CN108245632A - 解毒通络制剂 - Google Patents

解毒通络制剂 Download PDF

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CN108245632A
CN108245632A CN201611209867.3A CN201611209867A CN108245632A CN 108245632 A CN108245632 A CN 108245632A CN 201611209867 A CN201611209867 A CN 201611209867A CN 108245632 A CN108245632 A CN 108245632A
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chinese medicine
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赵巧云
王德伍
赵青朝
赵青团
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Zhengzhou Tiandiren Agricultural And Sideline Products Co Ltd
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Zhengzhou Tiandiren Agricultural And Sideline Products Co Ltd
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Abstract

本发明公开了一种用于治疗慢性肾病、慢性肾小球肾炎等症内服中药制剂，其特征在于，选择的中药原料及重量份分别是：大黄12克、土茯苓15克、黄芪15克、覆盆子16克、紫荆皮16克、穿山甲10克、血竭12克、丹参15克、厚朴15克、莱菔子18克、木香19克、藿香17克、车前子16克、姜半夏16克、冬虫夏草15克、木瓜15克、白头翁16克、金钱草18克。本发明所选用的原料药材药性效互补，规避了药物之间配伍的相恶、相畏、相杀之选，使药物相须、相使作用显著，具有清热除湿、滋补肝肾、活血化瘀的功效。内服治疗慢性肾病、慢性肾小球肾炎等症，具有确切疗效。

Description

解毒通络制剂
技术领域
本发明涉及中药领域，具体涉及一种解毒通络制剂，用于治疗慢性肾病、慢性肾小球肾炎等症内服中药制剂，具有清热除湿、滋补肝肾、活血化瘀的功效。
背景技术
慢性肾小球肾炎简称慢性肾炎，系指蛋白尿、血尿、高血压、水肿为基本临床表现，起病方式各有不同，病情迁延，病变缓慢进展，可有不同程度的肾功能减退，具有肾功能恶化倾向和最终将发展为慢性肾衰竭的一组肾小球病。由于本组疾病的病理类型及病期不同，主要临床表现可各不相同。疾病表现呈多样化。慢性肾炎可发生于任何年龄，但以青中年为主，男性多见。多数起病缓慢、隐袭。临床表现呈多样性，蛋白尿、血尿、高血压、水肿为其基本临床表现，可有不同程度肾功能减退，病情时轻时重、迁延，渐进性发展为慢性肾衰竭。实验室检查多为轻度尿异常，尿蛋白常在1～3g/d，尿沉渣镜检红细胞可增多，可见管型。血压可正常或轻度升高。肾功能正常或轻度受损（肌酐清除率下降或轻度氮质血症），这种情况可持续数年，甚至数十年，肾功能逐渐恶化并出现相应的临床表现（如贫血、血压增高等），进入尿毒症。
发明内容
本发明涉及中药领域，具体涉及一种用于治疗慢性肾病、慢性肾小球肾炎等症内服中药制剂，具有清热除湿、滋补肝肾、活血化瘀的功效。内服，可以用于慢性肾病、慢性肾小球肾炎等症治疗，具有确切疗效。
为实现上述目的本发明采用了如下的技术方案：本发明所述中药制剂选择的药材及重量份分别是：大黄12克、土茯苓15克、黄芪15克、覆盆子16克、紫荆皮16克、穿山甲10克、血竭12克、丹参15克、厚朴15克、莱菔子18克、木香19克、藿香17克、车前子16克、姜半夏16克、冬虫夏草15克、木瓜15克、白头翁16克、金钱草18克。
本发明选择的中药原料中：大黄：性味归经：味苦，性寒。归胃、脾、大肠、肝、心包经。功能主治：泻热通肠，凉血解毒，逐瘀通经。用于实热便秘，积滞腹痛，泻痢不爽，湿热黄疸，血热吐衄，目赤，咽肿，肠痈腹痛，痈肿疔疮，瘀血经闭，跌打损伤，水火烫伤；上消化道出血。酒大黄善清上焦血分热毒。用于目赤咽肿，齿龈肿痛。熟大黄泻下力缓，泻火解毒。用于火毒疮疡。大黄炭凉血化瘀止血。用于血热有瘀出血者。
土茯苓：【功能】解毒，除湿，利关节。主治：治梅毒，淋浊，筋骨挛痛，脚气，疗疔疮，痈肿，瘰疬，梅毒及汞中毒所致的肢体拘挛，筋骨疼痛。
黄芪：具有1、表虚自汗，多用于体虚表弱所致的自汗。2、阴虚盗汗；3、急性肾炎水肿，用于阳气不足所致的虚性水肿；4、慢性肾炎水肿、脾肾虚者； 5、阳气虚弱，用于疮疡久不溃破而内陷，有促进溃破及局限作用。6、疮疡久溃不愈，用于疮疡溃破后，久不收口，有生肌收口之作用；7、脾气虚证，虚弱倦怠，泄泻，中气下陷，脏器脱垂，食少纳呆诸症。8、肺气虚证。咳喘日久，气短神疲，痰雍于肺无力咯出。9、多汗而浮肿。10、用于气虚衰弱，倦怠乏力，或中气下陷、脱肛、子宫脱垂。性味：甘，微温。归经：归肺、脾、肝、肾经；有增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。
覆盆子：可入药，有明目、补肾作用。归肾，膀胱经。功效：补肝益肾，固精缩尿，明目。主阳痿早泄，遗精滑精，宫冷不孕，带下清稀，尿频遗溺，目昏暗，须发早白。
紫荆皮：为豆科植物紫荆的树皮。【性味】：味苦，平，无毒。【归经】：入肝、脾二经。【功效】：活血通经，消肿解毒。治风寒湿痹，妇女经闭、血气疼痛，喉痹，淋疾，痈肿，癣疥，跌打损伤，蛇虫咬伤。
穿山甲：用于活血散结，通经下乳，消痈溃坚。主血瘀经闭，症瘕，风湿痹痛，乳汁不下，痈肿，瘰疬等症。归经：胃经、肝经；药性：凉。
血竭：【功效】活血散瘀，定痛，止血生肌，敛疮。【主治】治跌打肿痛，内伤瘀痛；外伤出血不止,瘰疬，臁疮溃久不合。【性味归经】甘咸，平。入心、肝、脾经。
丹参：味微苦，性微寒。色赤，入心经。补心，生血，养心，定志，安神宁心，健忘怔忡，惊悸不寐，生新血，去瘀血，安生胎，落死胎。用于胸肋胁痛，风湿痹痛，症瘕结块，疮疡肿痛，跌仆伤痛，月经不调，经闭痛经，产后瘀痛等。治疗胸肋疼痛、症瘕结块，以及月经不调、经闭经痛具有良效。
厚朴：【性味】：苦；辛；性温【归经】：脾经；胃经；大肠经。【功能】：行气消积；燥湿除满；降逆平喘【主治】：食积气滞；腹胀便秘；湿阻中焦，脘痞吐泻；痰壅气逆；胸满喘咳。
莱菔子：性味：性平，味辛、甘。归经：归肺、脾、胃经。功能主治：消食除胀，降气化痰。主治食积气滞，脘腹胀满，嗳气，下痢后重，咳嗽痰多，喘促胸满。
木香：【功效分类】：理气药；行气药；温里药。【功效】：行气止痛；调中导滞。【主治】：胞胁胀满足；脘腹胀痛；哎吐泄泻；痢疾后重。
藿香：性微温，味辛甘，具有芳香化湿、发表解暑、解表散邪、利湿除风、清热止渴、和胃止呕、快气和中、健胃祛湿等功效。用于治疗头痛发热、风寒感冒、胸闷腹胀、胃寒疼痛、呕吐、泻痢、口臭等症，但阴虚火旺者忌食。藿香有杀菌功能，口含一叶可除口臭，预防传染病，并能用作防腐剂。夏季用藿香煮粥或泡茶饮服，对暑湿重症，脾胃湿阻，脘腹胀满，肢体重困，恶心呕吐有效。
车前子：性味：甘；淡；性微寒。归经：归肺经；肝经；肾经；膀胱经。功能：清热利尿；渗湿止泻；明目；祛痰。主治：主小便不利；淋浊带下；水肿胀满；暑湿泻痢；目赤障翳；痰热咳喘。
姜半夏：性味与归经：辛、温；有毒。归脾、胃、肺经。功能与主治：降逆止呕。用于呕吐反胃，胸脘痞闷，梅核气。
冬虫夏草：【化学成份】含水分10.84%，脂肪8.4%，粗蛋白25.32%，粗纤维18.53%，碳水化物28.90%，灰分4.10%。脂肪含饱和脂肪酸13.00%，不饱和脂肪酸82.2%。此外，还含虫草酸约7%，是奎宁酸的异构物。又含冬虫夏草素，是一种淡黄色结晶粉末，在试管内能抑制链球菌、鼻疽杆菌、炭疽杆菌、猪出血性败血症杆菌及葡萄状球菌的生长。另含维生素B120.29微克/100克。【功能主治】补虚损，益精气，止咳化痰。治痰饮喘嗽，虚喘，痨嗽，咯血，自汗盗汗，阳痿遗精，腰膝酸痛，病后久虚不复。
木瓜：含齐敦果酸、木瓜酚、皂甙、苹果酸、酒石酸、柠檬酸、维生素 C、黄酮类、鞣质。种子含氢氰酸。用于风湿痹痛、筋脉拘挛、脚气肿痛。解酒、去痰、顺气、止痢之效。木瓜有较好的舒筋活络作用，且能化湿，为治风湿痹痛所常用，筋脉拘挛者尤为要药。
白头翁：【性味】：味苦，性寒；【归经】：归胃经、大肠经；【功能】：具有清热解毒，凉血止痢，燥湿杀虫的功效。【主治】：热毒痢疾，鼻衄，血痔，带下，阴痒，痈疮，瘰疬。
金钱草：具有清热解毒，散瘀消肿，利湿退黄、祛风散寒之功效，可用于感冒咳嗽，头痛身疼，腹泻，热淋，沙淋，尿涩作痛，黄疸尿赤，痈肿疔疮，毒蛇咬伤，肝胆结石，尿路结石等症。性味归经：性甘；微苦；性凉；归肝；胆；肾；膀胱经。
本发明所选用的原料药材药性效互补，规避了药物之间配伍的相恶、相畏、相杀之选，使药物相须、相使作用显著，具有提高免疫力，清热除湿、滋补肝肾、活血化瘀的功效。内服治疗慢性肾病、慢性肾小球肾炎等症，具有确切疗效。
利用本发明所述用于治疗慢性肾病、慢性肾小球肾炎等症内服中药制剂，通过临床应用，取得了意想不到的满意效果；
本发明药物治疗慢性肾病、慢性肾小球肾炎等症临床观察：
1.一般资料
收治门诊患者共55例，年龄20~30岁12例，31~40岁20例，41~50岁15例，50岁以上8例。
2．具体实施病例如下：山东的关某，今年45岁，2年前患者因乏力、纳差、眼睑及双下肢间断性浮肿来到我医院，入院时检查，患者乏力，头晕的症状，暂无头痛、胸闷及心慌，腰部酸痛不适、纳差、恶心但无呕吐，睡眠欠佳，查体示血压120/80mmHg，精神差，双肺呼吸音清，未闻及干湿性啰音，心率82次/分，律齐无杂音，双下肢轻度浮肿，化验示尿蛋白(++)，潜血(—)。根据患者的症状，诊断为慢性肾小球肾炎。随投以本发明方剂21剂，日服1剂，早晚分2次温服，空腹开水冲服。随后来诊，腰部疼痛减轻，头晕症有所缓解。继服10个疗程，诸症皆除。嘱咐其，继续治疗一疗程巩固疗效。服数剂即愈。
具体实施方式
所述用于治疗慢性肾病、慢性肾小球肾炎等症内服中药制剂，其特征在于，选择的中药原料及重量份分别是：大黄12克、土茯苓15克、黄芪15克、覆盆子16克、紫荆皮16克、穿山甲10克、血竭12克、丹参15克、厚朴15克、莱菔子18克、木香19克、藿香17克、车前子16克、姜半夏16克、冬虫夏草15克、木瓜15克、白头翁16克、金钱草18克；
制备方法：大黄12克、土茯苓15克、黄芪15克、覆盆子16克、紫荆皮16克、穿山甲10克、血竭12克、丹参15克、厚朴15克、莱菔子18克、木香19克、藿香17克、车前子16克、姜半夏16克、冬虫夏草15克、木瓜15克、白头翁16克、金钱草18克；分别制成饮片，经过高压锅蒸煮杀菌50-70分钟，晾干，获得无菌原材料，进行密封包装，获得商品中药制剂饮品。

Claims (2)

1.用于治疗慢性肾病、慢性肾小球肾炎等症内服中药制剂，其特征在于，选择的中药原料及重量份分别是：大黄12克、土茯苓15克、黄芪15克、覆盆子16克、紫荆皮16克、穿山甲10克、血竭12克、丹参15克、厚朴15克、莱菔子18克、木香19克、藿香17克、车前子16克、姜半夏16克、冬虫夏草15克、木瓜15克、白头翁16克、金钱草18克。
2.根据权利要求1所述的治疗慢性肾病、慢性肾小球肾炎等症内服中药制剂，其特征在于：其制备方法为以下步骤：步骤一）称取原料药材：大黄12克、土茯苓15克、黄芪15克、覆盆子16克、紫荆皮16克、穿山甲10克、血竭12克、丹参15克、厚朴15克、莱菔子18克、木香19克、藿香17克、车前子16克、姜半夏16克、冬虫夏草15克、木瓜15克、白头翁16克、金钱草18克；
步骤二：将所获的饮片，经过高压锅蒸煮杀菌50-70分钟，晾干，获得无菌原材料；
步骤三：将所获的无菌原材料，进行密封包装，获得商品中药制剂饮品。
CN201611209867.3A 2016-12-24 2016-12-24 解毒通络制剂 Pending CN108245632A (zh)

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