CN108243607A - 用于免疫疗法的巨噬细胞的遗传工程 - Google Patents

用于免疫疗法的巨噬细胞的遗传工程 Download PDF

Info

Publication number
CN108243607A
CN108243607A CN201680065510.4A CN201680065510A CN108243607A CN 108243607 A CN108243607 A CN 108243607A CN 201680065510 A CN201680065510 A CN 201680065510A CN 108243607 A CN108243607 A CN 108243607A
Authority
CN
China
Prior art keywords
alternatives
cells
cell
immunocyte
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680065510.4A
Other languages
English (en)
Chinese (zh)
Inventor
考特尼·克兰
迈克尔·C·延森
卡拉·怀特·莫伊斯
尼科尔·利伯曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seattle Childrens Hospital
Original Assignee
Seattle Childrens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Childrens Hospital filed Critical Seattle Childrens Hospital
Publication of CN108243607A publication Critical patent/CN108243607A/zh
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/17Monocytes; Macrophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24Antigen-presenting cells [APC]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31Chimeric antigen receptors [CAR]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32T-cell receptors [TCR]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/521Chemokines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/56IFN-alpha
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0645Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Developmental Biology & Embryology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201680065510.4A 2015-09-09 2016-09-07 用于免疫疗法的巨噬细胞的遗传工程 Pending CN108243607A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562216224P 2015-09-09 2015-09-09
US62/216,224 2015-09-09
US201662361348P 2016-07-12 2016-07-12
US62/361,348 2016-07-12
PCT/US2016/050552 WO2017044487A1 (en) 2015-09-09 2016-09-07 Genetic engineering of macrophages for immunotherapy

Publications (1)

Publication Number Publication Date
CN108243607A true CN108243607A (zh) 2018-07-03

Family

ID=58240865

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680065510.4A Pending CN108243607A (zh) 2015-09-09 2016-09-07 用于免疫疗法的巨噬细胞的遗传工程

Country Status (9)

Country Link
US (3) US10525082B2 (https=)
EP (1) EP3347026A4 (https=)
JP (3) JP6959909B2 (https=)
CN (1) CN108243607A (https=)
AU (1) AU2016318773B2 (https=)
CA (1) CA2997912A1 (https=)
HK (1) HK1257460A1 (https=)
SG (1) SG10201913151TA (https=)
WO (1) WO2017044487A1 (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110760480A (zh) * 2019-07-09 2020-02-07 杭州师范大学 一种抗肿瘤nk细胞及其制备方法
CN111087460A (zh) * 2020-01-14 2020-05-01 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) 一种广谱型抗菌肽及其应用
CN111150748A (zh) * 2019-12-27 2020-05-15 杭州荣谷生物科技有限公司 重组溶瘤病毒在制备治疗消化道癌药物中的用途
WO2020125576A1 (zh) * 2018-12-17 2020-06-25 苏州克睿基因生物科技有限公司 一种在细胞中递送基因的方法
CN113748124A (zh) * 2019-02-27 2021-12-03 阿克蒂姆治疗有限公司 工程化以定植肿瘤、肿瘤驻留免疫细胞和肿瘤微环境的免疫刺激性细菌
CN114945375A (zh) * 2019-09-11 2022-08-26 小利兰·斯坦福大学托管委员会 嵌合正交受体蛋白和使用方法
CN115996733A (zh) * 2020-06-22 2023-04-21 南京传奇生物科技有限公司 用于免疫疗法的基因工程化γδT细胞
CN119020422A (zh) * 2024-10-28 2024-11-26 昆明医科大学 一种稳转萤火虫萤光素酶靶细胞株的构建方法及其应用

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2934532B1 (en) 2012-12-20 2019-10-23 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
GB201418965D0 (https=) 2014-10-24 2014-12-10 Ospedale San Raffaele And Fond Telethon
US20170151281A1 (en) 2015-02-19 2017-06-01 Batu Biologics, Inc. Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
CN108243607A (zh) 2015-09-09 2018-07-03 西雅图儿童医院(Dba西雅图儿童研究所) 用于免疫疗法的巨噬细胞的遗传工程
EP3411479A4 (en) 2016-02-04 2019-09-18 Zhenglun Zhu TREATMENT AND DIAGNOSIS OF INFLAMMATORY DISEASES
US11753653B2 (en) 2016-03-25 2023-09-12 Periphagen, Inc. High-transducing HSV vectors
JP7282521B2 (ja) 2016-04-08 2023-05-29 パーデュー・リサーチ・ファウンデイション Car t細胞療法のための方法および組成物
JP7178355B2 (ja) 2017-02-28 2022-11-25 エンドサイト・インコーポレイテッド Car t細胞療法のための組成物および方法
WO2018183447A1 (en) * 2017-03-28 2018-10-04 Zhenglun Zhu Methods of treating neoplastic diseases
EP4317422A3 (en) * 2017-04-13 2024-05-01 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
CN118147137A (zh) * 2017-05-17 2024-06-07 西雅图儿童医院(Dba西雅图儿童研究所) 生成哺乳动物t细胞活化诱导型合成启动子(syn+pro)以改善t细胞疗法
EP3652318A1 (en) 2017-07-11 2020-05-20 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
BR112020008478A2 (pt) * 2017-11-01 2020-10-20 Editas Medicine, Inc. métodos, composições e componentes para edição de crispr-cas9 de tgfbr2 em células t para imunota-rapia
WO2019099993A1 (en) * 2017-11-17 2019-05-23 Memorial Sloan-Kettering Cancer Center Methods and compositions for alleviating cytokine release syndrome
JP7549303B2 (ja) 2018-01-22 2024-09-11 エンドサイト・インコーポレイテッド Car t細胞の使用方法
CN112105382A (zh) 2018-02-23 2020-12-18 恩多塞特公司 用于car t细胞疗法的顺序方法
DE102018108612A1 (de) 2018-03-21 2019-09-26 Immatics US, Inc. Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen
US11267866B2 (en) 2018-04-04 2022-03-08 Nant Holdings Ip, Llc Immunoglobulin complex comprising interleukin-15
TWI784324B (zh) * 2018-04-12 2022-11-21 美商凱特製藥公司 利用腫瘤微環境之特性之嵌合受體t細胞治療
CN108727504B (zh) * 2018-04-16 2021-08-27 泉州向日葵生物科技有限公司 一种ifn与抗pd-l1抗体的融合蛋白及其应用
US10869888B2 (en) 2018-04-17 2020-12-22 Innovative Cellular Therapeutics CO., LTD. Modified cell expansion and uses thereof
JP7555822B2 (ja) 2018-04-19 2024-09-25 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア ゲノム編集のための組成物および方法
US12410231B2 (en) 2018-05-07 2025-09-09 Board Of Regents Of The University Of Texas System Natural killer cell products and methods
US12527821B2 (en) 2018-05-15 2026-01-20 The Brigham And Women's Hospital, Inc. Compositions and methods related to tumor cell killers and vaccines
US20210254068A1 (en) * 2018-06-19 2021-08-19 Regents Of The University Of Minnesota Genome engineering primary monocytes
WO2020014543A2 (en) 2018-07-11 2020-01-16 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
CN108823171A (zh) * 2018-07-24 2018-11-16 武汉赛云博生物科技有限公司 一种基因工程细胞及体外高效扩增nk细胞的方法
US12240915B2 (en) 2018-08-30 2025-03-04 Innovative Cellular Therapeutics Holdings, Ltd. Chimeric antigen receptor cells for treating solid tumor
GB201818110D0 (en) * 2018-11-06 2018-12-19 Macrophox Ltd Monocytes for cancer targeting
EP3876977A1 (en) 2018-11-06 2021-09-15 The Regents Of The University Of California Chimeric antigen receptors for phagocytosis
EP3883585A4 (en) * 2018-11-20 2022-12-14 Innovative Cellular Therapeutics Holdings, Ltd. MODIFIED CELL EXPRESSING THERAPEUTIC AND USES THEREOF
EP3917967A4 (en) * 2019-02-01 2023-02-08 Seattle Children's Hospital (DBA Seattle Children's Research Institute) Microenvironment sensors to regulate engineered gene expression
US12024709B2 (en) 2019-02-27 2024-07-02 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
JP2022531814A (ja) * 2019-03-12 2022-07-12 イノベイティブ セルラー セラピューティクス ホールディングス,エルティディ 改変細胞の増幅およびその応用
WO2020198510A1 (en) * 2019-03-28 2020-10-01 Sierra Oncology, Inc. Methods of treating cancer with chk1 inhibitors
US11013764B2 (en) 2019-04-30 2021-05-25 Myeloid Therapeutics, Inc. Engineered phagocytic receptor compositions and methods of use thereof
JP7831937B2 (ja) 2019-09-03 2026-03-17 クリエイト・メディシンズ,インコーポレーテッド ゲノム組込みのための方法および組成物
CA3151223A1 (en) * 2019-09-17 2021-03-25 Pravin T.P. Kaumaya Human anti-pd-l1 peptide vaccines and methods of their use
WO2021064655A1 (en) * 2019-10-02 2021-04-08 Massachusetts Institute Of Technology High-throughput genetic screening
US10980836B1 (en) 2019-12-11 2021-04-20 Myeloid Therapeutics, Inc. Therapeutic cell compositions and methods of manufacturing and use thereof
US12076343B2 (en) 2020-02-19 2024-09-03 Innovative Cellular Therapeutics Holdings, Ltd. Engineered safety in cell therapy
IL296511A (en) 2020-03-20 2022-11-01 Lyell Immunopharma Inc Novel recombinant cell surface markers
TW202204348A (zh) 2020-04-07 2022-02-01 美商西爾拉癌症醫學公司 Chk1抑制劑之合成方法
GB202007906D0 (en) 2020-05-27 2020-07-08 Univ Edinburgh Method of transfecting macrophages
US12043654B2 (en) 2020-06-02 2024-07-23 Innovative Cellular Therapeutics Holdings, Ltd. Anti-GCC antibody and CAR thereof for treating digestive system cancer
CN115867294A (zh) 2020-06-04 2023-03-28 凯瑞斯马治疗公司 嵌合抗原受体的新型构建体
CA3197423A1 (en) 2020-11-04 2022-05-12 Daniel Getts Engineered chimeric fusion protein compositions and methods of use thereof
TW202241508A (zh) * 2021-01-29 2022-11-01 美商艾歐凡斯生物治療公司 細胞介素相關之腫瘤浸潤性淋巴球組合物及方法
AU2022227686A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
EP4308133A4 (en) 2021-03-17 2025-01-22 Myeloid Therapeutics, Inc. MANIPULATED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF
AU2022272235A1 (en) 2021-05-11 2023-12-21 Create Medicines, Inc. Methods and compositions for genomic integration
KR20240055714A (ko) * 2021-07-09 2024-04-29 레전드 바이오테크 아일랜드 리미티드 돌연변이 il-15 조성물 및 이의 방법
WO2023053828A1 (ja) * 2021-09-30 2023-04-06 テルモ株式会社 化学療法制御装置、化学療法制御システム、化学療法制御装置の制御方法及び化学療法制御プログラム
US20250000974A1 (en) * 2021-10-27 2025-01-02 The Regents Of The University Of California Combination of human natural killer cells and macrophages for cancer therapy
CN114404600B (zh) * 2022-01-21 2023-06-27 首都医科大学附属北京同仁医院 一种用于治疗肿瘤的药物组合及其应用
CN114657143B (zh) * 2022-03-11 2022-10-25 西安电子科技大学 一种肿瘤微环境调控型car-单核/巨噬细胞及其制备方法和应用
IL316314A (en) * 2022-04-18 2024-12-01 Candel Therapeutics Inc Compositions and methods for viral vectors
US20250312486A1 (en) * 2022-04-18 2025-10-09 City Of Hope Compositions for restoring mecp2 gene function and methods of use thereof
WO2024215990A2 (en) * 2023-04-13 2024-10-17 William Marsh Rice University Regulated cells expressing cytokines
WO2025251079A1 (en) * 2024-05-31 2025-12-04 University Of Massachusetts Rna compositions and methods of use thereof in the treatment of cancer
WO2026062037A1 (en) 2024-09-18 2026-03-26 Myllia Biotechnology Gmbh Gene perturbation in human monocyte-derived macrophages
WO2026069312A1 (en) 2024-09-24 2026-04-02 Yeda Research And Development Co. Ltd. Immune cells expressing an inducible therapeutic agent and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101330830A (zh) * 2005-10-18 2008-12-24 国家犹太医学研究中心 条件无限增殖化长期干细胞和制备和使用所述细胞的方法
US20120003220A1 (en) * 2002-10-04 2012-01-05 Lieping Chen B7-DC Variants
CN103119054A (zh) * 2010-03-26 2013-05-22 达特茅斯大学理事会 Vista调节性t细胞介体蛋白、vista结合剂及其用途
WO2014201212A1 (en) * 2013-06-12 2014-12-18 The Board Of Trustees Of The Leland Stanford Junior University IgE ANTIBODIES FOR THE INHIBITION OF TUMOR METASTASIS
WO2015120363A1 (en) * 2014-02-10 2015-08-13 Emory University Expression of chimeric polypeptide with variable lymphocyte receptors on immune cells and uses for treating cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2286819A1 (en) 1997-04-17 1998-10-22 Flossie Wong-Staal Use of lentiviral vectors for antigen presentation in dendritic cells
US7919079B2 (en) 2006-03-31 2011-04-05 Biosante Pharmaceuticals, Inc. Cancer immunotherapy compositions and methods of use
US9023648B2 (en) * 2009-12-30 2015-05-05 University Of Massachusetts Method of transducing non-dividing myeloid cells utilizing chimeric murine leukemia viruses containing Vpx
CN110200997A (zh) * 2011-03-23 2019-09-06 弗雷德哈钦森癌症研究中心 用于细胞免疫治疗的方法和组合物
EP3692794A1 (en) 2011-09-16 2020-08-12 Baylor College of Medicine Targeting the tumor microenvironment using manipulated nkt cells
JP6850528B2 (ja) * 2012-02-13 2021-03-31 シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート 二重特異性キメラ抗原受容体およびその治療的使用
US9713635B2 (en) 2012-03-30 2017-07-25 Immune Design Corp. Materials and methods for producing improved lentiviral vector particles
US8323662B1 (en) * 2012-03-30 2012-12-04 Immune Design Corp. Methods useful for generating highly mannosylated pseudotyped lentiviral vector particles comprising a Vpx protein
CA2881981A1 (en) 2012-08-20 2014-02-27 Fred Hutchinson Cancer Research Center Method and compositions for cellular immunotherapy
EP2906684B8 (en) * 2012-10-10 2020-09-02 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
WO2014164544A1 (en) * 2013-03-09 2014-10-09 Baylor College Of Medicine Vascular-targeted t-cell therapy
RU2766690C2 (ru) 2015-07-28 2022-03-15 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Модифицированные моноциты/макрофаги, экспрессирующие химерные антигенные рецепторы, и их применения
US11352439B2 (en) 2015-08-13 2022-06-07 Kim Leslie O'Neill Macrophage CAR (MOTO-CAR) in immunotherapy
CN108243607A (zh) 2015-09-09 2018-07-03 西雅图儿童医院(Dba西雅图儿童研究所) 用于免疫疗法的巨噬细胞的遗传工程

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120003220A1 (en) * 2002-10-04 2012-01-05 Lieping Chen B7-DC Variants
CN101330830A (zh) * 2005-10-18 2008-12-24 国家犹太医学研究中心 条件无限增殖化长期干细胞和制备和使用所述细胞的方法
CN103119054A (zh) * 2010-03-26 2013-05-22 达特茅斯大学理事会 Vista调节性t细胞介体蛋白、vista结合剂及其用途
WO2014201212A1 (en) * 2013-06-12 2014-12-18 The Board Of Trustees Of The Leland Stanford Junior University IgE ANTIBODIES FOR THE INHIBITION OF TUMOR METASTASIS
WO2015120363A1 (en) * 2014-02-10 2015-08-13 Emory University Expression of chimeric polypeptide with variable lymphocyte receptors on immune cells and uses for treating cancer

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ALEJANDRO CHAVEZ等: "Highly efficient Cas9-mediated transcriptional programming", 《NATURE METHODS》 *
K NISHIHARA等: "Increased in vitro and in vivo tumoricidal activity of a macrophage cell line genetically engineered to express IFN-gamma, IL-4, IL-6, or TNF-alpha", 《CANCER GENE THRE》 *
OPHIR SHALEM等: "Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells", 《SCIENCE》 *
ROSENBERG S.A.: "《癌症生物治疗学 原理与实践 第3版》", 30 June 2005, 北京:人民军医出版社 *
S BOBADILLA等: "Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein", 《GENE THERAPY》 *
孙凌云: "《分子风湿病学》", 30 June 1997, 呼和浩特:内蒙古人民出版社 *
杜文力等: "《肿瘤科合理用药》", 31 January 2009, 北京:中国医药科技出版社 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020125576A1 (zh) * 2018-12-17 2020-06-25 苏州克睿基因生物科技有限公司 一种在细胞中递送基因的方法
CN113226336A (zh) * 2018-12-17 2021-08-06 苏州克睿基因生物科技有限公司 一种在细胞中递送基因的方法
EP3912629A4 (en) * 2018-12-17 2022-10-12 Cure Genetics Co., Ltd METHODS OF INTRODUCING GENE INTO CELLS
CN113226336B (zh) * 2018-12-17 2024-03-15 苏州克睿基因生物科技有限公司 一种在细胞中递送基因的方法
CN113748124A (zh) * 2019-02-27 2021-12-03 阿克蒂姆治疗有限公司 工程化以定植肿瘤、肿瘤驻留免疫细胞和肿瘤微环境的免疫刺激性细菌
CN110760480A (zh) * 2019-07-09 2020-02-07 杭州师范大学 一种抗肿瘤nk细胞及其制备方法
CN114945375A (zh) * 2019-09-11 2022-08-26 小利兰·斯坦福大学托管委员会 嵌合正交受体蛋白和使用方法
CN111150748A (zh) * 2019-12-27 2020-05-15 杭州荣谷生物科技有限公司 重组溶瘤病毒在制备治疗消化道癌药物中的用途
CN111087460A (zh) * 2020-01-14 2020-05-01 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) 一种广谱型抗菌肽及其应用
CN111087460B (zh) * 2020-01-14 2021-07-30 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) 一种广谱型抗菌肽及其应用
CN115996733A (zh) * 2020-06-22 2023-04-21 南京传奇生物科技有限公司 用于免疫疗法的基因工程化γδT细胞
CN119020422A (zh) * 2024-10-28 2024-11-26 昆明医科大学 一种稳转萤火虫萤光素酶靶细胞株的构建方法及其应用

Also Published As

Publication number Publication date
EP3347026A1 (en) 2018-07-18
HK1257460A1 (zh) 2019-10-18
AU2016318773A1 (en) 2018-04-12
US20240091256A1 (en) 2024-03-21
WO2017044487A1 (en) 2017-03-16
CA2997912A1 (en) 2017-03-16
EP3347026A4 (en) 2019-05-08
US20170087185A1 (en) 2017-03-30
JP2023109956A (ja) 2023-08-08
US11826384B2 (en) 2023-11-28
US20200155597A1 (en) 2020-05-21
JP2021118723A (ja) 2021-08-12
JP7298103B2 (ja) 2023-06-27
US10525082B2 (en) 2020-01-07
SG10201913151TA (en) 2020-03-30
JP6959909B2 (ja) 2021-11-05
AU2016318773B2 (en) 2024-08-01
JP2018528774A (ja) 2018-10-04

Similar Documents

Publication Publication Date Title
JP7298103B2 (ja) 免疫療法のためのマクロファージの遺伝子組換え
TWI908706B (zh) CARTyrin組成物和使用方法
JP2022087199A (ja) 細胞の異なる亜型の活性を選択的にモジュレートするための方法
Moyes et al. Genetically engineered macrophages: a potential platform for cancer immunotherapy
JP7233720B2 (ja) ヒトメソセリンを特異的に認識する細胞表面分子、il-7、及びccl19を発現する免疫担当細胞
TWI841576B (zh) 用於治療傳染病之共受體系統
JP2021121208A (ja) 改変t細胞に関する方法および組成物
US12358994B2 (en) Antibody-modified chimeric antigen receptor modified T cell and uses thereof
KR20190039397A (ko) 인간 백혈구 항원 제한된 감마 델타 t 세포 수용체 및 이의 사용 방법
AU2016328279A1 (en) Methods and compositions for reducing metastases
CN113727720A (zh) 用于治疗表达cldn6的癌症的嵌合抗原受体修饰的细胞
JP2025061188A (ja) キメラサイトカイン受容体
KR20210098940A (ko) Ebv 관련 암의 치료를 위한 항-lmp2 tcr-t 세포 요법
CN119998322A (zh) 基因编辑靶基因以增强自然杀伤细胞功能
WO2007142241A1 (ja) 抗cd38抗体を細胞表面に有する免疫担当細胞
CN102453701B (zh) 基因修饰CDR3δ移植型γδT淋巴细胞及其抑癌用途
CN111849905B (zh) 间充质干细胞靶向运输趋化因子和细胞因子的免疫疗法
JP2022547866A (ja) 同種異系細胞組成物と使用方法
CN115348868A (zh) 表达bcma特异性嵌合抗原受体的基因工程化t细胞及其在癌症疗法中的用途
Hughson et al. Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer
US20250222107A1 (en) Anti-bcma car to target immune-related disorders, compositions and method thereof
Bockman Reinvigorating Antitumor Immune Responses & Tumor Antigen Priming Through the Disruption of Tumor Treg Suppression
CN115975050A (zh) 嵌合的人源t细胞受体、核酸、载体、细胞和药物组合物
Xia Cancer Immunogene Therapy Using Viral Vectors Encoding Cytokines and Chimeric Antigen Receptors
TW202417617A (zh) 低免疫原性之經修飾細胞

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination