CN108186922A - A kind of preparation method of hypoglycemic composition - Google Patents
A kind of preparation method of hypoglycemic composition Download PDFInfo
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- CN108186922A CN108186922A CN201810134610.9A CN201810134610A CN108186922A CN 108186922 A CN108186922 A CN 108186922A CN 201810134610 A CN201810134610 A CN 201810134610A CN 108186922 A CN108186922 A CN 108186922A
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Classifications
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- Inorganic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
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Abstract
The present invention provides a kind of preparation methods of hypoglycemic composition, it includes the following steps：(1) bulk pharmaceutical chemicals are weighed；(2) it by ginseng extracting in water, then with papain enzymolysis, centrifuges, filter, being concentrated to give medicinal extract, it is spare；(3) by balsam pear extracting in water, filter, be concentrated to give medicinal extract, it is spare；(4) by Saussurea involucrata culture protease hydrolyzed, medicinal extract is then concentrated to give, it is spare；(5) by the medicinal extract mixing of step (2) (4), resistant dextrin is added in, is then spray-dried, it is spare；(6) it by corn stigma, Poria cocos, hawthorn, matrimony vine, Gynura procumbens (Lour.) Merr extracting in water, filtering, concentration, is then spray-dried, it is spare；(7) step (5) with the spray dried powder of step (6) is mixed, adds in pharmacy, health products or the acceptable auxiliary material of field of food or complementary ingredient is prepared into common preparation.The composition that preparation method of the present invention obtains has significant hypoglycemic effect, and application prospect is good.
Description
Technical field
The present invention relates to a kind of preparation methods of hypoglycemic composition.
Background technology
Diabetes (diabetes) are comprehensive metabolic disorder diseases characterized by hyperglycemia, with coronary heart disease, cancer simultaneously
The referred to as three big killers of human life seriously affect the physical and mental health of people.With people's living standards continue to improve and drink
That eats is irregular, and China's diabetes prevalence increases year by year, and the trend of rejuvenation is presented, and diabetes are had become as great public affairs
Hygienic issues altogether.
At present, clinical treatment diabetes are to use western medicine, but side effect is larger, such as biguanide drug curative effect mostly
It is low, long with generation hyperlactacidemia；Ioduria class medicine is long with damage liver, kidney and haemocyte and yellow amine medicine cross allergy, later stage
Generate secondary failure；Long with insulin, patient's body is made to generate pancreas islet mass formed by blood stasis, promotes microangiopathy occurrence and development, and Western medicine
Medical expense it is higher.And Chinese medicine Small side effects and price is relatively reasonable, therefore, prepare it is specific to diabetes curative effect in
Medicine drug is the active demand of numerous diabetics.
Invention content
The purpose of the present invention is to provide the preparation sides of a kind of drug that can be hypoglycemic, health food or food compositions
Method.
The present invention provides a kind of preparation methods of hypoglycemic composition, it includes the following steps：
(1) bulk pharmaceutical chemicals of following weight proportioning are weighed：1.6-3.4 parts of Saussurea involucrata culture, 7-27 parts of ginseng, balsam pear 50-80
Part, 36-74 parts of corn stigma, 28-52 parts of Poria cocos, 12-18 parts of hawthorn, 15-21 parts of matrimony vine, 35-50 parts of Gynura procumbens (Lour.) Merr, resistance paste
It is 16-30 parts smart；
(2) it by ginseng extracting in water, then with papain enzymolysis, centrifuges, filter, being concentrated to give medicinal extract, it is spare；
(3) by balsam pear extracting in water, filter, be concentrated to give medicinal extract, it is spare；
(4) by Saussurea involucrata culture protease hydrolyzed, medicinal extract is then concentrated to give, it is spare；
(5) by the medicinal extract mixing of step (2)-(4), resistant dextrin is added in, is then spray-dried, it is spare；
(6) it by corn stigma, Poria cocos, hawthorn, matrimony vine, Gynura procumbens (Lour.) Merr extracting in water, filtering, concentration, is then spray-dried,
It is spare；
(7) step (5) with the spray dried powder of step (6) is mixed, adds in pharmacy, health products or field of food and be subjected to
Auxiliary material or complementary ingredient be prepared into common preparation.
Wherein, in step (2), the method for extraction is：It is extracted 2 times in multi-function extractor, wherein, add water 20 for the first time
It measures again, 65 DEG C of temperature are soaked 30 minutes, then, are extracted 1.5 hours, are filtered at 95-100 DEG C；Second plus 10 times of amounts of water, it is other with the
Primary extracting method merges filtrate twice；
The method of enzymolysis is：The papain that mass percent is 3 ‰ is added in, it is small that 6 are digested under 30-40 DEG C or room temperature
When；
And/or concentration uses two effect concentration methods to relative density for 1.02 (65~70 DEG C).
Wherein, in step (3), the method for extraction is：It is extracted 2 times in multi-function extractor, wherein, add water 10 for the first time
It measures again, 100 DEG C are extracted 1 hour, filtering；For the second time plus 8 times of amounts of water, the extracting method of other same first times merge filtrate twice；
And/or concentration uses two effect concentration methods to relative density for 1.01 (65~70 DEG C).
Wherein, in step (4), the method for enzymolysis is：The water of the weight such as addition in Saussurea involucrata culture, then adds in final
Mass percent is 3 ‰ protease, and room temperature digests 12 hours；
And/or concentration uses two effect concentration methods to relative density for 1.01 (65~70 DEG C).
Wherein, in step (5), the parameter of spray drying is：Inlet air temperature is 150 DEG C, and leaving air temp is 85 DEG C, charging speed
It spends for 3.5-4.0Hz, tower body pressure difference is-100-- 200Pa.
Wherein, in step (6), the method for extraction is：It is extracted 2 times in multi-function extractor, wherein, add water 10 for the first time
It measures again, 100 DEG C are extracted 1 hour, filtering；For the second time plus 8 times of amounts of water, the extracting method of other same first times merge filtrate twice；
Concentration uses two effect concentration methods to relative density for 1.01 (65~70 DEG C)；
And/or the parameter of spray drying is：Inlet air temperature is 150 DEG C, and leaving air temp is 180 DEG C, and charging rate is
3.5-4.0Hz, tower body pressure difference are-100-- 200Pa.
Wherein, in step (7), after spray dried powder is mixed, add purified water, then tune pH value to 6.5, filling, sterilizing,
To obtain the final product.
Wherein, in step (1), the weight proportion of bulk pharmaceutical chemicals is：
2-3 parts of Saussurea involucrata culture, 9-25 parts of ginseng, 55-75 parts of balsam pear, 45-65 parts of corn stigma, 35-45 parts of Poria cocos, hawthorn
15 parts, 18 parts of matrimony vine, 45 parts of Gynura procumbens (Lour.) Merr, 20-25 parts of resistant dextrin.
Saussurea involucrata culture：Refer to aseptically, by the in vitro plant organ of saussurea involucrata, tissue, cell, embryo or primary
Plastid culture is cultivated on the culture medium manually prepared under conditions of manual control, make its organize or cell proliferation into
And the technology cultivated as required；Or its dedifferentiation is made to generate callus, and gradually differentiate organ again and grown up to
Whole plant and the culture produced.
Gynura procumbens (Lour.) Merr：For the dry rhizome of composite family Gynura Cass Gynura procumbens (Lour.) Merr, slightly sweet flavor is mild-natured, can promoting menstruation work
Network, inflammation-diminishing and cough-controlling, eliminating stasis to subdue swelling, blood activating and promoting tissue regeneration.It cooks edible or medicinal, there is reducing blood lipid, blood pressure lowering, hypoglycemic effect, it can
To replenish the calcium, anti influenza and hepatitis B, anti-flu, improve the immunity of the human body and other effects.
Wherein, in step (1), the weight proportion of bulk pharmaceutical chemicals is：
2 parts of Saussurea involucrata culture, 9 parts of ginseng, 55 parts of balsam pear, 65 parts of corn stigma, 45 parts of Poria cocos, 15 parts of hawthorn, 18 parts of matrimony vine,
45 parts of Gynura procumbens (Lour.) Merr, 20 parts of resistant dextrin；
Or,
3 parts of Saussurea involucrata culture, 25 parts of ginseng, 75 parts of balsam pear, 45 parts of corn stigma, 35 parts of Poria cocos, 15 parts of hawthorn, matrimony vine 18
Part, 45 parts of Gynura procumbens (Lour.) Merr, 25 parts of resistant dextrin.
Wherein, protein >=20% of the Saussurea involucrata culture, general flavone >=7%, moisture≤10%, ash content≤10%；
Preferably, the Saussurea involucrata culture is purchased from Dalian Puruikang Biotechnology Co.
Composition prepared by the method for the present invention can significantly reduce the blood glucose of diabetes and hyperglycemic patients, and can be effective
The insulin dosage of diabetic is reduced, therapeutic effect is notable；And it is suitable as the herbal cuisine food of diabetes and hyperglycemic patients
Product, application prospect are good.
Description of the drawings
Fig. 1 preparation process schematic diagrams of the present invention；Process carries out in 100,000 grades of clean areas in dotted line frame.
Specific embodiment
It is described further below with embodiment, but the present invention is not limited to these embodiments.
Saussurea involucrata culture：Dalian Puruikang Biotechnology Co；
Fresh goods quality requirement：Character：Aubergine bulk particle；Protein >=1%；General flavone >=0.4%；Moisture≤
96%；Ash content≤1%；
Dry product quality requirement：Character：Purplish grey powder；Protein >=20%；General flavone >=7%；Moisture≤10%；Ash content
≤ 10%.
Protease：Purchased from Hunan Ao Chi bio tech ltd, technical indicator：100000 vigor.
1 preparation method of the present invention of embodiment
Raw material：Saussurea involucrata culture (dry product) 0.2kg, ginseng 0.9kg, balsam pear 5.5kg, corn stigma 6.5kg, Poria cocos 4.5kg,
Hawthorn 1.5kg, matrimony vine 1.8kg, Gynura procumbens (Lour.) Merr 4.5kg, resistant dextrin 2kg, xylitol 0.02kg.
Preparation process is as follows：
(1) ginseng extracts
1. pre-treatment：If what is bought is active compound, it should also be chosen, impurity and the product that go mouldy of damaging by worms, remove non-edible
Then position carries out cutting.
2. extraction, filtering：Ginseng is thrown in multi-function extractor.For the first time plus 20 times of amounts of water, 65 DEG C of temperature are soaked 30 minutes,
Steam valve is opened, extraction pressure inside the tank is adjusted and must not exceed 0.2Mpa, open steam and be warming up to timing after slightly boiling, keep 95-
100 DEG C are extracted 1.5 hours, first cross 20 mesh sieve, in 100 mesh filter-cloth filterings, tapping is in enzymatic vessel；Second plus 10 times of amounts of water,
It is carried again once by the extracting method of first time, tapping, until filtrate is incorporated in enzymatic vessel twice, adds in quality hundred in enzymatic vessel
Divide than the papain for 3 ‰ (w/w), digested 6 hours under 30-40 degrees Celsius or room temperature, then high speed centrifugation, centrifugate
By ceramic membrane filter, liquid and impurity after filtering are centrifuged repeatedly.
3. concentration：Filtrate is pumped into two effect inspissators and is concentrated into relative density as 1.02 (65~70 DEG C).One effect concentration
60~75 DEG C of temperature, 0.03~0.05Mpa of vacuum degree；Two 50~55 DEG C, vacuum degree 0.03Mpa-0.07Mpa of thickening temperatures of effect,
0.06~0.10Mpa of steam pressure.Medicinal extract yield should be 100-120%, and medicinal extract is spare.
(2) balsam pear extracts
1. pre-treatment：If what is bought is active compound, it should also be chosen, impurity and the product that go mouldy of damaging by worms, remove non-edible
Then position carries out cutting.
2. extraction, filtering：Ginseng is thrown in multi-function extractor.For the first time plus 10 times of amounts of water, opening steam valve are adjusted
Section extraction pressure inside the tank must not exceed 0.2Mpa, opens steam and is warming up to timing after slightly boiling, be kept for 100 DEG C extract 1 hour, first mistake
20 mesh sieve, and in 100 mesh filter-cloth filterings, tapping is in receiver；Second plus 8 times of amounts of water, are carried again by the extracting method of first time
Once, tapping is in receiver, until filtrate is incorporated in receiver twice, high speed centrifugation, centrifugate passes through ceramic membrane filter, mistake
Liquid and impurity after filter are centrifuged repeatedly.
3. concentration：Filtrate is pumped into two effect inspissators and is concentrated into relative density as 1.01 (65~70 DEG C).One effect concentration
60~75 DEG C of temperature, 0.03~0.05Mpa of vacuum degree；Two 50~55 DEG C, vacuum degree 0.03Mpa-0.07Mpa of thickening temperatures of effect,
0.06~0.10Mpa of steam pressure.Medicinal extract yield should be 100-120%, and medicinal extract is spare.
(3) Saussurea involucrata culture (dry product) is handled
1. Saussurea involucrata culture (dry product) is placed in enzymatic vessel, the water of the weight such as addition stirs evenly, adds in quality percentage
Than the protease for 3 ‰ (w/w), digested 12 hours under room temperature.
2. concentration：Filtrate is pumped into and is concentrated into relative density in two effect inspissators and is by ceramic membrane filter by enzymolysis liquid
1.01 (65~70 DEG C).One 60~75 DEG C of thickening temperature of effect, 0.03~0.05Mpa of vacuum degree；Two 50~55 DEG C of thickening temperatures of effect,
Vacuum degree 0.03Mpa-0.07Mpa, 0.06~0.10Mpa of steam pressure.Medicinal extract yield is about 80%, and medicinal extract is spare.
(4) it mixes
Above-mentioned three kinds of medicinal extract is stirred 30 minutes, while add in quantitative resistant dextrin in mixing, obtained medicinal extract is standby
With.
(5) it is spray-dried
Steam pressure control is set as 150 DEG C between 0.4MPa-0.5MPa, by spray dryer inlet air temperature, outlet air
Temperature setting is 85 DEG C, and the medicinal extract that the 4th step is obtained is sent into spray dryer, and charging rate is arranged on 3.5-4.0Hz, tower
Body pressure difference is maintained at-100-- 200Pa, collects powder, and powder yield is 10.0-12.5%, and total Ginsenosides Content answers >=
0.1%, packaging bag is packed into, no more than bag volume 2/3, with vacuum machine vacuum-pumping and sealing, weighs labeling, it is spare.
(6) extraction of Chinese medicine material
1. pre-treatment：If what is bought is active compound, it should also be chosen, impurity and the product that go mouldy of damaging by worms, remove non-edible
Position.
2. extraction：Corn stigma, Poria cocos, hawthorn, matrimony vine, Gynura procumbens (Lour.) Merr are thrown in multi-function extractor.Add for the first time
10 times of amounts of water, open steam valve, adjust extraction pressure inside the tank and must not exceed 0.2Mpa, open after steam is warming up to slightly boiling and count
When, it is kept for 100 DEG C extract 1 hour, first crosses 20 mesh sieve, in 100 mesh filter-cloth filterings, tapping is in receiver；Second plus 8 times of water
Amount, is carried once again by the extracting method of first time, and tapping is in receiver, until filtrate is incorporated in receiver twice.
3. concentration：Filtrate is pumped into two effect inspissators and is concentrated into relative density as 1.01 (65~70 DEG C).One effect concentration
60~75 DEG C of temperature, 0.03~0.05Mpa of vacuum degree；Two 50~55 DEG C, vacuum degree 0.03Mpa-0.07Mpa of thickening temperatures of effect,
0.06~0.10Mpa of steam pressure.Medicinal extract yield is 65-70%, and medicinal extract is spare.
(7) Chinese medicine material concentrate is sent into spray dryer.Steam pressure control, will between 0.4MPa-0.5MPa
Spray dryer inlet air temperature is set as 150 DEG C, and leaving air temp is set as 180 DEG C, and charging rate is arranged on 3.5-4.0Hz, tower
Body pressure difference is maintained at-100-- 200Pa, collects powder, yield 10-15%, powder is packed into packaging bag, no more than bag volume 2/
3, with vacuum machine vacuum-pumping and sealing, labeling is weighed, it is spare.
(8) it mixes, allocate：Spray powder for being formulated inventory is put into the weight purified water such as addition in preparation tank, is steamed
Vapour is heated to 50 DEG C, heats while stirring to uniform, adds xylitol, is then slowly added into purified water constant volume 1000L, adjusts pH
To 6.5.
(9) it is filling：20ml/ bottles
(10) it sterilizes：108 DEG C of constant temperature sterilize 30 minutes.
(11) it packs.
2 preparation method of the present invention of embodiment
Raw material：Saussurea involucrata culture (dry product) 0.3kg, ginseng 2.5kg, balsam pear 7.5kg, corn stigma 4.5kg, Poria cocos 3.5kg,
Hawthorn 1.5kg, matrimony vine 1.8kg, Gynura procumbens (Lour.) Merr 4.5kg, resistant dextrin 2.5kg, xylitol 0.02kg.
Preparation process：With the preparation of embodiment 1.
Beneficial effects of the present invention are illustrated below by way of test example.
The effect of drug or health food prepared by 1 the method for the present invention of test example, is investigated
1st, composition prepared by Example 1 selects 20 to make a definite diagnosis diabetic, carries out compliance test result.
Specific method：It is eaten in 10 minutes after the meal, 3 times a day, each 20ml (equivalent solid content 6g), then with quick
Blood glucose meter detects.
It the results are shown in Table 1.
Table 1 data statistic (blood glucose value unit：MM/l)
As shown in Table 1, statistical data is shown：In 20 crowds, it is more than 10% to have 13 postprandial blood sugars to reduce ratio, is considered as
Effectively reduce blood glucose；It is more than 10% that 11 fasting blood-glucoses, which reduce ratio, and being considered as effectively reduces blood glucose；There is 1 to reduce insulin to use
Amount, therapeutic effect are notable.
2nd, composition prepared by Example 2 selects 20 to make a definite diagnosis diabetic, carries out compliance test result.
Specific method：It is eaten in 10 minutes after the meal, 3 times a day, each 20ml (equivalent solid content 6g), then with quick
Blood glucose meter detects.
It the results are shown in Table 2.
Table 2 data statistic (blood glucose value unit：MM/l)
As shown in Table 2, statistical data is shown：In 20 crowds, it is more than 10% to have 18 postprandial blood sugars to reduce ratio, is considered as
Effectively reduce blood glucose；It is more than 10% that 14 fasting blood-glucoses, which reduce ratio, and being considered as effectively reduces blood glucose；There are 17 to reduce insulin to use
Amount, therapeutic effect are notable.
To sum up, the composition that prepared by the method for the present invention can significantly reduce the blood glucose of diabetes and hyperglycemic patients, and
The insulin dosage of diabetic can be effectively reduced, therapeutic effect is notable；In addition, composition prepared by the method for the present invention is suitble to
As diabetes and the medicated food of hyperglycemic patients, and mouthfeel is good, and application prospect is good.
Claims (10)
1. a kind of preparation method of hypoglycemic composition, it is characterised in that：It includes the following steps：
(1) bulk pharmaceutical chemicals of following weight proportioning are weighed：1.6-3.4 parts of Saussurea involucrata culture, 7-27 parts of ginseng, 50-80 parts of balsam pear, jade
36-74 parts of rice palpus, 28-52 parts of Poria cocos, 12-18 parts of hawthorn, 15-21 parts of matrimony vine, 35-50 parts of Gynura procumbens (Lour.) Merr, resistant dextrin 16-
30 parts；
(2) it by ginseng extracting in water, then with papain enzymolysis, centrifuges, filter, being concentrated to give medicinal extract, it is spare；
(3) by balsam pear extracting in water, filter, be concentrated to give medicinal extract, it is spare；
(4) by Saussurea involucrata culture protease hydrolyzed, medicinal extract is then concentrated to give, it is spare；
(5) by the medicinal extract mixing of step (2)-(4), resistant dextrin is added in, is then spray-dried, it is spare；
(6) it by corn stigma, Poria cocos, hawthorn, matrimony vine, Gynura procumbens (Lour.) Merr extracting in water, filtering, concentration, is then spray-dried, it is standby
With；
(7) step (5) with the spray dried powder of step (6) is mixed, it is acceptable auxiliary adds in pharmacy, health products or field of food
Material or complementary ingredient are prepared into common preparation.
2. preparation method according to claim 1, it is characterised in that：
In step (2), the method for extraction is：It is extracted 2 times in multi-function extractor, wherein, for the first time plus 20 times of water is measured, 65 DEG C
Then temperature leaching 30 minutes, is extracted 1.5 hours, filtering at 95-100 DEG C；For the second time plus 10 times of amounts of water, other same first times carry
Method is taken, merges filtrate twice；
The method of enzymolysis is：The papain that mass percent is 3 ‰ is added in, is digested 6 hours under 30-40 DEG C or room temperature；
And/or concentration uses two effect concentration methods to relative density for 1.02 (65~70 DEG C).
3. preparation method according to claim 1, it is characterised in that：
In step (3), the method for extraction is：It is extracted 2 times in multi-function extractor, wherein, for the first time plus 10 times of water is measured, and 100
DEG C extraction 1 hour, filtering；For the second time plus 8 times of amounts of water, the extracting method of other same first times merge filtrate twice；
And/or concentration uses two effect concentration methods to relative density for 1.01 (65~70 DEG C).
4. preparation method according to claim 1, it is characterised in that：
In step (4), the method for enzymolysis is：The water of the weight such as addition, then adds in final mass percentage in Saussurea involucrata culture
Than the protease for 3 ‰, room temperature digests 12 hours；
And/or concentration uses two effect concentration methods to relative density for 1.01 (65~70 DEG C).
5. preparation method according to claim 1, it is characterised in that：
In step (5), the parameter of spray drying is：Inlet air temperature is 150 DEG C, and leaving air temp is 85 DEG C, charging rate for 3.5-
4.0Hz, tower body pressure difference are-100-- 200Pa.
6. preparation method according to claim 1, it is characterised in that：
In step (6), the method for extraction is：It is extracted 2 times in multi-function extractor, wherein, for the first time plus 10 times of water is measured, and 100
DEG C extraction 1 hour, filtering；For the second time plus 8 times of amounts of water, the extracting method of other same first times merge filtrate twice；
Concentration uses two effect concentration methods to relative density for 1.01 (65~70 DEG C)；
And/or the parameter of spray drying is：Inlet air temperature is 150 DEG C, and leaving air temp is 180 DEG C, charging rate for 3.5-
4.0Hz, tower body pressure difference are-100-- 200Pa.
7. preparation method according to claim 1, it is characterised in that：
In step (7), after spray dried powder is mixed, add purified water, then adjust pH value to 6.5, it is filling, sterilize to get.
8. according to the preparation method described in claim 1-7 any one, it is characterised in that：
In step (1), the weight proportion of bulk pharmaceutical chemicals is：
2-3 parts of Saussurea involucrata culture, 9-25 parts of ginseng, 55-75 parts of balsam pear, 45-65 parts of corn stigma, 35-45 parts of Poria cocos, hawthorn 15
Part, 18 parts of matrimony vine, 45 parts of Gynura procumbens (Lour.) Merr, 20-25 parts of resistant dextrin.
9. preparation method according to claim 8, it is characterised in that：
In step (1), the weight proportion of bulk pharmaceutical chemicals is：
2 parts of Saussurea involucrata culture, 55 parts of balsam pear, 65 parts of corn stigma, 45 parts of Poria cocos, 15 parts of hawthorn, 18 parts of matrimony vine, lies down 9 parts of ginseng
45 parts of chrysanthemum Radix Notoginseng, 20 parts of resistant dextrin；
Or,
3 parts of Saussurea involucrata culture, 75 parts of balsam pear, 45 parts of corn stigma, 35 parts of Poria cocos, 15 parts of hawthorn, 18 parts of matrimony vine, is put down at 25 parts of ginseng
Sleeping 45 parts of chrysanthemum Radix Notoginseng, 25 parts of resistant dextrin.
10. according to preparation method described in any one of claim 1-9, it is characterised in that：
Protein >=20%, general flavone >=7%, moisture≤10%, ash content≤10% of the Saussurea involucrata culture；
Preferably, the Saussurea involucrata culture is purchased from Dalian Puruikang Biotechnology Co.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108743728A (en) * | 2018-08-20 | 2018-11-06 | 江西佳家易购实业有限公司 | EGCG theanine sanqi tablets and its preparation process |
| CN111109587A (en) * | 2018-11-01 | 2020-05-08 | 韩连慧 | Food with effects of reducing blood glucose level in human body and enhancing immunity and preparation method thereof |
| CN112616973A (en) * | 2020-12-28 | 2021-04-09 | 安徽致鑫中药饮片有限公司 | Preparation method of bitter gourd substitutional tea with blood sugar reducing effect |
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| CN1471848A (en) * | 2003-07-08 | 2004-02-04 | 杜越新 | Food for regulating blood fat and blood sugar with haw powder and balsam pear powder as material |
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| CN111109587A (en) * | 2018-11-01 | 2020-05-08 | 韩连慧 | Food with effects of reducing blood glucose level in human body and enhancing immunity and preparation method thereof |
| CN112616973A (en) * | 2020-12-28 | 2021-04-09 | 安徽致鑫中药饮片有限公司 | Preparation method of bitter gourd substitutional tea with blood sugar reducing effect |
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