CN108187008A - It is a kind of to be used to treat Chinese medicine of gastric cancer and preparation method thereof - Google Patents
It is a kind of to be used to treat Chinese medicine of gastric cancer and preparation method thereof Download PDFInfo
- Publication number
- CN108187008A CN108187008A CN201810128441.8A CN201810128441A CN108187008A CN 108187008 A CN108187008 A CN 108187008A CN 201810128441 A CN201810128441 A CN 201810128441A CN 108187008 A CN108187008 A CN 108187008A
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- chinese medicine
- gastric cancer
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of for treating Chinese medicine of gastric cancer and preparation method thereof, using RADIX CURCUMAE as main ingredient, RADIX CURCUMAE has good antitumaous effect, under the collective effect of this 6 taste Chinese medicine of radix scutellariae, bletilla, Rabdosia amethystoides, dried orange peel, Poria cocos and lily so that the active ingredient of RADIX CURCUMAE retains as far as possible；And red ginseng, ganoderma lucidum and the mutual cooperation of royal jelly these types substance have the effect of reinforcing vital energy, veins takes off admittedly, and patient can be helped to restore itself vigour as early as possible, improve autoimmunity；Baked ginger has the effect of warming channel for arresting bleeding, warm in pain, and patient is allowed to reduce feeling of pain.And under the collective effect of fructus amomi, Radix Aucklandiae, pinellia, Radix Glycyrrhizae and hairyvein agrimony this 5 taste Chinese medicine so that the effective antitumor ingredient in RADIX CURCUMAE and Radix Astragali can be good at being absorbed by the body, and can just play anticancer effect in a short time, make patient's early recovery.The present invention is completely using Chinese medicine, and toxicity is extremely low, and human body is almost harmless, and expense is low, and therapeutic effect is pretty good, is suitble to large-scale popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, more particularly to a kind of Chinese medicine and its preparation side for being used to treat gastric cancer
Method.
Background technology
Gastric cancer is one of common malignant tumour.According to statistics, the annual new hair gastric cancer more than 100 ten thousand in the whole world, China accounts for about
40%, death about 800,000, China accounts for 30% or so, and China is one of incidence gastric cancer rate and the highest country of the death rate, incidence
It is world average level with the death rate more than twice.The common sympton of gastric cancer is epigastric discomfort or upper abdomen pain, after feed
Symptom is often aggravated, and with disease progression, the pain increased, and breaking-out is frequent, and is radiated to the small of the back, while be often accompanied by losing the appetite,
Lassitude and weak, nausea and vomiting, scorching hot, sallow complexion, body such as are become thin at the symptoms.
The main means of modern treatment gastric cancer are chemotherapy, radiotherapy, operative treatment, and the wherein chemotherapy of drug and operative treatment takes
Big with high and toxic side effect, chemotherapy, radiotherapy also have normal cell greatly to destroy and make while killing tumor cell
With making the hemopoietic system of human body and immune function severely damaged, increase the pain of patient, easily cause patient dead.
Invention content
In view of the deficiencies of the prior art, the present invention intends to provide a kind of Chinese medicine for being used to treat gastric cancer
And preparation method thereof, which has good therapeutic effect for gastric cancer, and has no toxic side effect.
To achieve the above object, the present invention provides following technical solutions：A kind of Chinese medicine for being used to treat gastric cancer, includes
Following parts by weight Chinese medicine：20-40 parts of RADIX CURCUMAE；10-20 parts of radix scutellariae；10-20 parts of bletilla；10-20 parts of Rabdosia amethystoides；Red ginseng 10-
20 parts；5-10 parts of fructus amomi；5-10 parts of dried orange peel；5-10 parts of Radix Aucklandiae；5-10 parts of pinellia；5-10 parts of baked ginger；3-5 parts of ganoderma lucidum；Radix Glycyrrhizae
3-5 parts；3-5 parts of royal jelly；3-5 parts of Poria cocos；1-2 parts of 1-2 parts of lily and hairyvein agrimony.
For the effect being optimal, the parts by weight of each Chinese medicine are 30 parts of RADIX CURCUMAE in the present invention；15 parts of radix scutellariae；Bletilla 15
Part；10 parts of Rabdosia amethystoides；10 parts of red ginseng；8 parts of fructus amomi；8 parts of dried orange peel；8 parts of Radix Aucklandiae；6 parts of pinellia；5 parts of baked ginger；4 parts of ganoderma lucidum；Radix Glycyrrhizae
4 parts；4 parts of royal jelly；3 parts of Poria cocos；1 part of lily；1 part of hairyvein agrimony.
The dosage form of the Chinese medicine can be one kind in capsule, tablet, water decoction, granule, tablet.
A kind of preparation method for the Chinese herbal granules for being used to treat gastric cancer：
Step 1：First, in accordance with formula weigh RADIX CURCUMAE, bletilla, Rabdosia amethystoides, red ginseng, fructus amomi, dried orange peel, Radix Aucklandiae, pinellia,
Baked ginger and royal jelly clean drying, are then placed in pure water and impregnate 2h, 1g Chinese medicines need 10-15ml pure water, and fast fire is fried open
Afterwards, then slowly 40min is decocted, pours out the decocting liquid of former 1/4 volume of pure water, adds the pure water of remaining decocting liquid volume 1/4；Continue slow
30min is decocted, then pours out the decocting liquid of former 1/4 volume of pure water, adds the water of remaining decocting liquid volume 1/4, continues pan-fried 30min slowly,
Then decocting liquid is poured out, mixes and stir evenly with preceding decocting liquid twice；
Step 2：Decocting liquid obtained in step 1 is concentrated under reduced pressure into the condensed cream one that relative density is 1.08；
Step 3：Ganoderma lucidum, Radix Glycyrrhizae, Poria cocos, lily and hairyvein agrimony have been weighed first, in accordance with formula, has then cleaned drying, powder
It is broken into after fine powder crosses 80 mesh sieve, is extracted 2 times, each 1.5h per 100g Chinese medicine timber-used 200-400mL70% ethyl alcohol, collect extraction
Liquid, collects extracting solution, and leaching puts 24 hours, then filters, obtain supernatant, then ethyl alcohol is recovered under reduced pressure, be concentrated into 60 DEG C, density is
1.08 condensed cream two；
Step 4：Condensed cream one and condensed cream two are uniformly mixed and obtain condensed cream, is subsequently added into mannitol and dextrin
Mixture, mixture weight are the 10% of condensed cream, then add in starch slurry, cross 16 mesh sieve series grains, dry, packing.
Drying temperature in drying is cleaned in step 1 and is set as 30-40 DEG C, drying time 2-3h.It cleans and dries in step 3
Drying temperature is 25-30 DEG C in dry, drying time 1-2h.
The mass ratio of mannitol and dextrin is 2 in the mixture of mannitol and dextrin in step 4:3.
The mass fraction of starch slurry is 15-20% in step 4, and the quality for adding in starch slurry is the 5- of condensed cream quality
10%.
Beneficial effects of the present invention：Using RADIX CURCUMAE as main ingredient, RADIX CURCUMAE has the effect of blood-breaking, inducing meastruation to relieve menalgia, and
And with good antitumaous effect, it contains sesquiterpenoid and sesquiterpene compound these anticancer active principles, but these
Anticancer active principle is difficult extraction, and compares and be difficult to be absorbed by the body；And radix scutellariae, bletilla, Rabdosia amethystoides, dried orange peel, Poria cocos and
Under the collective effect of this 6 taste Chinese medicine of lily so that the active ingredient of RADIX CURCUMAE is retained as far as possible, such as rcumenol, curcuma zedoary
These cancer-resisting substances of diketone, beta-elemene can be effectively retained；Radix Astragali also has a preferable antitumaous effect simultaneously, Radix Astragali with
The mutual cooperation of both RADIX CURCUMAEs so that the anticancer effect of this Chinese medicine greatly improves, can real service in patient, make patient early
Rehabilitation；
RADIX CURCUMAE is cold in nature, constitution of many patients itself is just weaker, may also have certain injury to human body, red in of the invention
Ginseng, ganoderma lucidum and royal jelly these types substance, which cooperate, has the effect of reinforcing vital energy, veins takes off admittedly, can help patient as early as possible
Restore itself vigour, improve autoimmunity, preferably resist tumour cell, reduce injury of the RADIX CURCUMAE to human body, ensure this
Invention is substantially nontoxic to human body；Baked ginger has the effect of warming channel for arresting bleeding, warm in pain, and patient is allowed to reduce feeling of pain.
Under the collective effect of this 5 taste Chinese medicine of fructus amomi, Radix Aucklandiae, pinellia, Radix Glycyrrhizae and hairyvein agrimony so that RADIX CURCUMAE and
Effective antitumor ingredient in Radix Astragali can be good at being absorbed by the body, and can just play anticancer effect in a short time, make patient
Early recovery.For the present invention completely using Chinese medicine, toxicity is extremely low, to human body almost without injury, can courageously use, while this hair
It is bright low relative to surgery cost, and therapeutic effect is pretty good, ordinary people can receive, and have very big market, be suitble to large-scale popularization.
Specific embodiment
Embodiment 1：A kind of Chinese medicine for being used to treat gastric cancer, including following parts by weight substance：30 parts of RADIX CURCUMAE；Radix scutellariae 15
Part；15 parts of bletilla；10 parts of Rabdosia amethystoides；10 parts of red ginseng；8 parts of fructus amomi；8 parts of dried orange peel；8 parts of Radix Aucklandiae；6 parts of pinellia；5 parts of baked ginger；Spirit
4 parts of sesame；4 parts of Radix Glycyrrhizae；4 parts of royal jelly；3 parts of Poria cocos；1 part of lily；1 part of hairyvein agrimony.
Specifically preparation method is：Step 1：First, in accordance with formula, weigh RADIX CURCUMAE, bletilla, Rabdosia amethystoides, red ginseng, fructus amomi,
Dried orange peel, Radix Aucklandiae, pinellia, baked ginger and royal jelly clean drying, and drying temperature is set as 30-40 DEG C, drying time 2-3h；
It is then placed in pure water and impregnates 2h, after 1g Chinese medicines need 10-15ml pure water, fast fire to be fried open, then pan-fried 40min slowly, pour out original
The decocting liquid of 1/4 volume of pure water adds the pure water of remaining decocting liquid volume 1/4；Continue pan-fried 30min slowly, then pour out former pure
The decocting liquid of 1/4 volume of water adds the water of remaining decocting liquid volume 1/4, continues pan-fried 30min slowly, then pours out decocting liquid, with preceding two
Secondary decocting liquid mixing stirs evenly；
Step 2：Decocting liquid obtained in step 1 is concentrated under reduced pressure into the condensed cream one that relative density is 1.08；
Step 3：Ganoderma lucidum, Radix Glycyrrhizae, Poria cocos, lily and hairyvein agrimony are cleaned into drying respectively, drying temperature is 25-30 DEG C, is dried
The dry time is 1-2h；It is then comminuted into after fine powder crosses 80 mesh sieve, is extracted 2 times per 100g Chinese medicine timber-used 200-400mL70% ethyl alcohol,
Each 1.5h collects extracting solution, collects extracting solution, and leaching puts 24 hours, then filters, obtain supernatant, then ethyl alcohol is recovered under reduced pressure,
60 DEG C are concentrated into, density is 1.08 condensed cream two；
Step 4：Condensed cream one and condensed cream two are uniformly mixed and obtain condensed cream, is subsequently added into mannitol and dextrin
Mixture, the mass ratio of mannitol and dextrin is 2 in mixture:3, mixture weight is the 10% of condensed cream, then adds in and forms sediment
Slurry, the mass fraction of starch slurry is 15-20%, and the quality for adding in starch slurry is the 5-10% of condensed cream quality, crosses 16 mesh sieve
Granulation, dry, packing.
Embodiment 2：A kind of Chinese medicine for being used to treat gastric cancer, including following parts by weight substance：RADIX CURCUMAE:20 parts；Radix scutellariae 10
Part；10 parts of bletilla；10 parts of Rabdosia amethystoides；10 parts of red ginseng；5 parts of fructus amomi；5 parts of dried orange peel；5 parts of Radix Aucklandiae；5 parts of pinellia；5 parts of baked ginger；Spirit
3 parts of sesame；3 parts of Radix Glycyrrhizae；3 parts of royal jelly；3 parts of Poria cocos；1 part of lily；1 part of hairyvein agrimony.
The preparation method is the same as that of Example 1.
Embodiment 3：A kind of Chinese medicine for being used to treat gastric cancer, including following parts by weight substance：RADIX CURCUMAE:40 parts；Radix scutellariae 20
Part；20 parts of bletilla；20 parts of Rabdosia amethystoides；10 parts of red ginseng；10 parts of fructus amomi；10 parts of dried orange peel；10 parts of Radix Aucklandiae；10 parts of pinellia；Baked ginger 10
Part；5 parts of ganoderma lucidum；5 parts of Radix Glycyrrhizae；5 parts of royal jelly；5 parts of Poria cocos；2 parts of lily；2 parts of hairyvein agrimony.
The preparation method is the same as that of Example 1.
Embodiment 4：A kind of Chinese medicine for being used to treat gastric cancer, including following parts by weight substance：25 parts of RADIX CURCUMAE；Radix scutellariae 15
Part；15 parts of bletilla；13 parts of Rabdosia amethystoides；13 parts of red ginseng；8 parts of fructus amomi；8 parts of dried orange peel；5 parts of Radix Aucklandiae；5 parts of pinellia；5 parts of baked ginger；Spirit
3 parts of sesame；4 parts of Radix Glycyrrhizae；5 parts of royal jelly；3 parts of Poria cocos；1 part of lily；2 parts of hairyvein agrimony.
The preparation method is the same as that of Example 1.
Embodiment 5：A kind of Chinese medicine for being used to treat gastric cancer, including following parts by weight substance：35 parts of RADIX CURCUMAE；Radix scutellariae 18
Part；18 parts of bletilla；10 parts of Rabdosia amethystoides；10 parts of red ginseng；5 parts of fructus amomi；5 parts of dried orange peel；10 parts of Radix Aucklandiae；10 parts of pinellia；6 parts of baked ginger；
4 parts of ganoderma lucidum；3 parts of Radix Glycyrrhizae；3 parts of royal jelly；4 parts of Poria cocos；1 part of lily；1 part of hairyvein agrimony.
The preparation method is the same as that of Example 1.
Drug effect is examined, animal pharmacodynamic experiment；
It is prepared using human gastric cancer GC-7901 model of nude mice bearing tumor：
Exponential phase tumour cell is selected, cell concentration is adjusted to 107/ ml, in mouse oxter, inoculated tumour cell hangs
Liquid 0.1ml, is equivalent to 106Cell/mouse, whole operation process are required to sterile working, observe the growing state of tumour daily.
After inoculation 15 days, to there is tumor nodule diameter up to 0.8cm in inoculation position, the indexs such as quality is harder regard as into knurl.
Experimental animal is grouped and administration：
Animal packet：It is divided into blank group, model group, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, reality
Apply 5 groups of example, every group 20.Blank group is using normal nude mice, remaining each group is using the nude mice into knurl.
Administration：Blank group gives physiological saline, and model group gives physiological saline, and 1 group to 5 groups of embodiment uses embodiment 1 to 5 respectively
Obtained Chinese herbal granules, each 6g/kg, every group of daily morning 8:00 gastric infusion is fed, once a day, the time 14
My god.
Testing index and method
General state：
Observe animal two weeks after grouping, the appetite of every group of mouse at the end of administration, drinking-water, body weights.Weight becomes
Weight before weight-administration after change=medication 14 days；Disappear for every group at the end of appetite, amount of drinking water=start medication to medication after 14 days
The total amount of consumption.
Gastric emptying measures
Prepare semisolid paste：10g sodium carboxymethylcelluloses are taken, are dissolved in 250mL distilled water, are separately added into milk powder 16g, sugar
8g, starch 8g, activated carbon end 2g, stir evenly, and are configured to the black semisolid paste of 300mL about 300g.Refrigerator cold-storage is used
Shi Huifu is administered the 14th day to room temperature, and after fasting 18 hours, intragastric administration on mice gives semisolid paste 0.8mL/ only.Neck is taken off after 20min
Vertebra puts to death mouse, opens fu jie and pricks stomach cardia and pylorus, takes stomach, full weight is claimed after being dried with filter paper, then cuts off body of stomach along greater curvature,
It is dried after washing away gastric content, claims net weight.Using stomach full weight and the difference of stomach net weight as residue weight in stomach, residue in stomach is calculated
The weight percent for accounting for filled semisolid paste is residual rate in stomach.It is rapid simultaneously to take out small intestine, directly it is laid on blank sheet of paper after gently removing
On, pylorus is measured to ileocecum portion overall length and pylorus to the distance in black semisolid paste forward position, is pasted with pylorus to black semisolid
The percentage that the distance in forward position accounts for pylorus to ileocecus overall length is Intestinal propulsive rate.
1 knurl mouse weight of table, appetite, amount of drinking water situation table
By table 1 as it can be seen that body weight evolution is most for blank group, model group body weight evolution is minimum, model group and blank pair
It is compared according to group, there is significant difference.The body weight evolution of experimental mouse is in blank group and mould in 1 to 5 group of the embodiment of the present invention
Between type group, and all close to blank group, wherein embodiment 1 can tentatively illustrate Chinese medicine made of the present invention very close to blank group
Particle has certain effect to killing tumour cell in stomach, has certain effect to treatment gastric cancer, is suitble to further genralrlization.
2 gastric emptying of table, alvine pushing rate situation table
| Group | Residual rate (%) in stomach | Intestinal propulsive rate (%) |
| Blank group | 23.05 | 75 |
| Model group | 53.68 | 40.21 |
| 1 group of embodiment | 27.62 | 72.12 |
| 2 groups of embodiment | 37.68 | 58.01 |
| 3 groups of embodiment | 35.43 | 60.22 |
| 4 groups of embodiment | 33.57 | 64.18 |
| 5 groups of embodiment | 31.08 | 67.82 |
As can be seen from Table 2：
(1) for model group compared with residual rate, Intestinal propulsive rate individual in the stomach of blank, the two has significant difference；Pass through
After taking Chinese medicine made of the present invention, it can be found that residual rate is greatly lowered in its stomach, Intestinal propulsive rate greatly improves especially
It is 1 group of embodiment, very close to blank group, that is, took the mouse for the Chinese medicine that embodiment 1 is prepared and the basic phase of normal mice
Together, further illustrate the Chinese medicine has good effect for treatment gastric cancer, can further be promoted.
Animal acute toxicity test
Tested Chinese medicine preparation：Granule manufactured by 1-5 of the embodiment of the present invention, by 1:2 add purified water, and solution is made, standby
With.
Experimental animal：Regular grade kunming mice, each embodiment 20 mouse of correspondence, weight 20g ± 5g, male and female are each
Half, female mice is without pregnant.
The solution that Chinese herbal granules of the present invention are prepared is poured into the stomach of experimental mouse, when given low reaches 780.2g lifes
During medicine/kg dosage, there is light activity reduction in mouse after administration, restores within 1 hour or so normal, 7 days is observed continuously after administration, nothing
One animal dead, overall health of patients, diet, to take the photograph water, urine and body weight increase normal.
Result of the test shows：The maximum dosage-feeding of granule manufactured by intragastric administration on mice EXAMPLE Example 1-5 is
780.2g crude drugs/kg/d (LD50 ＞ 780.2g crude drugs/kg).The daily clinical application total amount of traditional Chinese medicine powder of the present invention is up to
0.20g crude drugs/kg/d；By batheroom scale, the dosis tolerata of intragastric administration on mice water decoction is 3901 times of clinical patient, prompts the medicine acute
Toxicity is extremely low, clinical application safety.
5.5th, long-term toxicity test for animals
Tested Chinese medicine preparation：Chinese herbal granules obtained by embodiment of embodiment of the present invention 1-5, by 1:2 add purified water, are made molten
Liquid, it is spare.
Experimental animal：Regular grade SD rats, weight 210g ± 14g, half male and half female, female rats are without pregnant.
Method and result：
5 kinds of Chinese herbal granules：High, medium and low three dosage groups are divided into, per weight dosage is respectively patient's dose
180,60,20 times；Experimental mouse is randomly divided into 16 groups, every group of 20 experimental mouses, wherein 15 groups of difference gavages, 3 kinds of three dosage
Particle agent solution, remaining 1 group of gavage physiological saline (40 times of patient's dose)；All 16 groups of equal continuous gavages 180 days are seen
Animal general toxic reaction and severity are examined, checks each position by operating instruction after execution, and carry out hematology, ALT, BUN
And the pathological examination of the main organs such as the heart, liver, spleen, lung, kidney, stomach；By long-term feeding, it is anti-that 16 groups of rats do not occur toxicity
It should.It physically well develops.Macroscopic appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN are disease-free compared with the control group
Rationality changes.The not significant change such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, it is therefore contemplated that through proved by pathology, 5 kinds
Chinese herbal granules show animal without chronic toxicity.
Pass through two above toxicity test, it was demonstrated that the present invention by EXAMPLE Example 1-5 make granule be it is safe,
It has no toxic side effect, can be taken by patient.
Using RADIX CURCUMAE as main ingredient in the present invention, RADIX CURCUMAE has the effect of blood-breaking, inducing meastruation to relieve menalgia, and with fine
Antitumaous effect, it contains sesquiterpenoid and sesquiterpene compound these anticancer active principles, but these anticancer working substances
Matter is difficult extraction, and compares and be difficult to be absorbed by the body；And in radix scutellariae, bletilla, Rabdosia amethystoides, dried orange peel, Poria cocos and lily this 6 taste
Under the collective effect of medicine so that the active ingredient of RADIX CURCUMAE is retained as far as possible, such as rcumenol, curdione, β-elemi
These cancer-resisting substances of alkene can be effectively retained；Radix Astragali also has preferable antitumaous effect, both Radix Astragali and RADIX CURCUMAE phase simultaneously
Mutually cooperation so that the anticancer effect of this Chinese medicine greatly improves, can real service in patient, make patient's early recovery；
RADIX CURCUMAE is cold in nature, constitution of many patients itself is just weaker, may also have certain injury to human body, red in of the invention
Ginseng, ganoderma lucidum and royal jelly these types substance, which cooperate, has the effect of reinforcing vital energy, veins takes off admittedly, can help patient as early as possible
Restore itself vigour, improve autoimmunity, preferably resist tumour cell, reduce injury of the RADIX CURCUMAE to human body, ensure this
Invention is substantially nontoxic to human body；Baked ginger has the effect of warming channel for arresting bleeding, warm in pain, and patient is allowed to reduce feeling of pain.
Under the collective effect of this 5 taste Chinese medicine of fructus amomi, Radix Aucklandiae, pinellia, Radix Glycyrrhizae and hairyvein agrimony so that RADIX CURCUMAE and
Effective antitumor ingredient in Radix Astragali can be good at being absorbed by the body, and can just play anticancer effect in a short time, make patient
Early recovery.For the present invention completely using Chinese medicine, toxicity is extremely low, to human body almost without injury, can courageously use, while this hair
It is bright low relative to surgery cost, and therapeutic effect is pretty good, ordinary people can receive, and have very big market, be suitble to large-scale popularization.
The above is only the preferred embodiment of the present invention, and protection scope of the present invention is not limited merely to above-mentioned implementation
Example, all technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art
Those of ordinary skill for, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (7)
1. a kind of Chinese medicine for being used to treat gastric cancer, it is characterised in that：Include following parts by weight Chinese medicine：20-40 parts of RADIX CURCUMAE；
10-20 parts of radix scutellariae；10-20 parts of bletilla；10-20 parts of Rabdosia amethystoides；10-20 parts of red ginseng；5-10 parts of fructus amomi；5-10 parts of dried orange peel；Radix Aucklandiae
5-10 parts；5-10 parts of pinellia；5-10 parts of baked ginger；3-5 parts of ganoderma lucidum；3-5 parts of Radix Glycyrrhizae；3-5 parts of royal jelly；3-5 parts of Poria cocos；Lily
1-2 parts and 1-2 parts of hairyvein agrimony.
2. a kind of Chinese medicine for being used to treat gastric cancer according to claim 1, it is characterised in that：Preferably, Chinese medicine
Parts by weight are：30 parts of RADIX CURCUMAE；15 parts of radix scutellariae；15 parts of bletilla；10 parts of Rabdosia amethystoides；10 parts of red ginseng；8 parts of fructus amomi；8 parts of dried orange peel；Wood
It is 8 parts fragrant；6 parts of pinellia；5 parts of baked ginger；4 parts of ganoderma lucidum；4 parts of Radix Glycyrrhizae；4 parts of royal jelly；3 parts of Poria cocos；1 part of 1 part of lily and hairyvein agrimony.
3. a kind of Chinese medicine for being used to treat gastric cancer according to claim 1, it is characterised in that：The dosage form of the Chinese medicine can be
One kind in capsule, tablet, water decoction, granule, tablet.
4. a kind of preparation method of Chinese herbal granules for being used to treat gastric cancer according to claim 3, it is characterised in that：Packet
Include following steps,
Step 1：RADIX CURCUMAE, bletilla, Rabdosia amethystoides, red ginseng, fructus amomi, dried orange peel, Radix Aucklandiae, pinellia, baked ginger are weighed first, in accordance with formula
And royal jelly, drying is cleaned, is then placed in pure water and impregnates 2h, after 1g Chinese medicines need 10-15ml pure water, fast fire to be fried open,
It decocts 40min slowly again, pours out the decocting liquid of former 1/4 volume of pure water, add the pure water of remaining decocting liquid volume 1/4；Continue slow decoct
30min, then the decocting liquid of former 1/4 volume of pure water is poured out, the water of remaining decocting liquid volume 1/4 is added, continues pan-fried 30min slowly, so
Decocting liquid is poured out afterwards, mixes and stirs evenly with preceding decocting liquid twice；
Step 2：Decocting liquid obtained in step 1 is concentrated under reduced pressure into the condensed cream one that relative density is 1.08；
Step 3：Ganoderma lucidum, Radix Glycyrrhizae, Poria cocos, lily and hairyvein agrimony have been weighed first, in accordance with formula, drying has then been cleaned, is ground into
It after fine powder crosses 80 mesh sieve, is extracted 2 times, each 1.5h per 100g Chinese medicine timber-used 200-400mL70% ethyl alcohol, collects extracting solution, received
Collect extracting solution, leaching puts 24 hours, then filters, obtain supernatant, then ethyl alcohol is recovered under reduced pressure, be concentrated into 60 DEG C, density 1.08
Condensed cream two；
Step 4：Condensed cream one and condensed cream two are uniformly mixed and obtain condensed cream, is subsequently added into the mixing of mannitol and dextrin
Object, mixture weight are the 10% of condensed cream, then add in starch slurry, cross 16 mesh sieve series grains, dry, packing.
5. a kind of preparation method of Chinese herbal granules for being used to treat gastric cancer according to claim 4, it is characterised in that：Step
Drying temperature in drying is cleaned in rapid one and is set as 30-40 DEG C, drying time 2-3h.It is cleaned in step 3 and temperature is dried in drying
It is 25-30 DEG C to spend, drying time 1-2h.
6. a kind of preparation method of Chinese herbal granules for being used to treat gastric cancer according to claim 5, it is characterised in that：Step
The mass ratio of mannitol and dextrin is 2 in the mixture of mannitol and dextrin in rapid four:3.
7. a kind of preparation method of Chinese herbal granules for being used to treat gastric cancer according to claim 6, it is characterised in that：Step
The mass fraction of starch slurry is 15-20% in rapid four, and the quality for adding in starch slurry is the 5-10% of condensed cream quality.
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