CN110522028A - A kind of composition that protect liver is antifatigue and its application - Google Patents
A kind of composition that protect liver is antifatigue and its application Download PDFInfo
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- CN110522028A CN110522028A CN201910930910.2A CN201910930910A CN110522028A CN 110522028 A CN110522028 A CN 110522028A CN 201910930910 A CN201910930910 A CN 201910930910A CN 110522028 A CN110522028 A CN 110522028A
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- antifatigue
- composition
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- protect liver
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A—HUMAN NECESSITIES
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- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
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- Mycology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a kind of composition that protect liver is antifatigue, American ginseng saponin, astragalus polyose, polysaccharides, Blackfungus polyhexose and black tea powder pass through weight proportion appropriate, interaction, common compatibility in the composition, synergy improves antifatigue, anti-oxidant, liver protecting effect jointly；They are able to extend the mice burden swimming time after combining, improve glycogen deposit and activities of antioxidant enzymes, reduce the content of serum lactic, urea nitrogen and liver malonaldehyde, also have the function of apparent liver protecting.Taurine, lysine, inositol, niacin, vitamin B is added in the antifatigue composition of protect liver provided by the invention on the basis of American ginseng saponin, astragalus polyose, polysaccharides, Blackfungus polyhexose and black tea powder6And vitamin B12, antifatigue effect is improved, side effect of the composition to liver is further decreased, reaches better liver protecting and antifatigue effect.
Description
Technical field
The invention belongs to functional food fields, and in particular to a kind of composition that protect liver is antifatigue and its application.
Background technique
With the rapid development of society, people's lives rhythm is substantially improved, so that the pressure of people is more and more, body and mind
Fatigue.Fatigue is a kind of comprehensive physiological and biochemical procedure, is that body necessarily goes out after mental or physical exertion to a certain extent
Existing Physiological protection phenomenon, the 5th international movement biochemistry meeting definition: fatigue is that organism physiology process cannot maintain its function
In a certain specified level and/or scheduled exercise intensity cannot be maintained.Due to the factors such as environment, society, family, individual, people
Brain, psychology, muscle may be chronically at fatigue state, and interior free yl generates excessively, can attack biofilm system, cause rouge
Matter peroxidating, for hypoxgia etc., while can also generate the metabolites such as lactic acid, urea nitrogen, malonaldehyde, human body group is stimulated after accumulation
Cell or nervous system are knitted, homeostasis imbalance, load adaptability reduction and immunity degradation are caused, body is made to be in sub- strong
Health state may be further development of disease.Therefore, it relieves fatigue most important to body health, it has also become people are closed always
The hot spot of note.Anti-fatigue product emerges one after another currently on the market, but most product only add taurine, caffeine, niacinamide,
The additive components such as toner, sweetener, although have antifatigue effect, to the heavy load of internal organ, side effect is big, naturally at
It is point less, and contain a large amount of sugars, the harm such as obesity, fatty liver can be caused for a long time by largely taking, and not meet modern to health
Demand, therefore, have anti-fatigue effect, side effect be smaller or without side-effects, product rich in natural function ingredient increasingly
Favored by people.Compared with antifatigue chemical synthetic drug, the traditional Chinese medicine in China has that safety, ill-effect be few, drug effect
The features such as strong, is widely used using ginseng, root of kirilow rhodiola, Herba Epimedii as the Chinese medicine of representative, still, at present for antifatigue
Research of the research of Chinese medicine only for single medicinal material either food materials, these single raw materials there are effects limited, effect
And disadvantage prominent, that dosage is big.
Summary of the invention
For the technical problem more than solving, the present invention provides a kind of composition with anti-fatigue effect and its in food
Application in beverage, antifatigue composition provided by the invention have the function of liver protecting while antifatigue.
The object of the present invention is to provide a kind of compositions for having both liver protecting effect and anti-fatigue effect.
It is a further object of the present invention to provide a kind of beverages comprising above-mentioned composition.
Another object of the present invention is to provide a kind of application of above-mentioned composition in food and/or beverage.
Purpose according to the present invention, the antifatigue composition of protect liver provided by the invention, comprises the following components in parts by weight:
0.01-0.29 parts of American ginseng saponin, 0.01-0.29 parts of astragalus polyose, 0.01-0.29 parts of polysaccharides, black fungus
0.01-0.29 parts and black tea powder 0.001-0.045 parts of polysaccharide.
Said components may be raw material or raw extract comprising identical component content.
Fatigue is that its function cannot be maintained specified level or each organ under certain environmental conditions and cannot tie up by body
Hold a kind of physiological phenomenon of its scheduled exercise intensity.The reason for generating fatigue is varied, but fatigue is most directly most objective
Performance be exercise tolerance decline；Furthermore it needs largely to energize in movement, the increase of body oxygen consumption can cause internal freedom
Base generates increase, and membrane structure is caused to destroy, and internal superoxide dismutase (SOD) is the primary catalysis for eliminating oxygen radical
Agent；Free radical promotes polyunsaturated fatty acid peroxidating, metabolizable generation malonaldehyde (MDA)；It is in the flue caused by movement
Consumption with hepatic glycogen, muscle glycogen occurs simultaneously, hepatic glycogen, the reserves of muscle glycogen and metabolic capability be determine endurance it is important because
Element；Blood lactase acid, serum urea nitrogen are the Main Biochemicals for evaluating fatigue conditions, and lactic acid is that the whole of glucose anerobic glycolysis produces
Object, when body strenuous exercise, Serum lactic acid content increases, and body often will appear tired；And urea nitrogen is the main of protein metabolism
Final product, when body is in tired state, protein metabolism is reinforced, and serum urea nitrogen, which generates, to be increased.Shield provided by the invention
American ginseng saponin, astragalus polyose, polysaccharides, Blackfungus polyhexose and black tea powder pass through above-mentioned weight in the antifatigue composition of liver
Amount proportion, interaction, common compatibility is synergistic, improves antifatigue, anti-oxidant, liver protecting effect jointly.Its Chinese and Western
Radix Panacis Quinquefolii saponin is the characteristic activities component in a variety of chemical components in American Ginseng, and the American ginseng saponin of suitable concentration can mention
Hepatic glycogen, muscle glycogen content, the content of reduction blood urea nitrogen and blood lactase acid reach antifatigue in useful Mice Body in high abdomen
Purpose.The astragalus polyose of suitable concentration improve body to the adaptability of exercise load, in terms of have it is certain
Effect.Astragalus polyose can enhance antioxidant ability of organism, improve metabolism, increase sugar deposit in vivo.Polysaccharides is
It is rare in plant polyose to contain protein-polysaccharide, wherein the albumen master of the polysaccharide side chain of own carbon sugar composition and 18 kinds of amino acid composition
Chain has bioactivity, and modern medicine study thinks that body immunity can be improved in polysaccharides, enhances hematopoiesis function, liver protection drop
Pressure removes free radical, antifatigue effect.Blackfungus polyhexose has significantly and actively blood lactase acid, hepatic glycogen and muscle glycogen
It influences, but it is unobvious to the effect of serum urea nitrogen.Black tea powder of the invention is ground under low-temperature condition by black tea
Into subtle tea powder, original nutritional ingredient, the fragrance, taste of black tea are maintained very well, and nutrient is easier to be absorbed by the body.Black tea powder
In contain caffeine, cerebral cortex can be stimulated to carry out excitor nerve maincenter, refreshed oneself, enhance memory.After being combined between them
It is able to extend the mice burden swimming time, improves glycogen deposit and activities of antioxidant enzymes, reduces serum lactic, urea nitrogen and liver
The content of malonaldehyde also has the function of apparent liver protecting.
Preferably, the component is according to parts by weight further include:
0.001-0.05 parts of taurine, 0.001-0.02 parts of lysine, 0.001-0.012 parts of inositol, niacin 0.0001-
0.0018 part, vitamin B60.00001-0.00016 parts, vitamin B12 1×10-7-1.8×10-7Part.
The antifatigue composition of protect liver provided by the invention is more in American ginseng saponin, astragalus polyose, polysaccharides, black fungus
Taurine, lysine, inositol, niacin, vitamin B are added on the basis of sugar and black tea powder6And vitamin B12, improve antifatigue
Effect further decreases side effect of the composition to liver.Reach the antifatigue effect of better liver protecting.Wherein taurine
It is the conditionally essential amino acid of human body, taurine is a kind of Auto-regulator of organic infiltration, it is not only involved in adjusting cell volume,
Basis also is provided for the formation of bile salt, also plays important function in terms of the modulation of free calcium concentration in the cell；Lysine
It is alkaline essential amino acid, growth in humans can be promoted to develop, enhances immunity of organisms, while promoting the suction of other nutriments
It receives, there is synergistic effect between other nutrients, can preferably play the physiological function of other nutrients；Inositol is
The growth factor of object, has the function of fat metabolism and cholesterol, and liver fat, inositol and niacin, vitamin B are removed in help6
And vitamin B12Collective effect reduces cholesterol jointly, keeps total balance of the body.The antifatigue composition of above-mentioned protect liver, it is preferable that
It comprises the following components in parts by weight:
0.1538 part of American ginseng saponin, 0.1538 part of astragalus polyose, 0.1538 part of polysaccharides, Blackfungus polyhexose 0.1538
Part, 0.025 part of black tea powder, 0.05 part of taurine, 0.02 part of lysine, 0.01 part of inositol, 0.001 part of niacin, vitamin B6
0.0001 part and vitamin B12 1×10-7Part.
The antifatigue composition of protect liver provided by the invention is by above-mentioned component and content collective effect, phase interaction
With synergy.
The present invention provides a kind of beverage that protect liver is antifatigue, including following components in percentage by weight:
Jujube inspissated juice 16wt%, concentrated haw juice 4wt%, Mint Essence 0.05wt%, Sucralose 0.01wt%, on
The antifatigue composition 0.7213001wt% of the protect liver stated, surplus is water.
Jujube inspissated juice in the antifatigue beverage of protect liver provided by the invention is 65-70 ° of Brix, and concentrated haw juice is
49-70°Brix。
The present invention provides a kind of beverage of composition antifatigue comprising above-mentioned protect liver, includes above-mentioned protect liver in the beverage
Jujube inspissated juice, concentrated haw juice, Mint Essence and the trichlorine sugarcane of antifatigue composition and adjusting mouthfeel and nutritive value
Sugar, obtained beverage protect liver, anti-fatigue effect are prominent, and sweet mouthfeel, audient's range are wide.
The antifatigue composition of above-mentioned protect liver provided by the invention can be applied in food or beverage.
The antifatigue composition of above-mentioned protect liver provided by the invention is capable of in the addition food and beverage of suitable concentration, so that
Food and beverage have protect liver and antifatigue effect.
Preferably, content of the antifatigue composition of the protect liver in food is 0.0441101-
1.28896018wt%.
It is further preferred that content of the antifatigue composition of the protect liver in food is 0.7213001wt%.
Preferably, the content of the antifatigue composition of the protect liver in the beverage is 0.0441101-
1.28896018wt%.
It is further preferred that the content of the antifatigue composition of the protect liver in the beverage is 0.7213001wt%.
By the present inventor the study found that the antifatigue composition of above-mentioned protect liver not only itself component ratio need it is suitable
When, and the additive amount in food or beverage also has a certain impact to protect liver and antifatigue effect.By the group of above-mentioned content
It closes object to be added into food or beverage, not only liver protection can be reached but also antifatigue effect.
The invention has the benefit that
1. American ginseng saponin, astragalus polyose, polysaccharides, black fungus in the antifatigue composition of protect liver provided by the invention
By weight proportion appropriate, interaction, common compatibility is synergistic, improves antifatigue, antioxygen jointly for polysaccharide and black tea powder
Change, the effect of liver protecting；They are able to extend the mice burden swimming time after combining, improve glycogen deposit and antioxidase
Activity reduces the content of serum lactic, urea nitrogen and liver malonaldehyde, also has the function of apparent liver protecting.The present invention
Base of the antifatigue composition of the protect liver of offer in American ginseng saponin, astragalus polyose, polysaccharides, Blackfungus polyhexose and black tea powder
Taurine, lysine, inositol, niacin, vitamin B are added on plinth6And vitamin B12, antifatigue effect is improved, is further dropped
Side effect of the low composition to liver reaches the antifatigue effect of better liver protecting.
2. the antifatigue composition of protect liver provided by the invention is using homologous substance as raw material, component is highly-safe, respectively
It is mutually cooperateed between component, promotes effect, reduce toxic side effect, be added in food or beverage, obtained product safety is nontoxic
Side effect can be eaten for a long time, health care with higher and economic value.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
It obtains other drawings based on these drawings.
Fig. 1 is the schematic diagram that each group composition influences mouse hepatic glycogen content；
Fig. 2 is the schematic diagram that each group composition influences mouse muscle glycogen content；
Fig. 3 is the schematic diagram that each group composition influences mice serum lactic acid content；
Fig. 4 is the schematic diagram that each group composition influences mice serum uric acid nitrogen content；
Fig. 5 is schematic diagram of each group composition to mouse liver superoxide dismutase (SOD) activity influence；
Fig. 6 is schematic diagram of each group composition to mouse liver glutathione peroxidase (GSH-Px) activity influence；
Fig. 7 is schematic diagram of each group composition to mouse liver catalase (CAT) activity influence；
Fig. 8 is the schematic diagram that each group composition influences mouse liver malonaldehyde (MDA) content；
Fig. 9 is schematic diagram of each group composition to mice serum glutamic-pyruvic transaminase (ALT) activity influence；
Figure 10 is schematic diagram of each group composition to mice serum glutamic-oxalacetic transaminease (AST) activity influence；
Figure 11 is schematic diagram of each group composition to mice serum alkaline phosphatase (ALP) activity influence.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
Every 1 parts by weight in following embodiment represent 1g.
Embodiment 1
A kind of composition that protect liver is antifatigue, comprises the following components in parts by weight: 0.01 part of American ginseng saponin, astragalus polyose
0.01 part, 0.01 part of polysaccharides, 0.01 part and 0.001 part of black tea powder of Blackfungus polyhexose.
Embodiment 2
A kind of composition that protect liver is antifatigue, comprises the following components in parts by weight: 0.1538 part of American ginseng saponin, Radix Astragali is more
0.1538 part of sugar, 0.1538 part of polysaccharides, 0.1538 part and 0.025 part of black tea powder of Blackfungus polyhexose.
Embodiment 3
A kind of composition that protect liver is antifatigue, comprises the following components in parts by weight: 0.29 part of American ginseng saponin, astragalus polyose
0.29 part, 0.29 part of polysaccharides, 0.29 part and 0.045 part of black tea powder of Blackfungus polyhexose.
Embodiment 4
A kind of composition that protect liver is antifatigue, comprises the following components in parts by weight: 0.29 part of American ginseng saponin, astragalus polyose
0.29 part, 0.29 part of polysaccharides, 0.29 part of Blackfungus polyhexose, 0.045 part of black tea powder, 0.05 part of taurine, lysine 0.02
Part, 0.012 part of inositol, 0.0018 part of niacin, vitamin B60.00016 part, vitamin B12 1.8×10-7Part.
Embodiment 5
A kind of composition that protect liver is antifatigue, comprises the following components in parts by weight: 0.01 part of American ginseng saponin, astragalus polyose
0.01 part, 0.01 part of polysaccharides, 0.01 part of Blackfungus polyhexose, 0.001 part of black tea powder, 0.001 part of taurine, lysine
0.001 part, 0.001 part of inositol, 0.0001 part of niacin, vitamin B60.00001 part and vitamin B12 1×10-7Part.
Embodiment 6
A kind of composition that protect liver is antifatigue, comprises the following components in parts by weight: 0.1538 part of American ginseng saponin, Radix Astragali is more
0.1538 part of sugar, 0.1538 part of Blackfungus polyhexose, 0.025 part of black tea powder, 0.05 part of taurine, relies by 0.1538 part of polysaccharides
0.02 part of propylhomoserin, 0.01 part of inositol, 0.001 part of niacin, vitamin B60.0001 part and vitamin B12 1×10-7Part.
Embodiment 7
A kind of beverage that protect liver is antifatigue, including following components in percentage by weight: jujube inspissated juice 16wt%, hawthorn are dense
Contracting juice 4wt%, Mint Essence 0.05wt%, Sucralose 0.01wt%, the antifatigue composition of the protect liver that embodiment 5 provides
0.0441101wt%, that is, American ginseng saponin 0.01wt%, astragalus polyose 0.01wt%, polysaccharides 0.01wt%, black fungus are more
Sugared 0.01wt%, black tea powder 0.001wt%, taurine 0.001wt%, lysine 0.001wt%, inositol 0.001wt%, niacin
0.0001wt%, vitamin B60.00001wt% and vitamin B12 1×10-7Wt%, surplus are water.
Embodiment 8
A kind of food that protect liver is antifatigue, including following components in percentage by weight: the protect liver that embodiment 4 obtains is antifatigue
Composition 1.28896018wt%, that is, American ginseng saponin 0.29wt%, astragalus polyose 0.29wt%, polysaccharides 0.29wt%,
Blackfungus polyhexose 0.29wt% black tea powder 0.045wt%, taurine 0.05wt%, lysine 0.02wt%, inositol
0.012wt%, niacin 0.0018wt%, vitamin B60.00016wt%, vitamin B12 1.8×10-7Wt%, supplemented by surplus
Material.
Embodiment 9
A kind of beverage that protect liver is antifatigue, including following components in percentage by weight: jujube inspissated juice 16wt%, hawthorn are dense
Contracting juice 4wt%, Mint Essence 0.05wt%, Sucralose 0.01wt%, the antifatigue composition of the protect liver that embodiment 6 provides
0.7213001wt%, that is, American ginseng saponin 0.1538wt%, astragalus polyose 0.1538wt%, polysaccharides 0.1538wt% are black
Auricularia polysaccharide 0.1538wt%, black tea powder 0.025wt%, taurine 0.05wt%, lysine 0.02wt%, inositol
0.01wt%, niacin 0.001wt%, vitamin B60.0001wt% and vitamin B12 1×10-7Wt%, surplus are water.
Comparative example 1
A kind of composition that protect liver is antifatigue, comprises the following components in parts by weight: 0.3077 part of American ginseng saponin, Radix Astragali is more
0.3077 part of sugar, 0.3077 part of Blackfungus polyhexose, 0.05 part of black tea powder, 0.05 part of taurine, relies ammonia by 0.3077 part of polysaccharides
0.02 part of acid, 0.01 part of inositol, 0.001 part of niacin, vitamin B60.0001 part, vitamin B121×10-7Part.
Test example
1. anti-fatigue test
The composition that embodiment 6, comparative example 1 are obtained evaluates antifatigue effect and liver protecting by internal pharmacodynamic test
The effect of.
The specific method is as follows
Experimental animal: SPF grades of kunming mices, male, 18-22g are purchased from Beijing dimension limited public affairs of tonneau China experimental animal technology
Department, credit number: SCXK (capital) 2016-0006.Raising temperature: 2322 DEG C, relative humidity: 5525%, normal variation, bright round the clock
Dark alternating, light application time 8:00-20:00, free diet, drinking-water.
Experimental method: mouse adaptive feeding is randomly divided into 2 batches after a week, according to weight, every batch of set 1 control group and
2 test sample groups, the specific situation that is grouped are shown in Table 1, using gastric infusion, control group stomach-filling drinking water, test sample group difference
The aqueous solution for the composition that stomach-filling embodiment 6, comparative example 1 obtain.
The aqueous solution of embodiment 6 is that the composition that embodiment 6 obtains is added to the water, and the protect liver that embodiment 6 provides is anti-
Composition 0.7213001wt%, that is, American ginseng saponin 0.1538wt% of fatigue, astragalus polyose 0.1538wt%, polysaccharides
0.1538wt%, Blackfungus polyhexose 0.1538wt%, black tea powder 0.025wt%, taurine 0.05wt%, lysine
0.02wt%, inositol 0.01wt%, niacin 0.001wt%, vitamin B60.0001wt% and vitamin B12 1×10-7Wt%,
Surplus is water.
The aqueous solution of comparative example 1 is that the composition that comparative example 1 obtains is added to the water, i.e. American ginseng saponin
0.3077wt%, astragalus polyose 0.3077wt%, polysaccharides 0.3077wt%, Blackfungus polyhexose 0.3077wt%, black tea powder
0.05wt%, taurine 0.05wt%, lysine 0.02wt%, inositol 0.01wt%, niacin 0.001wt%, vitamin
B60.0001wt%, vitamin B121×10-7Wt%, surplus are water.
The aqueous solution that 1 group of stomach-filling embodiment 6 of given the test agent obtains, 2 groups of stomach-filling comparative examples 1 of given the test agent obtain water-soluble
Liquid, dosage are respectively 9.1 times of composition levels in the aqueous solution of embodiment 6, comparative example 1 (according to the agent of people and mouse
Conversion coefficient is measured to calculate), stomach-filling volume is 0.1mL/10g b.w, daily stomach-filling 1 time, and every 3d weighs 1 adjustment stomach-filling amount, is connected
Continuous stomach-filling 30d.Be administered daily since 1d after 30min each group by mouse be placed in swimming trunk (depth of water 30cm, 25 DEG C 21 of water temperature
DEG C) in carry out adaptability swimming instruction, swimming time is by 10min/d, by day increase 5min to swimming time be 30min,
It maintains until experiment terminates.
1 mice group of table
1.1 swimming with a load attached to the body experiment
After first mouse last dose 30min, by 5% weight sheet lead of mouse tail root weight bearing, it is placed in the depth of water at least
In 30cm, 25 DEG C 21 DEG C of water temperature of swimming trunk, record mouse from swim to death time, i.e. mice burden swimming when
Between, the judgment criteria of dead mouse is that mouse head submerged 10s cannot still emerge, and the results are shown in Table 2.
Influence (x2s, n=10) of the 2 each group composition of table to the mice burden swimming time
Note: * indicates there is significant difference, p < 0.05 compared with the control group.
The raising of exercise tolerance is the most directly performance of anti-fatigue effect, as shown in Table 2, compared with the control group, test sample
Product 1 and 2 can significantly improve mice burden swimming time (p < 0.05), and rate elongation is respectively 87.52% and 71.89%.
The detection of 1.2 biochemical indicators
After second batch mouse last dose 30min, mouse is placed in the swimming trunk of the depth of water at least 30cm, 25 DEG C 21 DEG C of water temperature
Eyeball is extractd after went swimming 90min, rest 60min immediately and takes blood, 4 DEG C stand overnight, and 4000g is centrifuged 10min, serum is separated ,-
20 DEG C of refrigerators save, for measuring serum lactic, urea nitrogen, ALT, AST, ALP content.It is put to death immediately after taking blood, wins mouse
Liver and skeletal muscle, physiological saline are blotted after cleaning with filter paper, and -80 DEG C of refrigerators save after liquid nitrogen flash freezer, for measuring in liver
Glycogen content in glycogen, SOD, GSH-Px, CAT, MDA and muscle, the result is shown in Figure 1-11.
1.2.1 influence of each group composition to mouse hepatic glycogen and muscle glycogen content
Glycogen is most important energy matter in movement, and a large amount of glycogens can be consumed after body movement, energizes insufficient easy production
Raw fatigue, body deposit glycogen is more, more energy can be provided for body movement, thus the generation of delay fatigue.By Fig. 1-2
It is found that compared with the control group, given the test agent 1 and 2 can significantly improve mouse hepatic glycogen and muscle glycogen content (p < 0.05), for
Hepatic glycogen, without significant difference between given the test agent 1 and 2, for muscle glycogen, given the test agent 1 is apparently higher than given the test agent 2, shows
Given the test agent 1 and 2 can improve the deposit of Glycogen, and given the test agent 1 is better than test sample in terms of improving muscle glycogen deposit
Product 2.
1.2.2 influence of each group composition to mice serum lactic acid and urea nitrogen content
After body strenuous exercise, body glucose is changed into anerobic glycolysis by aerobic oxidation, and lactic acid is glucose anaerobic ferment
The final product of solution can influence the normal functions such as organismic internal environment stable state and response to oxidative stress, so as to cause fatigue after accumulation.By
Fig. 3 is it is found that compared with the control group, given the test agent 1 and 2 can significantly reduce serum lactic content (p < 0.05), 1 He of given the test agent
Without significant difference between 2.
Urea nitrogen is the metabolite of protein energy supply, after body strenuous exercise, due to energy matter insufficient supply, can be led
Protein or amino acid production capacity are caused, urea nitrogen is generated, reduces the load adaptability of body, generates fatigue.From the figure 3, it may be seen that with
Control group is compared, and given the test agent 1 and 2 can significantly reduce serum urea nitrogen content (p < 0.05), and the load for improving body is suitable
Ying Xing, without significant difference between given the test agent 1 and 2.
1.2.3 influence of each group composition to SOD in Mice, GSH-Px, CAT and MDA content
After body strenuous exercise, a large amount of active oxygen radicals are generated, attack biofilm system, cause lipid that peroxidating occurs
Damage, free radical can also destroy internal erythrocyte membrane, influence red blood cell fortune oxygen ability, accelerate the generation of organism fatigue, meanwhile, machine
Body protects body to draw from free radical there is also a series of enzyme systems for having and removing free radical, anti-lipid peroxidation damage
The damage risen mainly includes SOD, GSH-Px and CAT.By Fig. 5-8 it is found that compared with the control group, given the test agent 1 and 2 can be shown
Write and improve mouse liver SOD, GSH-Px and CAT activity, and reduce mouse liver MDA content, the GSH-Px of given the test agent 1 and
CAT activity is significantly higher than given the test agent 2, and showing given the test agent 1 and 2 can be improved the activity of body antioxidase, removes body
Excessive free radical reduces level of lipid peroxidation, and 1 effect of given the test agent is better than given the test agent 2.
2. protect liver is tested
Each group composition is on the active influence of mouse ALT, AST and ALP
Chronic fatigue can also cause hepar damnification, and when liver cell is damaged, serum ALT activities are increased, and work as hepatocellular injury
Seriously, when jeopardizing mitochondria, serum AST activity is increased, when the diseases in the liver and gallbladder such as hepatitis, jaundice, cholestasis occur, serum
ALP activity increases.By Fig. 9-11 it is found that compared with the control group, given the test agent 2 can significantly increase mice serum ALT, AST and ALP
Activity, and the Serum ALT of given the test agent 1, AST and ALP activity show long term administration given the test agent 2 to mouse without significant changes
Liver has certain damaging action, and given the test agent 1 has certain protective role to mouse liver.
The present invention is had good by the given the test agent 1 that embodiment 6 obtains it can be seen from the result of table 2 and Fig. 1-11
Antifatigue, anti-oxidant and protection liver effect, although the given the test agent 2 obtained by comparative example 1 also have it is good antifatigue and
Antioxidant effect, but have certain damaging action to liver.This illustrates the antifatigue composition of protect liver provided by the invention for eating
After product or beverage, protection liver effect antifatigue simultaneously can be reached by proportion appropriate and additive amount.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of composition that protect liver is antifatigue, which is characterized in that comprise the following components in parts by weight:
0.01-0.29 parts of American ginseng saponin, 0.01-0.29 parts of astragalus polyose, 0.01-0.29 parts of polysaccharides, Blackfungus polyhexose
0.01-0.29 parts and black tea powder 0.001-0.045 parts.
2. the antifatigue composition of protect liver according to claim 1, which is characterized in that the component is also wrapped according to parts by weight
It includes:
0.001-0.05 parts of taurine, 0.001-0.02 parts of lysine, 0.001-0.012 parts of inositol, niacin 0.0001-0.0018
Part, vitamin B60.00001-0.00016 parts, vitamin B12 1×10-7-1.8×10-7Part.
3. the antifatigue composition of protect liver according to claim 2, which is characterized in that comprise the following components in parts by weight:
0.1538 part of American ginseng saponin, 0.1538 part of astragalus polyose, 0.1538 part of polysaccharides, 0.1538 part of Blackfungus polyhexose,
0.025 part of black tea powder, 0.05 part of taurine, 0.02 part of lysine, 0.01 part of inositol, 0.001 part of niacin, vitamin B6
0.0001 part and vitamin B12 1×10-7Part.
4. a kind of beverage that protect liver is antifatigue, which is characterized in that including following components in percentage by weight: jujube inspissated juice
16wt%, concentrated haw juice 4wt%, Mint Essence 0.05wt%, Sucralose 0.01wt%, protect liver as claimed in claim 3
Antifatigue composition 0.7213001wt%, surplus are water.
5. application of the antifatigue composition of any protect liver of claim 1-3 in food.
6. application according to claim 5, which is characterized in that content of the antifatigue composition of the protect liver in food
For 0.0441101-1.28896018wt%.
7. application according to claim 6, which is characterized in that content of the antifatigue composition of the protect liver in food
For 0.7213001wt%.
8. the application of the antifatigue composition of any protect liver of claim 1-3 in the beverage.
9. application according to claim 8, which is characterized in that the content of the antifatigue composition of the protect liver in the beverage
For 0.0441101-1.28896018wt%.
10. application according to claim 9, which is characterized in that the antifatigue composition of the protect liver containing in the beverage
Amount is 0.7213001wt%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111793140A (en) * | 2020-06-29 | 2020-10-20 | 吉林农业大学 | Black fungus oligosaccharide for protecting oxidative damage of liver cells and preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103211259A (en) * | 2013-04-22 | 2013-07-24 | 河南省淼雨饮品股份有限公司 | Anti-fatigue vitamin health care beverage and preparation method thereof |
| CN103766888A (en) * | 2012-10-26 | 2014-05-07 | 苏州市洋海电子有限公司 | Preparation containing American ginseng extract |
| CN103766885A (en) * | 2012-10-26 | 2014-05-07 | 苏州市洋海电子有限公司 | Health food for alleviating physical fatigue |
| CN106173687A (en) * | 2016-08-11 | 2016-12-07 | 吉林医药学院 | A kind of health beverage containing Auricularia polycose |
| CN106418069A (en) * | 2016-09-12 | 2017-02-22 | 福建万亿店中店电子商务有限责任公司 | Beverage having efficacies of neutralizing effect of alcoholic drinks and protecting liver |
| CN109222094A (en) * | 2018-09-10 | 2019-01-18 | 陈石良 | A kind of antifatigue complex capsule and preparation method thereof |
-
2019
- 2019-09-29 CN CN201910930910.2A patent/CN110522028A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103766888A (en) * | 2012-10-26 | 2014-05-07 | 苏州市洋海电子有限公司 | Preparation containing American ginseng extract |
| CN103766885A (en) * | 2012-10-26 | 2014-05-07 | 苏州市洋海电子有限公司 | Health food for alleviating physical fatigue |
| CN103211259A (en) * | 2013-04-22 | 2013-07-24 | 河南省淼雨饮品股份有限公司 | Anti-fatigue vitamin health care beverage and preparation method thereof |
| CN106173687A (en) * | 2016-08-11 | 2016-12-07 | 吉林医药学院 | A kind of health beverage containing Auricularia polycose |
| CN106418069A (en) * | 2016-09-12 | 2017-02-22 | 福建万亿店中店电子商务有限责任公司 | Beverage having efficacies of neutralizing effect of alcoholic drinks and protecting liver |
| CN109222094A (en) * | 2018-09-10 | 2019-01-18 | 陈石良 | A kind of antifatigue complex capsule and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111793140A (en) * | 2020-06-29 | 2020-10-20 | 吉林农业大学 | Black fungus oligosaccharide for protecting oxidative damage of liver cells and preparation method and application thereof |
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