CN103611099B - 一种治疗脚气的中药 - Google Patents
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Abstract
本发明涉及一种治疗脚气的中药，其特征在于，它是由以下重量配比的原料药材制备而成：漆大姑根6份、千金花5份、千脚虫1份、秦艽5份、二仙桃3份、蜂房2份、猫眼草2份、筋骨草4份、风湿木3份、欧当归4份、檀香3份、芙蓉花5份、枇杷叶3份、瓜蒌2份、 木通1份、大黄4份、黄柏4份、莪术3份、万年柏3份、甘草5份。临床实验证明，本发明能够安全有效治疗脚气。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗脚气的中药。
背景技术
脚气是侵犯表皮、毛发和趾甲的浅部霉菌病，是一种传染性的皮肤病。脚气的危害不仅是瘙痒、脱皮、起疱、真菌传播，还会引起手癣和灰指甲。更严重的是，搔抓会导致局部细菌感染，可发展成淋巴管炎、蜂窝组织炎及丹毒，可谓后患无穷。目前脚气治疗主要是应用抗生素，疗效低，且副作用大。因此研究开发一种安全有效治疗脚气的中药非常有临床实用价值。
本发明中药所涉及药材的研究现状如下：
漆大姑根：本品为大戟科植物毛果算盘子的根。【性味】味苦；涩；性平。【归经】大肠经。【功能主治】清热解毒；祛湿止痒。主肠炎；痢疾；牙痛；咽喉痛；乳腺炎；皮肤湿疹；烧伤；白带。【用法用量】15-60g。
千金花：本品为菊科植物佩兰的花。【性味】味苦;辛;性平。【功能主治】化湿宣气。主痢疾【用法用量】3-6g。
千脚虫：本品为节肢动物门多足纲圆马陆科马陆Prospirobolus joannsi （Brolemann），以全体入。【性味】辛，温。有毒。【功能主治】破积解毒。主治腹中症积，化瘜肉，并治扁桃体炎。外治一切疮毒。【用法用量】 1～3钱。
秦艽：本品为龙胆科植物大叶龙胆、粗茎龙胆或西藏龙胆的根。【性味】苦；辛；微寒。【归经】胃；肝；胆经。【功能主治】祛风湿；舒筋络；清虚热；利湿退黄。主风湿痹通痛；筋骨拘挛；手足不遂；骨蒸潮热；小儿疳热；湿热黄疸。。
二仙桃：为兰科植物香花羊耳蒜的全草。【性味】味辛；苦；性温。【功能主治】解毒消肿；祛风除湿。主疮疡肿毒；风寒湿痹；白带；腰痛；咳嗽。【用法用量】6-15g。
蜂房：本品为胡蜂科昆虫果马蜂Polistes olivaceous （DeGeer）、日本长脚胡蜂Polistes japonicus Saussure 或异腹胡蜂Parapolybia varia Fabricius的巢。【性味】甘，平。【归经】归胃经。【功能主治】祛风，功毒，杀虫，止痛。用于龋齿牙痛，疮疡肿毒，乳痈，瘰疬，皮肤顽癣，鹅掌风。【用法用量】 3～5g。
猫眼草:本品为大戟科大戟属植物猫眼草Euphorbia lunulata Bunge的全草。性味】味苦；性微寒；有毒。【归经】肺；肝经。【功能主治】镇咳；祛痰；散结；逐水；拔毒；杀虫。主痰饮咳喘；水肿；瘰疬；疥癣；无名肿毒。【用法用量】3-9g。
筋骨草：唇形科筋骨草属植物筋骨草Ajuga decumbens Thunb.的全草。【性味】味苦；性寒。【功能主治】清热解毒；凉血消肿。主咽喉肿痛；肺热咯血；跌打肿痛。【用法用量】内服：煎汤，15-30g。
风湿木：本品为夹竹桃科风湿木Rauvolfia latifrons Tsiang，以根、茎入药。【功能主治】祛风活血。主治风湿痛；外用可接骨。
欧当归：本品为伞形科杆物欧当归的根。【性味】味辛；微甘；性微温。【功能主治】活血调经；利尿。主经闭；痛经；头晕；头痛；肢麻；水肿。【用法用量】6-15g。
檀香：本品为檀香科檀香属植物檀香Santalum album L.树干的心材。【性味】辛，温。【归经】归脾、胃、心、肺经。【功能主治】行气温中，开胃止痛。用于寒凝气滞，胸痛，腹痛，胃痛食少；冠心病，心绞痛。【用法用量】 2～5g。
芙蓉花：为锦葵科植物木芙蓉的花。【性味】辛；微苦；凉。【归经】肺；心；肝经。【功能主治】清热解毒；凉血止血；消肿排脓。主肺热咳嗽；吐血；目赤肿痛；崩漏；白带；腹泻；腹痛；痈肿；疮疖；毒蛇咬伤；水火烫伤；跌打损伤。【用法用量】9-15g。
枇杷叶：本品为蔷薇科植物枇杷Eriobotrya japonica （Thunb.）Lindl.的干燥叶。【性味】苦，微寒。【归经】归肺、胃经。【功能主治】清肺止咳，降逆止呕。用于肺热咳嗽，气逆喘急，胃热呕逆，烦热口渴。【用法用量】 6～9g。
瓜蒌：本品为葫芦科植物栝楼Trichosanthes kirilowii Maxim. 或双边栝楼Trichosan-thes rosthornii Harms 的干燥成熟果实。【性味】甘、微苦、寒。【归经】归肺、胃、大肠经。【功能主治】清热涤痰，宽胸散结，润燥滑肠。用于肺热咳嗽，痰浊黄稠，胸痹心痛，结胸痞满，乳痈，肺痈，肠痈肿痛，大便秘结。【用法用量】 9～15g。
木通：本品为木通科植物木通、三叶木通或白木通的滕茎。【性味】苦；性寒。【归经】心；脾；肾；小肠；膀胱经。【功能主治】清热利尿；活血通脉。主小便赤赤；淋浊；水肿；胸中烦热；喉喉疼痛；口舌生疮；风湿痹痛；乳汁不通；经闭；痛经。【用法用量】3-6g。
大黄：本品为蓼科植物掌叶大黄Rheum palmatum L。、 唐古特大黄Rheum tanguticum Maxim。 ex Balf。或药用大黄Rheum officinale Baill。的干燥根及根茎。【性味】苦，寒。【归经】归脾、胃、大肠、肝、心包经。【功能主治】泻热通肠，凉血解毒，逐瘀通经。用于实热便秘，积滞腹痛，泻痢不爽，湿热黄疸，血热吐衄，目赤，咽肿，肠痈腹痛，痈肿疔疮，瘀血经闭，跌打损伤，外治水火烫伤；上消化道出血。酒大黄善清上焦血分热毒。用于目赤咽肿，齿龈肿痛。熟大黄泻下力缓，泻火解毒。用于火毒疮疡。大黄炭凉血化瘀止血。用于血热有瘀出血症。【用法用量】 3～30g。
黄柏：本品为芸香科植物黄皮树Phellodendron chinense Schneid.或黄檗Phellodendron amurense Rupr.的干燥树皮。【性味】苦，寒。【归经】归肾、膀胱经。【功能主治】清热燥湿，泻火除蒸，解毒疗疮。用于湿热泻痢，黄疸，带下，热淋，脚气，痿{辟}，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹瘙痒。盐黄柏滋阴降火。用于阴虚火旺，盗汗骨蒸。【用法用量】 3～12g.
莪术：本品为姜科植物莪术Curcuma aerugionosa Roxb.的根茎。【性味】味辛；苦；性温【归经】归肝、脾经。【功能主治】行气破血；消积止痛。主血气心痛；饮食积滞；脘腹胀痛；血滞经闭；痛经；症瘕瘤痞块；跌打损伤。【用法用量】3-10g
万年柏：为蕨类铁角蕨科铁角蕨属植物虎尾铁角蕨，以全草入药。【性味】苦、甘，凉。【功能主治】清热解毒，平肝镇惊，止痛。用于肝炎，小儿疳积，牙痛，毒蛇咬伤。【用法用量】2～5g。
甘草：本品为豆科甘草属植物甘草Glycyrrhiza uralensis Fisch.的根和根状茎。【性味】甘；平。【归经】脾；胃；心；肺经。【功能主治】益气补中；缓急止痛；润肺止咳；泻火解毒；调和诸药。主倦怠食少；肌瘦面黄；心悸气短；腹痛便溏；四肢挛急疼痛；脏躁；咳嗽气喘；咽喉肿痛；痈疮肿痛；小儿胎毒；及药物、食物中毒。【用法用量】内服：煎汤，2-10g。
发明内容
本发明旨在提供一种治疗脚气的中药，通过选择合适的药材及其配比，达到安全有效治愈脚气的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗脚气的中药，其特征在于，它是由以下重量配比的原料药材制备而成：漆大姑根6份、千金花5份、千脚虫1份、秦艽5份、二仙桃3份、蜂房2份、猫眼草2份、筋骨草4份、风湿木3份、欧当归4份、檀香3份、芙蓉花5份、枇杷叶3份、瓜蒌2份、 木通1份、大黄4份、黄柏4份、莪术3份、万年柏3份、甘草5份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2012年1月-2013年9月间共收集50例脚气患者，年龄18-66岁，病程1-20天。随机分为：治疗组25例，对照组25例。两组性别、年龄等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗方法
对照组用绿源霜外用药膏，按说明书用，疗程10天。
治疗组口服本发明按照具体实施例1制得的胶囊，每日2次。疗程10天。
2.2观察项目：实验前后，对疼痛，发痒、发红面大小、及血液生化指标化验记录。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常，半年内未见复发。好转：临床症状减轻，实验室检查改善或正常。无效：临床症状、实验室检查无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(%) |
| 治疗组 | 25 | 20 | 3 | 5 | 1（4%） | 80% |
| 对照组 | 25 | 6 | 6 | 13 | 11（44%） | 48% |
可见，本发明制得的药物能够安全有效治疗脚气。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取漆大姑根6g、千金花5g、千脚虫1g、秦艽5g、二仙桃3g、蜂房2g、猫眼草2g、筋骨草4g、风湿木3g、欧当归4g、檀香3g、芙蓉花5g、枇杷叶3g、瓜蒌2g、 木通1g、大黄4g、黄柏4g、莪术3g、万年柏3g、甘草5g；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗脚气。口服，每日分早晚两次服用。
具体实施例2
称取漆大姑根6g、千金花5g、千脚虫1g、秦艽5g、二仙桃3g、蜂房2g、猫眼草2g、筋骨草4g、风湿木3g、欧当归4g、檀香3g、芙蓉花5g、枇杷叶3g、瓜蒌2g、 木通1g、大黄4g、黄柏4g、莪术3g、万年柏3g、甘草5g；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗脚气。口服，每日一次。
具体实施例3
称取漆大姑根6g、千金花5g、千脚虫1g、秦艽5g、二仙桃3g、蜂房2g、猫眼草2g、筋骨草4g、风湿木3g、欧当归4g、檀香3g、芙蓉花5g、枇杷叶3g、瓜蒌2g、 木通1g、大黄4g、黄柏4g、莪术3g、万年柏3g、甘草5g；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人一天用量的颗粒剂。
用于治疗脚气。口服，每日分早中晚三次服用。
Claims (1)
1.一种治疗脚气的中药，其特征在于，它是由以下重量配比的原料药材制备而成：漆大姑根6份、千金花5份、千脚虫1份、秦艽5份、二仙桃3份、蜂房2份、猫眼草2份、筋骨草4份、风湿木3份、欧当归4份、檀香3份、芙蓉花5份、枇杷叶3份、瓜蒌2份、 木通1份、大黄4份、黄柏4份、莪术3份、万年柏3份、甘草5份。
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