CN101574146B - Sports nutritional supplement containing HMB - Google Patents
Sports nutritional supplement containing HMB Download PDFInfo
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- CN101574146B CN101574146B CN200810106031XA CN200810106031A CN101574146B CN 101574146 B CN101574146 B CN 101574146B CN 200810106031X A CN200810106031X A CN 200810106031XA CN 200810106031 A CN200810106031 A CN 200810106031A CN 101574146 B CN101574146 B CN 101574146B
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Abstract
The invention relates to a sports nutritional supplement containing HMB. The sports nutritional supplement takes HMB as a main raw material, and also comprises phosphate and taurine; moreover, the supplement can be added with creatine. The supplement can effectively reduce the decomposition of protein (muscle) after a strenuous exercise, increase the lean body mass, obviously relieve the damage extent of muscular cells, resist the exercise fatigue and improve the athletic ability of an organism.
Description
Technical field
The present invention relates to a kind of nourishing tonic for sport, specifically, be a kind of be main with HMB, be used phosphate, taurine, also can add the nourishing tonic for sport of creatine.
Background technology
HMB is the abbreviation of β-hydroxy-β-methylbutyrate (beta-hydroxy-Beta-methyl butyric acid), is at first found in 1988 by Steven doctor Nissen.People such as Nissen do time spent at protein in the synthetic and anti-catabolic process at the research leucine; Find leucine and wherein between metabolin KIC (α-ketoisocaproate; KIC) can save the utilization of nitrogen in the body; Play an important role aspect synthetic at muscle, when observing the reverse metabolic pathway of KIC, found HMB.Leucine is a branched-chain amino acid, belongs to essential amino acid, can not produce in vivo, and is very important to health, and the mankind must rely on diet to guarantee leucic picked-up, and HMB is leucic mesostate.Movement human uses HMB can promote muscle volume to increase and improves strength, goes back incendivity fat, increases endurance.At present, though publication number be CN1417190 and CN1434025 patent report the synthetic method of HMB amino-acid salt, still have nothing to do and use, especially with the report of phosphate coupling in this field in HMB.
Since HMB in 1996 gets into nutriment market, caused numerous medical science and nutritionist's very big interest.Nowadays, the same creatine of HMB, lactalbumin become sportsman and body builder's favorite exercise nutritional supplement together.HMB has the purposes of phenomenal growth muscle, burning fat, and existing various sportsmen are using HMB in the U.S., and have obtained good effect.Comprising one of sportsman the most healthy and the strongest in vigorous and graceful champion Bill Davey and Dan Gwantney, the whole America professional football league (NFL) Shannon Sharpe etc., and the message of tool sensational effect is " swimmer that wins the gold medal of 1996 Games in Atlanta replenishes HMB and reaps no little benefit in training ".At present, also rarely known by the people at China HMB, the relevant bibliographical information that uses is seldom arranged.
For sport people, strenuous exercise usually causes that muscle breakdown is ubiquitous problem, for they provide the nutritional supplement of science, economy, to satisfy the requirement of training, is the huge problem of pendulum in face of the worker.The invention provides a kind of comparatively science, economic nourishing tonic for sport, the protein (muscle) that can effectively reduce after the strenuous exercise decomposes, and the damage that alleviates muscle cell improves the body movement ability.
Summary of the invention
The purpose of this invention is to provide a kind of is main with HMB, is used phosphate, taurine, also can add the nourishing tonic for sport of creatine.
Nourishing tonic for sport provided by the present invention, it comprises following parts by weight of component:
HMB 2.5～3.5
Taurine 2.5～3.5
Disodic alkaliine 0.8～1.2
Potassium phosphate 1～1.5.
Nourishing tonic for sport provided by the present invention, it specifically comprises following parts by weight of component:
HMB 2.5
Taurine 3
Disodic alkaliine 1
Potassium phosphate 1.2.
Nourishing tonic for sport provided by the present invention also can add creatine, and its weight portion can be 15～16, is preferably 15.
Nourishing tonic for sport provided by the present invention; Can add suitable auxiliary material; Like pharmaceutically acceptable auxiliary materials such as starch, dextrin, talcum powder, cane sugar powder, ethanol, Hydroxypropyl methylcellulose (HPMC), sodium carboxymethyl starch (CMS-Na), dolomols; Select as required and adjust, be mixed with pharmaceutically acceptable formulations such as tablet, granule, capsule, pill.
Nourishing tonic for sport provided by the present invention, the preferred capsule of pharmaceutical dosage form, its preparation method is following: above-mentioned each component is crossed 40 mesh sieves successively according to ratio from small to large, get the retentate on the sieve, remove impurity, bulky grain is pulverized with pulverizer, sieves; Then according to ascending order, the material approaching weight ratio mixes successively, fully stirs, and pours capsule into and fills in the mould; Process capsule, the powder of polishing capsule surface with container packing such as medicine bottles, adds drier, cotton in the container; Seal electromagnetic induction film afterwards, spiral cover, sterilization.
Nourishing tonic for sport provided by the present invention has following technique effect:
1, obviously reduces the degree of injury of musculature;
2, the protein (muscle) after the minimizing strenuous exercise decomposes, and increases lean body mass;
3, burning fat strengthens endurance;
4, resisted motion fatigue improves the body movement ability.
HMB is the catabolite of leucine (branched-chain amino acid), there are some researches show in the muscle about 10% the oxidable HMB of resolving into of leucine, and the HMB that generates has 20% to excrete with urine.It is generally acknowledged; The HMB that in muscle, produces has only few part to stay for muscle to use; Most other tissues of body that supply utilize; But the HMB nearly 30% of injection or extra absorption can be absorbed by muscle, and this just shows that musculature will be the main place of HMB metabolism when concentration is high.
Use HMB that anabolism is strengthened, this possibly be that backward-acting by HMB causes.When having enough HMB to supply other organization activity to utilize in the body, superfluous HMB is just used by muscle, perhaps through replenishing, blood plasma HMB concentration is raise, and body just can not decompose the muscular tissue of oneself, removes to discharge leucine and makes HMB for other metabolic activity utilization.
Mechanism of action about HMB; At present; The most convictive hypothesis is by propositions such as Nissen; They think that HMB can be muscle and immune system and provides precursor supporting cell repair the most fast, and this precursor is exactly HMG-CoA (β-hydroxy-β-methylglutaryl coenzyme, a HMG-CoA).Therefore; Behind motional injury, HMB is decomposed into HMG-CoA in muscle and some immunocyte, is used to participate in the synthetic of cholesterol; Can control the function and the growth of cell like this; Make cell membrane be able to repair fast, in addition, have the increase that sufficient HMG-CoA is enough to support muscle volume in the muscle cell membrane process of expansion.Another hypothesis thinks that HMB can reduce that protein decomposes and reduce the muscle damage degree, the minimizing that this myogen decomposes can make muscle fibre rapidly nerve raise (neural recruitment), as the raising of catalyst accelerating force.
HMB can effectively combine superfluous phosphate.Yet for the endurance exercise person of health, this has been not a good thing just.In normal vital movement, phosphate is very important mineral matter concerning body, and endurance exercise person relies on it to reach the summit of sports achievement.In fact phosphatic replenishing has the effect that potential promotion function strengthens.The present invention is main with HMB, is aided with phosphate, is exactly in order to replenish the phosphate that HMB consumes in the motion process, to be able to give full play to guarantee phosphatic latent effect.
Creatine effect and HMB effect do not belong to same type.HMB influences the balance of protein metabolism in the growth course of newborn musculature, have anti-destructive effect simultaneously, makes the decomposition of muscular tissue be reduced to minimum degree, and therefore, HMB can make the burning of motion back muscle growth and fat double.But the increase that replenishes moisture in the irritation cell of creatine is increased the osmotic pressure of cell, and the while is synthesizing of stimulating protein also, and fat free body weight is increased.
Taurine can resisted motion fatigue generation and improve the locomitivity of body.Though taurine is not participated in protein metabolism, it is that important physical active material and locomitivity are in close relations.
The specific embodiment
Following examples are used to further specify content of the present invention, but should not be construed as limitation of the present invention.Under the situation that does not deviate from the present invention's spirit and essence, modification or replacement to the inventive method, step or condition are done all belong to scope of the present invention.
Embodiment 1
Get HMB 3mg, taurine 2.5mg, disodic alkaliine 1.1mg, potassium phosphate 1.2mg crosses 40 mesh sieves with above-mentioned each component according to ratio from small to large successively, gets the retentate on the sieve, removes impurity, and bulky grain is pulverized with pulverizer, sieves; Then according to ascending order, the material approaching weight ratio mixes successively, stirs, and pours capsule into and fills in the mould; Process capsule, the powder of polishing capsule surface with container packing such as medicine bottles, adds drier, cotton in the container; Seal electromagnetic induction film afterwards, spiral cover, sterilization.
Embodiment 2
Get HMB 2.5mg, taurine 3mg, disodic alkaliine 0.8mg, potassium phosphate 1.5mg; Creatine 15mg, starch 20mg crosses 40 mesh sieves with above-mentioned each component according to ratio from small to large successively, gets the retentate on the sieve; Remove impurity, bulky grain is pulverized with pulverizer, sieves; Then according to ascending order, the material approaching weight ratio mixes successively, stirs; The ethanol 20mg of use 80% makes suitable softwood as binder, and above softwood is waved the granulator granulation through the YK-160 type of 12 mesh sieve eyes, processes wet granular; The wet granular component is divided, treat alcohol volatilization fully after, material is inserted in the multi-functional granulator of DPL-30 type in batches, 50 ℃ of fluidized dryings one hour, makes the final products moisture Control in 5%; Carry out whole grain and packing again.
Embodiment 3
Get HMB3.5mg, taurine 3.5mg, disodic alkaliine 1.2mg, potassium phosphate 1mg, creatine 16mg; Starch 3mg, dextrin 1mg, cane sugar powder 5mg crosses 40 mesh sieves with above-mentioned each component according to ratio from small to large successively; Get the retentate on the sieve, remove impurity, bulky grain is pulverized with pulverizer, sieves; Add the HPMC of above-mentioned material gross weight 1% and 1.5% CMS-Na, with all above-mentioned mixing of materials, the ethanol water 15mg of adding 60% fully stirs, and processes softwood; Above softwood is waved the granulator granulation through the YK-160 type of 12 mesh sieve eyes, process wet granular; The wet granular component is divided, treat alcohol volatilization fully after, material is inserted in the multi-functional granulator of DPL-30 type in batches, at 60 ℃ of fluidized dryings, processes dried particle; With adding dolomol 0.1mg in the particle, be pressed into tablet with tablet press machine; Tablet is carried out packing, add drier, cotton, envelope electromagnetic induction film, spiral cover, sterilization.
Embodiment 4
Get HMB 3mg, taurine 2.5mg, disodic alkaliine 1.1mg, potassium phosphate 1.2mg, starch 8mg crosses 40 mesh sieves with above-mentioned each component according to ratio from small to large successively, gets the retentate on the sieve, removes impurity, and bulky grain is pulverized with pulverizer, sieves; Then according to ascending order, the material approaching weight ratio mixes successively, stirs; The HPMC that adds above-mentioned material gross weight 2.5% again adds groove with all materials and mixes in the machine, and the adding appropriate amount of purified water is closed and sticked together, and processes softwood; Softwood is put into pill behind the pellet processing machine, oven dry, polishing is carried out packing behind the whole ball, makes pill.
Experimental example 1
Nourishing tonic for sport of the present invention is to the observation on effect of application evaluation of movement human
1, experimental subjects: sports 16 schoolboys of sports school of Beijing Sport University, health check-up health is qualified.16 schoolboys are divided into 2 groups at random, every group 8 people.The equal informed consent of experimenter, ordinary circumstance is seen table 1:
Table 1 experimenter ordinary circumstance
2, experimental design: double blinding, dual analog, placebo experiment.
3, experimental technique:
Experimental group sportsman takes the capsule product of embodiment 1, and control group is taken the starch capsule.The experimenter after taking for 4 weeks, indexs such as the athletic aerobic of retest, anaerobic ability.
Aerobic capacity is measured: use the EG/900 cycle ergometer, and initial load 80W, every 3min increasing load 40W raises step by step and loads to 240W, uses PE300 heart rate telemetering appearance recorded heart rate simultaneously.Every grade of Mo Caier blood is surveyed blood lactic acid, with broadcasting method in the Mader, calculates 4mM lactic acid anaerobic threshold (AT).
The anaerobic aptitude tests: use Monark 829 cycle ergometers to pedal beginning soon by light resistance, the 3-5s internal resistance is added to given load (resistance is a body weight for humans X0.085), pedals 30s soon with all strength.Test period is given oral encouragement all the time, surveys 30s anaerobic merit peak value and mean value; Motion back 3min surveys blood lactic acid value.
Biochemical indicator is measured: blood lactic acid is with YSI-232 lactic acid analysis-e/or determining.
The test of skeletal muscle tissue assessment of impairments index: adopt the semi-automatic analysis-e/or determining serum CK of EppendorfCOM-F-6124 type, kit builds up company by Nanjing and provides.
4, result
4.1 influence to aerobic capacity
Table 2 nourishing tonic for sport of the present invention is to the influence of movement human 4mM lactic acid anaerobic threshold
Carry out paired t-test, P＞0.05 before and after taking
Can find out experimental group and the pairing work done quantity of control group 4mM lactic acid threshold and heart rate there are no significant from table 2 result and change.From this reflection aerobic capacity good index of 4mM lactic acid threshold, it is little to the aerobic capacity influence to replenish this nutritional supplement.
4.2 influence to the anaerobic ability
Table 3 nourishing tonic for sport of the present invention is to the influence of 30s maximum intensity load back blood lactic acid
Carry out paired t-test, P＜0.05 before and after taking medicine
Can find out that from table 3 experimental group sportsman 30s maximum intensity load back blood lactic acid drops to 11.97 scholar 1.04mMol/L by 13.26 scholar 0.86mMol/L, have significant difference, and control group does not have significant change.
Table 4 nourishing tonic for sport of the present invention is to the influence of movement human anaerobic merit
Carry out paired t-test, P＜0.01 before and after taking medicine
Can find out that from table 4 experimental group anaerobic merit peak value rises to 680.19 scholar 21.36w by the preceding 628.67 scholar 24.66w that take medicine; Has significant difference; Show that replenishing this product has remarkable meaning to improving the ATP-CP system, and control group anaerobic merit peak value and mean value all there is not significant difference.
4.3 influence to the CK index
Table 5 nourishing tonic for sport of the present invention is to the influence of serum CK
Carry out paired t-test, P＜0.05 before and after taking medicine
Table 5 shows that the SCK of control group (CK) content does not have marked change; And the CK value of experimental group is starkly lower than control group after 4 weeks, shows that this product has significant effect to the degree of injury that reduces musculature.
5. conclusion
Product of the present invention can obviously alleviate the degree of injury of musculature, improves the anaerobic ability.
Above embodiment only is used to explain the present invention; And be not limitation of the present invention; The those of ordinary skill in relevant technologies field under the situation that does not break away from the spirit and scope of the present invention, can also be made various variations and modification; Therefore all technical schemes that are equal to also belong to category of the present invention, and scope of patent protection of the present invention should be defined by the claims.
Claims (8)
1. nourishing tonic for sport, its active component is made up of the component of following weight portion:
HMB 2.5～3.5，
Taurine 2.5～3.5,
Disodic alkaliine 0.8～1.2,
Potassium phosphate 1～1.5.
2. nourishing tonic for sport as claimed in claim 1 is characterized in that, active component is made up of the component of following weight portion:
HMB 2.5，
Taurine 3,
Disodic alkaliine 1,
Potassium phosphate 1.2.
3. according to claim 1 or claim 2 nourishing tonic for sport is characterized in that, also further contains the auxiliary material that one or more is selected from starch, dextrin, talcum powder, cane sugar powder, ethanol, dolomol, HPMC or CMS-Na.
4. nourishing tonic for sport as claimed in claim 3 is characterized in that, said nourishing tonic for sport is tablet, granule, capsule or pill.
5. a nourishing tonic for sport is characterized in that, its active component is made up of the component of following weight portion:
HMB 2.5～3.5，
Taurine 2.5～3.5,
Disodic alkaliine 0.8～1.2,
Potassium phosphate 1～1.5,
Creatine 15～16.
6. nourishing tonic for sport as claimed in claim 5 is characterized in that, its active component is made up of the component of following weight portion:
HMB 2.5，
Taurine 3,
Disodic alkaliine 1,
Potassium phosphate 1.2,
Creatine 5.
7. like claim 5 or 6 described nourishing tonic for sport, it is characterized in that, also further contain the auxiliary material that one or more is selected from starch, dextrin, talcum powder, cane sugar powder, ethanol, dolomol, HPMC or CMS-Na.
8. nourishing tonic for sport as claimed in claim 7 is characterized in that, said nourishing tonic for sport is tablet, granule, capsule or pill.
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| CN200810106031XA CN101574146B (en) | 2008-05-07 | 2008-05-07 | Sports nutritional supplement containing HMB |
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| CN200810106031XA CN101574146B (en) | 2008-05-07 | 2008-05-07 | Sports nutritional supplement containing HMB |
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| CN101574146B true CN101574146B (en) | 2012-06-13 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8916217B2 (en) | 2010-01-29 | 2014-12-23 | Abbott Laboratories | Aseptically packaged nutritional liquids comprising HMB |
| US9241508B2 (en) | 2010-01-29 | 2016-01-26 | Abbott Laboratories | Nutritional emulsions comprising calcium HMB |
| US9521859B2 (en) | 2010-06-10 | 2016-12-20 | Normanella T. Dewille | Substantially clear nutritional liquids comprising calcium HMB and soluble protein |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101569412B (en) * | 2009-06-01 | 2012-12-05 | 北京康比特体育科技股份有限公司 | Sports nutrition supplement and application thereof |
| MX2012008778A (en) * | 2010-01-29 | 2012-09-07 | Abbott Lab | Nutritional powders comprising spray dried hmb. |
| US9693577B2 (en) | 2010-01-29 | 2017-07-04 | Abbott Laboratories | Method of preparing a nutritional powder comprising spray dried HMB |
| ES2625740T3 (en) * | 2013-03-15 | 2017-07-20 | Abbott Laboratories | Nutritional compositions that include calcium beta-hydroxy-beta-methylbutyrate, casein phosphopeptide and protein |
| CN103704711B (en) * | 2013-12-31 | 2014-12-10 | 程刚 | Granules with anti-fatigue and health-care function |
| RU2605280C1 (en) * | 2016-01-12 | 2016-12-20 | Антон Павлович Переверзев | Combination of components for improvement of physical parameters in individuals involved in heavy physical activity |
| EP3463327B1 (en) * | 2016-05-25 | 2024-04-17 | TSI Group Co., Ltd. | Stabilization of beta-hydroxyisovaleric acid formulations in soft gel capsules |
| CN106596771B (en) * | 2016-12-14 | 2019-03-29 | 广州白云山汉方现代药业有限公司 | A method of beta-hydroxy-Beta-methyl butyric acid content in measurement soybean peptide protein powder |
| CN106509883A (en) * | 2016-12-29 | 2017-03-22 | 北京康比特体育科技股份有限公司 | Soft energy bars capable of rapidly supplementing energy and preparation method thereof |
| CN113854565A (en) * | 2021-10-09 | 2021-12-31 | 重庆市三品功能食品研究院有限公司 | Protein rod for increasing muscle and relieving fatigue and preparation method thereof |
| CN115462523B (en) * | 2022-08-24 | 2024-05-14 | 仁和全域(上海)大健康研究院有限公司 | Composition for improving exercise capacity as well as preparation method and application thereof |
-
2008
- 2008-05-07 CN CN200810106031XA patent/CN101574146B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 吕美，陈代文.蛋氨酸及其羟基类似物的吸收和代谢.《新饲料》.2007,5－8. * |
| 曾志刚,郝选明,邱红.补充β- 羟基- β甲基丁酸盐( HMB) 在运动训练中的生理效应.《中国运动医学杂志》.2007,第26卷(第1期),120-123. * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8916217B2 (en) | 2010-01-29 | 2014-12-23 | Abbott Laboratories | Aseptically packaged nutritional liquids comprising HMB |
| US9241508B2 (en) | 2010-01-29 | 2016-01-26 | Abbott Laboratories | Nutritional emulsions comprising calcium HMB |
| US9521859B2 (en) | 2010-06-10 | 2016-12-20 | Normanella T. Dewille | Substantially clear nutritional liquids comprising calcium HMB and soluble protein |
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| CN101574146A (en) | 2009-11-11 |
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