CN109222094A - A kind of antifatigue complex capsule and preparation method thereof - Google Patents
A kind of antifatigue complex capsule and preparation method thereof Download PDFInfo
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- CN109222094A CN109222094A CN201811051282.2A CN201811051282A CN109222094A CN 109222094 A CN109222094 A CN 109222094A CN 201811051282 A CN201811051282 A CN 201811051282A CN 109222094 A CN109222094 A CN 109222094A
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- capsule
- antifatigue
- complex
- complex capsule
- icariin
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- 230000002929 anti-fatigue Effects 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000000284 extract Substances 0.000 claims abstract description 36
- TZJALUIVHRYQQB-XFDQAQKOSA-N Icariin Natural products O(C)c1ccc(C2=C(O[C@H]3[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)C(=O)c3c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)c(C/C=C(\C)/C)c3O2)cc1 TZJALUIVHRYQQB-XFDQAQKOSA-N 0.000 claims abstract description 17
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- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 17
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- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 2
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- RJGDLRCDCYRQOQ-UHFFFAOYSA-N anthrone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3CC2=C1 RJGDLRCDCYRQOQ-UHFFFAOYSA-N 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
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- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical class OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of antifatigue complex capsule, each component content in every 500mg capsule 's content are as follows: polysaccharides 200~300 mg, 75~100mg of American ginseng extract, 50~100mg of Astragalus Root P.E, 40~75mg of eucommia ulmoides extracts, 25~60mg of icariin.Preparation method is: first weighing raw material according to the ratio, is ground, cross 60 meshes, obtain mixed-powder, then using conventional capsule fill process, resulting composite powder is packed into capsule shells to get complex capsule.Complex capsule prepared by the present invention can extend the mice burden swimming time, reduce the blood lactase acid level of mouse after movement, increase mouse liver glycogen reserves.It is tested through crowd's test-meal, the fatigue symptoms such as lassitude and weak, pain in low back and legs, sexual disorder can be relieved, illustrated that this product has good anti-fatigue effect, and without side-effects to human body, can take for a long time.
Description
Technical field
The present invention relates to a kind of health foods more particularly to a kind of antifatigue complex capsule and preparation method thereof.
Background technique
Fatigue refers to the weak of the body function as caused by many reasons such as hyperkinesia, sleep insuffience, disease, subjective
On there are the senses of discomfort such as lassitude and weak, DOMS, insomnia, palpitaition, and lead to that immunocompetence is low, easily catches a cold, declines naturally
The symptoms such as old acceleration, the decline of working and learning ability, here it is our usually described " sub-health states ".Brainstrust points out,
High intensity work or prolonged exercise easily cause " chronic fatigue syndrome ", " overworking death ", diabetes, hyperlipidemia, hypertension, swell
A variety of diseases such as tumor, cancer；On the other hand, organism oxidative damage caused by the accumulation of machine interior free yl, and promote
Aging acceleration, immunity degradation one of the major reasons.Showing China at present according to statistics has people more than half to be in slow
The state of fatigue syndrome, fatigue state person is up to 70% in Urban population, and this ratio is also constantly increasing, and holds
Aging caused by continuous over fatigue and oxidative damage has become a kind of common social phenomenon of modern society, causes the generally pass of people
The great attention of note and medical field.Therefore, related antifatigue, anti-oxidant, anti-aging the health food of exploitation and drug, alleviate because
The deterioration of living environment and high-strung work and stress improve people's lives quality and the general level of the health with important
Meaning.
Resisting for selling on domestic market be tired, anti-aging labor product a multitude of names, can be roughly divided into two types: Yi Leishi
Conventional functional beverage is reached by consumed nutrient in supplement movement and maintains body normal physiological function, alleviates
The purpose of fatigue, such as red ox, force health-care belong to such, and the general active constituent content of this kind of product is low, and dose is big, timeliness
Difference；Another kind of is Chinese herbal and crude drugs preparations, i.e., using Chinese medicine as oral healthcare food or drug made of primary raw material, in this kind of product
Have and much declared patent of invention, if patent No. CN97106041.X discloses a kind of SOD health-care tonic wine, the patent is with Chinese holly
Tens of taste Chinese medicines such as matrimony vine, ant, cortex cinnamomi, Gorgon fruit, lotus seeds, Herba Epimedii, Rehmannia glutinosa, Morinda officinalis, Semen Cuscutae, jujube and pure grain
Wine impregnates, and is filtered, is blent, obtains the health protection tonic wine for integrating medical treatment, health protection, nourishing, health；The patent No.
200410058060.5 disclose a kind of antifatigue health food capsule, the patent by thizoma curculiginis, Herba Epimedii, Rehmannia glutinosa, god bone fat,
After deer whip drying and crushing, mixing compounding is packed into capsule and obtains having effects that resist tired health-care edible capsule.But existing production
Product are in place of Shortcomings in terms of curative effect and safety.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of easy to use, without side-effects to human body, significant in efficacy
Antifatigue complex capsule.
Another technical problem to be solved by this invention is to provide the preparation method of the antifatigue complex capsule.
To solve the above problems, a kind of antifatigue complex capsule of the present invention, it is characterised in that: in the complex capsule
Containing polysaccharides, American ginseng extract, Astragalus Root P.E, eucommia ulmoides extracts, icariin, in every 500mg capsule 's content
Each component content are as follows:
200~300 mg of polysaccharides,
75~100mg of American ginseng extract,
50~100mg of Astragalus Root P.E,
40~75mg of eucommia ulmoides extracts,
25~60mg of icariin.
The American ginseng extract specification is 10:1.
The Astragalus Root P.E specification is 10:1.
The eucommia ulmoides extracts specification is 10:1.
A kind of preparation method of antifatigue complex capsule as described above, it is characterised in that: weigh Chinese holly first, in accordance with proportion
Qi polysaccharide, American ginseng extract, Astragalus Root P.E, eucommia ulmoides extracts and icariin cross 60 meshes after being ground, and must mix
Then mixed-powder is packed into capsule shells using routine encapsulation fill process, antifatigue complex capsule is made by powder.
Compared with the prior art, the present invention has the following advantages:
(1) raw material used in the present invention is all integration of drinking and medicinal herbs kind, is had no toxic side effect, and safety is taken, and can be used as food or guarantor
Health food uses.
(2) it is proved by pharmacological evaluation, oral health composition of the present invention can improve body machine caused by labour excessively
Can be weak, have the effects that significantly to strengthen the body resistance to consolidate the constitution, qi and activate blood circulation, strengthening by means of tonics.
Specific embodiment
Combined with specific embodiments below, the present invention is described in further detail, but embodiments of the present invention are simultaneously
The range that not limited to this embodiment indicates.
Embodiment 1:
This antifatigue complex capsule, it is characterised in that: in the complex capsule containing polysaccharides,
American ginseng extract, Astragalus Root P.E, eucommia ulmoides extracts, icariin, each component content in every 500mg capsule 's content
Are as follows: polysaccharides 200mg, American ginseng extract 100mg, Astragalus Root P.E 80mg, eucommia ulmoides extracts 60mg, icariin
60mg。
The preparation method of this antifatigue complex capsule, it is characterised in that: claim commercially available polysaccharides 2000g, west first
American ginseng extract 1000g, Astragalus Root P.E 800g, eucommia ulmoides extracts 600g, icariin 600g cross 60 mesh after being ground
Sieve, obtains mixed-powder, and mixed-powder is then packed into capsule shells using routine encapsulation fill process, obtains capsule 10000, often
The average net weight 500mg of grain.
Instructions of taking and dosage: it is oral, adult daily 3 times, 2 tablets each time.
Embodiment 2:
This antifatigue complex capsule, it is characterised in that: contain polysaccharides, American ginseng extract, Huang in the complex capsule
Stilbene extract, eucommia ulmoides extracts, icariin, each component content in every 500mg capsule 's content are as follows: polysaccharides 300mg, west
American ginseng extract 75mg, Astragalus Root P.E 50mg, eucommia ulmoides extracts 50mg, icariin 25mg.
The preparation method of this antifatigue complex capsule, it is characterised in that: claim commercially available polysaccharides 3000g, west first
American ginseng extract 750g, Astragalus Root P.E 500g, eucommia ulmoides extracts 500g, icariin 250g cross 60 meshes after being ground,
Mixed-powder is obtained, mixed-powder is then packed by capsule shells using routine encapsulation fill process, obtains capsule 10000, every
Average net weight 500mg.
Instructions of taking and dosage: it is oral, adult daily 3 times, 2 tablets each time.
Embodiment 3:
This antifatigue complex capsule, it is characterised in that: contain polysaccharides, American ginseng extract, Huang in the complex capsule
Stilbene extract, eucommia ulmoides extracts, icariin, each component content in every 500mg capsule 's content are as follows: polysaccharides 230mg, west
American ginseng extract 85mg, Astragalus Root P.E 100mg, eucommia ulmoides extracts 40mg, icariin 45mg.
The preparation method of this antifatigue complex capsule, it is characterised in that: claim commercially available polysaccharides 2300g, west first
American ginseng extract 8850g, Astragalus Root P.E 1000g, eucommia ulmoides extracts 400g, icariin 450g cross 60 mesh after being ground
Sieve, obtains mixed-powder, and mixed-powder is then packed into capsule shells using routine encapsulation fill process, obtains capsule 10000, often
The average net weight 500mg of grain.
Instructions of taking and dosage: it is oral, adult daily 3 times, 2 tablets each time.
Anti-fatigue effect detection:
The antifatigue effect of Mouse oral complex capsule of the present invention is tested:
With the resulting antifatigue complex capsule (hereinafter referred to as capsule) of embodiment 2 for test medicine.
Selection Kunming kind healthy male mice, 18-22 grams of weight, totally 160.Loaned swimming test and biochemical indicator (blood
Clear urea nitrogen, lactic acid, hepatic glycogen) used in animal be randomly divided into 4 groups, every group 10, be respectively 0.25g/kg by dosage
, 0.5g/kg, 1.0g/kg point be basic, normal, high 3 dosage groups and 1 blank control group.Using distilled water as solvent, by tested material
It is configured to required concentration, mouse is given by the oral stomach-filling of 20mL/kg stomach-filling volume, carries out indices after continuous gavage 30 days
Observation, blank control group is with equal amount of distilled water stomach-filling.
(1) to the influence of mice burden swimming:
The measurement of walking weight load:
After last gives tested material 30 minutes, mouse is set in swimming trunk went swimming, depth of water 35cm, 25 ± 0.5 DEG C of water temperature, small
The sheet lead of 5% weight of rat-tail root load, record mouse swimming started to the dead time as the mice burden swimming time
(min)。
Mice burden swimming test result: it is shown in Table 1:
As can be seen from Table 1, take the swimming time of each reagent set mouse of the antifatigue complex capsule of the present invention obviously higher than
The value of control group illustrates that the antifatigue complex capsule of the present invention has the function of significantly extending the mice burden swimming time.
(2) influence to mouse items biochemical indicator after movement:
The measurement of serum urea nitrogen content:
After last gives tested material 30min, eye is plucked after the not swimming with a load attached to the body 90min in the water that temperature is 30 DEG C, rest 60min
Ball blood sampling, sets 4 DEG C of refrigerator 3h, and 2000rpm is centrifuged 15min after blood clotting, and serum Self-made reagent is taken to use diacetyl-oxime method,
Measure urea nitrogen content.
The measurement of hepatic glycogen content:
After last gives 30 min of tested material, the not swimming with a load attached to the body 90min in the water that temperature is 30 DEG C puts to death immediately, takes liver
It is dirty to be blotted after physiological saline rinses with filter paper, liver 200mg is accurately weighed, 8 mL trichloroacetic acids are added, every pipe is homogenized 1min,
Homogenate is poured into centrifuge tube, 15 min are centrifuged with 3000rpm, supernatant is transferred in another test tube, 1mL supernatant is taken
It is put into 10 centrifuge tubes, 95% ethyl alcohol 4mL is added, mixes well and is placed on 37-40 DEG C of water-bath 3h, test tube is centrifuged in 3000rpm
15 min carefully outwell supernatant and take precipitating after making test tube handstand 10min, and anthrone method measures hepatic glycogen content.
The measurement of Serum lactic acid content:
After last gives tested material 30 minutes, with glass capillary by eyeball of mouse angular vein 20 μ l of blood sampling, it is added prior
It has been added in the 5mL test tube of 0.48ml 1%NaF solution, has added 1.5mL protein precipitant, oscillation mixes, in 3000rpm
10 min are centrifuged, take supernatant spare.It does not bear a heavy burden after animal blood taking, stops after temperature is 30 DEG C of water went swimming 10min, stand
Again from endocanthion 20 μ l of blood sampling i.e. after 20 μ l, quiet rest 20min of endocanthion blood sampling, processing method is same as above.On three time points
Supernatant presses Self-made reagent measuring method measurement lactic acid content, and blood lactase acid area under the curve is calculated as follows:
Blood lactase acid area under the curve=5 × (stop after 0min blood lactase acid value+2 × swimming after blood lactase acid value+3 × swimming before swimming
Cease 20min blood lactase acid value)
Biochemical Indexes result after mouse movement: 2 are shown in Table:
As can be seen from Table 2, the serum urea content of middle and high dosage group mouse is significantly below control group, and middle and high dosage group is small
The hepatic glycogen content of mouse is significantly higher than control group, and the Serum lactic acid content of middle and high dosage group mouse is substantially less than control group, explanation
The antifatigue complex capsule of the present invention can reduce the serum urea content of mouse after movement, have to the blood lactase acid raising of mouse after movement
Inhibiting effect, while having the function of increasing Glycogen deposit or reducing glycogen use.Thus, the antifatigue compound adhesive of the present invention
Capsule plays the role of good alleviation physical fatigue.
The antifatigue effect of human oral's anti-fatigue health-caring composition of the present invention is tested:
Testing program: the selection age 45-65 years old to have 3 class such as physical tiredness out of strength, pain in low back and legs, sexual disorder tired
The patient of labor symptom takes orally the antifatigue complex capsule that embodiment 2 obtains as test-meal subjects, patient, 3 times a day, early,
In, evening it is each primary, 2 tablets each time, warm water is taken after mixing it with water, and is continuously taken 3 months.
Patient does not receive any other antifatigue remedy measures in duration of medication.
Judgment criteria: it is judged according to invalid, effective, effective three standards, the curative effect judgment criteria of different type patient
It is shown in Table 3:
Efficacy result:
It continuous observation 3 months, is judged according to invalid, effective, effective three standards, the results are shown in Table 4:
As can be seen from Table 4, the various fatigue symptoms for taking the patient of the antifatigue complex capsule of the present invention are very significantly improved,
The total effective rate of this test-meal test reaches 81% or more.Therefore, antifatigue complex capsule prepared by the present invention has significant anti-
Hit the health-care efficacies such as fatigue, qi and activate blood circulation, strengthening by means of tonics.
Claims (6)
1. a kind of antifatigue complex capsule, it is characterised in that: extracted in the complex capsule containing polysaccharides, American Ginseng
Object, Astragalus Root P.E, eucommia ulmoides extracts, icariin, each component content in every 500mg capsule 's content are as follows:
200~300 mg of polysaccharides,
75~100mg of American ginseng extract,
50~100mg of Astragalus Root P.E,
40~75mg of eucommia ulmoides extracts,
25~60mg of icariin.
2. a kind of antifatigue complex capsule according to claim 1, it is characterised in that: the American ginseng extract specification
For 10:1.
3. a kind of antifatigue complex capsule according to claim 1, it is characterised in that: the Astragalus Root P.E specification is
10:1.
4. a kind of antifatigue complex capsule according to claim 1, it is characterised in that: the eucommia ulmoides extracts specification is
10:1.
5. a kind of antifatigue complex capsule according to claim 1, it is characterised in that: the icariin is that single glycosides contains
The icariin extract of 50% or more amount.
6. a kind of preparation method of the described in any item antifatigue complex capsules of Claims 1 to 5, it is characterised in that: main packet
Include following preparation step:
(1) raw material is weighed according to the ratio, is mixed, and is crossed 60 meshes, is obtained composite powder；
(2) using conventional capsule fill process, the resulting composite powder of step (1) is packed into capsule shells, is obtained antifatigue multiple
Close capsule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110522028A (en) * | 2019-09-29 | 2019-12-03 | 承德润雨科技有限公司 | A kind of composition that protect liver is antifatigue and its application |
-
2018
- 2018-09-10 CN CN201811051282.2A patent/CN109222094A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110522028A (en) * | 2019-09-29 | 2019-12-03 | 承德润雨科技有限公司 | A kind of composition that protect liver is antifatigue and its application |
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Application publication date: 20190118 |