CN108210536A - A kind of ginsenoside particle and preparation method thereof - Google Patents

A kind of ginsenoside particle and preparation method thereof Download PDF

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Publication number
CN108210536A
CN108210536A CN201810285552.XA CN201810285552A CN108210536A CN 108210536 A CN108210536 A CN 108210536A CN 201810285552 A CN201810285552 A CN 201810285552A CN 108210536 A CN108210536 A CN 108210536A
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CN
China
Prior art keywords
ginsenoside
particle
preparation
raw material
mesh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810285552.XA
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Chinese (zh)
Inventor
孙华庚
李月
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JIANFENG NATURAL PRODUCT R&D DEVELOPMENT Co Ltd TIANJIN
Original Assignee
JIANFENG NATURAL PRODUCT R&D DEVELOPMENT Co Ltd TIANJIN
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Filing date
Publication date
Application filed by JIANFENG NATURAL PRODUCT R&D DEVELOPMENT Co Ltd TIANJIN filed Critical JIANFENG NATURAL PRODUCT R&D DEVELOPMENT Co Ltd TIANJIN
Priority to CN201810285552.XA priority Critical patent/CN108210536A/en
Publication of CN108210536A publication Critical patent/CN108210536A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Abstract

The present invention provides a kind of ginsenoside particle and preparation method thereof, belongs to food processing technology field.The ginsenoside particle is made of the raw material of following weight percentage:Ginsenoside raw material 2% 50%, dextrin 5% 90%;The preparation method includes weighing, mixing, softwood processed, granulation, drying, whole grain, sieving.The ginsenoside particle of the present invention has the grain graininess of 40 80 mesh, and good fluidity, dissolubility is good, and content is high.It can be very good to carry out compounding addition with other products, improve product quality, curative effect.

Description

A kind of ginsenoside particle and preparation method thereof
Technical field
The present invention relates to a kind of ginsenoside particles and preparation method thereof.
Background technology
Modern social development's speed is fast, and people’s lives rhythm is gradually accelerated, and allegro life makes people obtain more While the material life got well, the degree of fatigue of body itself is also aggravating.In order to alleviate physical fatigue, in addition to appropriate exercise Outside body, the quick method for eliminating physical fatigue is reached by additionally supplementing various substances needed for body, trace element etc. Also it is gradually accepted by people.
Ginseng has tonifying five zang organs, soothe the nerves, determines the effect of soul, stop palpitate with fear, remove pathogenic factor, improving eyesight happy intelligence development, and long term usage is made light of one's life by commiting suicide Macrobiosis is used as excellent tonic product always for thousands of years.
Invention content
The purpose of the present invention is invent a kind of particle containing certain content of ginsenoside.
The second object of the present invention is to provide a kind of preparation method of ginsenoside particle
Technical scheme of the present invention is summarized as follows:
1st, a kind of ginsenoside particle, is made in parts by weight of following raw materials according:Ginsenoside raw material 2%-50%, dextrin 5%-90%
Preferably:Ginsenoside raw material 33%, dextrin 67%.
2nd, a kind of preparation method of ginsenoside particle, includes the following steps:
(1)It weighs:Following raw materials according is weighed by weight percentage:Ginsenoside raw material 2%-50%, dextrin 5%-90%;
(2)Mixing:By the ginsenoside raw material and the abundant mixing of dextrin, 80 mesh screens are crossed;
(3)Softwood processed:By step(2)In mixed powder 15kg be transferred in trough type mixing machine, open trough type mixing machine, it is quick plus Enter 30% ethanol solution 5.4kg, continuously stir 5min softwoods;
(4)Granulation:Made softwood is transferred to and is waved in comminutor, 16 mesh screens carry out oscillating granulation;
(5)It is dry:It will make pellet to be transferred in drying cart and be dried, 24 hours drying times, 45 DEG C of drying temperature;
(6)Whole grain:Made ginsenoside particle is subjected to whole grain with oscillating granulator, sieve used is 40 mesh;
(7)Sieving:By step(6)Institute's pelleting is sieved with shaking screen, and upper screen is 40 mesh, and lower screen is 80 mesh.
Preferably:Ginsenoside raw material 33%, dextrin 67%.
In the ginsenoside particle of the present invention, the ginsenoside containing certain content, ginsenoside is the main work(of ginseng Imitate ingredient.Ginseng is for keeping fit and healthy, prolonging life with significant effect.Ginsenoside is to the central nervous system of adjusting people System, cardiac stimulant, antifatigue, Auto-regulator metabolism etc. have apparent effect, so to treatment nervous system cardiovascular systems, endocrine System and a variety of diseases of reproductive system have good therapeutic effect.
The ginsenoside particle of the present invention has the grain graininess of 40-80 mesh, and good fluidity, dissolubility is good, and content is high.It can To carry out compounding addition with other products well, product quality, curative effect are improved.
Specific embodiment
Below by specific embodiment, the present invention is further illustrated, and the embodiment of the present invention is to make this field Technical staff more fully understand the present invention, but be not used to impose any restrictions the present invention.
Embodiment 1
A kind of ginsenoside particle and preparation method thereof includes each component of following weight percent:Ginsenoside raw material 33, paste Essence 67%.
The production method of the present embodiment:
(1)It weighs:Following raw materials according is weighed by weight percentage:Ginsenoside raw material 33%, dextrin 67%;
(2)Mixing:By the ginsenoside raw material and the abundant mixing of dextrin, 80 mesh screen 2 times are crossed;
(3)Softwood processed:By step(2)In mixed powder 15kg be transferred in trough type mixing machine, open trough type mixing machine, it is quick plus Enter 30% ethanol solution 5.4kg, continuously stir 5min softwoods;
(4)Granulation:Made softwood is transferred to and is waved in comminutor, 16 mesh screens carry out oscillating granulation;
(5)It is dry:It will make pellet to be transferred in drying cart and be dried, 24 hours drying times, 45 DEG C of drying temperature;
(6)Whole grain:Made ginsenoside particle is subjected to whole grain with oscillating granulator, sieve used is 40 mesh;
(7)Sieving:By step(6)Institute's pelleting is sieved with shaking screen, and upper screen is 40 mesh, and lower screen is 80 mesh.
Embodiment 2
A kind of ginsenoside particle and preparation method thereof includes each component of following weight percent:Ginsenoside raw material 15%, Dextrin 85%.
The production method of the present embodiment:
(1)It weighs:Following raw materials according is weighed by weight percentage:Ginsenoside raw material 15%, dextrin 85%;
(2)Mixing:By the ginsenoside raw material and the abundant mixing of dextrin, 80 mesh screen 2 times are crossed;
(3)Softwood processed:By step(2)In mixed powder 15kg be transferred in trough type mixing machine, open trough type mixing machine, it is quick plus Enter 30% ethanol solution 5.4kg, continuously stir 5min softwoods;
(4)Granulation:Made softwood is transferred to and is waved in comminutor, 16 mesh screens carry out oscillating granulation;
(5)It is dry:It will make pellet to be transferred in drying cart and be dried, 24 hours drying times, 45 DEG C of drying temperature;
(6)Whole grain:Made ginsenoside particle is subjected to whole grain with oscillating granulator, sieve used is 40 mesh;
(7)Sieving:By step(6)Institute's pelleting is sieved with shaking screen, and upper screen is 40 mesh, and lower screen is 80 mesh.
Embodiment 3
A kind of ginsenoside particle and preparation method thereof includes each component of following weight percent:Ginsenoside raw material 45%, Dextrin 55%.
The production method of the present embodiment:
(1)It weighs:Following raw materials according is weighed by weight percentage:Ginsenoside raw material 45%, dextrin 55%;
(2)Mixing:By the ginsenoside raw material and the abundant mixing of dextrin, 80 mesh screen 2 times are crossed;
(3)Softwood processed:By step(2)In mixed powder 15kg be transferred in trough type mixing machine, open trough type mixing machine, it is quick plus Enter 30% ethanol solution 5.4kg, continuously stir 5min softwoods;
(4)Granulation:Made softwood is transferred to and is waved in comminutor, 16 mesh screens carry out oscillating granulation;
(5)It is dry:It will make pellet to be transferred in drying cart and be dried, 24 hours drying times, 45 DEG C of drying temperature;
(6)Whole grain:Made ginsenoside particle is subjected to whole grain with oscillating granulator, sieve used is 40 mesh;
(7)Sieving:By step(6)Institute's pelleting is sieved with shaking screen, and upper screen is 40 mesh, and lower screen is 80 mesh.
Embodiment 4
A kind of ginsenoside particle and preparation method thereof includes each component of following weight percent:Ginsenoside raw material 10%, Dextrin 90%.
The production method of the present embodiment:
(1)It weighs:Following raw materials according is weighed by weight percentage:Ginsenoside raw material 10%, dextrin 90%;
(2)Mixing:By the ginsenoside raw material and the abundant mixing of dextrin, 80 mesh screen 2 times are crossed;
(3)Softwood processed:By step(2)In mixed powder 15kg be transferred in trough type mixing machine, open trough type mixing machine, it is quick plus Enter 30% ethanol solution 5.4kg, continuously stir 5min softwoods;
(4)Granulation:Made softwood is transferred to and is waved in comminutor, 16 mesh screens carry out oscillating granulation;
(5)It is dry:It will make pellet to be transferred in drying cart and be dried, 24 hours drying times, 45 DEG C of drying temperature;
(6)Whole grain:Made ginsenoside particle is subjected to whole grain with oscillating granulator, sieve used is 40 mesh;
(7)Sieving:By step(6)Institute's pelleting is sieved with shaking screen, and upper screen is 40 mesh, and lower screen is 80 mesh.
Therapeutic effect:
For show the present invention to keeping fit and healthy, fatigue-relieving the effect of, the present invention with 1 products made thereby of embodiment to ginsenoside Grain carries out human body eating effect experiment.
For often work overtime stay up late, operating pressure is big, feels the tired clerk of body often;When often carrying out long Between, weight muscle power staff;It just recovers from a dangerous illness for some, physically weak, the all-overish patient of body weight.In this 3 class crowd into Row eating effect is tested.It tests component and uses 15-25 Sui;25-35 Sui;35-45 Sui;45-55 Sui four age groups, every group 20 People, each 10 people of men and women.Experimental group eats 1 products made thereby of embodiment, 2 times a day, takes in content of ginsenoside 100mg every time.
Tracking test 1 month, each frank improvement of age group physical fatigue of experimental group, effective percentage reach 98%.
The above description is merely a specific embodiment, but protection scope of the present invention is not limited thereto, any Those familiar with the art in the technical scope disclosed by the present invention, can readily occur in change or replacement, should all contain Lid is within protection scope of the present invention.Therefore, protection scope of the present invention described should be subject to the protection scope in claims.

Claims (12)

1. a kind of ginsenoside particle and preparation method thereof, it is characterized in that being made by weight percentage of following raw materials according:Ginseng soap Glycosides raw material 2%-50%, dextrin 5%-90%.
2. a kind of ginsenoside particle and preparation method thereof according to claim 1, it is characterized in that the ginsenoside raw material 33%th, dextrin 67%.
3. a kind of ginsenoside particle and preparation method thereof according to claim 1, it is characterized in that ginsenoside raw material used Middle content of ginsenoside is 30%.
4. a kind of ginsenoside particle and preparation method thereof, it is characterized in that including the following steps:
(1)It weighs:Following raw materials according is weighed by weight percentage:Ginsenoside raw material 2%-50%, dextrin 5%-90%;
(2)Mixing:By the ginsenoside raw material and the abundant mixing of dextrin, 80 mesh screens are crossed;
(3)Softwood processed:By step(2)In mixed powder be transferred in trough type mixing machine, open trough type mixing machine, rapidly join second Alcoholic solution continuously stirs softwood processed;
(4)Granulation:Made softwood is transferred to and is waved in comminutor, carries out oscillating granulation;
(5)It is dry:It will make pellet to be transferred in drying cart and be dried;
(6)Whole grain:Made ginsenoside particle is subjected to whole grain with oscillating granulator;
(7)Sieving:By step(6)Institute's pelleting is sieved with shaking screen.
5. a kind of ginsenoside particle and preparation method thereof according to claim 4, it is characterized in that ginsenoside raw material 33%, Dextrin 67%.
6. a kind of ginsenoside particle and preparation method thereof according to claim 4, it is characterized in that step(3)Described in system it is soft During material, the ratio of powder and ethanol solution is 15:5.4.
7. a kind of ginsenoside particle and preparation method thereof according to claim 4, it is characterized in that step(3)Described in ethyl alcohol Solution is the ethanol solution of 30% ethanol content.
8. a kind of ginsenoside particle and preparation method thereof according to claim 4, it is characterized in that step(3)Described in it is continuous Mixing time is 5 minutes.
9. a kind of ginsenoside particle and preparation method thereof according to claim 4, it is characterized in that step(4)Described in wave Sieve used in granulator is 16 mesh.
10. a kind of ginsenoside particle and preparation method thereof according to claim 4, it is characterized in that step(5)Described in do Dry drying time is 24 hours, and drying temperature is 45-50 DEG C.
11. a kind of ginsenoside particle and preparation method thereof according to claim 4, it is characterized in that step(6)Described in it is whole Sieve used in grain is 40 mesh.
12. a kind of ginsenoside particle and preparation method thereof according to claim 4, it is characterized in that step(7)Described in shake The upper screen for swinging sieve is 40 mesh, and lower screen is 80 mesh.
CN201810285552.XA 2018-04-03 2018-04-03 A kind of ginsenoside particle and preparation method thereof Pending CN108210536A (en)

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Application Number Priority Date Filing Date Title
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Publication Number Publication Date
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111973642A (en) * 2020-08-05 2020-11-24 华中农业大学 Ginseng granules and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101138545A (en) * 2006-09-08 2008-03-12 广州天安医药科技有限公司 Clathrate compound containing ginsenoside Rg2 and method of preparing the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101138545A (en) * 2006-09-08 2008-03-12 广州天安医药科技有限公司 Clathrate compound containing ginsenoside Rg2 and method of preparing the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111973642A (en) * 2020-08-05 2020-11-24 华中农业大学 Ginseng granules and preparation method thereof

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Application publication date: 20180629