CN104887739A - Angelica sinensis-astragalus membranaceus blood replenishing oral tablets, as well as preparation method and application thereof - Google Patents
Angelica sinensis-astragalus membranaceus blood replenishing oral tablets, as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses angelica sinensis-astragalus membranaceus blood replenishing oral tablets, as well as a preparation method and application thereof. The angelica sinensis-astragalus membranaceus blood replenishing oral tablets comprise the following raw materials by weight: 40 percent of angelica sinensis-astragalus membranaceus extracts, 25 to 45 percent of xylitol, 2 to 10 percent of povidone, 0.2 to 1.0 percent of magnesium stearate, and the balance of starch. The angelica sinensis-astragalus membranaceus blood replenishing oral tablets as well as the preparation method and application thereof have the advantages that the compatibility of medicines and the preparation technology are simple and reasonable; the quality is stable and reliable; the cost is low; the toxic and side effects are low; not only are the blood activating and replenishing functions of angelica sinensis retained, but also the efficacies of improving human immunity and nourishing body of astragalus membranaceus are realized; the angelica sinensis-astragalus membranaceus blood replenishing oral tablets are high in drug loading capacity, tastes good, and are light in weight and small in size, thereby being convenient to carry and take at any time. Therefore, not only are large quantities of excipients are saved, but also the characteristics of traditional Chinese medicine are confirmed. The angelica sinensis-astragalus membranaceus blood replenishing oral tablets, as well as the preparation method and application thereof are suitable for not only mechanical mass production, but also family-style production in a grossroot unit.
Description
Technical field
The present invention relates to medical art, particularly relate to one and return stilbene to enrich blood buccal tablet and its production and use.
Background technology
Fatigue is a kind of phenomenon that people's successive learning or work decline with behind efficiency, can be divided into physiological fatigue and psychological fatigue.Along with the development of economy, accelerating of people's rhythm of life, come from society, family, work and individual pressure also increasing, and a lot of people is owing to being not good at the fatigue regulating health and psychology, accumulation forms vicious cycle, and produce a series of mental illness, finally cause into overtired syndrome.Just there will be corresponding physiological reaction, such as difficulty falling asleep, insomnia, Yi Xing, dreaminess, attention are not usually concentrated, be reluctant and people speaks more words; After light exercise, pulse is just acutely beated, cardiopalmus, asthma; Appetite obviously reduces, the decline of body weight unknown cause, and the often violent pain of head, chest are felt to feel oppressed; Dim complexion, pachylosis; Shoulder and cervical region feel numb; Have an uncertain temper; Easily forgetful, amblyacousia, tinnitus, eyelid and other muscle is usually beated, to the subhealth state problem such as thing is not positive, finally will cause decline and the psychological disease of people's quality of life.
Radix Angelicae Sinensis Angelica sinensis (Oliv.) Diels begins to be loaded in Shennong's Herbal, is the dry root of umbelliferae angelica.There is benefiting blood and regulating blood circulation, effect of menstruction regulating and pain relieving, loosening bowel to relieve constipation (Chinese Pharmacopoeia. [S] .2005,89).The Radix Astragali is the dry root of leguminous plant Radix Astragali Astragalus membranaceus (Fisch) Bge., have effects such as improving myocardial ischemia, defying age, immunomodulating and antioxidation (Chinese Pharmacopoeia [s]. a .2010,283).Research display, the Radix Astragali has certain antifatigue effect (Song Qiang etc., world's combination of Chinese and Western medicine magazine, 2007,2 (6): 335-337).But the stilbene of returning that up to the present, there is not yet prepared by Radix Angelicae Sinensis and this 2 taste Chinese medicine of the Radix Astragali is enriched blood the report of buccal tablet about antifatigue effect.
Stilbene buccal tablet of enriching blood is returned to be with Radix Angelicae Sinensis and the Radix Astragali for raw material, the slow down aging developed through ultrasonic assisted technique extraction process and the new drug of resisting fatigue.Our early-stage Study shows, astragalus polysaccharides of returning prepared from a certain proportion of Radix Angelicae Sinensis and the Radix Astragali has the effect such as antioxidation and slow down aging.At present, clinically the compound preparation (Guiqibuxue oral liquid, Guiqishengxue Granules and return stilbene nourishing blood and invigorating qi oral liquid) of Radix Angelicae Sinensis and the Radix Astragali although provide new method for the patient suffering from insufficiency of vital energy and blood, spiritlessness and weakness and palpitation and insomnia etc.But these compound preparations are expensive, complicated component, and be not easy to carry and take.
Summary of the invention
Object of the present invention is just to overcome above-mentioned shortcoming, provides one to have resisting fatigue and slow down aging, is easy to carry and conveniently takes, and comparatively stable stilbene of returning is enriched blood buccal tablet.The present invention utilizes the water extract of Radix Angelicae Sinensis and the Radix Astragali to be prepared into the form of buccal tablet, both the effect of the blood circulation promoting and enriching of Radix Angelicae Sinensis had been remained, give full play to again the enhancing body immunity of the Radix Astragali, the effect such as nourish the body, solve a lot of nutrition in Radix Angelicae Sinensis and the Radix Astragali, as the problem of protein, aminoacid and mineral flux, and utilize sweeting agent to mask to return stilbene to enrich blood the bitter taste of Radix Angelicae Sinensis in buccal tablet component, remain comfortable mouthfeel, lightweight, volume is little, and stability is strong, is beneficial to people and carries and take at any time.
The object of the present invention is to provide and return stilbene buccal tablet of enriching blood preparing the purposes in slow down aging and resisting fatigue medicine, its objective is the waste not only solving a lot of beneficiating ingredient in Radix Angelicae Sinensis and Huangqi Compound preparation, and for improving human life quality, the research and development of resisting fatigue and slow down aging medicine provide a new way.
The present invention adopts following technical scheme:
Stilbene buccal tablet of enriching blood of returning of the present invention comprises the raw material of following percentage by weight: return stilbene extract 40%, xylitol 25-45%, polyvidone 2-10%, magnesium stearate 0.2-1.0%, starch to be added into 100%.
Preferred: stilbene buccal tablet of enriching blood of returning of the present invention comprises the raw material of following percentage by weight: return stilbene extract 40%, xylitol 35%, polyvidone 6%, magnesium stearate 0.5%, starch to be added into 100%.
The enrich blood concrete steps of preparation method of buccal tablet of stilbene of returning of the present invention are as follows:
(1) be first ground into Powdered respectively by Radix Angelicae Sinensis and Milkvetch Root, then mix homogeneously, the weight proportion of Radix Angelicae Sinensis and the Radix Astragali is: Radix Angelicae Sinensis 1-5 part; Radix Astragali 5-25 part;
(2) add pure water by Radix Angelicae Sinensis and Radix Astragali mixed-powder, both w/vs are 1:2g/ml, supersound process 30 minutes under room temperature, ultrasonic power: 800 watts, reusable heat water reflux, extract, 2 times; Pure water is supplied, circumfluence distillation 4h in 70-90 DEG C of water-bath 1st time according to quality of medicinal material 8-16 ratio doubly; Add pure water, circumfluence distillation 3h in 70-90 DEG C of water-bath, merging filtrate according to quality of medicinal material 5-10 ratio doubly 2nd time, then the relative density be evaporated under 80 degrees Celsius is 1.30-1.32 by filtrate, must return stilbene extract;
(3) what step (2) obtained returns the lyophilization of stilbene extract, micronizing, crosses 100 mesh sieves and must return stilbene extract powder; Meanwhile, xylitol, polyvidone, magnesium stearate and starch are also crossed 100 mesh sieves respectively;
(4) stilbene is returned to enrich blood the preparation of buccal tablet:
To stilbene extract powder, xylitol, polyvidone, magnesium stearate and starch be returned by proportioning example mix homogeneously after sieving, then add edible ethanol and stir, then granulate, dry, tabletting, make finished product, and carry out ultraviolet radiation sterilization, detect, pack.
In step (1), the weight proportion of preferred Radix Angelicae Sinensis and the Radix Astragali is: Radix Angelicae Sinensis 1 part; The Radix Astragali 5 parts.
Stilbene of returning of the present invention enriches blood buccal tablet for resisting fatigue, slow down aging.
The present invention's application modern science and technology, have employed the preparation of ultrasound assisted extraction technology and return stilbene extract fine powder, complicated for Radix Angelicae Sinensis clinically, Huangqi Compound formulation ingredients, be not easy to the shortcoming of carrying and taking, the present invention only have employed 2 taste Chinese medicines (Radix Angelicae Sinensis and the Radix Astragali) and adds a certain proportion of adjuvant, especially in the selection of diluent, the xylitol of sugar alcohols has been selected, both buccal tablet prepared by the present invention can have been made to be taken by diabetics, also mask and return stilbene to enrich blood the bitter taste of Radix Angelicae Sinensis in buccal tablet component, remain comfortable mouthfeel.Also solve a lot of nutrition in Radix Angelicae Sinensis and the Radix Astragali, as the problem of protein, aminoacid and mineral flux simultaneously.
Good effect of the present invention is as follows:
Compared with prior art, compatibility of the present invention and preparation technology are simple, rationally; Steady quality, reliably; With low cost; Toxic and side effects is little, has both remained the effect of the blood circulation promoting and enriching of Radix Angelicae Sinensis, and had both again the Radix Astragali and improved body immunity, the effect such as nourish the body.Prepared return stilbene enrich blood buccal tablet content of dispersion high (drug loading is large), mouthfeel is good, lightweight, volume is little, be beneficial to people and carry and take at any time.Both save a large amount of excipient, meet again traditional Chinese medical science Medicinal Trait; Both be applicable to mechanization produce on a large scale, the small workshop mode being also applicable to grass-roots unit is produced.
In addition, this dosage form, by Sublingual and the rapid absorption portion medicine of oral cavity buccal surface mucosa, possesses onset advantage rapidly, effectively can improve bioavailability.
The present invention prepares through wet granule compression tablet method and returns stilbene to enrich blood buccal tablet, method (resisting fatigue experiment) research adopting mice to continue swimming time returns stilbene to enrich blood the antifatigue effect of buccal tablet, result display: return stilbene buccal tablet of enriching blood to have effect of good fatigue alleviating.
Result of the test shows, prepared by the present invention return stilbene enriches blood buccal tablet is through accelerated test 6 months and long term test after 12 months, its outward appearance, weight, hardness, melting time and content are all there are no significant change, illustrate that this product has good stability in this packaging (drug packaging aluminum foil compound bag), all meet Chinese Pharmacopoeia I (2010 editions) regulation.
Detailed description of the invention
The following examples describe in further detail of the present invention.
Embodiment 1
Stilbene buccal tablet of enriching blood of returning of the present invention comprises the raw material of following percentage by weight: return stilbene extract 40%, xylitol 25%, polyvidone 4%, magnesium stearate 0.3%, starch to be added into 100%.
The enrich blood concrete steps of preparation method of buccal tablet of stilbene of returning of the present invention are as follows:
(1) be first ground into Powdered respectively by Radix Angelicae Sinensis and Milkvetch Root, then mix homogeneously, the weight proportion of Radix Angelicae Sinensis and the Radix Astragali is: Radix Angelicae Sinensis 5 parts; The Radix Astragali 1 part;
(2) add pure water by Radix Angelicae Sinensis and Radix Astragali mixed-powder, both w/vs are 1:2g/ml, supersound process 30 minutes under room temperature, ultrasonic power: 800 watts, reusable heat water reflux, extract, 2 times; Pure water is supplied 1st time, circumfluence distillation 4h in 70 DEG C of water-baths according to the ratio of quality of medicinal material 8 times; Add pure water according to the ratio of quality of medicinal material 5 times 2nd time, circumfluence distillation 3h in 70 DEG C of water-baths, merging filtrate, then the relative density be evaporated under 80 degrees Celsius is 1.30-1.32 by filtrate, must return stilbene extract;
(3) what step (2) obtained returns the lyophilization of stilbene extract, micronizing, crosses 100 mesh sieves and must return stilbene extract powder; Meanwhile, xylitol, polyvidone, magnesium stearate and starch are also crossed 100 mesh sieves respectively;
(4) stilbene is returned to enrich blood the preparation of buccal tablet:
Return stilbene extract powder 40%, xylitol 25%, polyvidone 4%, magnesium stearate 0.3%, starch after sieving are added into 100%, mix homogeneously, the edible ethanol adding 35% again stirs, then granulation, dry, tabletting, make finished product, and carry out ultraviolet radiation sterilization, detect, pack.
Embodiment 2
Stilbene buccal tablet of enriching blood of returning of the present invention comprises the raw material of following percentage by weight: return stilbene extract 40%, xylitol 35%, polyvidone 6%, magnesium stearate 0.5%, starch to be added into 100%.
The enrich blood concrete steps of preparation method of buccal tablet of stilbene of returning of the present invention are as follows:
(1) be first ground into Powdered respectively by Radix Angelicae Sinensis and Milkvetch Root, then mix homogeneously, the weight proportion of Radix Angelicae Sinensis and the Radix Astragali is: Radix Angelicae Sinensis 5 parts; The Radix Astragali 5 parts;
(2) add pure water by Radix Angelicae Sinensis and Radix Astragali mixed-powder, both w/vs are 1:2g/ml, supersound process 30 minutes under room temperature, ultrasonic power: 800 watts, reusable heat water reflux, extract, 2 times; Pure water is supplied 1st time, circumfluence distillation 4h in 90 DEG C of water-baths according to the ratio of quality of medicinal material 16 times; Add pure water according to the ratio of quality of medicinal material 10 times 2nd time, circumfluence distillation 3h in 90 DEG C of water-baths, merging filtrate, then the relative density be evaporated under 80 degrees Celsius is 1.30-1.32 by filtrate, must return stilbene extract;
(3) what step (2) obtained returns the lyophilization of stilbene extract, micronizing, crosses 100 mesh sieves and must return stilbene extract powder; Meanwhile, xylitol, polyvidone, magnesium stearate and starch are also crossed 100 mesh sieves respectively;
(4) stilbene is returned to enrich blood the preparation of buccal tablet:
Return stilbene extract powder 40%, xylitol 35%, polyvidone 6%, magnesium stearate 0.5%, starch after sieving are added into 100%, mix homogeneously, add 35% edible ethanol again to stir, then granulation, dry, tabletting, make finished product, and carry out ultraviolet radiation sterilization, detect, pack.
Embodiment 3
Stilbene buccal tablet of enriching blood of returning of the present invention comprises the raw material of following percentage by weight: return stilbene extract 40%, xylitol 45%, polyvidone 8%, magnesium stearate 0.7%, starch to be added into 100%.
The enrich blood concrete steps of preparation method of buccal tablet of stilbene of returning of the present invention are suddenly as follows:
(1) be first ground into Powdered respectively by Radix Angelicae Sinensis and Milkvetch Root, then mix homogeneously, the weight proportion of Radix Angelicae Sinensis and the Radix Astragali is: Radix Angelicae Sinensis 1 part; The Radix Astragali 5 parts;
(2) add pure water by Radix Angelicae Sinensis and Radix Astragali mixed-powder, both w/vs are 1:2g/ml, supersound process 30 minutes under room temperature, ultrasonic power: 800 watts, reusable heat water reflux, extract, 2 times; Pure water is supplied 1st time, circumfluence distillation 4h in 80 DEG C of water-baths according to the ratio of quality of medicinal material 12 times; Add pure water according to the ratio of quality of medicinal material 8 times 2nd time, circumfluence distillation 3h in 80 DEG C of water-baths, merging filtrate, then the relative density be evaporated under 80 degrees Celsius is 1.30-1.32 by filtrate, must return stilbene extract;
(3) what step (2) obtained returns the lyophilization of stilbene extract, micronizing, crosses 100 mesh sieves and must return stilbene extract powder; Meanwhile, xylitol, polyvidone, magnesium stearate and starch are also crossed 100 mesh sieves respectively;
(4) stilbene is returned to enrich blood the preparation of buccal tablet:
Return stilbene extract powder 40%, xylitol 45%, polyvidone 8%, magnesium stearate 0.7%, starch after sieving are added into 100%, mix homogeneously, then the edible ethanol adding 35% stirs, then granulation, dry, tabletting, make finished product, and carry out ultraviolet radiation sterilization
Detect, pack.
Stilbene is returned to enrich blood buccal tablet and return stilbene extract to alleviate the Effect study of mice fatigue
The Effect study of stilbene enriches blood buccal tablet alleviates mice fatigue that prepared by the embodiment of the present invention 2 return.
1, laboratory animal is divided into groups and is gavaged administration
After 150 mice adaptabilities are fed 1w, be divided into 5 groups at random by body weight: return stilbene enrich blood buccal tablet low (0.5g/kg.d), in (1g/kg.d), high (2g/kg.d) 3 dosage groups (wherein returning stilbene extract to be 40%), return stilbene extract group (0.8g/kg.d, stilbene is returned to enrich blood to return in buccal tablet stilbene extract equal with high dose) and Normal group, often organize 30, each experiment randomly draws 10 from corresponding group, batch experiment.Often body weight zero difference between group.Each experimental group according to corresponding dosage gavage mice, the same volume of matched group gavage (0.02ml/g.d) distilled water, successive administration 15d.
2, the Effect study of mice fatigue is alleviated
2.1 power exhaust swimming test: at the galvanized wire of each load body weight 5% of mouse tail root after last gavage 30min, put into water tank swimming, water temperature 30 ± 2 DEG C.The power of recommending with reference to McARDLE exhausts criterion, i.e. mouse head submerged, still can not return the water surface be considered as power and exhaust through 10s.The time that record swimming time started to power exhausts is as mice swimming time.
Table 1 returns stilbene to enrich blood buccal tablet and return stilbene extract on the impact of mice swimming time
Compare with Normal group,
*p<0.01;
Compare with returning stilbene extract group,
##p<0.01.
After gastric infusion 15d, carry out power and exhaust swimming test, the results are shown in Table 1.Return stilbene buccal tablet 3 dosage groups of enriching blood (low, in, high) and return stilbene extract group mice swimming time to be all significantly higher than control group mice, 1.5 times (P<0.01) of Normal group mice respectively, 2.2 times (P<0.01), 3.0 times (P<0.01) and 2.2 times (P<0.01), this result is pointed out, stilbene is returned to enrich blood buccal tablet and return stilbene extract all can significant prolongation mice swimming time, wherein high dose group effect is the most obvious, with same dose return compared with stilbene extract, mice swimming time longer (P<0.01), also be, the enrich blood effect of buccal tablet of stilbene is returned to be better than returning stilbene extract, and buccal tablet presents dose-dependence (within 0.5g/kg to 2g/kg scope).
2.2 Mouse whole blood Plasma lactates: gastric infusion 15d continuously, after 30min after last administration and swimming with a load attached to the body (2% of body weight) 30min, pluck eyeball and get blood examination survey full blood lactic.
Table 2 returns stilbene to enrich blood buccal tablet and return stilbene extract on the impact of Mouse whole blood lactic acid
Compare with Normal group,
*p<0.01;
*p<0.05;
Compare with returning stilbene extract group,
#p<0.05
After last gastric infusion 30min and swimming with a load attached to the body (2% of body weight) 30min, eye socket blood sampling detects full blood lactic respectively, the results are shown in Table 2.Before motion, each dosage group Mouse Blood lactate level compared with Normal group without significant difference (P>0.05); After motion, the blood lactase acid level of each dosage group mice is significantly lower than Normal group (P<0.01, P<0.05), illustrate and return stilbene to enrich blood buccal tablet and return stilbene extract can suppress the rising of exercised rats lactic acid, and high dose returns stilbene buccal tablet of enriching blood to suppress the effect of lactic acid to be obviously better than to return stilbene extract (P<0.01).
Mouse Blood determination of urea nitrogen after 2.3 motions: last gastric infusion 30min, without swimming with a load attached to the body 90min, pulls mice out and dries, after quiet 60min, pluck eyeball blood-letting and enter in anticoagulant tube, and centrifuging and taking blood plasma adopts automatic clinical chemistry analyzer to detect.
Table 3 returns stilbene to enrich blood buccal tablet and return stilbene extract on the impact of Mouse Blood blood urea nitrogen after motion
Compare with Normal group,
*p<0.05;
Return stilbene enrich blood buccal tablet and return stilbene extract to affect exercised rats blood urea nitrogen the results are shown in Table 3.Compared with Normal group, after each dosage group mouse movement, blood urea nitrogen has reduction trend, but significant difference (P<0.05) compared with only between high dose group with Normal group, not statistically significant between all the other each group and Normal groups.This result is pointed out, with same dose return compared with stilbene extract, high dose returns stilbene buccal tablet of enriching blood obviously can reduce the urea nitrogen levels (P<0.01) of exercised rats.
According to " function of health food assessment process and the method for inspection " (function of health food assessment process and method of inspection that 1996 promulgate, 1996,10-12), if endurance exercise experiment (swimming with a load attached to the body and pole-climbing) of more than or and the biochemical indicator (blood lactase acid, blood urea nitrogen, liver/muscle glycogen etc.) of more than two or two are the positive, can judge that tested material has antifatigue effect.Therefore, this result of study can be thought and returns stilbene to enrich blood buccal tablet and return stilbene extract all to have obvious antifatigue effect, and returns stilbene buccal tablet of enriching blood to be better than same dose and to return stilbene extract.
Prepared by the present invention return stilbene the enriches blood stability study of buccal tablet
1. experimental condition and method
According to the Pharmacopoeia of the People's Republic of China (version two in 2010), " medicine stability test guideline is " about the requirement of study on the stability project for annex XIXC, it is carried out to the acceleration (temperature 40 DEG C+2 DEG C of 6month by a definite date, relative humidity 75% scholar 5%) and (temperature is 25 DEG C of scholars 2 DEG C for a long time, relative humidity 60% ± lO%) stability test investigation, detect in 1,2,3 and 6month sampling respectively, and compare with the result of 0month.
1.1 accelerated test
Test sample 3 batches, drug packaging aluminum foil compound bag is packed, and is 40 DEG C ± 2 DEG C, places under the condition of relative humidity 75% ± 5% in temperature.Sample respectively once at duration of test the 0th, l, 2,3 and 6 the end of month, detect by stability high spot reviews project.Its quality examination project is respectively: (get three batches of buccal tablets each, 20, accurately weighed, average sheet weighs 0.974, and weight differential is less than ± 5% for outward appearance, weight differential.)。Hardness measurement (measuring the hardness of 20 within 7 ~ 9kg scope with tablet four-function analyzer).Melting time (at least reaching more than 15 minutes containing changing in mouth).Testing result is in table 4.
1.2 long term test
Test sample 3 batches, drug packaging aluminum foil compound bag is packed, and is 25 DEG C of scholars 2 DEG C, places under the condition of relative humidity 60% ± lO% in temperature.At duration of test, respectively at 0 month, 3 months, 6 months, 9 months, 12 samplings at the end of month once, detect by stability high spot reviews project.Its quality examination project is respectively: outward appearance, weight differential (get three batches of buccal tablets, accurately weighed, weight differential is less than ± and 5%), hardness measurement (every sheet hardness on average within 3-5kg scope), melting time (at least reaching more than 15 minutes containing changing in mouth).Testing result is in table 5.
Stilbene buccal tablet accelerated test result returned by table 4
Stilbene buccal tablet long-term test results returned by table 5
Result of the test shows, this product is through accelerated test 6 months and long term test after 12 months, its outward appearance, weight, hardness, melting time and content are all there are no significant change, illustrate that this product has good stability in this packaging (drug packaging aluminum foil compound bag), all meet Chinese Pharmacopoeia I (2010 editions) regulation.
Although illustrate and describe embodiments of the invention, for the ordinary skill in the art, be appreciated that and can carry out multiple change, amendment, replacement and modification to these embodiments without departing from the principles and spirit of the present invention, scope of the present invention is by claims and equivalents thereof.
Claims (5)
1. return stilbene to enrich blood a buccal tablet, it is characterized in that: described stilbene buccal tablet of enriching blood of returning comprises the raw material of following percentage by weight: return stilbene extract 40%, xylitol 25-45%, polyvidone 2-10%, magnesium stearate 0.2-1.0%, starch to complement to 100%.
2. return stilbene to enrich blood buccal tablet as claimed in claim 1, it is characterized in that: described stilbene buccal tablet of enriching blood of returning comprises the raw material of following percentage by weight: return stilbene extract 40%, xylitol 35%, polyvidone 6%, magnesium stearate 0.5%, starch to complement to 100%.
3. prepare and return stilbene to enrich blood the method for buccal tablet as claimed in claim 1 or 2, it is characterized in that: the concrete steps of described method are as follows:
(1) be first ground into Powdered respectively by Radix Angelicae Sinensis and Milkvetch Root, then mix homogeneously, the weight proportion of Radix Angelicae Sinensis and the Radix Astragali is: Radix Angelicae Sinensis 1-5 part; Radix Astragali 5-25 part;
(2) add pure water by Radix Angelicae Sinensis and Radix Astragali mixed-powder, both w/vs are 1:2g/ml, supersound process 30 minutes under room temperature, ultrasonic power: 800 watts, reusable heat water reflux, extract, 2 times; Pure water is supplied, circumfluence distillation 4h in 70-90 DEG C of water-bath 1st time according to quality of medicinal material 8-16 ratio doubly; Add pure water, circumfluence distillation 3h in 70-90 DEG C of water-bath, merging filtrate according to quality of medicinal material 5-10 ratio doubly 2nd time, then the relative density be evaporated under 80 degrees Celsius is 1.30-1.32 by filtrate, must return stilbene extract;
(3) what step (2) obtained returns the lyophilization of stilbene extract, micronizing, crosses 100 mesh sieves and must return stilbene extract powder; Meanwhile, xylitol, polyvidone, magnesium stearate and starch are also crossed 100 mesh sieves respectively;
(4) stilbene is returned to enrich blood the preparation of buccal tablet:
To stilbene extract powder, xylitol, polyvidone, magnesium stearate and starch be returned by proportioning example mix homogeneously after sieving, then add edible ethanol and stir, then granulate, dry, tabletting, make finished product, and carry out ultraviolet radiation sterilization, detect, pack.
4. preparation method as claimed in claim 3, it is characterized in that: in step (1), the weight proportion of Radix Angelicae Sinensis and the Radix Astragali is: Radix Angelicae Sinensis 1 part; The Radix Astragali 5 parts.
5. return stilbene to enrich blood the purposes of buccal tablet for resisting fatigue, slow down aging as claimed in claim 1 or 2.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477180A (en) * | 2015-12-09 | 2016-04-13 | 兰州大学 | Traditional Chinese medicine composition for treating chronic fatigue syndrome |
| CN115777826A (en) * | 2022-11-14 | 2023-03-14 | 上海市杨浦区青少年科技站 | An antifatigue chewing gum containing radix Angelicae sinensis and radix astragali extract |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846706A (en) * | 2011-06-30 | 2013-01-02 | 苏州知微堂生物科技有限公司 | Preparation process of integration-type novel formulation of Angelica sinensis blood enrichment decoction and production method thereof |
| CN103432157A (en) * | 2013-09-06 | 2013-12-11 | 兰州理工大学 | Preparation method of concentrated pills of angelica sinensis and astragalus membranaceus polysaccharide |
| CN103705567A (en) * | 2013-12-31 | 2014-04-09 | 四川省畜牧科学研究院 | Angelica sinensis blood-replenishing granule and preparation method thereof |
-
2015
- 2015-06-11 CN CN201510317916.4A patent/CN104887739A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846706A (en) * | 2011-06-30 | 2013-01-02 | 苏州知微堂生物科技有限公司 | Preparation process of integration-type novel formulation of Angelica sinensis blood enrichment decoction and production method thereof |
| CN103432157A (en) * | 2013-09-06 | 2013-12-11 | 兰州理工大学 | Preparation method of concentrated pills of angelica sinensis and astragalus membranaceus polysaccharide |
| CN103705567A (en) * | 2013-12-31 | 2014-04-09 | 四川省畜牧科学研究院 | Angelica sinensis blood-replenishing granule and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘强等: "《中药新产品开发》", 31 March 2013, 中国医药科技出版社 * |
| 科学技术文献出版社: "《绿色精细化工——天然产品制造法（第3集）》", 31 January 2008, 科学技术文献出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477180A (en) * | 2015-12-09 | 2016-04-13 | 兰州大学 | Traditional Chinese medicine composition for treating chronic fatigue syndrome |
| CN115777826A (en) * | 2022-11-14 | 2023-03-14 | 上海市杨浦区青少年科技站 | An antifatigue chewing gum containing radix Angelicae sinensis and radix astragali extract |
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