JP6901569B2 - 抗うつ化合物およびその製造方法と使用 - Google Patents

抗うつ化合物およびその製造方法と使用 Download PDF

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JP6901569B2
JP6901569B2 JP2019536014A JP2019536014A JP6901569B2 JP 6901569 B2 JP6901569 B2 JP 6901569B2 JP 2019536014 A JP2019536014 A JP 2019536014A JP 2019536014 A JP2019536014 A JP 2019536014A JP 6901569 B2 JP6901569 B2 JP 6901569B2
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substituted
groups
hydrogen
compound
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JP2020503341A (ja
JP2020503341A5 (enExample
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チャンカン フアン
チャンカン フアン
ヤン リ
ヤン リ
フアリャン ジアン
フアリャン ジアン
ヤン シエ
ヤン シエ
フェイ グオ
フェイ グオ
ジューション リ
ジューション リ
ミンツァン チェン
ミンツァン チェン
ミンユエ チェン
ミンユエ チェン
チャオリン スン
チャオリン スン
ユー ガオ
ユー ガオ
シャオティン ティエン
シャオティン ティエン
ペイ フー
ペイ フー
ビン チャン
ビン チャン
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シャンハイ インスティチュート オブ マテリア メディカ，チャイニーズ アカデミー オブ サイエンシーズ
シャンハイ インスティチュート オブ マテリア メディカ，チャイニーズ アカデミー オブ サイエンシーズ
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
JP2019536014A 2016-12-30 2017-12-29 抗うつ化合物およびその製造方法と使用 Active JP6901569B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201611260514.6 2016-12-30
CN201611260514.6A CN108264535A (zh) 2016-12-30 2016-12-30 一种抗抑郁化合物及其制备方法和应用
PCT/CN2017/120134 WO2018121770A1 (zh) 2016-12-30 2017-12-29 一种抗抑郁化合物及其制备方法和应用

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JP2020503341A5 JP2020503341A5 (enExample) 2021-05-27
JP6901569B2 true JP6901569B2 (ja) 2021-07-14

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US (1) US11142543B2 (enExample)
EP (1) EP3564253B1 (enExample)
JP (1) JP6901569B2 (enExample)
CN (2) CN108264535A (enExample)
WO (1) WO2018121770A1 (enExample)

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Publication number Priority date Publication date Assignee Title
CN109988218B (zh) * 2017-12-29 2022-11-25 中国科学院上海药物研究所 一种菝葜皂苷元衍生物及其制备方法和应用
WO2019129176A1 (zh) * 2017-12-29 2019-07-04 中国科学院上海药物研究所 一种菝葜皂苷元衍生物及其制备方法和应用
CN109206472A (zh) * 2018-09-27 2019-01-15 华东理工大学 薯蓣皂苷元衍生物、其药物组合物及其应用
CN109053854B (zh) * 2018-09-29 2021-05-14 深圳清博汇能医药科技有限公司 基于知母菝契皂苷元结构的衍生物、药物组合物及其应用
CN112142817B (zh) * 2019-06-26 2021-10-22 中国科学院上海药物研究所 一种抗抑郁甾体化合物
CN113831381A (zh) * 2020-06-24 2021-12-24 中国科学院上海药物研究所 一种用于治疗抑郁症的甾体化合物
CN113831382A (zh) * 2020-06-24 2021-12-24 中国科学院上海药物研究所 一种甾体化合物
CN113292629B (zh) * 2021-06-21 2022-04-26 西南民族大学 薯蓣皂苷元羟肟酸类衍生物及其制备方法和应用
CN116621912B (zh) * 2022-02-18 2026-07-10 北京清博汇能医药科技有限公司 基于菝契皂苷元结构的衍生物及其药物组合物的用途
EP4477225A4 (en) * 2022-02-18 2026-01-21 Beijing Phytovent Pharmaceutical Tech Co Ltd USE OF A SARSASAPOGENIN STRUCTURE-BASED DERIVATIVE AND ASSOCIATED PHARMACEUTICAL COMPOSITION

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GB9923077D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
PL213697B1 (pl) * 2002-03-27 2013-04-30 Phytopharm Plc Substancje czynne do stosowania w leczeniu chorób, zwlaszcza chorób neurodegeneracyjnych
WO2005051381A1 (en) * 2003-11-26 2005-06-09 Biovitrum Ab Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R)
WO2005051380A1 (en) 2003-11-26 2005-06-09 Biovitrum Ab Substituted urea-octahydroindols as antagonists of melanin concentrating hormone receptor 1 (mch1r)
US20050245495A1 (en) * 2004-04-07 2005-11-03 Chen Zhao Azacyclosteroid histamine-3 receptor ligands
US7879834B2 (en) 2004-08-19 2011-02-01 Vertex Pharmaceuticals Incorporated Spiroindoline modulators of muscarinic receptors
CN101214253B (zh) 2008-01-07 2011-09-21 中国人民解放军第二军医大学 知母皂苷b-ⅱ用于制备抗抑郁产品的用途
WO2009109477A1 (en) 2008-03-05 2009-09-11 F. Hoffmann-La Roche Ag 2-aminoquinolines
CN101768202B (zh) 2009-02-18 2013-10-30 沈阳药科大学 知母中菝葜皂苷元及其衍生物的制备方法及其医药新用途
CN102924559B (zh) * 2012-11-16 2015-10-28 沈阳药科大学 菝葜皂苷元衍生物及其制备和应用
WO2015163318A1 (ja) * 2014-04-25 2015-10-29 レジリオ株式会社 アルツハイマー病の治療剤を含む、神経細胞の軸索の機能不全が関与する疾患の治療剤
WO2019129176A1 (zh) 2017-12-29 2019-07-04 中国科学院上海药物研究所 一种菝葜皂苷元衍生物及其制备方法和应用

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WO2018121770A1 (zh) 2018-07-05
CN110121502B (zh) 2022-09-23
JP2020503341A (ja) 2020-01-30
EP3564253A1 (en) 2019-11-06
EP3564253A4 (en) 2020-07-29
US20200385418A1 (en) 2020-12-10
US11142543B2 (en) 2021-10-12
CN110121502A (zh) 2019-08-13
CN108264535A (zh) 2018-07-10
EP3564253B1 (en) 2024-10-30

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