
| CN113831382A (zh) * | 2020-06-24 | 2021-12-24 | 中国科学院上海药物研究所 | 一种甾体化合物 |
| WO2023155757A1 (zh) * | 2022-02-18 | 2023-08-24 | 北京清博汇能医药科技有限公司 | 基于菝契皂苷元结构的衍生物及其药物组合物的用途 |
| CN116621912A (zh) * | 2022-02-18 | 2023-08-22 | 北京清博汇能医药科技有限公司 | 基于菝契皂苷元结构的衍生物及其药物组合物的用途 |
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| EP3564253B1 (en) | 2024-10-30 |
| JP6901569B2 (ja) | 2021-07-14 |
| CN110121502B (zh) | 2022-09-23 |
| US11142543B2 (en) | 2021-10-12 |
| US20200385418A1 (en) | 2020-12-10 |
| JP2020503341A (ja) | 2020-01-30 |
| EP3564253A1 (en) | 2019-11-06 |
| WO2018121770A1 (zh) | 2018-07-05 |
| CN110121502A (zh) | 2019-08-13 |
| EP3564253A4 (en) | 2020-07-29 |
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