CN108175838B

CN108175838B - Fuming and washing medicine for treating blood-heat type psoriasis

Info

Publication number: CN108175838B
Application number: CN201810251951.4A
Authority: CN
Inventors: 王吉坤; 王冬青
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-03-26
Filing date: 2018-03-26
Publication date: 2021-03-16
Anticipated expiration: 2038-03-26
Also published as: CN108175838A

Abstract

The invention discloses a fumigation medicine for treating blood-heat psoriasis, which is prepared by putting pomegranate rind, carpesium, radix sophorae flavescentis, rheum officinale, honeysuckle, fructus forsythiae, scutellaria baicalensis, cortex dictamni, rhizoma smilacis glabrae, radix sileris, golden cypress, dandelion, herba violae and coptis chinensis into a decoction pot, adding water which is 5-15 times of the total amount of traditional Chinese medicines, soaking for 1-3 hours, decocting with slow fire until the medicinal liquid is reduced by about 1/3-1/5, filtering out medicinal residues, taking the medicinal liquid, putting the medicinal liquid into a fumigation machine, and fumigating and washing patients with blood-heat psoriasis at the temperature of 38-42 ℃. The invention has the advantages of high cure rate, small side effect and difficult relapse, and has the beneficial effects of clearing heat, not damaging yin, moistening dryness, protecting skin and not generating drug resistance.

Description

Fuming and washing medicine for treating blood-heat type psoriasis

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, relates to a medicine for treating psoriasis, and particularly relates to a fumigation-washing medicine for treating blood-heat psoriasis.

Background

Psoriasis is a common chronic inflammatory skin disease and has the characteristics of stubborn and recurrent. The etiology is unknown, and the disease is considered to be caused by the interaction of various factors such as genetic factors and environmental factors. The disease is obviously seasonal, and the disease condition of most patients is aggravated in spring and winter and relieved in summer. The initial age is usually 10-30 years, and may occur at any age, with more men than women. Clinically, the traditional Chinese medicine is divided into four common types, namely an ordinary type, a pustule type, a joint type and a red skin disease type. The skin lesion is characterized in that erythema pimple appears at first, the surface is covered with a layer of silvery white scales, the skin is dry and dry, desquamation and crusting are generated, and some skin symptoms are connected into a piece like a map, have pruritus, pus flowing water, blood stain and witness. At present, the western medicine generally adopts oral medicines such as vitamins, antibiotics, anti-tumor medicines, heavy metals, immunomodulators or agonists, medicines acting on the nervous system and the like or external medicines such as hormones, keratinocyte, cytotoxic agents and the like, and generally combines ultraviolet irradiation, photochemical method and the like to comprehensively treat the disease. However, clinical practice proves that the medicines and the therapies often generate toxic and side effects and have a plurality of contraindications.

Disclosure of Invention

In order to solve the problems in the prior art, the invention discloses a fumigation medicine for treating blood-heat psoriasis, which has the advantages of high cure rate, safety, no toxic or side effect, difficult relapse, convenient use, no restriction of places and environments, no toxic or side effect, no damage to yin by clearing heat, dryness moistening and skin care, no drug resistance generation, and capability of being decocted by a fumigation machine or a pot and then subjected to fumigation

The invention is realized by the following technical scheme:

the invention discloses a fumigation-washing medicine for treating blood-heat psoriasis, which is prepared from the following raw materials in parts by weight:

15-25 parts of pomegranate bark, 15-25 parts of common carpesium fruit, 15-25 parts of radix sophorae flavescentis, 8-16 parts of rheum officinale

Honeysuckle flower 25-35 parts of weeping forsythia 8-16 parts of baikal skullcap root 8-16 parts of dittany bark 8-16 parts

20-40 parts of glabrous greenbrier rhizome, 20-40 parts of divaricate saposhnikovia root, 8-16 parts of amur corktree bark, 10-20 parts of dandelion

20-40 parts of Chinese violet, 8-16 parts of goldthread root.

As a preferred embodiment, the fumigation medicine for treating blood-heat psoriasis is prepared from the following raw materials in parts by weight:

18-22 parts of pomegranate bark, 18-22 parts of common carpesium fruit, 18-22 parts of radix sophorae flavescentis, 10-14 parts of rumex madaio

28-32 parts of honeysuckle, 10-14 parts of fructus forsythiae, 10-14 parts of scutellaria baicalensis, 10-14 parts of cortex dictamni

25-35 parts of glabrous greenbrier rhizome, 25-35 parts of divaricate saposhnikovia root, 10-14 parts of amur corktree bark, 12-18 parts of dandelion

25-35 parts of Chinese violet and 10-14 parts of goldthread root.

pomegranate bark 20 parts, carpesium 20 parts, flavescent sophora root 20 parts, rhubarb root 12 parts

Honeysuckle flower 30 parts, weeping forsythia 12 parts, baikal skullcap root 12 parts, dittany bark 12 parts

Glabrous greenbrier rhizome 30 parts, divaricate saposhnikovia root 30 parts, amur corktree bark 12 parts, dandelion 15 parts

30 parts of Chinese violet and 12 parts of coptis root.

The invention also discloses a preparation method of the fumigation medicine for treating blood-heat psoriasis, which comprises the steps of firstly putting the traditional Chinese medicine raw materials in proportion into a medicine decocting pot, adding water which is 5-15 times of the total amount of the traditional Chinese medicine, soaking for 1-3 hours, then decocting with slow fire until the medicine juice is reduced by about 1/3-1/5, filtering out medicine residues, taking the medicine juice, and putting the medicine juice into a fumigation machine; the traditional Chinese medicine raw materials can also be used for other existing fumigation apparatuses, and if necessary, the method for decocting the traditional Chinese medicine is adjusted; of course, the medicine decocting pot or the household stainless steel pot can be used for fumigation and washing.

The traditional Chinese medicine raw materials and the formula are selected according to the traditional Chinese medicine theory and the ancestral experience, and repeated practice and screening of years of research and experience, and the medicine property and the efficacy are combined. According to the invention, the common carpesium fruit is matched with the Chinese violet and the pomegranate rind, so that the Chinese violet has better anti-inflammatory and cooling effects, and can have good treatment effects on the psoriasis symptoms such as dry skin, desquamation and scabbing, pus discharge and running water; the carpesium abrotanoides is matched with the cortex dictamni, the honeysuckle and the golden cypress, so that the honeysuckle has better antipyretic, detoxication and sterilization effects and longer drug effect, and the generation rate of drug resistance of intractable psoriasis patients is reduced; the compatibility of the divaricate saposhnikovia root, the philippine violet herb, the baical skullcap root, the golden thread and the weeping forsythia improves the cure rate of psoriasis and prevents relapse; the radix sophorae flavescentis can reduce the cold property of the cortex phellodendri and the rheum officinale, and achieves the effects of moistening dryness and protecting skin by a fumigation therapy without damaging yin through clearing heat on the premise of further reducing side effects.

According to the characteristics of fumigation, washing and introduction of traditional Chinese medicines, the traditional Chinese medicine composition takes medicine properties and efficacies as main materials, combines the compatible components with long-term practical experience, has obvious treatment effect on psoriasis, especially blood-heat psoriasis, greatly reduces the generation rate and the medicine resistance of the medicine resistance, and is not easy to relapse; has no hormone and no side effect, can be used by pregnant women and lactating women, and has good therapeutic effect.

Detailed Description

The following description is presented to disclose the invention so as to enable any person skilled in the art to practice the invention. The preferred embodiments in the following description are given by way of example only, and other obvious variations will occur to those skilled in the art.

Example 1

A fumigation-washing medicine for treating blood-heat psoriasis is prepared from the following raw materials in parts by weight: 15g of pomegranate bark, 25 g of common carpesium fruit, 15g of lightyellow sophora root, 16 g of rhubarb root, 2 g of honeysuckle flower, 16 g of weeping forsythia fruit, 8 g of baical skullcap root, 16 g of densefruit pittany root-bark, 20 g of glabrous greenbrier rhizome, 40 g of divaricate saposhnikovia root, 8 g of amur corktree bark, 20 g of dandelion, 20 g of Chinese violet and 16 g of coptis chinensis;

putting the traditional Chinese medicine raw materials in proportion into a decocting pot, adding water which is 5 times of the total amount of the traditional Chinese medicine, soaking for 3 hours, decocting with slow fire until the decoction is reduced by about 1/5, filtering to remove residues, taking the decoction, putting the decoction into a fumigating machine, and fumigating and washing patients with blood-heat psoriasis at the temperature of 38-42 ℃.

Example 2

A fumigation-washing medicine for treating blood-heat psoriasis is prepared from the following raw materials in parts by weight: 25 g of pomegranate bark, 15g of carpesium abrotanoides, 25 g of radix sophorae flavescentis, 8 g of rheum officinale, 35 g of honeysuckle, 8 g of fructus forsythiae, 16 g of scutellaria baicalensis, 8 g of cortex dictamni, 40 g of rhizoma smilacis glabrae, 20 g of radix sileris, 16 g of golden cypress, 10 g of dandelion, 40 g of herba violae and 8 g of coptis chinensis;

putting the traditional Chinese medicine raw materials in proportion into a decocting pot, adding water 15 times of the total amount of the traditional Chinese medicine, soaking for 1 hour, decocting with slow fire until the decoction is reduced by about 1/3, filtering to remove residues, taking the decoction, putting into a fumigating machine, and fumigating and washing patients with blood-heat psoriasis at the temperature of 38-42 ℃.

Example 3

A fumigation-washing medicine for treating blood-heat psoriasis is prepared from the following raw materials in parts by weight: 18 g of pomegranate bark, 22 g of common carpesium fruit, 18 g of lightyellow sophora root, 14 g of rhubarb root, 28 g of honeysuckle flower, 14 g of weeping forsythia, 10 g of baical skullcap root, 14 g of dittany bark, 25 g of glabrous greenbrier rhizome, 35 g of divaricate saposhnikovia root, 10 g of amur corktree bark, 18 g of dandelion, 25 g of Chinese violet and 14 g of goldthread root;

putting the traditional Chinese medicine raw materials in proportion into a decocting pot, adding water 12 times of the total amount of the traditional Chinese medicine, soaking for 2 hours, decocting with slow fire until the decoction is reduced by about 1/4, filtering to remove residues, taking the decoction, putting the decoction into a fumigating machine, and fumigating and washing patients with blood-heat psoriasis at the temperature of 38-42 ℃.

Example 4

A fumigation-washing medicine for treating blood-heat psoriasis is prepared from the following raw materials in parts by weight: 22 g of pomegranate bark, 18 g of common carpesium fruit, 22 g of lightyellow sophora root, 10 g of rhubarb root, 32 g of honeysuckle flower, 10 g of weeping forsythia, 14 g of baical skullcap root, 10 g of dittany bark, 35 g of glabrous greenbrier rhizome, 25 g of divaricate saposhnikovia root, 14 g of amur corktree bark, 12 g of dandelion, 35 g of philippine violet herb and 10 g of goldthread root;

putting the traditional Chinese medicine raw materials in proportion into a medicine decocting pot, adding water with the amount 8 times of the total amount of the traditional Chinese medicine, soaking for 1.5 hours, decocting with slow fire until the medicine juice is reduced by about 1/4, filtering to remove medicine residues, taking the medicine juice to obtain the traditional Chinese medicine, putting the traditional Chinese medicine into a fumigating machine, and fumigating and washing patients with blood-heat psoriasis at the temperature of 38-42 ℃.

Example 5

A fumigation-washing medicine for treating blood-heat psoriasis is prepared from the following raw materials in parts by weight: 20 g of pomegranate bark, 20 g of carpesium abrotanoides, 20 g of radix sophorae flavescentis, 12 g of rheum officinale, 30 g of honeysuckle, 12 g of fructus forsythiae, 12 g of scutellaria baicalensis, 12 g of cortex dictamni, 30 g of rhizoma smilacis glabrae, 30 g of divaricate saposhnikovia root, 12 g of golden cypress, 15g of dandelion, 30 g of philippine violet herb and 12 g of coptis chinensis;

putting the traditional Chinese medicine raw materials in proportion into a medicine decocting pot, adding water which is 10 times of the total amount of the traditional Chinese medicine, soaking for 2.5 hours, decocting with slow fire until the medicine juice is reduced by about 1/5, filtering out medicine residues, taking the medicine juice to obtain the traditional Chinese medicine composition, putting the traditional Chinese medicine composition into a fumigating machine, and fumigating and washing patients with blood-heat psoriasis at the temperature of 38-42 ℃.

1.1 in the research process of the invention, patients are all selected for clinic visit of dermatology department, and the psoriasis is diagnosed as blood-heat type, and the diagnosis standard is according to the traditional Chinese medicine science. The clinical manifestations are that rash appears continuously, the development is rapid, the rash appears drop-shaped, the color is bright red, the scale is increased, the pruritus is severe, and sieve-shaped bleeding points are caught; dry mouth and tongue, sore throat, vexation, irritability, dry stool, yellow and red urine; the tongue is red, thin and yellow with thin coating, and the pulse is wiry, slippery or rapid, and 200 cases are selected in total.

1.2 randomized into two groups: the treatment groups comprise 100 cases, 45 cases for men, 55 cases for women, 2 cases for pregnant women and 1 case for lactation; age 19-58 years, average 32.5 years; the course of the disease is 7 days to 5 years, and the average is 2 months. The control group comprises 100 cases, 47 cases for men, 53 cases for women, 0 case for pregnant women and 0 case for lactation; age 21-54 years, mean 29.5 years; the course of the disease is 7 days to 4 years, and the average is 1.8 months. The comparison difference of age, sex, disease course and disease condition of two groups has no statistical significance (P >0.05) and is comparable.

1.3 treatment groups: the fumigation and washing medicine of the embodiment 5 is used for carrying out fumigation and washing treatment on patients with blood-heat psoriasis for 1 to 2 treatment courses, each treatment course comprises 10 days, 1 dose per day, and 1 to 2 times per dose, and the medicine juice left after the first fumigation and washing is thrown away or used for the second fumigation and washing on the day;

control group: the Chinese medicine standard of the Xiaoyin capsule Z20000110 is used; produced by Shaanxi Momeide pharmaceutical Co., Ltd.) 5-7 granules, 3 times per day, 10 days as one treatment course, 1-2 treatment courses;

contraindications:

1. during administration, fried sticky food, cold solid hard food, non-digestible and irritant food are prohibited;

2. oral administration is prohibited.

1.4 clinical treatment effects:

the curative effect standard is as follows: efficacy was assessed according to the international general psoriasis lesion area severity index (PASI) scoring criteria.

And (3) healing: the PASI integral is reduced by more than or equal to 90 percent, the skin damage is completely removed or only a few bit of damage is remained, and the pruritus disappears;

the effect is shown: the skin is reduced by 60 to 89 percent, the skin damage is reduced by more than 60 percent, and the skin is occasionally itchy;

the method has the following advantages: the skin damage is reduced by 25-9%, the skin damage is removed by more than 30%, and the skin is still itchy;

and (4) invalidation: the integral is reduced by less than 25%, the skin damage is reduced by less than 30% or is not improved, and the skin is obviously itchy and cannot be tolerated;

the effective rate is calculated by healing, obvious effect and effective total. The patients with recovery and significant effect are observed by follow-up observation, and after 6 months, if the PASI score is increased by 50 percent compared with the PASI score when the treatment is stopped, the disease is judged to be relapse.

1.5 treatment results were as follows:

the two data sets were compared using the x2 test, and P <0.05 was statistically significant.

From the data in the table, the effective rate (curing with more significant effect) is obviously better than that of the control group when the fumigation medicament for treating the blood-heat psoriasis is used for fumigation; the half-year recurrence rate of the two groups of patients with recovery and obvious effect is obviously lower than that of the control group, and no toxic or side effect exists.

The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. The fumigation-washing medicine for treating blood-heat psoriasis is characterized by being prepared from the following raw materials in parts by weight:

20-40 parts of Chinese violet, 8-16 parts of goldthread root.

2. The fumigation and washing medicine for treating blood-heat psoriasis as claimed in claim 1, which is prepared from the following raw materials in parts by weight:

25-35 parts of Chinese violet and 10-14 parts of goldthread root.

3. The fumigation and washing medicine for treating blood-heat psoriasis as claimed in claim 1, which is prepared from the following raw materials in parts by weight:

30 parts of Chinese violet and 12 parts of coptis root.